LOCUS       NM_001393629            5746 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens RIMS binding protein 2 (RIMBP2), transcript variant
            25, mRNA.
ACCESSION   NM_001393629 XM_011538104
VERSION     NM_001393629.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5746)
  AUTHORS   Davis,B.A., Chen,H.Y., Ye,Z., Ostlund,I., Tippani,M., Das,D.,
            Sripathy,S.R., Wang,Y., Martin,J.M., Shim,G., Panchwagh,N.M.,
            Moses,R.L., Farinelli,F., Bohlen,J.F., Li,M., Luikart,B.W.,
            Jaffe,A.E. and Maher,B.J.
  TITLE     TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of
            RIMBP2 in Patient-Derived Cortical Neurons
  JOURNAL   Biol Psychiatry 95 (7), 662-675 (2024)
   PUBMED   37573005
  REMARK    GeneRIF: TCF4 Mutations Disrupt Synaptic Function Through
            Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
REFERENCE   2  (bases 1 to 5746)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5746)
  AUTHORS   Hollingworth,P., Sweet,R., Sims,R., Harold,D., Russo,G.,
            Abraham,R., Stretton,A., Jones,N., Gerrish,A., Chapman,J.,
            Ivanov,D., Moskvina,V., Lovestone,S., Priotsi,P., Lupton,M.,
            Brayne,C., Gill,M., Lawlor,B., Lynch,A., Craig,D., McGuinness,B.,
            Johnston,J., Holmes,C., Livingston,G., Bass,N.J., Gurling,H.,
            McQuillin,A., Holmans,P., Jones,L., Devlin,B., Klei,L.,
            Barmada,M.M., Demirci,F.Y., DeKosky,S.T., Lopez,O.L., Passmore,P.,
            Owen,M.J., O'Donovan,M.C., Mayeux,R., Kamboh,M.I. and Williams,J.
  CONSRTM   GERAD Consortium; National Institute on Aging Late-Onset
            Alzheimer's Disease Family Study Group
  TITLE     Genome-wide association study of Alzheimer's disease with psychotic
            symptoms
  JOURNAL   Mol Psychiatry 17 (12), 1316-1327 (2012)
   PUBMED   22005930
REFERENCE   4  (bases 1 to 5746)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 5746)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
  REMARK    GeneRIF: RIMBP2 is identified in humans
REFERENCE   6  (bases 1 to 5746)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   7  (bases 1 to 5746)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073912.38, AC095350.8 and AC063926.36.
            
            On Feb 23, 2021 this sequence version replaced XM_011538104.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000690449.1/ ENSP00000509157.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC073912.38        15761-15838         c
            79-213              AC095350.8         54911-55045         c
            214-303             AC063926.36        57494-57583
            304-426             AC063926.36        68641-68763
            427-531             AC063926.36        96395-96499
            532-582             AC063926.36        104668-104718
            583-787             AC063926.36        118711-118915
            788-933             AC063926.36        124071-124216
            934-1010            AC063926.36        125135-125211
            1011-1120           AC063926.36        130142-130251
            1121-1933           AC063926.36        132751-133563
            1934-2085           AC063926.36        136895-137046
            2086-2535           AC063926.36        138120-138569
            2536-2682           AC063926.36        140531-140677
            2683-2841           AC063926.36        147074-147232
            2842-3558           AC063926.36        150553-151269
            3559-3667           AC063926.36        152850-152958
            3668-3849           AC063926.36        161105-161286
            3850-4018           AC063926.36        162624-162792
            4019-4122           AC063926.36        167582-167685
            4123-4194           AC063926.36        169168-169239
            4195-4329           AC063926.36        175598-175732
            4330-5746           AC063926.36        177862-179278
FEATURES             Location/Qualifiers
     source          1..5746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..5746
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="RIMS binding protein 2"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
     exon            1..78
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..213
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..303
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..426
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..531
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..4518
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="isoform l is encoded by transcript variant 25; RIM
                     binding protein 2; protein phosphatase 1, regulatory
                     subunit 133"
                     /codon_start=1
                     /product="RIMS-binding protein 2 isoform l"
