LOCUS       NM_004292               4419 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Ras and Rab interactor 1 (RIN1), transcript variant 1,
            mRNA.
ACCESSION   NM_004292
VERSION     NM_004292.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4419)
  AUTHORS   Osei Saahene,R., Barnes,P., Yeboah,F.A., Agbo,E., Asante,D.B. and
            Arhin,S.K.
  TITLE     Expression of RAS and RAB interactor 1 (RIN1) in head and neck
            tumors at selected hospital in Ghana
  JOURNAL   PLoS One 19 (4), e0301295 (2024)
   PUBMED   38635569
  REMARK    GeneRIF: Expression of RAS and RAB interactor 1 (RIN1) in head and
            neck tumors at selected hospital in Ghana.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4419)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 4419)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   4  (bases 1 to 4419)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   5  (bases 1 to 4419)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4419)
  AUTHORS   Afar,D.E., Han,L., McLaughlin,J., Wong,S., Dhaka,A., Parmar,K.,
            Rosenberg,N., Witte,O.N. and Colicelli,J.
  TITLE     Regulation of the oncogenic activity of BCR-ABL by a tightly bound
            substrate protein RIN1
  JOURNAL   Immunity 6 (6), 773-782 (1997)
   PUBMED   9208849
REFERENCE   7  (bases 1 to 4419)
  AUTHORS   Han,L., Wong,D., Dhaka,A., Afar,D., White,M., Xie,W., Herschman,H.,
            Witte,O. and Colicelli,J.
  TITLE     Protein binding and signaling properties of RIN1 suggest a unique
            effector function
  JOURNAL   Proc Natl Acad Sci U S A 94 (10), 4954-4959 (1997)
   PUBMED   9144171
REFERENCE   8  (bases 1 to 4419)
  AUTHORS   Han,L. and Colicelli,J.
  TITLE     A human protein selected for interference with Ras function
            interacts directly with Ras and competes with Raf1
  JOURNAL   Mol Cell Biol 15 (3), 1318-1323 (1995)
   PUBMED   7862125
REFERENCE   9  (bases 1 to 4419)
  AUTHORS   Colicelli,J., Nicolette,C., Birchmeier,C., Rodgers,L., Riggs,M. and
            Wigler,M.
  TITLE     Expression of three mammalian cDNAs that interfere with RAS
            function in Saccharomyces cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 88 (7), 2913-2917 (1991)
   PUBMED   1849280
REFERENCE   10 (bases 1 to 4419)
  AUTHORS   Trowbridge,I.S., Lesley,J., Trotter,J. and Hyman,R.
  TITLE     Thymocyte subpopulation enriched for progenitors with an
            unrearranged T-cell receptor beta-chain gene
  JOURNAL   Nature 315 (6021), 666-669 (1985)
   PUBMED   3874369
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L36463.1, BC014417.1, BQ956294.1, BG163919.1 and AP001107.5.
            
            On Nov 23, 2018 this sequence version replaced NM_004292.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L36463.1, SRR3476690.1091027.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311320.9/ ENSP00000310406.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                L36463.1           96-116
            22-1978             BC014417.1         7-1963
            1979-1980           BQ956294.1         758-759
            1981-2143           L36463.1           2076-2238
            2144-2557           BG163919.1         20-433
            2558-2566           L36463.1           2653-2661
            2567-2589           BG163919.1         444-466
            2590-4419           AP001107.5         70497-72326         c
FEATURES             Location/Qualifiers
     source          1..4419
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..4419
                     /gene="RIN1"
                     /note="Ras and Rab interactor 1"
                     /db_xref="GeneID:9610"
                     /db_xref="HGNC:HGNC:18749"
                     /db_xref="MIM:605965"
     exon            1..118
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..2384
                     /gene="RIN1"
                     /note="isoform 1 is encoded by transcript variant 1; ras
                     inhibitor 1; ras inhibitor RIN1; ras inhibitor JC99; ras
