LOCUS       NM_015672               6105 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RIMS binding protein 3 (RIMBP3), mRNA.
ACCESSION   NM_015672 XM_371429 XM_942124
VERSION     NM_015672.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6105)
  AUTHORS   Liu,X., Zang,C., Wu,Y., Meng,R., Chen,Y., Jiang,T., Wang,C.,
            Yang,X., Guo,Y., Situ,C., Hu,Z., Zhang,J. and Guo,X.
  TITLE     Homeodomain-interacting protein kinase HIPK4 regulates
            phosphorylation of manchette protein RIMBP3 during spermiogenesis
  JOURNAL   J Biol Chem 298 (9), 102327 (2022)
   PUBMED   35931115
  REMARK    GeneRIF: Homeodomain-interacting protein kinase HIPK4 regulates
            phosphorylation of manchette protein RIMBP3 during spermiogenesis.
REFERENCE   2  (bases 1 to 6105)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6105)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6105)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6105)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   6  (bases 1 to 6105)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6105)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   8  (bases 1 to 6105)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
REFERENCE   9  (bases 1 to 6105)
  AUTHORS   Hirosawa,M., Nagase,T., Murahashi,Y., Kikuno,R. and Ohara,O.
  TITLE     Identification of novel transcribed sequences on human chromosome
            22 by expressed sequence tag mapping
  JOURNAL   DNA Res 8 (1), 1-9 (2001)
   PUBMED   11258795
REFERENCE   10 (bases 1 to 6105)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023490.5.
            
            On May 17, 2019 this sequence version replaced NM_015672.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB051453.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619918.1/ ENSP00000483386.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5796              AC023490.5         122611-128406       c
            5797-6105           AC023490.5         122302-122610       c
FEATURES             Location/Qualifiers
     source          1..6105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..6105
                     /gene="RIMBP3"
                     /gene_synonym="RIM-BP3; RIM-BP3.1; RIM-BP3.A; RIMBP3.1;
                     RIMBP3A"
                     /note="RIMS binding protein 3"
                     /db_xref="GeneID:85376"
                     /db_xref="HGNC:HGNC:29344"
                     /db_xref="MIM:612699"
     exon            1..6105
                     /gene="RIMBP3"
                     /gene_synonym="RIM-BP3; RIM-BP3.1; RIM-BP3.A; RIMBP3.1;
                     RIMBP3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             486..5405
                     /gene="RIMBP3"
                     /gene_synonym="RIM-BP3; RIM-BP3.1; RIM-BP3.A; RIMBP3.1;
                     RIMBP3A"
                     /note="RIMS binding protein 3.1"
                     /codon_start=1
                     /product="RIMS-binding protein 3A"
                     /protein_id="NP_056487.1"
                     /db_xref="CCDS:CCDS46665.1"
                     /db_xref="GeneID:85376"
                     /db_xref="HGNC:HGNC:29344"
                     /db_xref="MIM:612699"
                     /translation="MAKDSPSPLGASPKKPGCSSPAAAVLENQRRELEKLRAELEAER
