LOCUS       NM_175921               5246 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens RAB7A interacting MON1-CCZ1 complex subunit 1
            (RIMOC1), mRNA.
ACCESSION   NM_175921
VERSION     NM_175921.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5246)
  AUTHORS   Yan,B.R., Li,T., Coyaud,E., Laurent,E.M.N., St-Germain,J., Zhou,Y.,
            Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A
            localization and stability during mitophagy
  JOURNAL   Autophagy 18 (4), 829-840 (2022)
   PUBMED   34432599
REFERENCE   2  (bases 1 to 5246)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5246)
  AUTHORS   Schmutz,J., Martin,J., Terry,A., Couronne,O., Grimwood,J.,
            Lowry,S., Gordon,L.A., Scott,D., Xie,G., Huang,W., Hellsten,U.,
            Tran-Gyamfi,M., She,X., Prabhakar,S., Aerts,A., Altherr,M.,
            Bajorek,E., Black,S., Branscomb,E., Caoile,C., Challacombe,J.F.,
            Chan,Y.M., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Grigoriev,I., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Israni,S.,
            Jett,J., Kadner,K., Kimball,H., Kobayashi,A., Lopez,F., Lou,Y.,
            Martinez,D., Medina,C., Morgan,J., Nandkeshwar,R., Noonan,J.P.,
            Pitluck,S., Pollard,M., Predki,P., Priest,J., Ramirez,L.,
            Retterer,J., Rodriguez,A., Rogers,S., Salamov,A., Salazar,A.,
            Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N., Wheeler,J.,
            Wu,K., Yang,J., Dickson,M., Cheng,J.F., Eichler,E.E., Olsen,A.,
            Pennacchio,L.A., Rokhsar,D.S., Richardson,P., Lucas,S.M.,
            Myers,R.M. and Rubin,E.M.
  TITLE     The DNA sequence and comparative analysis of human chromosome 5
  JOURNAL   Nature 431 (7006), 268-274 (2004)
   PUBMED   15372022
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY116483.1, BF439305.1, AC034222.5, BQ272495.1, CN345108.1 and
            AL833916.1.
            
            On Nov 22, 2018 this sequence version replaced NM_175921.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.277452.1,
                                           SRR1803611.24231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381647.7/ ENSP00000371061.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                HY116483.1         2-37
            37-676              BF439305.1         1-640
            677-2173            AC034222.5         116179-117675
            2174-2478           BQ272495.1         1-305
            2479-2898           CN345108.1         2-421
            2899-5246           AL833916.1         1-2348
FEATURES             Location/Qualifiers
     source          1..5246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..5246
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /note="RAB7A interacting MON1-CCZ1 complex subunit 1"
                     /db_xref="GeneID:285636"
                     /db_xref="HGNC:HGNC:27750"
                     /db_xref="MIM:620266"
     exon            1..124
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..909
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /note="UPF0600 protein C5orf51"
                     /codon_start=1
                     /product="RAB7A-interacting MON1-CCZ1 complex subunit 1"
                     /protein_id="NP_787117.3"
                     /db_xref="CCDS:CCDS34151.1"
                     /db_xref="GeneID:285636"
                     /db_xref="HGNC:HGNC:27750"
                     /db_xref="MIM:620266"
                     /translation="MAAAVSSVVRRVEELGDLAQAHIQQLSEAAGEDDHFLIRASAAL
                     EKLKLLCGEEKECSNPSNLLELYTQAILDMTYFEENKLVDEDFPEDSSSQKVKELISF
                     LSEPEILVKENNMHPKHCNLLGDELLECLSWRRGALLYMYCHSLTKRREWLLRKSSLL
