LOCUS       XM_024446369            7858 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens regulating synaptic membrane exocytosis 1
            (RIMS1), transcript variant X1, mRNA.
ACCESSION   XM_024446369
VERSION     XM_024446369.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_024446369.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7858
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..7858
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="regulating synaptic membrane exocytosis 1; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 13 ESTs, 395 long SRA reads, 14 Proteins, and
                     97% coverage of the annotated genomic feature by RNAseq
                     alignments, including 3 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:22999"
                     /db_xref="HGNC:HGNC:17282"
                     /db_xref="MIM:606629"
     CDS             475..5427
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     1 isoform X1"
                     /protein_id="XP_024302137.1"
                     /db_xref="GeneID:22999"
                     /db_xref="HGNC:HGNC:17282"
                     /db_xref="MIM:606629"
                     /translation="MSSAVGPRGPRPPTVPPPMQELPDLSHLTEEERNIIMAVMDRQK
                     EEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSPRLHQQFESYKEQVRKIGEEA
                     RRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMW
                     VCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPREKKARLQERSRS
                     QTPLSTAAASSQDAAPPSAPPDRSKGAEPSQQALGPEQKQASSRSRSEPPRERKKTPG
                     LSEQNGKGALKSERKRVPKTSAQPVEGAVEERERKERRESRRLEKGRSQDYPDTPEKR
                     DEGKAADEEKQRKEEDYQTRYRSDPNLARYPVKPPPEEQQMRMHARVSRARHERRHSD
                     VALPRTEAGAALPEGKAGKRAPAAARASPPDSPRAYSAERTAETRAPGAKQLTNHSPP
                     APRHGPVPAEAPELKAQEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSES
                     VRPSPPKPHRSKRGGKKRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDLDYYW
                     LDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDSGALLGLKVVGGK
                     MTDLGRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSE
                     PQVEIIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQ
                     VLPGQLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRT
                     KTVKKILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETA
                     LLDDEPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEV
                     DDGIGVVPPGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVP
                     LQRSLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELLMLPRAKRGRS
                     AECLHTTSELQPFLDRARSASTNCLRPDTSLHSPERERHSRKSERSSIQKQTRKGTAS
                     DAERVLPTCLSRRGHAAPRATDQPVIRGKHPARSRSSEHSSIRTLCSMHHLVPGGSAP
                     PSPLLTRMHRQRSPTQSPPADTSFSSRRGRQLPQVPVRSGSIEQEQEKYNSSTKGIRT
                     QVQRDYDICPNCLSVVDYKPRSFYFRPFPLHVGVSYFTSLVVEERTRQMKMKVHRFKQ
                     TTGSGSSQELDREQYSKYNIHKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSST
                     SFMSEQSERPRGRISSFTPKMQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAV
                     GTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEM
                     RKMVRQPSRESTDGSINSYSSEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLAT
                     PAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTR
                     IARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMV
                     IGWYKLFPPSSLVDPTLTPLTRRASQSSLESSTGPPCIRS"
ORIGIN      
        1 aaattggagg cagcagagcc tgggagcagc ctccacggcg gcagcggccg ccccagtccc
       61 agccccagcc ccagccccag ccccgccccc gccccgcgcc ccgccggaga cgcccggatc
      121 ggcggagcct ggcgcgagcc ctcgccccct cgcctctccc gccgcgcctc cgcctgcccg
      181 cccccgccgg ccgaggctgg gctgcgggag gcggccgggc ggccccgagc ttcgctaggg
      241 cgaccaaaac aaaggcagca tccggggctg ggtggatgca aacaaccatg aaagactggg
      301 ttctcgctct ccccggctct gctgctgctg ctgctgccgc cgccgccgct gctcctcctc
      361 ctgccgccgc cgctagggct ccgctgtgag ggggaagcag gggcgcagct gctgggcgtg
      421 catccgaaag gtgagagcca gagagcgagc agagggggcg ggcaggccac gaaaatgtcc
      481 tcggccgtgg ggccccgcgg tcctcgccca cccacggtgc ctccccccat gcaagagctg
      541 cccgacctga gccacctgac cgaagaggag aggaacatta tcatggcagt gatggaccgg
      601 cagaaggaag aggaggaaaa agaagaagcc atgctcaagt gtgttgtcag ggacatggcg
      661 aagcctgctg cctgcaaaac accaagaaat gctgaaaacc agccccacca accttcaccg
      721 agattgcatc aacagtttga aagctataag gaacaagtga gaaaaatagg ggaagaagcg
      781 cggcgttacc agggcgagca caaagacgat gctccgactt gtggaatctg tcataaaaca
      841 aagtttgctg atgggtgcgg tcatctctgc tcctattgtc gcactaagtt ctgtgcgcgc
      901 tgcggaggcc gcgtgtctct acggtcaaac aacgaggaca aagtggttat gtgggtatgc
      961 aatttatgtc gaaagcaaca agaaatctta accaaatctg gggcatggtt ctttggaagt
     1021 ggccctcagc agacaagtca ggatggaacc ctgagtgata cagctacagg tgctggctct
     1081 gaggtaccaa gagaaaagaa agcacgactc caagagcgat cgcggtctca gacaccccta
     1141 agcacagcag ctgcctcctc ccaggatgct gctcctccca gcgcaccacc agacaggagc
     1201 aaaggggctg agccctcgca gcaagccttg gggcctgaac agaagcaggc ttcatccagg
     1261 tctagaagtg aacctcctag agagagaaag aagaccccag ggctttccga gcagaatggc
     1321 aaaggagccc tgaagagcga gcggaaacgc gtgccaaaga cctcagcgca gcccgtggag
     1381 ggggccgtcg aagaacggga gcgcaaagaa aggcgggaaa gccgaaggct tgagaaaggg
     1441 cgatcacagg attacccaga cacgccggaa aaacgggatg agggcaaagc ggcggatgag
     1501 gaaaagcaaa gaaaagagga ggattatcag accaggtacc gcagcgaccc gaacctagct
     1561 cggtacccgg tgaaaccgcc gcctgaggag cagcagatgc gcatgcacgc ccgggtgtcc
     1621 cgcgccaggc acgagcggcg ccacagcgac gtggcgctcc cgcgcaccga ggcgggcgcg
     1681 gcgctgccgg agggcaaggc cggcaaacgc gcgccggcgg cagccagggc ctcgccgccg
     1741 gactcgccgc gggcttactc ggctgagaga actgcggaga ccagggcgcc gggcgccaag
     1801 cagctaacga accacagccc gccggcgccc agacatgggc cggttcccgc agaagccccg
     1861 gagctcaaag cccaggagcc cctcaggaag cagagccgcc tggaccccag ctcggcggtc
     1921 ctcatgcgga aggccaagcg cgagaaggtg gagaccatgc tgcggaacga ctctttgagc
     1981 tcagaccagt ccgagtcggt gcggccgtcc ccgcccaagc cgcaccggtc caagagaggc
     2041 ggcaagaagc ggcagatgtc ggtgagcagc tctgaggagg agggcgtgtc gacgcccgag
     2101 tacaccagct gcgaggacgt ggagctggag agcgagagcg tcagcgagaa aggtgatttg
     2161 gattattact ggttggatcc tgccacgtgg cacagccggg agacatcacc tattagttcg
     2221 catcctgtaa cgtggcaacc atctaaagag ggggaccgat taattggacg tgttattctt
     2281 aacaagagaa caaccatgcc caaagactca ggtgcattgc tgggtctgaa agttgttgga
     2341 ggaaaaatga ctgacttagg acgacttggt gctttcatca ccaaagtaaa gaagggtagc
     2401 ctagcagatg tagttggaca cctaagagca ggggatgaag ttctagaatg gaatggtaaa
