LOCUS       NM_182970               5411 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens regulating synaptic membrane exocytosis 4 (RIMS4),
            transcript variant 2, mRNA.
ACCESSION   NM_182970
VERSION     NM_182970.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5411)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5411)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 5411)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   4  (bases 1 to 5411)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL118522.32 and BU167487.1.
            
            On Jun 2, 2019 this sequence version replaced NM_182970.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126807.1, BC104190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372851.8/ ENSP00000361942.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AL118522.32        72477-72684         c
            209-919             BU167487.1         1-711
            920-5411            AL118522.32        13946-18437         c
FEATURES             Location/Qualifiers
     source          1..5411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..5411
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /note="regulating synaptic membrane exocytosis 4"
                     /db_xref="GeneID:140730"
                     /db_xref="HGNC:HGNC:16183"
                     /db_xref="MIM:611601"
     exon            1..372
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1085
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /note="isoform 2 is encoded by transcript variant 2;
                     regulating synaptic membrane exocytosis protein 4;
                     rab3-interacting molecule 4; RIM4 gamma"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     4 isoform 2"
                     /protein_id="NP_892015.1"
                     /db_xref="CCDS:CCDS13338.1"
                     /db_xref="GeneID:140730"
                     /db_xref="HGNC:HGNC:16183"
                     /db_xref="MIM:611601"
                     /translation="MERSQSRLSLSASFEALAIYFPCMNSFDDEDAGDSRRLKGAIQR
                     STETGLAVEMPSRTLRQASHESIEDSMNSYGSEGNLNYGGVCLASDAQFSDFLGSMGP
                     AQFVGRQTLATTPMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLE
                     NGICIAKKKTKVARKSLDPLYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARV
                     LLEELDLTTLAVGWYKLFPTSSMVDPATGPLLRQASQLSLESTVGPCGERS"
     exon            373..511
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            512..624
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            625..726
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            727..866
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            867..5411
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5389..5394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /note="hexamer: ATTAAA"
     polyA_site      5411
                     /gene="RIMS4"
                     /gene_synonym="C20orf190; RIM 4; RIM-4; RIM4; RIM4-gamma;
                     RIM4gamma"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgct gcgccgccac cgccgccgcc accgccgccg ccgccgccgc cgccagcagc
       61 acagcgcgcc tcgggctccg cgcgccgcca gctcctggcc cgcccgccgg ccccgccgcg
      121 cccgccagcc ccgcagcgga gcctcggccc ggccccgggc cgccgccacc acgccgcgcg
