LOCUS       NM_001350457            5640 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens regulating synaptic membrane exocytosis 1 (RIMS1),
            transcript variant 51, mRNA.
ACCESSION   NM_001350457
VERSION     NM_001350457.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5640)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5640)
  AUTHORS   Hirano,M., Takada,Y., Wong,C.F., Yamaguchi,K., Kotani,H.,
            Kurokawa,T., Mori,M.X., Snutch,T.P., Ronjat,M., De Waard,M. and
            Mori,Y.
  TITLE     C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 alpha1
            subunits are differentially regulated by Rab3-interacting molecule
            proteins
  JOURNAL   J Biol Chem 292 (22), 9365-9381 (2017)
   PUBMED   28377503
  REMARK    GeneRIF: Electrophysiological characterization of VDCC currents
            revealed that the suppressive effect of RIM2alpha on
            voltage-dependent inactivation (VDI) was stronger than that of
            RIM1alpha for the CaV2.1 variant containing the region encoded by
            exons 44 and 47.
REFERENCE   3  (bases 1 to 5640)
  AUTHORS   Warwick,A.N., Shawkat,F. and Lotery,A.J.
  TITLE     Retinitis pigmentosa and bilateral cystoid macular oedema in a
            patient heterozygous for the RIM1 mutation previously associated
            with cone-rod dystrophy 7
  JOURNAL   Ophthalmic Genet 38 (2), 178-182 (2017)
   PUBMED   27176872
  REMARK    GeneRIF: This is the first reported case of bilateral cystoid
            macular edema in association with the RIM1 mutation. Overall, our
            findings were more consistent with a phenotype of retinitis
            pigmentosa.
REFERENCE   4  (bases 1 to 5640)
  AUTHORS   Ruhle,F., Witten,A., Barysenka,A., Huge,A., Arning,A., Heller,C.,
            Krumpel,A., Mesters,R., Franke,A., Lieb,W., Riemenschneider,M.,
            Hiersche,M., Limperger,V., Nowak-Gottl,U. and Stoll,M.
  TITLE     Rare genetic variants in SMAP1, B3GAT2, and RIMS1 contribute to
            pediatric venous thromboembolism
  JOURNAL   Blood 129 (6), 783-790 (2017)
   PUBMED   28011674
  REMARK    GeneRIF: The study identified a region on chromosome 6 comprising
            the genes SMAP1, B3GAT2, and RIMS1 as novel susceptibility locus
            for pediatric venous thromboembolism.
REFERENCE   5  (bases 1 to 5640)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 5640)
  AUTHORS   Wang,Y., Liu,X., Biederer,T. and Sudhof,T.C.
  TITLE     A family of RIM-binding proteins regulated by alternative splicing:
            Implications for the genesis of synaptic active zones
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14464-14469 (2002)
   PUBMED   12391317
REFERENCE   7  (bases 1 to 5640)
  AUTHORS   Ohtsuka,T., Takao-Rikitsu,E., Inoue,E., Inoue,M., Takeuchi,M.,
            Matsubara,K., Deguchi-Tawarada,M., Satoh,K., Morimoto,K.,
            Nakanishi,H. and Takai,Y.
  TITLE     Cast: a novel protein of the cytomatrix at the active zone of
            synapses that forms a ternary complex with RIM1 and munc13-1
  JOURNAL   J Cell Biol 158 (3), 577-590 (2002)
   PUBMED   12163476
REFERENCE   8  (bases 1 to 5640)
  AUTHORS   Schoch,S., Castillo,P.E., Jo,T., Mukherjee,K., Geppert,M., Wang,Y.,
            Schmitz,F., Malenka,R.C. and Sudhof,T.C.
  TITLE     RIM1alpha forms a protein scaffold for regulating neurotransmitter
            release at the active zone
  JOURNAL   Nature 415 (6869), 321-326 (2002)
   PUBMED   11797009
REFERENCE   9  (bases 1 to 5640)
  AUTHORS   Coppola,T., Magnin-Luthi,S., Perret-Menoud,V., Gattesco,S.,
            Schiavo,G. and Regazzi,R.