                     interaction/interference protein 1"
                     /codon_start=1
                     /product="ras and Rab interactor 1 isoform 1"
                     /protein_id="NP_004283.2"
                     /db_xref="CCDS:CCDS31614.1"
                     /db_xref="GeneID:9610"
                     /db_xref="HGNC:HGNC:18749"
                     /db_xref="MIM:605965"
                     /translation="MESPGESGAGSPGAPSPSSFTTGHLAREKPAQDPLYDVPNASGG
                     QAGGPQRPGRVVSLRERLLLTRPVWLQLQANAAAALHMLRTEPPGTFLVRKSNTRQCQ
                     ALCMRLPEASGPSFVSSHYILESPGGVSLEGSELMFPDLVQLICAYCHTRDILLLPLQ
                     LPRAIHHAATHKELEAISHLGIEFWSSSLNIKAQRGPAGGPVLPQLKARSPQELDQGT
                     GAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGAVPS
                     QTERLPPCQLLRRESSVGYRVPAGSGPSLPPMPSLQEVDCGSPSSSEEEGVPGSRGSP
                     ATSPHLGRRRPLLRSMSAAFCSLLAPERQVGRAAAALMQDRHTAAGQLVQDLLTQVRA
                     GPEPQELQGIRQALSRARAMLSAELGPEKLLSPKRLEHVLEKSLHCSVLKPLRPILAA
                     RLRRRLAADGSLGRLAEGLRLARAQGPGAFGSHLSLPSPVELEQVRQKLLQLLRTYSP
                     SAQVKRLLQACKLLYMALRTQEGEGAGADEFLPLLSLVLAHCDLPELLLEAEYMSELL
                     EPSLLTGEGGYYLTSLSASLALLSGLGQAHTLPLSPVQELRRSLSLWEQRRLPATHCF
                     QHLLRVAYQDPSSGCTSKTLAVPPEASIATLNQLCATKFRVTQPNTFGLFLYKEQGYH
                     RLPPGALAHRLPTTGYLVYRRAEWPETQGAVTEEEGSGQSEARSRGEEQGCQGDGDAG
                     VKASPRDIREQSETTAEGGQGQAQEGPAQPGEPEAEGSRAAEE"
     exon            119..299
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            300..414
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..487
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..579
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..1317
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1623
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1755
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1907
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..4419
                     /gene="RIN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2552..2557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIN1"
                     /note="hexamer: AATAAA"
     polyA_site      2596
                     /gene="RIN1"
                     /note="major polyA site"
     regulatory      4401..4406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIN1"
                     /note="hexamer: AATAAA"
     polyA_site      4419
                     /gene="RIN1"
ORIGIN      
        1 attctcttcc tgaagcgaag gagctcccag ccatggaaag ccctggagag tcaggcgcgg
       61 gctctcctgg agcccccagc ccgtccagct tcactactgg gcacctggcg agagaaaagc
      121 cagcccagga cccactgtat gacgtgccca atgccagcgg cgggcaggca ggcgggccgc
      181 agcggccggg gcgcgttgtg agcctgcggg agcgcctgct gctcacccgg cccgtgtggc
      241 tgcagctgca agccaacgca gcggccgcac tgcacatgct gaggaccgag cccccgggga
      301 cgttcctcgt gcggaaatct aacacccgcc agtgccaggc cctgtgcatg cggttgcctg
      361 aagccagtgg cccctccttc gtctccagcc actacatcct ggagagccct ggcggcgtct
      421 ccttggaggg ctcggagctc atgttcccag acctagtcca gctcatctgt gcctactgcc
      481 acacccggga catccttctc ctcccgctgc agctccccag agccatccac cacgcagcca
      541 ctcacaaaga gctggaggcc atctcccatc tgggcattga gttctggagc tcctccctca
      601 acatcaaggc tcagcggggc ccggctggag gcccagtgtt gccccagctg aaggcccggt
      661 cccctcaaga gctggaccag ggcaccggag ccgccttgtg cttcttcaac cccctgttcc
      721 cgggggacct agggcccacc aagcgggaga aattcaagag aagcttcaaa gtgcgcgtgt
      781 ccacagagac ctccagcccc ctgtctccac ctgccgtgcc acctcccccc gtccccgtgc
      841 tgccaggggc agtccccagc cagacagagc ggctgccccc ttgccagctg ctacggaggg
      901 agagctcagt ggggtaccgc gtgccagcag gcagtggccc tagccttccg cctatgccct
      961 ccctccaaga ggtggactgc ggctccccca gcagctccga ggaggagggg gtgccagggt
     1021 cccgggggag cccagcgacc tcaccccacc tgggccgccg acgacctctg cttcggtcca
     1081 tgagcgccgc cttctgctcc ctactggcac cggagcggca ggtgggccgg gctgcggcag
     1141 cactgatgca ggaccgacac acagccgcgg gccagctggt gcaggaccta ctgacccagg