                     KKYLLDGISYLLQMLNYRCPIQLNEGVSFQDLDTAKLLSAGIFSDIHLLAMMYSGEMC
                     YWGSKYCADQQPENHEVDTSVSGAGCTTYKEPLDFREVGEKILKKYVSVCEGPLKEQE
                     WNTTNAKQILNFFHHRCN"
     exon            125..231
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            232..378
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            379..510
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            511..625
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /inference="alignment:Splign:2.1.0"
     exon            626..5246
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5227..5232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /note="hexamer: AATAAA"
     polyA_site      5246
                     /gene="RIMOC1"
                     /gene_synonym="C5orf51"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcacc cgccgattgt ggccatggcg gccgcagtct ctagtgtggt gagacgagtg
       61 gaagagctcg gggatctggc tcaggcccac atacagcaac ttagcgaagc tgccggtgaa
      121 gatgatcact ttttaattcg ggcctctgca gcattagaaa aattgaaact cctgtgtgga
      181 gaagagaaag aatgttcaaa tccatcaaat cttctagaac tttacacaca ggctattttg
      241 gacatgacat attttgagga gaacaagcta gtagatgaag attttcctga agactcttct
      301 tcacagaaag taaaagagct gattagtttt ctttcagaac cagaaatttt agtaaaggaa
      361 aataatatgc atccaaaaca ctgcaatttg cttggggatg agctactgga atgtctctct
      421 tggagacgag gagccctgct gtatatgtat tgtcattctc ttaccaaaag aagagagtgg
      481 ctcttaagaa aatccagttt gcttaaaaag taccttcttg atggaatcag ttacttgcta
      541 cagatgctaa attatcgatg tcctatccag ttaaatgaag gagtttcttt ccaagatcta
      601 gacacagcta aattactgag tgcaggaata tttagtgaca ttcatctgct ggctatgatg
      661 tacagtggag aaatgtgtta ctggggatcg aagtattgtg ctgatcagca accagaaaat
      721 catgaagtgg atactagtgt gtctggagcg ggctgcacta catacaagga acccttggat
      781 ttccgagaag taggagaaaa aatcttgaaa aagtatgtat ctgtgtgtga aggacccctg
      841 aaagaacaag aatggaatac aacgaatgca aaacaaattt taaacttctt tcatcatcgc
      901 tgtaactagt aagttcatct agtccttttc aaatagaaaa acaacaaaac ccatgaaatg
      961 gaaaagagag ttccaaaaaa gaagacctgt tgatactgaa tatgagaaca ttacactgca
     1021 taaagatatc cagcttgggt accctactaa aacaacatca ccatcttttt cattatatat
     1081 tagtaaacct atgaagggat gattctttaa tttctaaagt gttgttcaaa ctcaccttaa
     1141 aatacagatg ttatgtcact aataatgagt agtaacccaa tttagcttta caaagatttt
     1201 ttctattact tttttttttt attgtggtat atgtaacaca agtttaccat ttttatcatc
     1261 tttagattat ttttaaatct cactaccttg aagtttgcca tgcttcagaa attaaagtca
     1321 agttacttca ctgctttgaa tacatactat ggatataaat gtaggcaaaa tgaaagatta
     1381 tgactaatat tcagattcca ttttcaataa ggtaaataat gaaagatctc acaaaggaat
     1441 cattgtgttt aattattttg ccatgtatta ctaattgtat ttaaaatttc tacttccctt
     1501 aggcatttta taaaaattta aaaattattt ttctattttg tttaaaagac aatgcatggc
     1561 ttttcaagtg agtaatgaag ataaaaacca agctaggtta gtctaccatt agttcatatg
     1621 tttttgtagc acatcttttc ataacatact gaaattttaa tgttttttgc ctttaataat
     1681 aggggtgagt gttaaaggcc agagagccta acttgatatc ttgctcatgg tctttctgtc
     1741 tacctcaact cctgttgtca tctttggatg atctttctga taccttgctg ataccttgga
     1801 cttctgccca gtgactttat tacattccag cagcttactc ccgtggccgc actttgaatg
     1861 tcaccacctt gagtttctct ttctggtaaa atttcagtaa ctgataactg ccctcttttc
     1921 agttttttca cttccttatt ttattgactt ttctctcctt tatgctcatt ccacattctt
     1981 cagttccttc ttaccccctt ttcttgactg ctccccttcc tcctaaactg tcagcccctt
     2041 tcaggctttc ttccctatcc accctcagct ttatgggata ctatatgaac taatctcacc
     2101 agttattctt ctttccctgg tcttttagtc tagtcctttg gcaagccctc aacctcagat
     2161 taatcctatt tattatctac cttttcgggg atgctgagtt ctttgtgatg ggtagtcctt
     2221 caaagtagaa tcactacaag tgtctcactt cagccttaga aaagccctca atgtaaacct
