LOCUS       NM_014747               7259 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulating synaptic membrane exocytosis 3 (RIMS3),
            mRNA.
ACCESSION   NM_014747 XM_375720
VERSION     NM_014747.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7259)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7259)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7259)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 7259)
  AUTHORS   Huang,X.F., Mao,J.Y., Huang,Z.Q., Rao,F.Q., Cheng,F.F., Li,F.F.,
            Wang,Q.F. and Jin,Z.B.
  TITLE     Genome-Wide Detection of Copy Number Variations in Unsolved
            Inherited Retinal Disease
  JOURNAL   Invest Ophthalmol Vis Sci 58 (1), 424-429 (2017)
   PUBMED   28118666
  REMARK    GeneRIF: We identified four novel CNVs in three different genes
            (one duplication in USH2A gene, two duplications in CEP290 gene,
            and one duplication in RIMS2 gene) in total four families, at a
            detection rate of 8% (4/50).
REFERENCE   6  (bases 1 to 7259)
  AUTHORS   Kumar,R.A., Sudi,J., Babatz,T.D., Brune,C.W., Oswald,D., Yen,M.,
            Nowak,N.J., Cook,E.H., Christian,S.L. and Dobyns,W.B.
  TITLE     A de novo 1p34.2 microdeletion identifies the synaptic vesicle gene
            RIMS3 as a novel candidate for autism
  JOURNAL   J Med Genet 47 (2), 81-90 (2010)
   PUBMED   19546099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7259)
  AUTHORS   Weidenhofer,J., Scott,R.J. and Tooney,P.A.
  TITLE     Investigation of the expression of genes affecting cytomatrix
            active zone function in the amygdala in schizophrenia: effects of
            antipsychotic drugs
  JOURNAL   J Psychiatr Res 43 (3), 282-290 (2009)
   PUBMED   18490030
  REMARK    GeneRIF: Western blot analysis shows increased piccolo protein
            expression in the amygdala in schizophrenia.
REFERENCE   8  (bases 1 to 7259)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   9  (bases 1 to 7259)
  AUTHORS   Wang,Y. and Sudhof,T.C.
  TITLE     Genomic definition of RIM proteins: evolutionary amplification of a
            family of synaptic regulatory proteins
  JOURNAL   Genomics 81 (2), 126-137 (2003)
   PUBMED   12620390
REFERENCE   10 (bases 1 to 7259)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031289.1.
            
            On Aug 18, 2018 this sequence version replaced NM_014747.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87074.1, SRR18074967.2952452.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372684.8/ ENSP00000361769.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AL031289.1         56581-56869
            290-464             AL031289.1         74421-74595
            465-712             AL031289.1         80307-80554
            713-854             AL031289.1         86206-86347
            855-967             AL031289.1         89082-89194
            968-1069            AL031289.1         92891-92992
            1070-1209           AL031289.1         93314-93453
            1210-7259           AL031289.1         95534-101583
FEATURES             Location/Qualifiers
     source          1..7259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..7259
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /note="regulating synaptic membrane exocytosis 3"
                     /db_xref="GeneID:9783"
                     /db_xref="HGNC:HGNC:21292"
                     /db_xref="MIM:611600"
     exon            1..289
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            290..464
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..712