     2461 cccctgccgg gagctacaaa tgaagaagtt tacaacatta ttttagaatc aaaatcagaa
     2521 cctcaagttg aaattattgt ttcaaggcct attggtgaca ttccccggat tcctgagagc
     2581 tcccaccctc cactggagtc cagttcaagt tcctttgaat ctcagaagat ggaaaggcct
     2641 tccatttctg ttatttctcc aacaagtcct ggagctctaa aagatgcccc acaagtctta
     2701 ccagggcaac tttctgtgaa gttgtggtat gataaagtgg gacaccagct gattgtaaat
     2761 gttctgcaag caacagatct acctgctaga gtagatggac gtcctcgaaa tccctatgta
     2821 aaaatgtatt ttcttccaga tagaagtgat aaaagtaaaa ggaggaccaa aacagtaaag
     2881 aaaatactag aaccaaaatg gaatcaaact tttgtctatt cacatgtaca tcgtagagat
     2941 tttagagaac gaatgttaga aataactgtg tgggaccaac caagagtgca agaagaagaa
     3001 agtgaatttc ttggagagat cctcatagaa ttggagacag cgcttttaga tgatgaaccg
     3061 cattggtata aacttcagac acatgatgag tcttcactac ctctgcctca gccatcacct
     3121 ttcatgccaa ggcgacatat tcatggagaa agctctagca aaaagctaca aagatctcag
     3181 cgaatcagtg atagtgacat ctcagattat gaggttgatg atggtattgg cgtagttcct
     3241 ccaggctata ggtctagtgc tagagaaagt aaatctacaa cattaactgt gccagaacag
     3301 caaagaacaa ctcatcaccg ctcacgttca gtatctcctc atcgcggcaa tgatcaggga
     3361 aagccgcgtt cacgtttacc aaatgtgcca ttacagagga gtttagatga aattcatcca
     3421 acaagaaggt cacgttctcc aaccagacac catgatgcct cccgaagtcc agttgatcat
     3481 agaaccagag atgtggatag tcagtattta tcagaacaag acagtgagct tcttatgctg
     3541 cccagagcaa aacgaggacg aagtgcagaa tgcctacata ctaccagtga actgcagccc
     3601 tttcttgaca gggctaggag tgctagtacc aactgcttga gaccagatac tagtttgcat
     3661 tcaccagaac gagaaaggca ctccagaaag tctgaaagat ctagcatcca aaaacagact
     3721 aggaaaggca ctgcctctga tgcagaaagg gttctcccaa catgtctttc tagaagggga
     3781 cacgcagccc caagagcaac tgatcagcca gtcattaggg gaaaacatcc tgctcgctca
     3841 aggtcgagtg agcactctag tatcagaaca ctgtgttcta tgcaccacct tgtccctgga
     3901 gggtcggcgc caccttctcc gcttctgaca agaatgcacc gacagagaag tccaacacaa
     3961 tctcctccag cagacacatc gttcagcagt cgcaggggaa gacagctccc acaagtgcca
     4021 gtgagaagcg gcagtataga acaagaacaa gaaaaatata actcttccac aaaaggaata
     4081 aggacacaag ttcagagaga ttatgacatt tgcccaaact gcttgtcagt agtagactac
     4141 aaacccagat ctttttactt tcgacctttt cctctacatg ttggtgtatc ctattttaca
     4201 agcttagtag tggaggagcg aacaagacag atgaaaatga aagtgcatcg atttaagcag
     4261 acaacagggt ctggttctag tcaagaactt gatcgcgagc aatattccaa gtataacata
     4321 cataaagatc agtacagaag ctgtgataac gtctctgcca aatcatcaga tagtgatgtc
     4381 agtgatgttt ccgccatttc ccgaaccagc agtgcctcac gcctcagcag cacaagcttt
     4441 atgtcagagc aatctgagcg ccccaggggt agaatcagtt catttacccc caaaatgcaa
     4501 ggcagacgga tggggacttc aggaagatcc atcatgaaga gcaccagtgt cagtggagag
     4561 atgtacacac tggagcataa tgacggcagc cagtcagaca cagctgtggg tacagttgga
     4621 gcaggtggaa agaaacggag atccagcctt agtgccaaag tggttgccat agtgtctcga
     4681 aggagtagaa gcacatccca gcttagtcaa acagagtcgg gccacaaaaa gttaaaaagt
     4741 accatccaga gaagcacaga aacaggcatg gcagctgaaa tgagaaagat ggtaaggcag
     4801 ccgagccgag agtctactga tggcagcatc aacagttaca gctctgaggg caatttaata
     4861 tttcctggag tgcgactggg agctgacagt caattcagtg attttcttga tggattggga
     4921 ccagcccagc ttgttggccg ccaaaccctt gccacccctg caatgggtga tatacaaata
     4981 ggaatggagg acaaaaaggg ccaattagaa gtggaagtca ttagagcacg aagcctcaca
     5041 caaaagcctg gttccaaatc tacacctgct ccatatgtca aagtatatct tttggaaaat
     5101 ggggcctgta tagccaagaa gaagacaaga attgcacgaa aaacccttga tcctttgtat