                     AGWRAERRRFAARERQLREEAERERRQLADRLRSKWEAQRSRELRQLQEEMQREREAE
                     IRQLLRWKEAEQRQLQQLLHRERDGVVRQARELQRQLAEELVNRGHCSRPGASEVSAA
                     QCRCRLQEVLAQLRWQTDGEQAARIRYLQAALEVERQLFLKYILAHFRGHPALSGSPD
                     PQAVHSLEEPLPQTSSGSCHAPKPACQLGSLDSLSAEVGVRSRSLGLVSSACSSSPDG
                     LLSTHASSLDCFAPACSRSLDSTRSLPKASKSEERPSSPDTSTPGSRRLSPPPSPLPP
                     PPPPSAHRKLSNPRGGEGSESQPCEVLTPSPPGLGHHELIKLNWLLAKALWVLARRCY
                     TLQAENKQLRRAGCPYQADEKVKRLKVKRAELTGLARRLADRARKLQETNLRAVSAPI
                     PGESCAGLELCQVFARQRARDLSEQASAPLAKDKQIEELRQECHLLQARVASGPCSDL
                     HTGRGGPCTQWLNVRDLDRLQRESQREVLRLQRQLMLQQGNGGAWPEAGGQSATCEEV
                     RRQMLALERELDQRRRECQELGAQAAPARRRGEEAETQLQAALLKNAWLAEENGRLQA
                     KTDWVRKVEAENSEVRGHLGRACQERDASGLIAEQLLQQAARGQDRQQQLQRDPQKAL
                     CDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHARPEDYAVSQPNRD
                     IQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSEGSMWATVPSS
                     PTLDRDTASEVDDLEPDSVSLALEMGGSAAPAAPKLKIFMAQYNYNPFEGPNDHPEGE
                     LPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQIPDSYIPGCLPAKSPDLG
                     PSQLPAGQDEALEEDSLLSGKAQGVVDRGLCQMVRVGSKTEVATEILDTKTEACQLGL
                     LQSMGKQGLSRPLLGTKGVLRMAPMQLHLQNVTATSANITWVYSSHRHPHVVYLDDRE
                     HALTPAGVSCYTFQGLCPGTHYRARVEVRLPRDLLQVYWGTMSSTVTFDTLLAGPPYP
                     PLDVLVERHASPGVLVVSWLPVTIDSAGSSNGVQVTGYAVYADGLKVCEVADATAGST
                     LLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQIPEDFFMCHRWPETPPFSYTCGDP
                     STYRVTFPVCPQKLSLAPPSAKASPHNPGSCGEPQAKFLEAFFEEPPRRQSPVSNLGS
                     EGECPSSGAGSQAQELAEAWEGCRKDLLFQKSPQNHRPPSVSDQPGEKENCSQHMGTS
                     KSPAPGFIHLRTECGPRKEPCQEKAALERVLRQKQDAQGFTPPQLGASQQYASDFHNV
                     LKEEQEALCLDLWGTERREERREPEPHSRQGQALGVKRGCQLHEPSSALCPAPSAKVI
                     KMPRGGPQQLGTGANTPARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQD
                     THDFYLSECNRQVGNIPGRLVAEMEVGTEQTDRRWRSPAQGNLPSVAHLEDFQGLTIP
                     QGSSLVLQGNSKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMD
                     DQGFYYGELGGHRGLVPAHLLDHMSLHGH"
ORIGIN      
        1 ccagccacct gacccaaata caccacctga acccacgacc aggtatgccc acaccccatg
       61 ggtggcctta acacacacac cctgcccctt tctccaagta caggagcagc agcccagact
      121 tccctcgggg caccgcggcc tgcttgggac tgcacagtgc ctgggagggt gcctggggag
      181 ggtcacaagg gacttggtgc tagaagcagg aaaagtgtag ggaccggaaa agcccccgtg
      241 catcctggaa gggacatggg ccagtttgag caggggtgtg ggagtccagc cctggccttg
      301 ccaggtggag aggcgcctgg gccagacatc cgcggcagga ggcgggggaa catgccaaga
      361 ggcggaaggg gcacgcggag acccccaggg ggcgccggaa ggggcgcgcc gggcggtcgg
      421 cggcggccgt tggcgagctg aggcctgcca ggcgaagtct ggagaccagc cgggccgcgg
      481 ccgcaatggc caaggactcg cccagcccct tgggcgcgtc gcccaagaag ccgggctgct
      541 ccagcccggc ggcggcagtg ctggagaacc agaggcggga gctggagaag ctacgggcgg
      601 agctggaggc ggagcgggca ggctggcggg cggaacggcg gcgcttcgct gcccgggagc
      661 gccagctgcg tgaggaggcc gagcgggagc ggcgacagct ggctgaccgt ctgcgctcca
      721 agtgggaggc acagcgcagc cgggagttgc ggcagctgca agaggagatg cagcgggaac
      781 gcgaggccga gatccggcag ctgctgcgct ggaaggaggc cgagcagcgg cagctgcagc