     1201 tgcgggctgg gcccgagccc caggagctgc agggcatccg tcaggcgctg agccgggccc
     1261 gggccatgct gagtgcggag ctgggccctg agaagctgct gtcgcctaag aggctggaac
     1321 atgtcctgga gaagtcattg cattgctctg tgctcaagcc tctccggccc atcctggcag
     1381 cccgcctgcg gcgccggctt gccgcagacg gctccctggg ccgcctagct gagggcctcc
     1441 gcctggcccg ggcccagggc cccggagcct tcgggtccca cctgagcctg ccctccccag
     1501 tagagttgga gcaagtgcgc cagaagctgc tgcagctgct ccgcacctac tcacccagcg
     1561 cccaggtcaa gcggctcctg caggcctgca agctgctcta catggccctg aggacccagg
     1621 aaggggaggg cgcgggtgcc gacgagttcc tgcctctgct gagcctcgtc ttggcccact
     1681 gtgaccttcc tgagctgctg ctggaggccg agtacatgtc ggagctgctg gagcccagcc
     1741 tgcttactgg agagggtggc tactacctga ccagcctctc tgccagcctg gccctgctga
     1801 gtggcctggg tcaggcccac accctcccac tgagccccgt gcaggagcta cggcgctccc
     1861 tcagcctctg ggagcagcgc cgcctgcctg ccacccactg cttccagcac ctcctccgag
     1921 tagcctatca ggatcccagc agtggctgca cctccaagac cctggccgtg cccccagaag
     1981 cctcgattgc caccctgaac cagctctgtg ccaccaagtt ccgagtgacc cagcccaaca
     2041 cttttggcct cttcctgtac aaggagcagg gctaccaccg cctgccccct ggggccctgg
     2101 cccacaggct gcccaccact ggctacctcg tctaccgccg ggcggagtgg cctgagaccc
     2161 agggggctgt gacagaggag gagggcagtg ggcagtcaga ggcaagaagc agaggggagg
     2221 agcaagggtg ccagggagat ggggatgctg gggtcaaagc cagccccagg gacattcggg
     2281 aacagtctga gacaactgct gaagggggcc agggtcaagc ccaggaaggc cctgctcagc
     2341 caggggaacc agaggcagag ggaagccggg cagcagagga gtagcttgaa gtggccagaa
     2401 gggtcattcg gggcgggaga ccctgagcct gctgagaaat ccttttagcg ccagcaagcc
     2461 ccacccaggg ccctgtcctg tgtctgccac cacctttgtc tgatacttgt ttccagggaa
     2521 gctgggggaa ctgccacatc tgaggaactg gaataaagat gagggggctt cgggggcccc
     2581 cagactgtgt gcccaaggcc ccttgcctct tgttcttctc ccccagctga gggtgagcca
     2641 gcctgcaatg agggtgtgcc aagtgggggc gaatccgaca gatgcccaac ctctgacgtg
     2701 gggagggtga cggtctcagc tccttttacc cttcccctca tgggcatggc tgaggcaggg
     2761 ctccacccaa gtatctccca ccaggctggg acttccagac cctaaaaggt tccaatggct
     2821 cttaggtgtc aggaggattt agagaggcca cagaacagca gcaaaggctt ggggcccacc
     2881 cctgtcctgg acaccagaag gacctgcacc tgcaagcctc agtactctca tctgtaaagt
     2941 ggggacacta ttgctgccct gctcggctcc cagaagtgtc ccagtgatca aaatgggtga
     3001 ttttgctaca agcagagctc atggcagaaa gggagggaga gagctgggct gctaactctc
     3061 tcccggagtc cgctctctgc cagacagggc tcccacctgc tgatgcccag ttcagggagg
     3121 ttattcccct ggaaatcagg ccctggggag aaagtaccca agttacagtc tctccccaag
     3181 atttggagtc ctcccaggcc ctccagcatc tctggggaga tccaccagct ggcagataag
     3241 cttccagaat ggagaggggg ctcagaaacc atgctctctg cactaaactc ttggccctca
     3301 caaaagcttt acttggccat gacttgttgg gcccactgag ggtcaggaaa gtgactccca
     3361 ggatgtcata tagcaagtcc ttaagggttc ccccgcccaa accagggcat caggttccaa
     3421 ctccaccctc cattctaagc cacccacaaa ggccggggca gcccccaagg aagcccagag
     3481 caggcagcaa atccaaacaa ggaaaagtgc cgaccaccaa ccacgagggg gtgtgcacgg
     3541 cccgggaatc tgccgagagg gtgaccaccc aggggtgagg gcgcctccaa ggctgcagca
     3601 gcagaggggg tcccgggcct tgcagtccag cagcatcagg caacctgggg acagcgcagg
     3661 ggccaaggcc actggccccc aggtccctta gattctgggg tctgggtaag gccagcctct
     3721 tgggggccat ccccaggaag gaaggaattg tccccttatg gaggatgacc ccagaggctc
     3781 tctcctcggg cactgagcac agaggggacg tcagcccaaa tgtcagacat gacaactggg
     3841 aggtagaaat cgtggacatt ggctttttgg gtttttttgt ttgtttgttt gtttgagatg
     3901 gagttttgct ctgtcgctct ggctaaagtg cagtggtgcc atctcggctc acagcaacct
     3961 tcgcctccca gttcaagtga ttctcctgcc tcagcctccc gagtagctgg gactacaggt
     4021 gtgcaccacc acacctggct aatttttgtg ttactagtag agacggggtt tccccatgtt
     4081 ggccaggctg gtctcaaact cccgacctca ggtgatccgc ccgccttggc ctcccaaagt
     4141 actgggatta caggcgtgag ctaccacacc cagccagaca ttgactttca gatgagcagt
     4201 ccagatacag cccagttgca cggctcccat tttttttgtc actaggccac cagcagctct
     4261 tccctcccca cttccacgcc ctcccaaggt tctcgctgat aggaagtgtc ccgttggctc
     4321 ttctattccc ctccctgttt caccactcac ccctagtgcc tcacacagtc caatgctgag
     4381 cacaaatgcc ataggtgttc aataaatgtt gttcactga
//