     5161 cagcagtctc tggtttttga tgaaagtcca cagggtaaag ttcttcaggt gattgtctgg
     5221 ggagactatg gcagaatgga ccacaaatgc tttatgggtg tggctcagat cttgttggaa
     5281 gaactcgacc tgtccagcat ggtgatcgga tggtacaaat tgttcccacc gtcctcactg
     5341 gtggatccca cactcactcc cctcacccgg cgggcttccc agtcatctct ggaaagttca
     5401 actgggcctc cctgtattcg atcatagtga actcatacca gagtcattcc aataaaactc
     5461 tacttttcag gataataatc tgaaccagat atttcatgat cgaaagcatt gttggagaca
     5521 gacaatcaac ttgtgttttg cctgtagtag tttttcaata atatgtccca attgttattt
     5581 aaaacatggc ttcatatgac agaacaaggc aatctatcaa atttacagga agaatcaaca
     5641 tgctggtgag agtcactgat gcttctaaca aatagaaaaa gaggaaactt taaatccacg
     5701 catacacgta cacacacaca tgcacacaca cacacaccaa attgaacaaa ctggaaactc
     5761 tcactctgtg aaaagttgta ttctacacat ttctgcacag accacaagca gtgttatttc
     5821 cctgatgttt gagttgtttt gttcttttgt gtgttttgtt tatttgtgtg ttgtttgttg
     5881 gttttcgttt cttgagtttt tgttttgttt tcaccacatc tgttatttcc actagttttt
     5941 ttttggctgt gtcatgacag gcctcatgat gctaacagag attcttccct tcttttttcc
     6001 aaaagcacca aaaaaaaggg ctgaagtagt ctctgtagca tctccccaaa gtgttaaaca
     6061 gctacataag gtgaagccaa ggaagggttt cactagcttt cattttataa ttatttaaag
     6121 tcttatgtgt ggatacccaa gagacaaaaa gttatcttcc aaaataaata atcacagaag
     6181 tactttttta atgaagagcc tatctgtttg cattctagaa aattaattta tggtttccat
     6241 tgttttgcat ggaagacttt taaagaagtc aatctgcaac taatgctggg gactaaaact
     6301 aactgcataa ttgtactttg aaaacactcc ttgtaatgcc tttttcttcc tgatattaaa
     6361 aaaatgctca tgtgtataaa ccatactttg acttcccaaa aatggtgact aggaatggat
     6421 ttgagcctaa gacactttga gctatgccca ggcttctcag ccatacctca gtgtagacac
     6481 atccatctgc cctggaaaga gcatggtatg agctgttcaa tattccactg gaaattccag
     6541 ttgaaatatt ctgcactaaa ctattgtttt tattgaattt tagtttacat ttctttgaga
     6601 ttgatgcaag cacaaagctt gattttttaa tgcaaagtat cttacttttt ggggggaaaa
     6661 taaacaaaat gaactttcaa tttgcatttt catttagttt ctcttggcct tgaatttccc
     6721 ttgtgacatt ctgtacatgt gctacaaact gcagtctctg caggtgcatt gatatgttct
     6781 ccctcctttt atgagtcact ccacttttgt gattacacaa atagagcagc atgacttgga
     6841 actgttcaga gctgcatgca cattttgtaa aaaaaaaaaa ttttaaaaag aaaagaaaca
     6901 aaaggttatt taataatgta tgttagttcc acataggcca gcttgtatgt tgcatgtact
     6961 tgtacagttt gcttgttaat tactataccg aaataaccaa gaaatctaag ccatccactt
     7021 ttgttataga cattttgcag gttttagcca gactcagtct ctgggtctgt ggtgaaatgt
     7081 ctatagatgg actttatttt ttaccctccg gaaaacgtga tgtagtacgg accaaattcc
     7141 ttctaataaa tattttggtg tagattccta ctgtggggct gtaacacatg tagacactgt
     7201 gtacacacta ggttttaatt catagacata ctgcctgcac caagtgaatt atttattatt
     7261 atttacacat gccagaatta tctgcccatc attccacagg gcacagattg accactgctc
     7321 accatgctga gtaggaggaa ctgaagcatt ggtgcacttc tactagattc cgttctgtct
     7381 tagtggccaa caatcaactg attataattg ggtagtatct ttctattttg accacttgtc
     7441 ttaacactcc cctgtgcttt taaatgaaat tccaattcat gtatgtaaac atgtttaata
     7501 aaatttactt ttcatgtcag tcagtagcca tatgtgttct atgtcttgcc agatttccat
     7561 tgtgggttct atggtgcaaa atgggagcca ggccatggga aggggaggct ggggtttgtt
     7621 gtctgctgcg ggcatttgac ttgacttgtc actgcactat attatgtctt aatcgatggc
     7681 ccaaagggta ctttgcatca catacaagtt ttcacttcgt cagcctgtct aagtgagcac
     7741 atgactatac ttctgaaaag tggcattatt aaaaataata aatctcagta agaatcaaat
     7801 ggaaggttgt tttctgctgc tgtttgaatg tgctaataaa agagacaact ctattgtc
//