      841 agctgctgca ccgggagcgc gatggcgtgg tgcgccaagc ccgggagctg cagcgccagc
      901 tggccgagga gctggtgaac cgcggccact gtagccgccc gggggcgtcc gaggtttccg
      961 cggcgcagtg ccgctgtcgc ctgcaggaag tgttggcgca gcttcgctgg cagactgacg
     1021 gcgagcaggc ggcgcgcatc cgctatctgc aggcggcgct ggaggtggag cgccagctct
     1081 tcctcaagta catcctggcg cacttccgcg ggcacccggc tttgtcggga tcaccggacc
     1141 cccaagctgt gcattccttg gaagaaccgc tgccccagac ctccagcggc tcttgccacg
     1201 cccccaaacc cgcctgccaa ctcggatctc tagacagcct gagtgctgaa gtcggtgtgc
     1261 gctcccgctc gctaggcctg gtgtcctctg cgtgctccag ctccccagac ggcctgctct
     1321 ccacgcacgc cagctccctt gattgcttcg cacctgcgtg ttcccgctcg cttgacagca
     1381 cccggagcct ccccaaggcc tccaaatccg aggagcggcc ctcctcacca gacacctcca
     1441 cccctggctc ccggaggctc tcgccgccac catcgccact cccgccgcca ccaccaccgt
     1501 cagcccacag gaaactcagc aacccgcggg gaggagaagg ctctgagagc cagccctgcg
     1561 aagtcctgac tccctcaccc ccgggcctgg gccaccacga gctgataaag ctgaactggc
     1621 tgctggccaa ggcgttgtgg gtgctggcgc gccgctgtta taccctgcaa gcggagaaca
     1681 agcagctgcg gcgtgcaggc tgcccctacc aggcagacga gaaggtgaag cggctcaagg
     1741 taaagcgcgc ggagctgacc gggctcgcgc ggcgcctagc tgaccgcgcc cgcaagctgc
     1801 aggagaccaa cctccgggcc gtgagcgcgc ctatacccgg cgagagttgc gccggcctgg
     1861 agctgtgcca agtctttgcc cgccagcgcg ctcgggacct gtcggagcag gcgagcgcgc
     1921 cgctggccaa ggacaagcag atcgaagagc tgcggcagga gtgccacctc ctgcaggcgc
     1981 gtgtcgcctc gggtccctgc agcgacctgc atactggaag gggcggcccc tgcacccagt
     2041 ggctcaacgt cagagactta gaccgcctgc agcgcgagtc ccagcgggaa gtgctgcgcc
     2101 tgcagaggca gttgatgctt cagcagggca acggtggcgc ttggcccgag gcgggcggcc
     2161 agagcgcaac ctgcgaggag gtgcgacggc agatgctggc gctggagcgc gagctggacc
     2221 agcggcggcg cgagtgccag gagctgggcg cgcaggcggc cccggcgcgg cgacgtggcg
     2281 aggaggccga gacacagctg caggcggcgc tgctcaaaaa cgcctggctg gcggaggaga
     2341 atgggcggct gcaggccaag accgactggg tgcggaaggt ggaggctgag aatagcgaag
     2401 tgcgcggcca cctgggccgc gcgtgtcaag agcgcgatgc ctccggcttg atcgccgaac
     2461 agctgctgca gcaggcggcg cgcgggcagg acaggcagca gcagctgcaa cgcgacccgc
     2521 agaaggccct gtgtgacctc catccttcct ggaaggagat acaggcgctc cagtgtcggc
     2581 ctggtcaccc tcctgaacag ccctgggaga ccagtcaaat gccggagtcc caagttaaag
     2641 gtagcagaag gcccaagttc cacgcacggc ctgaagacta cgcagtgtca cagcccaaca
     2701 gagacataca ggagaaaagg gaagcctccc tcgaggagag cccagttgcc cttggggagt
     2761 cagccagtgt cccccaagtt tcagagacag tccctgccag ccaacctctg tccaagaaaa
     2821 ccagctccca gtcaaactcc tcctctgagg ggtcgatgtg ggccaccgtg ccgtcctccc
     2881 ctactctgga cagggacaca gccagtgagg tggatgacct ggagcctgac agcgtgtccc
     2941 tggccctgga aatggggggc tcggcggctc ctgctgcccc caagctcaag atcttcatgg
     3001 ctcagtataa ctacaaccca tttgaggggc ccaatgatca ccctgagggt gagctgcccc
     3061 tcacagctgg ggactacata tatatcttcg gggacatgga tgaggatggc ttctatgagg
     3121 gggagcttga ggatggccgg cgggggctgg tgccctccaa cttcgtggag cagattccgg
     3181 acagctacat cccaggctgc ctgcctgcca aatcccctga tcttggcccc agtcaactcc
     3241 cagcggggca ggatgaagct ctggaggaag acagcttatt atctgggaaa gcccagggag
     3301 tggtggacag agggctgtgc cagatggtca gggtgggctc caagacagaa gtagcaacag
     3361 agatcctgga taccaagacg gaagcctgcc agctgggctt gctgcagagc atggggaagc
     3421 agggcctctc cagacccctt ctggggacca aaggggtgct ccgtatggct cccatgcagc