  TITLE     Direct interaction of the Rab3 effector RIM with Ca2+ channels,
            SNAP-25, and synaptotagmin
  JOURNAL   J Biol Chem 276 (35), 32756-32762 (2001)
   PUBMED   11438518
REFERENCE   10 (bases 1 to 5640)
  AUTHORS   Betz,A., Thakur,P., Junge,H.J., Ashery,U., Rhee,J.S., Scheuss,V.,
            Rosenmund,C., Rettig,J. and Brose,N.
  TITLE     Functional interaction of the active zone proteins Munc13-1 and
            RIM1 in synaptic vesicle priming
  JOURNAL   Neuron 30 (1), 183-196 (2001)
   PUBMED   11343654
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590011.5, AL445256.18 and
            AL035633.18.
            
            On Jun 2, 2019 this sequence version replaced NM_001350457.1.
            
            Summary: The protein encoded by this gene is a RAS gene superfamily
            member that regulates synaptic vesicle exocytosis. This gene also
            plays a role in the regulation of voltage-gated calcium channels
            during neurotransmitter and insulin release. Mutations have
            suggested a role cognition and have been identified as the cause of
            cone-rod dystrophy type 7. Multiple transcript variants encoding
            different isoforms have been described for this gene. [provided by
            RefSeq, Mar 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.24937.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AL590011.5         148896-149225
            331-398             AL445256.18        14897-14964
            399-509             AL445256.18        16742-16852
            510-609             AL445256.18        18947-19046
            610-733             AL445256.18        23438-23561
            734-780             AL445256.18        26939-26985
            781-893             AL445256.18        29139-29251
            894-1024            AL445256.18        31454-31584
            1025-1196           AL445256.18        32045-32216
            1197-1350           AL445256.18        32339-32492
            1351-1422           AL445256.18        33885-33956
            1423-1579           AL445256.18        39249-39405
            1580-1705           AL445256.18        40110-40235
            1706-1795           AL445256.18        47084-47173
            1796-1867           AL445256.18        65171-65242
            1868-1980           AL035633.18        6475-6587
            1981-2093           AL035633.18        21799-21911
            2094-2260           AL035633.18        28047-28213
            2261-2496           AL035633.18        48141-48376
            2497-2635           AL035633.18        105138-105276
            2636-2748           AL035633.18        107238-107350
            2749-2850           AL035633.18        112789-112890
            2851-2990           AL035633.18        113495-113634
            2991-5640           AL035633.18        115036-117685
FEATURES             Location/Qualifiers
     source          1..5640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..5640
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="regulating synaptic membrane exocytosis 1"
                     /db_xref="GeneID:22999"
                     /db_xref="HGNC:HGNC:17282"
                     /db_xref="MIM:606629"
     exon            1..330
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..3209
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="isoform 51 is encoded by transcript variant 51;
                     RAB3-interacting protein 2; rab3-interacting molecule 1;
                     rab-3-interacting protein 2"