      181 ccgtactccg cgtcaagaat ggggcggcca agctgcccaa gccgcccgcc gccgccgccg
      241 ccgccgcggc cgaggcgccc ggcgccggcg cgggcatgga gcgctcgcag agccgcctca
      301 gtctgtccgc ctccttcgag gcgctcgcca tctacttccc gtgcatgaac tccttcgacg
      361 acgaggacgc aggggacagc cggaggctga agggggccat ccagaggagc acggagacgg
      421 gcctggcagt ggagatgccc agccggacac tgcgccaggc cagccacgag tccattgagg
      481 acagcatgaa cagctatggc tcagagggca accttaacta tggaggagtt tgcctggcgt
      541 cggacgccca gttcagtgac ttcctgggaa gcatggggcc ggcacagttt gtgggccgcc
      601 agaccctggc caccacaccc atgggggatg tggagatcgg tctgcaggag cggaacggtc
      661 agttggaggt ggacattatc caggctcggg gactgacagc caagccaggc tccaagacac
      721 tgccagcggc ctacatcaag gcctacctgc tagagaatgg catctgcatt gccaagaaga
      781 agaccaaagt cgctcgcaag tcgctggacc cactgtataa ccaggtgctg ctgtttcctg
      841 agagtcccca gggcaaagtc ctccaggtga tcgtgtgggg gaactacggg cggatggagc
      901 ggaagcagtt catgggtgtg gctcgcgtgc tgctggagga gctggacttg accaccctgg
      961 ccgtgggctg gtacaagctc ttccccacct cctccatggt ggacccagcc acaggccccc
     1021 tgctccggca ggcatcccag ttgtccctcg agagcaccgt ggggccctgc ggagaacgat
     1081 cttagtgctg gaatggggag gggctcccca agatggcctg gagaccaccc agccctgacc
     1141 tgggacccca ggcccagggg cacattgaac aggaggacgg ggctctcccc cacagtgggg
     1201 aagcagaacg gggagacctg cccccccttg ggcccctcct caccccttct ttgcctccta
     1261 cccccgagac ctcccctctc ccaacgggat tggctacact tttgacttgg ccggttcttg
     1321 acctggtgga tgtggctgca gtccagagaa aggaaagatt gaggtggcag agcagaccac
     1381 tctcccttcc caaactgtcc aacttctccc cctttttgcc tcctcggaag ctcgctgccc
     1441 agagccatgt ccagaaccca gccggccatc tccatggtgc caattaccag caagtgtctt
     1501 tcctgcggca ccgggttcag gcagctactc ctgccccaga gatgaagggg cagctttgca
     1561 aggatccgga gccagctccc aggggcccag agccccccac ttgaagagga gcttgagctt
     1621 ccctctgcct gcccgtggaa ggagctttgc cgcagcctgt ccgagtccat ccgtccgtcc
     1681 cctcctgcct gcccctcttc tggtggctct aggaattggg gttcagcagg gaccaaagga
     1741 aaggaggagg tgccgggggc ctggcacaga cccctaggtg cctcgctcca tgggattgca
     1801 acaagctagt ttaggaaccg ctggcggact agaaagaatg ttgtcgtctg tgttccggtg
     1861 gaggagctgt ggaacctgag tttccagaac cccaacccta gagagcattt gggggtgctg
     1921 tattggaggg ggaggctaag gaaagttggg attgggactg gtggtgccaa gataagggtt
     1981 tctcaaattg gagaacccct ccttgttgca tgaggtcaat ggtcatcctg tctacccacc
     2041 ctgcctccag gccagggggc tggggaggca aatagagccc ccctatttta gtctttttaa
     2101 aaaaaacatc ctatactaag ggcagaaccc actgccccgg cctcaattac cttggctgaa
     2161 ggaaagatgg cggtaggaga gaaaagtgaa gaggcgtgag tgtaagaact gggagattcc
     2221 ttttccagca ggcctgggta gctgccttcc cagcccagcc ctccctgggg cctgcgggag
     2281 cccttttgca tgcaagggag gatggaggct ggcccctctt tatagaagca catttctgcc
     2341 acctcccctg ggaggcaccc agaagcctgc cactctttac ctagtccctg ctgtgtaggg
     2401 cgtagtccag gttagctagg tagagttagt gctccaagcc ctggggcctg ttcttagctc
     2461 atgcatagtc cttacagagt cccaggaccg ggggtggaga ggagcctcaa gtacattcca
     2521 ggagaccact gtctcctcgc tggcctgggc ctagatgggg cagcctggct cacaggaggc
     2581 cagcccctcc tcctccgccc ccttccttcc cttgtccccg tagggttata gctggagctg
     2641 cctgttatac tcggctgttc tgatttatta ttcttggtac tgactttctt tatgagggac
     2701 tcctaagggt tgtaggacct tggcagaggg ggcctggtct ccattagagg gtgttgtttt
     2761 ctcctgagga cacccaggct gcctttggtc ccaccctgtt cctggtcccg gtcccggtcc