     3481 tacacctgca gaatgtcaca gccacatcag ccaacatcac ctgggtctac agcagccacc
     3541 gccaccccca tgtggtatat cttgatgacc gagagcatgc cctgacccca gcgggcgtga
     3601 gctgctacac cttccagggc ctgtgccccg gcacgcacta ccgggcgcgg gtggaggtgc
     3661 ggctgccacg ggacttgctg caggtgtatt ggggaactat gtcctccacc gtcaccttcg
     3721 acacactctt ggcaggacct ccctacccac cgctggatgt gctggtggag cgccatgcct
     3781 cgccaggtgt cctggtggtc agctggctcc ctgtgaccat tgactcagct gggtcctcca
     3841 atggagtcca ggtcaccggt tatgctgtgt atgcagatgg gcttaaggtt tgtgaggtcg
     3901 ccgatgccac tgctgggagc accctattgg aattctccca gctacaggtg cccctcacgt
     3961 ggcagaaggt ctcagtgaga accatgtcac tctgtggtga gtccctggat tcagtgcctg
     4021 ctcagatccc cgaggacttc ttcatgtgtc accgatggcc agagactcca ccctttagct
     4081 acacttgtgg cgacccatcc acctacagag tcaccttccc cgtctgcccc cagaagctgt
     4141 cactggctcc tccgagtgcc aaggccagcc cccacaaccc tggaagctgc ggggagcccc
     4201 aggccaagtt cctagaagca ttctttgaag aacccccaag gaggcaatcc ccagtgtcca
     4261 acctgggctc agaaggagaa tgtccgagtt caggggctgg cagccaagcc caggagcttg
     4321 cagaggcctg ggagggctgt agaaaggacc tgctctttca gaagagtccc cagaaccaca
     4381 ggccaccttc agtcagtgac cagcctgggg agaaggaaaa ttgctcccag cacatgggca
     4441 ccagcaaaag ccctgctcca ggattcatcc atctacgcac cgagtgtggg cccaggaaag
     4501 aaccgtgtca ggaaaaggct gcccttgaga gggtacttcg gcaaaagcaa gatgcccaag
     4561 ggttcacacc tccccagctg ggcgccagcc aacagtatgc atctgacttc cataacgttt
     4621 tgaaggagga gcaggaggca ctgtgcttgg atctgtgggg cacagagagg cgagaggaga
     4681 ggagggagcc tgagccccac agcaggcaag gacaagctct gggggtgaag agagggtgcc
     4741 agctccatga gcccagctcg gcactgtgtc cagctccatc cgccaaagtc atcaagatgc
     4801 ccaggggtgg cccccaacag ctggggacgg gggccaacac tccagccagg gtctttgtgg
     4861 ccctctctga ttacaacccc ctggtgatgt ctgccaacct caaggctgca gaggaggagc
     4921 tggtcttcca gaaaaggcag ttgctaagag tgtggggctc tcaggacacc catgatttct
     4981 acctcagcga gtgcaacagg caagtgggca atatccccgg gcgcctagtg gctgagatgg
     5041 aggtggggac agagcagact gataggaggt ggcgttctcc ggcccaaggg aacctgcctt
     5101 ctgtggccca cctcgaggac tttcaggggc tcaccatccc ccagggttcc tccctggtgc
     5161 tccaggggaa ctccaagaga ctcccactgt ggactccaaa gatcatgata gcagctctgg
     5221 actatgatcc tggggatggg caaatggggg gccaggggaa gggcaggctg gcgctgaggg
     5281 caggagacgt ggtcatggtt tacgggccca tggatgacca aggattctat tatggagagt
     5341 tgggcggcca caggggcctg gttcctgccc acctgctgga tcacatgtcc ctccatggac
     5401 actgagcaag catccttgcc caggtagtgg cctctggctg ctcacaccct gccagaggag
     5461 aagcaagcgt tcagaccctc acaccagcac ccctcctcac caccataagt agcatgtgct
     5521 ccaagtgcca ctgtgttaaa ctgatggtag tccttaagcg tcccctaggc tctgaaagta
     5581 gcaggactta agcctgagtt atttgcaaaa gcaaacacaa caagccaacc cctgagagtc
     5641 tgagaagcca tttcaaagtt gctgataact atggcaggta tacggagaag cgcctttttc
     5701 tgtggccaat gtgtgttttc tctgggaggt taaggttatc tgtccattgc cttgtacgaa
     5761 agtctcaaga aaagtctaca tcttaaaaaa gaaaaagcaa tctgagtgtt atttttggga
     5821 tgtgagggtg atctggctgc gacatgtgtc accccattga tcatcagggt tgattcggct
     5881 gatctggctg actaggcggg tatccccttc ctccctcacc actccatgtg cgtccctcca
     5941 gaagctgtgt gctcaatgga agaggatgac catccccgat agaggacgat cggtcttcag
     6001 tcaagagtat aagagtagct gcgctcccct gctagaacct ccaaacgagc tctcagaatg
     6061 ttatttttct gtcttatgtc caacccctca ttaaaatgtt catag
//