     2281 tatgtttgtt actagggtgg cctctctccc atttcccgct gtggctgagc caaacttcat
     2341 tactttcctt aggccctctg cccctcccct agcatatggc tctttctcct attgaacaga
     2401 aaattgagac tatgaagagg tcaacttgta tttaccaact ttactcattt tcccatttta
     2461 gaggaaaaga ggttgcctgc ttcctatcaa aggcgactct gtgctacatg ttggtttcat
     2521 cttcgctgtc tctctcattt ccccacaaag tgttgtctca ctttctgcct accttttagg
     2581 tattgatctt cactatattt ttttctctct ctctcttttt tttttttact ttacatattt
     2641 tatacaatgt cattcataac tatggcttct tttaccacct gtaataacag actgagtctc
     2701 aaacctgtaa cttgtatcct gacttatctc ttgctttcta aaccttgttt ctaactgtct
     2761 atcaaatatc ttcattagac atcccacagt aattttaagc tcagtgtttc caaacgtcaa
     2821 gtcctcatct gttatataaa atcctttctg ctttgtaagt tttctctttt tgggattttc
     2881 cgcagatcag ggcaacacag aatgactacc ttcccagcca tgtctctgca gtcatcctgt
     2941 gtaatcatgt tctagtccag tgttgctcaa acagttaaaa tccaggctgc ttttggtaaa
     3001 catacaaatt ctgatataga gcctctgtgg caaagggaat ttctcagttc ctgccccagc
     3061 ccccttgttt atcattacac agctaagatt tttatttaac ttagcatttt agcaagtttt
     3121 cttatgaaaa tacctttgtg ctttctaagt ataaagattt aaattatttt taatacggtt
     3181 tttagaacca cagactatcc ctctttttag agcatcctga tcaattgcaa gtacttccac
     3241 ttcttcccta aatgcgcttt gtgtgttttc cacctcagta gccttgcaca catcattact
     3301 tctgcatcct tctttgtgac caagtgaata cctacctacc tcttaggact cagcttcagt
     3361 gattctgttt tcataggctt tttaaagccc ttttcagtca aattagatgc tcctttgttc
     3421 tggtccttta ctcttcccct cccatgttgt cgcactgatc acactgcttt gtaattattt
     3481 tctttattgt tggtaaactc catattttaa aaatttacct gtatacatag tgcttaatgc
     3541 atggtaggcc cttagtaatg tttttgaatt aatgaggcat gattctaaat gccaaacttt
     3601 gcacaaaaag ttgttgctat tggattccaa actgctatgc cctctatacc agtggctgac
     3661 aaggcatata gggatatatg ccatcctgag aggagtaaag tgtttagatt ctgaacctga
     3721 gaaaagagaa ctttctctta agaagttgga aacttcattt taccttcgtg accctggtag
     3781 accacttggt ctcactggtt ggtacaatta tgagggtagt actgggtgct ttttatacaa
     3841 ctttccatcc cccacacagt tggagaataa tttgtagacc atggcagtta aaatgctttt
     3901 tactctggtg tattatagaa taatgaacac atttttatat atgttaaagc ctgctaaatc
     3961 attcacttag aatgaagtaa cctcaaggta ccaaataccc cacataagga aagtactaca
     4021 ctaaattcac tcaactattg tatgcctacc atatgccaga ttttatccta gaccctgagg
     4081 atatagcttt ttaaaacccc ctcctgtttc agagcttata ttctagtgga ggaagttaga
     4141 caagcatttt aagtaataaa tgtatagaga gtgtcaagtg atgagtacca tgaagaagaa
     4201 taaatgaggg taaggggcta gtgtgatagg gagaggggtg ggatgccatc atatttaggg
     4261 gtggttggga actgtctact gctttagcat ttgtgtcttc aaatttctct cctttggtta
     4321 tataccttgc gtattccgca cattgataaa gtttctttct tacagaagtt ctgatattga
     4381 attaaggaat gggtcactac ttaagacttt atcatttcag ctacacataa aaggtttctc
     4441 tcccctatgg attttgctaa tggttgagtg atacctaaag gccttgttgc attttttaca
     4501 cttggggttt ctcttcggtt tgaattctct catggttacc aaaactctgt taaaggactt
     4561 ttcacagtcg ttaaatgtgt atggctcttt cccaatatga atttttttga tgttaactag
     4621 gcttttagac ttagttaaag acctgtgtgc tctgctgcat ttatagggtt ttgggctgct
     4681 gagaataatt gatgctgatt aaggtgcaaa tcatgactaa agacttttct ttcttctttt
     4741 gcatatagta gagtgaggtg agggtcgtgg ctaaaacccc acaataactt tacattccta
     4801 gctttacagt cttgctgtga attctctggt gttcattaaa gtgtgagctg tgttaaaagg
     4861 cattcttaga ttcattttaa ccacattttt aaaaactcac agttggttaa catgatggtt
     4921 tcagattgct tgcctctttt ctctttctac cttacagggc tccttttcta gcttaaataa
     4981 gggtactcca tctgccacag aatccaggat tctatagttt tttagtttca cttccctatg
     5041 ttcttttttt ttttttaatt tttaacaatg agatgatacc atgttacagc ggtattacat
     5101 taagatacat ttaatatagc cacaattaaa gtatgtatta tgtatttatg ctggtgttct
     5161 ttcatgttat ttcttctagt gaaaatttcc aagtaaactg ttattgagca tatacatttt
     5221 taaaaaaata aaaccataca ccccta
//
