LOCUS       NM_001297776            4931 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ribosomal modification protein rimK like family member
            B (RIMKLB), transcript variant 2, mRNA.
ACCESSION   NM_001297776
VERSION     NM_001297776.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4931)
  AUTHORS   Lodder-Gadaczek,J., Becker,I., Gieselmann,V., Wang-Eckhardt,L. and
            Eckhardt,M.
  TITLE     N-acetylaspartylglutamate synthetase II synthesizes
            N-acetylaspartylglutamylglutamate
  JOURNAL   J Biol Chem 286 (19), 16693-16706 (2011)
   PUBMED   21454531
  REMARK    GeneRIF: ribosomal modification protein rimK-like family member A
            (Rimkla) gene is a NAAG synthetase (NAAGS-II), which synthesizes
            the N-acetylated tripeptide N-acetylaspartylglutamylglutamate
            (NAAG(2))
REFERENCE   2  (bases 1 to 4931)
  AUTHORS   Becker,I., Lodder,J., Gieselmann,V. and Eckhardt,M.
  TITLE     Molecular characterization of N-acetylaspartylglutamate synthetase
  JOURNAL   J Biol Chem 285 (38), 29156-29164 (2010)
   PUBMED   20643647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092490.10.
            
            On Nov 22, 2018 this sequence version replaced NM_001297776.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.199081.1,
                                           SRR1660807.15090.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535829.6/ ENSP00000445863.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC092490.10        51604-51910
            308-538             AC092490.10        67424-67654
            539-769             AC092490.10        103475-103705
            770-856             AC092490.10        105570-105656
            857-1060            AC092490.10        107503-107706
            1061-4931           AC092490.10        126934-130804
FEATURES             Location/Qualifiers
     source          1..4931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..4931
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /note="ribosomal modification protein rimK like family
                     member B"
                     /db_xref="GeneID:57494"
                     /db_xref="HGNC:HGNC:29228"
                     /db_xref="MIM:614054"
     exon            1..307
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            308..538
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..1524
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /EC_number="6.3.2.41"
                     /EC_number="6.3.1.17"
                     /note="family with sequence similarity 80, member B;
                     ribosomal protein S6 modification-like protein B;
                     N-acetylaspartyl-glutamate synthetase B;
                     beta-citryl-glutamate synthase B; NAAG synthetase B;
                     N-acetyl-aspartyl-glutamate synthetase B;
                     N-acetyl-aspartylglutamate synthetase B"
                     /codon_start=1
                     /product="beta-citrylglutamate synthase B"
                     /protein_id="NP_001284705.1"
                     /db_xref="CCDS:CCDS41748.1"
                     /db_xref="GeneID:57494"
                     /db_xref="HGNC:HGNC:29228"
                     /db_xref="MIM:614054"
                     /translation="MCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAV
                     VMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDSDITVLRHLEKMGCRL
                     MNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGGHENFAKMIDEAEVLEFPMVVKNT
                     RGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTML
                     RCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVC
                     EANANVGFIAFDKACNLDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELG
                     PPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIKLLVD"
     exon            539..769
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            770..856
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1060
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..4931
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3444..3449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /note="hexamer: ATTAAA"
     polyA_site      3464
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /note="major polyA site"
     regulatory      4906..4911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /note="hexamer: AATATA"
     polyA_site      4931
                     /gene="RIMKLB"
                     /gene_synonym="FAM80B; NAAGS; NAAGS-I"
                     /note="major polyA site"
ORIGIN      
        1 gcggcaggcg agtgagggaa cgaggagcgg ccgggtgtga gtgtgtggga gtgagagtgt
       61 gtgggagtgg ggtgagggag aagctgacgg gacgcgaggc tgtgagaaac tgggcgagtg
      121 tgcgaggacg cccggccagc ctgcgggagc cgcagtcggc ggaggagaaa ggaggcggct
      181 cccggtatcc cgaccccctc cccctcctct ccttccccca cttccagccg cccggcggcc
      241 cgcgcttcct cgaaggcccc agcccggctc agtcggccga gagcgaggga ggagcccccc
      301 gacccaggta gacgttacat ccaagaggaa ataatccagg caaggaagca caagctgatc
      361 aagatgtgta gttctgtggc tgccaagttg tggtttttga cagatcgtcg catcagggaa
      421 gactatcctc aaaaagagat tttacgagca ttgaaggcca aatgttgtga ggaggaactg
      481 gactttaggg ctgtggtgat ggatgaggtg gtgctgacaa tcgagcaagg aaacctgggt
      541 ctgcggatca atggagagct aatcactgcc tacccacaag tggtggtagt cagagtacca
      601 accccttggg tgcaaagtga tagtgacatc actgttttgc gccatctaga gaagatggga
      661 tgtcggttaa tgaaccgacc tcaagccatc ctgaactgcg ttaataagtt ctggacattt
      721 caagagttgg ctggccatgg tgttcctctg ccggatactt tctcttatgg tggccacgaa
      781 aattttgcta aaatgattga tgaggctgaa gttctggagt tcccaatggt agtaaagaat
      841 acgcggggtc acagaggtaa agctgttttc ttggctcgag ataagcacca tttggctgat
      901 ctaagccatc ttattcgcca tgaagcgcca tacctgttcc agaagtatgt taaagagtct
      961 catggacggg atgtacgtgt cattgtcgtg ggaggccgtg tggttggcac catgttacgt
     1021 tgttcaacag atgggagaat gcaaagcaac tgctcattag gtggtgtggg gatgatgtgc
     1081 tcattgagtg aacaagggaa gcagctagct atccaggtgt ctaatatcct ggggatggat
     1141 gtgtgtggca ttgatctgct gatgaaagat gacggctcct tctgcgtctg tgaggccaat
     1201 gcaaatgtag gtttcatcgc ctttgataag gcttgtaatc tagatgtagc tggtatcata
     1261 gcagactatg ccgcctccct tctaccctct ggccggctca cccggcgtat gtccctgctc
     1321 tccgtggtgt ccactgccag tgagactagt gagccggagc tgggtccccc agccagcact
     1381 gctgttgaca acatgagtgc aagttccagc tctgttgaca gcgaccctga aagcacggag
     1441 cgagagctgc tcaccaagct cccagggggc ctgttcaaca tgaaccagct gctagccaat
     1501 gaaatcaaac tactggtgga ctgactccac tggtaattaa ccaacaaaac ccttgtaaaa
     1561 ctttctttct tcttttctat ttttaaaacc aacttgcaat gctgttcatg gaggatgctc
     1621 aggaagatga gagaaaatta gtaggattag ttggagagag tgggagatag atgagacctc
     1681 tgctagtaag atgttacttt catttacaaa tcctacaaat agagaggcag aataggtggg
     1741 gtatagaaaa atgtcaggct ctcatagtta cccttttaaa ttgctaaaaa atgtgtatgc
     1801 tcataggcca tgaggaacaa atactttttt tttttcatgg tcccttgctt ttgtttttgt
     1861 acaaaaaaaa atggttttgc tacaaatatc caagtagcat aacttcacat tgtgttggaa
     1921 gatttgtcat cagtgaggaa aacatctgca taaattacag gaatttttgt attatacagc
     1981 tctgaaaatt ctgccatttc cttattaact agcagcttta gtttgtagtt tatgaaatct