                     /codon_start=1
                     /product="regulating synaptic membrane exocytosis protein
                     1 isoform 51"
                     /protein_id="NP_001337386.1"
                     /db_xref="GeneID:22999"
                     /db_xref="HGNC:HGNC:17282"
                     /db_xref="MIM:606629"
                     /translation="MCAPGIHVSSEGWEEVRSVDSEEGTIEARRAVAGDLDYYWLDPA
                     TWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDSGALLGLKVVGGKMTDL
                     GRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVE
                     IIVSRPIGDIPRIPESSHPPLESSSSSFESQKMERPSISVISPTSPGALKDAPQVLPG
                     QLSVKLWYDKVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVK
                     KILEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDD
                     EPHWYKLQTHDESSLPLPQPSPFMPRRHIHGESSSKKLQRSQRISDSDISDYEVDDGI
                     GVVPPVGYRSSARESKSTTLTVPEQQRTTHHRSRSVSPHRGNDQGKPRSRLPNVPLQR
                     SLDEIHPTRRSRSPTRHHDASRSPVDHRTRDVDSQYLSEQDSELQPFLDRARSASTNC
                     LRPDTSLHSPERERHSRKSERSSIQKQTRKGTASDAERMHRQRSPTQSPPADTSFSSR
                     RGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSSQELDREQYSKYNI
                     HKDQYRSCDNVSAKSSDSDVSDVSAISRTSSASRLSSTSFMSEQSERPRGRISSFTPK
                     MQGRRMGTSGRSIMKSTSVSGEMYTLEHNDGSQSDTAVGTVGAGGKKRRSSLSAKVVA
                     IVSRRSRSTSQLSQTESGHKKLKSTIQRSTETGMAAEMRKMVRQPSRESTDGSINSYS
                     SEGNLIFPGVRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVE
                     VIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESP
                     QGKVLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVDPTLTPL
                     TRRASQSSLESSTGPPCIRS"
     exon            331..398
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..509
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..609
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..733
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..780
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..893
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1024
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1196
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1350
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1422
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1579
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1705
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1795
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1867
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1980
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2093
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2260
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2496
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2635
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2748
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2850
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2990
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..5640
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5279..5284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="hexamer: AATAAA"
     polyA_site      5301
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="major polyA site"
     regulatory      5617..5622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="hexamer: AATAAA"
     polyA_site      5640
                     /gene="RIMS1"
                     /gene_synonym="CORD7; RAB3IP2; RIM; RIM1"
                     /note="major polyA site"