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..1422
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /note="Rab-3 interacting molecule 3; RIM3 gamma;
                     rab-3-interacting molecule 3"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     3"
                     /protein_id="NP_055562.2"
                     /db_xref="CCDS:CCDS30687.1"
                     /db_xref="GeneID:9783"
                     /db_xref="HGNC:HGNC:21292"
                     /db_xref="MIM:611600"
                     /translation="MFNGEPGPASSGASRNVVRSSSISGEICGSQQAGGGAGTTTAKK
                     RRSSLGAKMVAIVGLTQWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQ
                     GSRESTDGSTNSNSSDGTFIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDV
                     HIAIMDRSGQLEVEVIEARGLTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTC
                     DPLYQQALLFDEGPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKL
                     FPTSSVADSTLGSLTRRLSQSSLESATSPSCS"
     exon            713..854
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            855..967
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1069
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1209
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..7259
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7238..7243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /note="hexamer: ATTAAA"
     polyA_site      7259
                     /gene="RIMS3"
                     /gene_synonym="NIM3; RIM 3; RIM3"
                     /note="major polyA site"
ORIGIN      
        1 gctttgcacc cggcggcgac tgaaaacggt ggctgctgcg gagccggcag cgcaggcggg
       61 cggagcggag ctgcccccgt ggtggcgggc gatgcccccg tgagcctccc tcgccgcccc
      121 tccccgcccc gcgtgcctat ccactcggag tccgcgccag cctggggccg ggccgcgcct
      181 actgccgggt tcgcggggcg gggtcccggg gcagcacctg ccccgccttg cggagccgcc
      241 tcggcctgtg gaggccccct ccctgtctgg accccggccc cacctccgga cccttttatc
      301 acatcgcctc ctctgggagc ctgccctgat tgccttcacc tcatttcttg aaaattggtg
      361 ttttggcaga agtcaattga agccttgtgc aaatgcccta ggggtgtgct gttgggaggc
      421 agccccctgt gatgcggaac accaggctca gattcatcag ttcgagctgc ctgaggccct
      481 gccaccccgg ggaccatgtt taacggggag ccaggtcctg cctcatctgg ggcctccagg
      541 aatgtggtgc ggagctccag cattagcggt gaaatctgcg gatcccagca agccgggggc
      601 ggggctggga ccaccaccgc caagaagcgg cggagcagcc tgggtgccaa gatggtggcc
      661 atcgtgggcc tgactcagtg gagcaagagc acactccagc ttccgcagcc tgaaggggcc
      721 accaagaagc tgcgcagcaa catccgccgg agcacggaga caggcatcgc ggtggagatg
      781 cggagccggg tcacacgcca gggcagccgg gagtccaccg atgggagcac caacagcaac
      841 agctccgacg gcacgttcat cttccccact acccggctag gggctgaaag ccagttcagc
      901 gatttcctgg atgggctggg accagctcag attgtggggc gacagacact ggcaacacca
      961 cccatgggag atgtgcacat tgccatcatg gaccggagtg gccagctgga ggtggaagtg
     1021 attgaagctc ggggcctgac ccccaaacca ggctccaaat ccctcccagc cacctatatc
     1081 aaggtttacc tgctggagaa tggggcctgc ttggccaaga agaagacaaa gatgaccaag
     1141 aagacctgtg atcccctgta ccagcaggct ctgctctttg acgagggacc ccagggcaag
     1201 gtgctgcagg tgatcgtctg gggagactat ggccgcatgg accacaagtg cttcatgggc
     1261 atggcccaga tcatgctgga cgagctggac ctcagcgccg cggtcaccgg ctggtacaaa
     1321 ctcttcccca cctcctcagt ggcagactcc acactcggat ccctcaccag gcgcctgtcc
     1381 cagtcttccc tggagagtgc caccagcccc tcatgctctt aaggatgtca ggaagaggcc
     1441 aggatggtgg tgtggggagg ggtgcctgct ggccccatgt cctcccctgt acatagtctt
     1501 cgtgtctttc tggacccctt gtcctgctgc atgcctgttg gctactgggc tcatcccagc