     2821 cagtcccacc aggcaactcc ttccacccgg aaattcttcc cttcccttag cctgtggaaa
     2881 ccctgggtat tctttaaagt tctggtcaat gtatatcacc tccacagagc tgcttaccct
     2941 gcactgggaa ggggagatgg agacgccccc tttacccagg aggtcttcag agtttcctgg
     3001 gaccgcggtg ggtggaatcc caaggctggg ggtggaagga gcagggctct ggagggattc
     3061 gcattcaagg cacagaattg gccccttgcc tgtttgtttt tctaaccagt gtgatttctc
     3121 tgctgttcgt ttattactta ccattggaat attttgagcc aggagagcgc cttctctctc
     3181 cagccatcac cgctgtggtt gttcaggggt agcttttcaa aaacagggca gagcctggct
     3241 gtcccaacca gggggagcag gggcttggcc ctgacagcct gagcccttcc cctggtgtct
     3301 gcacagcctt tataaagaga gagagagctc cgaagcaata acaacacctg ggggtggtca
     3361 gtgagggccc cctcaatgat tttcttgttt gttctgtgaa atcccgctca cctcctggag
     3421 gggtggagca gctgggggct ggagccctgt ttctttgtgt catcgtgagc atgtgcccct
     3481 tcccaggggc tgtgaccatt gggtgtggga actacggtct gtcctcacca agggatgggg
     3541 gtttggggag gagagtgaca ttttcatcat tagcttcgga gaagcttcaa gcccatcctg
     3601 tccccgctac tgcctggccc cttgctgact caggctgcac tgtttgaaga ggagcagaga
     3661 ggctggcact aggggccact ggggggctgg ggtctccagg ggatgactgt tttcaatctc
     3721 tgggccaaga tcacatgcag gataccatgg gaaggagcca tctccactct ccttctccag
     3781 aacccccttg aagggccttt gggaccatta gtccatttcc attttacaga caaggaaatc
     3841 aagacccagc ttgggggaaa agccacccct ggagtcacct gtgtgttcag tggcaccccc
     3901 agcctgggtc ccctcctccc aatagaggct gagccggagc cagggcagta tgaggtgggg
     3961 ctgccactgc ccatacctcc tcctcccttc tttctttgaa gcctaatggc cccccaaaag
     4021 atgggcagga caagctgtag cccatctgag aggttgggaa actgaggccc agaaacagga
     4081 agtgactcac acaagacccc tcagcaaggg tgcaaagggg gaagaactag gggctccatt
     4141 gttcttcagg cgacaggaga ccgttgctcc agtgcatgtc tgctgggaca aggattcctg
     4201 gcctcgaagc cctgggctgc acagccctac tgggctccac ctctataaac cagtgacttc
     4261 tctgggcctg ggtctggggg agagggttgc cagggagact cagctctcct tgggggctgg
     4321 cccagctgac tgagggtaca caggattggg tctagacctt gatgcctggg tggagggccc
     4381 ttgtaagggg ccatagcctc ttcaggacca actggaggga gagttaggaa acaccagctc
     4441 ctgcctgggg cagtgaggga atgggagcag ctgtgggcgc ctcatttcag gcaagtcctc
     4501 cccaaacctt cagatgcagt gagacctggc cttcctgttg tgcttttcag actttgtttt
     4561 cagaatgctt ttatctcgag tgtgcccttc ggccctcaca agagcccctg gggagtaggt
     4621 ggtggcctgt gccgtcatcc ccatttcaaa gcagggagct gaggtcctgg gaggggaaag
     4681 tgcttgcctg aggtcccact gtgttagtgg gtgggcagga ctggaactcg gttctccaac
     4741 agcccagagc tcactctttt acacccagag gtggagcagg tggcttaggg ggtggttatg
     4801 tacttcacaa gccaattccc ttcagccagg agctcctggg tgcatttccg tgtcagaaac
     4861 agtaccgagt cccaccccct ctggaggcac agctgttgcg tcaggcaagg tcacctgcat
     4921 ttatttattg agcagcagtg ctgtgtcagg cccagggacc gagcccctct ccctgttccc
     4981 ctatggtgtc tccgaggccc tctgggaggg ccccacatct ggagcagcac ctcagagtgg
     5041 acagaaagca ttagcgtcca cgagctcacc cgacgccgag cctgtgaggt gggctgatgg
     5101 tgcccgtcta acccagcgct tcagggaggt cagaatggag ccgaacccag ggctgtgagc
     5161 atcacctctg gagccctttc actttatgac tgcttcctgg acgggtggtg ggaaggcagg
     5221 agcctgggtc cttaggctgg gggcctctct ccatccaccc acctttccct cattccctct
     5281 cttggagcag cagccgccca ggcctttagg gagggagggt ttctggggcc cttgggttgg
     5341 agtggggtcg cgttgcattg tgttcatgac catgtagctc atgttgaaat taaagttttt
     5401 ggcttttcta a
//