ORIGIN      
        1 gcacagtgcc tgcagtgacc tgagtcagtc atgcaaggag actttcttgt tctcacacca
       61 atgttttatt tcagtttcca ttttctgctg gtcctgttgt tcaatgatat aagcagagtg
      121 atgaaggagg cgcttcacac tcttcttaga taagatcttg agcagcagag agtggtttaa
      181 acagcaaggc ttaaatctct caagctggat ttatttccaa gtttgctgtc atgtgtgcac
      241 ctgggattca tgtctcttca gaagggtggg aagaagtgag gtctgttgat tccgaagagg
      301 gaacaattga agctcgacga gcagttgctg gtgatttgga ttattactgg ttggatcctg
      361 ccacgtggca cagccgggag acatcaccta ttagttcgca tcctgtaacg tggcaaccat
      421 ctaaagaggg ggaccgatta attggacgtg ttattcttaa caagagaaca accatgccca
      481 aagactcagg tgcattgctg ggtctgaaag ttgttggagg aaaaatgact gacttaggac
      541 gacttggtgc tttcatcacc aaagtaaaga agggtagcct agcagatgta gttggacacc
      601 taagagcagg ggatgaagtt ctagaatgga atggtaaacc cctgccggga gctacaaatg
      661 aagaagttta caacattatt ttagaatcaa aatcagaacc tcaagttgaa attattgttt
      721 caaggcctat tggtgacatt ccccggattc ctgagagctc ccaccctcca ctggagtcca
      781 gttcaagttc ctttgaatct cagaagatgg aaaggccttc catttctgtt atttctccaa
      841 caagtcctgg agctctaaaa gatgccccac aagtcttacc agggcaactt tctgtgaagt
      901 tgtggtatga taaagtggga caccagctga ttgtaaatgt tctgcaagca acagatctac
      961 ctgctagagt agatggacgt cctcgaaatc cctatgtaaa aatgtatttt cttccagata
     1021 gaagtgataa aagtaaaagg aggaccaaaa cagtaaagaa aatactagaa ccaaaatgga
     1081 atcaaacttt tgtctattca catgtacatc gtagagattt tagagaacga atgttagaaa
     1141 taactgtgtg ggaccaacca agagtgcaag aagaagaaag tgaatttctt ggagagatcc
     1201 tcatagaatt ggagacagcg cttttagatg atgaaccgca ttggtataaa cttcagacac
     1261 atgatgagtc ttcactacct ctgcctcagc catcaccttt catgccaagg cgacatattc
     1321 atggagaaag ctctagcaaa aagctacaaa gatctcagcg aatcagtgat agtgacatct
     1381 cagattatga ggttgatgat ggtattggcg tagttcctcc agtaggctat aggtctagtg
     1441 ctagagaaag taaatctaca acattaactg tgccagaaca gcaaagaaca actcatcacc
     1501 gctcacgttc agtatctcct catcgcggca atgatcaggg aaagccgcgt tcacgtttac
     1561 caaatgtgcc attacagagg agtttagatg aaattcatcc aacaagaagg tcacgttctc
     1621 caaccagaca ccatgatgcc tcccgaagtc cagttgatca tagaaccaga gatgtggata
     1681 gtcagtattt atcagaacaa gacagtgaac tgcagccctt tcttgacagg gctaggagtg
     1741 ctagtaccaa ctgcttgaga ccagatacta gtttgcattc accagaacga gaaaggcact
     1801 ccagaaagtc tgaaagatct agcatccaaa aacagactag gaaaggcact gcctctgatg
     1861 cagaaagaat gcaccgacag agaagtccaa cacaatctcc tccagcagac acatcgttca
     1921 gcagtcgcag gggaagacag ctcccacaag tgccagtgag aagcggcagt atagaacaag
     1981 caagcttagt agtggaggag cgaacaagac agatgaaaat gaaagtgcat cgatttaagc
     2041 agacaacagg gtctggttct agtcaagaac ttgatcgcga gcaatattcc aagtataaca
     2101 tacataaaga tcagtacaga agctgtgata acgtctctgc caaatcatca gatagtgatg
     2161 tcagtgatgt ttccgccatt tcccgaacca gcagtgcctc acgcctcagc agcacaagct
     2221 ttatgtcaga gcaatctgag cgccccaggg gtagaatcag ttcatttacc cccaaaatgc
     2281 aaggcagacg gatggggact tcaggaagat ccatcatgaa gagcaccagt gtcagtggag
     2341 agatgtacac actggagcat aatgacggca gccagtcaga cacagctgtg ggtacagttg
     2401 gagcaggtgg aaagaaacgg agatccagcc ttagtgccaa agtggttgcc atagtgtctc
     2461 gaaggagtag aagcacatcc cagcttagtc aaacagagtc gggccacaaa aagttaaaaa
     2521 gtaccatcca gagaagcaca gaaacaggca tggcagctga aatgagaaag atggtaaggc
     2581 agccgagccg agagtctact gatggcagca tcaacagtta cagctctgag ggcaatttaa
     2641 tatttcctgg agtgcgactg ggagctgaca gtcaattcag tgattttctt gatggattgg
     2701 gaccagccca gcttgttggc cgccaaaccc ttgccacccc tgcaatgggt gatatacaaa
     2761 taggaatgga ggacaaaaag ggccaattag aagtggaagt cattagagca cgaagcctca