     1561 tggcagtgga gactgtagtg tgtgcgtgtg tgcgtgcgtg tgtgtgtgtg tgtacgtgac
     1621 cacgttctat ctgttcattt gtctgggtat agtcactcct ggtgatgata tgggctgaaa
     1681 tgtctccacg tctctttgtg tcttgttgaa aagaaaccca aaggagtgtt gtgtggacat
     1741 gactcaccct gaggagtctc cagggatgga ggtggggcat gcggccactg gtcggtgctg
     1801 cctggtcctg gcctggggca gagcctgtgt gttcttcacc tgtgcctgct cctggtggtc
     1861 tctgctttgt tttctgtctt gtcttttgtt ccactcttga ctctcccggc tctgccactg
     1921 ttttctgaga aatgtagcat ccgctgcagc tggccacact gagggccctc tgggaacccc
     1981 accccactgg agccgctccg gcagctcttc ctgccactga atgcgttctg cagcatgtag
     2041 catgcccacc tagctccctg gccagggccc tggggaggca gagggtaccc aggggactga
     2101 gggcttagaa atgactttct ctatgaggct ggaacctcct ccttcttcca gtgaagcacg
     2161 aggtcttggt tccagggttc ctggccaggt gcccccttag catttgttct tcatctcctg
     2221 tctcttcaag cctccccact ccaccgtgcc gaaggagctc tgccagtggg cctgggcagg
     2281 cagccacaga gggcatgtta tctgctaaag caaacagtcc tcctgaggcc ctgagggtgg
     2341 ccctgacccc ctcagggctc attcctggtg ggcatgactc ggtaaggagg ttctgtgggt
     2401 agggctgttt gctggaataa ggagggctga ggctgagttg ttccccgcca ctgttgagga
     2461 tcccatctga catttgggga ttcactgcat gaagttgttc atttggggct ccagtttttg
     2521 tgcatttcca gaccagggtc cctgtctggg agctcagact tagctgggct ccagcagcct
     2581 ggctccggac tctcgtctgc caccatcacc agctctgtct aagcaatact tacccctccg
     2641 ggcttccctg ctttcctgtg ccccactgct gccctctgca gagccatctg ctccaggcac
     2701 ccacctgcct ctgcttgctt tctcacccat gtctggttgg agcttctcac agccactcaa
     2761 accctgactt gatttgacaa ctgggccctg ttggtggaga ccagtgcctg aactggaccc
     2821 tgtgaaatct gtcccgtggg aatcctgaag tctgactcag gaatgcccag acctgtccct
     2881 gtccctcctc agctctaggg tgaaaggcga gaggttgcac aggacatgga cagagcagcc
     2941 cttgggtttg tatctggtag gggagaaagc agcaggacag tggaggtgtg tggaaggcac
     3001 tctttccacc tctctccagg cattatcccc aggtgctgaa atggctgtgg ccccagcacc
     3061 tgaggcaggg gtacgctacc tggggtagca gtagaaaggt cttggggtct gaatgacttg
     3121 gggcctccat tcataaccaa agttgtaggg gcatggaggc agtggcgcct tatggatagg
     3181 tcatctcagc ccaaagggcc tccttggctg gcatggttct gtgttacgtt gaagccagag
     3241 tcttataaca cctcccaaga aagatagggg aagaagccag aaccccacct ggcctgccca
     3301 caggacaaga agtgggtaag ggcaggaagg aaatgaacgg agttagctcc caggctccta
     3361 tctctgcctg agcctctatt cttatattat cagagaaagg gaccattggg tgcatagaga
     3421 tggggaggag gccactgggc tgaattttct ctttaggcgg aaatgctctc cccaggccca
     3481 ttgcgttcgt caagttcttg gaaatggaca aagggctctg tcctcctcga ccctagtggg
     3541 ggatcaagaa ggaaactccg ttgcaaaagg gtattttaat ctcctgttta tgatatattc
     3601 acctctagag cagtcactgt cagggtgttg cgaaaatact ctacaccttt gggatgatag
     3661 ggttgttagt gacccacagg acagtataga tgtttgtgga tgtagcactg agtggtgata
     3721 cccagaccag cagtcacccc aggaagtggg ggctacccat accctcattc ctctggtggg
     3781 gagctgcctg cagagaggcc tgccactggg ggttccaggc cgtggtgacc cttgcctctg
     3841 gggaagggtt agcacagggg aggttctagc tggaggaggg gtctgatgtg ctggtaactt
     3901 gggctgacct acctacagtc cctggctgcc aaaactgctc agcagttggg ccactccact
     3961 attccacctc tctaaaagaa ggtaatttcc tccccaaatt gaccttgggg aattattctt
     4021 ttaacccttt gcaccaaata agttactcat ccccacctgg attttacccc atgagggtaa
     4081 agttgtgtga ggctgacacg tctgtgtgat gcagtgtggc tgcacttaag ggtctgtttc
     4141 tcagcatcat ggatgcaggg gcttgtctga aaagccactc tggacctagc ctgtcccaga
     4201 agaggagaat gcacaagtgt aactcctggt tgtttgctgg ggtgggggag catctgctgt
     4261 ttgaggacgg ggggtgggga aggaaggaac atgatccctc cagaagtctc ccaccctggg
     4321 gccaactcac tgccatgttc agtgtcccgg ctccaaatgc ccccttgccc agatgaaacc
     4381 ctgcagtggt tacaggaatg gagctctttg tcattccacc tcctctggtc aggcgaggtt