     2041 tgaggggctc ttttactggg atttcttatt tttttgtttt ttcccgctta atttggtggg
     2101 aggtcaaatt gaatataacc caataaaggc ttcttaatga caaaattggc atgtttgcat
     2161 gatgaaatgg aaatgaacag tattgcaatg tccggtatac aaaataacat taattcaatg
     2221 tagataaaat tacactagtt taaaatatgt gcattcactt gtatttgtta gtgttttagt
     2281 cttttttgaa agatgtgctc tgttaatgtt gctttttttt ttttttttaa tacatgctag
     2341 tctaacattt cctgctctat gcctgcatct ttaacaatgg ccaaagtgaa gaaaatgcta
     2401 ccttttttgt taacaagaca ctgacttgaa acatgtacat ttaaagcctt ttattttttc
     2461 cctttttgtt ttggtagttg ggcatttaaa taaggacaag gaaaaatatt tttgggggca
     2521 aatcaagagc ctatgagttc taagtataaa gctgaagtga tttcgaatgc cagcgttata
     2581 tatttgcatt tttcacattt tacgagggag tatatgtgta tgtgtgtgca cgcatgcatg
     2641 tgtatgtgtt ttgctttttg tttccatcaa ctaatcaaaa aggataattt agaaaatgga
     2701 gcatgatggg aaacagagtt tttgacttta aaaaacagat gagttgtttt cataagtaga
     2761 ctccactggg gtagaggtat tcaccttaaa acatagggtg agtagatgct tttttaggcc
     2821 tttttgtgta tatgtacgtt gtttgttttt ttccttttgt ttctagcctg ttcagtgtac
     2881 agtttattca aggctacatg cttttcttta atgcttctgg ctatgcattt tctcttttta
     2941 catataggat ttgggattgg gggtgggttg gatgtttttg tttggggact tatttagtag
     3001 tattgagtct cttatagccc tactcttaag ccttcaatac tgtccactct ttatattcct
     3061 ttacttgcag aatttataaa agcccccaaa ctgcatataa tatgagcctt taaaacatgg
     3121 gtaaaactaa tcccattgat gggtttggat ggtatgttaa gaaatggaga tgctgcagag
     3181 cccaacgtaa ttttttaaac agcaagtttt ccatctccct acgaatcctc tgaagctttt
     3241 acccaagccc tttcttgcct ctccagtgct attttccttc agatggacct taaacataat
     3301 ttcttggaca ctactagaga gacttcgagg caataataaa agatcagtat taaccagcta
     3361 taacagaggt ttgatcatgc ttacttgtac agtttttccc ccgttttaaa aaggaatgta
     3421 ataaaatttg ttttttccat agaattaaat aatattaaaa ttgagtgaaa ggttgattgt
     3481 tgatgaatag aatagtacct ctcatctgtg cagtgtctca tttcacctca gagaaaagga
     3541 tacataagag gagtttgtaa tttatcttag gatattctaa ttgcatttaa aagaacttat
     3601 cttgcgcagg gtaaatgggg gactcacata catatattaa tacctctgac tcattaacag
     3661 aaagaaatac ttggtacttc tttcgctgaa tgaccatact gtggaggatg catactattt
     3721 ggtatagaga aataaatgag gaagaaagaa ctgcttaatt aaattatcat tcatatgttc
     3781 atatagagac catctggttg ccatgtgtat tatgacacat acactttgaa tagttacata
     3841 tcacaagtat gtagttcatg tttgtgttgg tggggtaagg catcaggaaa aatgtagtta
     3901 gtcttttctt aacttatacc aaattaacca actatattat aggaaatatg tgaaattagt
     3961 tcattagctt tattcactat tatgcattca catgatatta aaacgtacac tcacatgtta
     4021 gaatgaaaag agcagtagtt atcttagatt ttaaaaacat ggatatcttc ttgaattcct
     4081 tcaagattga ggtagagaat aagagcaaat cattctggaa gtaccttaag gaaacaaaca
     4141 gcagcagata tttaggttaa acttattttc ataattgttt aataactttt gtataatctt
     4201 cattgctatt atgagagaga atgtatatat caaatatgtg taatgataaa atctgaattg
     4261 taaaattttt gtatattgtt aaaattgtaa ttctaaattg tatttcaaaa atgattattt
     4321 ctgatattgt ttttatgtca cccatgatga aaactggact ttatatatct aaacatacaa
     4381 gtatgaacta ttctatttaa aatttttaat agtttttttc ttttttggtg cctataattg
     4441 attggtcatt tctgctggct tttctccaat gaacattgaa atcttcctgt atatgttacc
     4501 aataagaaaa ctaccctgga acagtagaaa aacccaacaa gagacttggc attcatcaag
     4561 cacattatca gactttgaga acatattgaa ggcattgact ttgaaaatca tctctttttc
     4621 tcaagaagaa agcaatggag aagcaaattt gtttcattca gtgaatcccc agtttggggc
     4681 ttgtggggct tagagacatt gtgaaatcaa atcttgtgtt atacttttct cctggctcac
     4741 tttttttgag aaggtttatg ggctatttgg ctggtgagac acgatcccct cctaagaaaa
     4801 tgtaggtgct cagacaggta accactgctg ctactgtttt tatttgtttg tttgttcaat
     4861 tttatttaag atttgttttt gttgtactag gattttaaaa aatgtaatat attgcaggat
     4921 ttataaccag g
//