     2821 cacaaaagcc tggttccaaa tctacacctg ctccatatgt caaagtatat cttttggaaa
     2881 atggggcctg tatagccaag aagaagacaa gaattgcacg aaaaaccctt gatcctttgt
     2941 atcagcagtc tctggttttt gatgaaagtc cacagggtaa agttcttcag gtgattgtct
     3001 ggggagacta tggcagaatg gaccacaaat gctttatggg tgtggctcag atcttgttgg
     3061 aagaactcga cctgtccagc atggtgatcg gatggtacaa attgttccca ccgtcctcac
     3121 tggtggatcc cacactcact cccctcaccc ggcgggcttc ccagtcatct ctggaaagtt
     3181 caactgggcc tccctgtatt cgatcatagt gaactcatac cagagtcatt ccaataaaac
     3241 tctacttttc aggataataa tctgaaccag atatttcatg atcgaaagca ttgttggaga
     3301 cagacaatca acttgtgttt tgcctgtagt agtttttcaa taatatgtcc caattgttat
     3361 ttaaaacatg gcttcatatg acagaacaag gcaatctatc aaatttacag gaagaatcaa
     3421 catgctggtg agagtcactg atgcttctaa caaatagaaa aagaggaaac tttaaatcca
     3481 cgcatacacg tacacacaca catgcacaca cacacacacc aaattgaaca aactggaaac
     3541 tctcactctg tgaaaagttg tattctacac atttctgcac agaccacaag cagtgttatt
     3601 tccctgatgt ttgagttgtt ttgttctttt gtgtgttttg tttatttgtg tgttgtttgt
     3661 tggttttcgt ttcttgagtt tttgttttgt tttcaccaca tctgttattt ccactagttt
     3721 ttttttggct gtgtcatgac aggcctcatg atgctaacag agattcttcc cttctttttt
     3781 ccaaaagcac caaaaaaaag ggctgaagta gtctctgtag catctcccca aagtgttaaa
     3841 cagctacata aggtgaagcc aaggaagggt ttcactagct ttcattttat aattatttaa
     3901 agtcttatgt gtggataccc aagagacaaa aagttatctt ccaaaataaa taatcacaga
     3961 agtacttttt taatgaagag cctatctgtt tgcattctag aaaattaatt tatggtttcc
     4021 attgttttgc atggaagact tttaaagaag tcaatctgca actaatgctg gggactaaaa
     4081 ctaactgcat aattgtactt tgaaaacact ccttgtaatg cctttttctt cctgatatta
     4141 aaaaaatgct catgtgtata aaccatactt tgacttccca aaaatggtga ctaggaatgg
     4201 atttgagcct aagacacttt gagctatgcc caggcttctc agccatacct cagtgtagac
     4261 acatccatct gccctggaaa gagcatggta tgagctgttc aatattccac tggaaattcc
     4321 agttgaaata ttctgcacta aactattgtt tttattgaat tttagtttac atttctttga
     4381 gattgatgca agcacaaagc ttgatttttt aatgcaaagt atcttacttt ttggggggaa
     4441 aataaacaaa atgaactttc aatttgcatt ttcatttagt ttctcttggc cttgaatttc
     4501 ccttgtgaca ttctgtacat gtgctacaaa ctgcagtctc tgcaggtgca ttgatatgtt
     4561 ctccctcctt ttatgagtca ctccactttt gtgattacac aaatagagca gcatgacttg
     4621 gaactgttca gagctgcatg cacattttgt aaaaaaaaaa aattttaaaa agaaaagaaa
     4681 caaaaggtta tttaataatg tatgttagtt ccacataggc cagcttgtat gttgcatgta
     4741 cttgtacagt ttgcttgtta attactatac cgaaataacc aagaaatcta agccatccac
     4801 ttttgttata gacattttgc aggttttagc cagactcagt ctctgggtct gtggtgaaat
     4861 gtctatagat ggactttatt ttttaccctc cggaaaacgt gatgtagtac ggaccaaatt
     4921 ccttctaata aatattttgg tgtagattcc tactgtgggg ctgtaacaca tgtagacact
     4981 gtgtacacac taggttttaa ttcatagaca tactgcctgc accaagtgaa ttatttatta
     5041 ttatttacac atgccagaat tatctgccca tcattccaca gggcacagat tgaccactgc
     5101 tcaccatgct gagtaggagg aactgaagca ttggtgcact tctactagat tccgttctgt
     5161 cttagtggcc aacaatcaac tgattataat tgggtagtat ctttctattt tgaccacttg
     5221 tcttaacact cccctgtgct tttaaatgaa attccaattc atgtatgtaa acatgtttaa
     5281 taaaatttac ttttcatgtc agtcagtagc catatgtgtt ctatgtcttg ccagatttcc
     5341 attgtgggtt ctatggtgca aaatgggagc caggccatgg gaaggggagg ctggggtttg
     5401 ttgtctgctg cgggcatttg acttgacttg tcactgcact atattatgtc ttaatcgatg
     5461 gcccaaaggg tactttgcat cacatacaag ttttcacttc gtcagcctgt ctaagtgagc
     5521 acatgactat acttctgaaa agtggcatta ttaaaaataa taaatctcag taagaatcaa
     5581 atggaaggtt gttttctgct gctgtttgaa tgtgctaata aaagagacaa ctctattgtc
//