     4441 cactgtgcat atggcagaga caggagtggc cctgcagtga tgttgggttg tgggcaggga
     4501 cagtgatgga tgactcagag cgtctgtctt tgtatttctg ctctgttcat tctgtcccac
     4561 tttcttcata gactcctttt ccctgcaatg ggtttttggt atgaaaaagg ctccagtaaa
     4621 tggagccaag tcttggtttg acaaggggaa cttgatcctt cagggaagaa tcatctccaa
     4681 aatgactccc catctggttt cttctaccac ccaattctac taggaaagga gcacttagga
     4741 ggctcttggg atgcagcaag tcccaggcaa tgccagcatt tcatgggggc tgaggcagaa
     4801 cccaggagct ccaagaaagg ccacccatag agctcatcct ctgtggaatc actgccggtt
     4861 agaacactga ggtcaagcca gtcctcccat ggtcatgcca cccaccaggg aagcatgcct
     4921 gatctcttct ttactgccag ccttgaggag agcagaagcc tccattttta aagacaataa
     4981 agacctccaa gggtacttct ttggaaatga aatgtagcac aatcttagcc tacgttacca
     5041 ggagccctga catgcaacca gggtccctct tccatgccct gctgcccagg agttgctgag
     5101 ctcctcttcc cctggggttc cagccctcct aatacctcat attccccatc ttcctcagcc
     5161 cagaaagcaa tggggcttta gtgatgctcc tcttttgtgt ctctctggtt gcctctagca
     5221 ctgtgcaaac tctgcaagaa attgctgcct ttgcttgatg ttgtagatga gttgccctcc
     5281 acctggctgg agagatggca catcattcag ggccagaagg ttgtccagca gtgtttctgc
     5341 agtggctgca gggagatgga aaagaagagc cctgcttccc tgcctcctcc tacctttctc
     5401 ttccactcct cagagttttc ttctccagta tcctgacatg taaagagatt ctttaaaatg
     5461 ctgcttcttc tactggactg tctttcactg agtagtcagg gaggagatga aaatgtggac
     5521 acatcccccc gccttctccc tcaacctttt cactcacgtc agaagaggtt ggggcaaaac
     5581 aaaacaagca tgattgaaga gcaggggaag cccacacaat caggtgagcc ctgatggggg
     5641 ctggactggc ctggtctggc tgggaaagga ttcttttaaa agcgtgcctg agcatctcag
     5701 agcaatgtca gtgatgccaa agagagcaac ttggcctcct tgggcaccaa ctctgatggc
     5761 tgagttgcac aaacgtggct cagatgttgg catgcccgat ggtgggacct tgttctctga
     5821 taaagggctt aatctttcca tgtagcaaag caactttccc tccctcccct ccccccgaac
     5881 cctgagcttg ggcttgtgtg ggcccagcat ggctgtgcct gtgagggaag ccacatcagt
     5941 gagagaaagt tgcattctct caggggccta gattggcttg gggcaggtgc ttgttgaaaa
     6001 gcatgagtgt ttctgctttg ggaaaccctt ccagggctct ggttggaaac ttggccagta
     6061 aggacagggc cttgggcctc ccaaggagtt cacaatgatg ccaggaaggg tccctgagcc
     6121 tgggttccag tcagcttggc taacagaatg gggcttggga attccagggg caactgagca
     6181 tccaccccat tagccagtga tctggacagg gacagctggc tacagggaat caaaggctgt
     6241 tctgtacagt tttaccagaa actgtgacct tgggtaaggc tcctcacttt tctgggcctc
     6301 aacttcctca tctgcaaaat cagagcatta gctgctctcc ccatgattcc ctcccagttt
     6361 taattaaaag tctctgatct ggagcacatg agggttgcga gcctggtgca cctggttcct
     6421 gtctccgtgg gctggtttcc ttcagcccct gatgcccagg ctgggtgcag gctctcatct
     6481 ggtccatgcc cagatgctgc ctcagacaag aactctggga atcctaacag actctgcttt
     6541 cctctcttcg tggtttgtcc tccctctttt attcttgtgt aatgatgaga cataattaag
     6601 ggtcatctac aatggacaat tttcaaggtg ctgatgtgat gtcacaacct ccgctacatc
     6661 ctgagtaagt cagtgtcccc aacagcagat gaggctgggt ctttcctcat ttctgcttct
     6721 gggatgacat cagtgggaga gttgaagatc tgagaattct aaaggaaatg ttctctgatg
     6781 ggaggagaga gggaacttat ttcccttcaa agtagtttgc ttcttaagac cactcctccc
     6841 tccagaatgt ctttaaccag acatcatttc agaaggtggg gcagctgctt ccttaggaag
     6901 agtgggcctg atagctcaac caactccttt agcatgtaaa ctcacagaag gcaagaaccc
     6961 ctttttttag actttccaaa tgcatcctgc aaagagagag atagctgata gggactgaca
     7021 agcacactgt ttagataaga agcaattagc cttttatatc tgtgctctat acattttcta
     7081 tgtgcagcat ctttcctaac ttgttgtggt tcccgggtgg caggtgcaca gctgggaggg
     7141 actgccggct gtttcgtaca acattcttgc caattccctt gaggagaaaa ttcttcacat
     7201 ggcttctgca tgtacagtat ttgggcagca aaacatgatt aaagtcagtt tgaaaatgg
//