                     /protein_id="NP_001380558.1"
                     /db_xref="CCDS:CCDS91776.1"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
                     /translation="MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKAQVEAKKEHE
                     GAVRLLESKVRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGSAVAPLDISTAP
                     SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGS
                     ARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLY
                     VYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGL
                     EGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGW
                     EPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRG
                     SSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSHVIFLNEEEFDIVK
                     AARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQ
                     DVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAV
                     ELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSKPLASSGV
                     PETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQGTPVS
                     TTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGASVD
                     DFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGT
                     SHNALKDCTDHRTSEGTFWEQPEFPHQPHRKRLFSIPEVAEEDGECCGLLHKQGAGPS
                     PRARTGLAREPRPGRPYRGDEAPRGSWFPVKHRGSGAVPHVEDFLLEDRGCRFSRSAT
                     RSPDSGLDCGSEEDESRFGFGNTVAACSPGPGHCPCRRGPRPLLARRRTLTRQSSVEE
                     DFGEQVGPGGLLRNDDPQPGPERPPPRKHGWGEPTEHQDFRGVWKKSITMPDSRAAAP
                     HAKPPPRVAQGPLILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLS
                     PDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKD
                     ADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGR
                     RHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQK
                     GLVPSNFLEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRVPPEGSGTARRAPSPTVHLH
                     SGSPTSSMGSGSPGRGREMSSKKKKGLLSKGKKLLKKLGAVK"
     exon            532..582
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..787
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..933
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1010
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1120
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1933
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2085
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2535
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2682
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2841
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..3558
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3667
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3668..3849
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3850..4018
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4122
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4123..4194
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4195..4329
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..5746
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4996..5001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      5019
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
     regulatory      5723..5728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      5746
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtaat ctgacacagt acactgcagt tgtctccgag gtgaacctcc ggagccttgg
       61 cacagctcgc ttctaaagct tggaaatgac ccgccacacc tgaagcctgc aggtgctgag
      121 gccacattcg atcagaccca agctttggga gaccgctggg gaaatttccc acttcctctc
      181 ctgagaccag gaactcagca gagaaacttt gtggaaaatg aactgaagga tgccacccag
      241 ggagagtatc tcctgagatc ccatcatgca ggccttccca caagggcccg gcagcatgac
      301 aaggtgaagg cagagtatgt gcatctcaac catccgctca ccctcgtgac cagagagcgc
      361 gatttggccg tgaaggagaa acaccagctc caagccaagc tggagaacct agaacaggtc
      421 ctgaagcata tgcgagaggc ggctgaacgg cggcagcagc tgcagttgga gcatgaccag
      481 gccctggctg ttctcagtgc caagcagcag gaaattgacc ttctgcagaa ggctcaggtt
      541 gaggctaaga aggagcatga aggcgcagtg cggctgctag agtccaaggt tcgagagctg
      601 gaagagaaat gccggactca aagtgagcag ttcaacctgc tgtcccggga cctggagaag
      661 ttccggcagc acgctggcaa gattgacctg ctgggtggca gcgcggtggc ccccctggac
      721 atctccacgg cccccagcaa gcctttccca cagttcatga atggcctagc cacctccctc
      781 ggcaaaggtc aggagagcgc tattggaggc agctctgcga tcggtgaata tatccggccc
      841 cttccgcagc ctggtgacag gccggagcct ctgtccgcca agcccacctt cctgtcgaga
      901 tccggtagcg caagatgcag atctgagtca gacatggaga atgaacggaa ttccaatacc
      961 tccaagcaga gatactcggg gaaggtccac ctctgtgttg cccgctatag ttacaacccc
     1021 ttcgatggac cgaacgagaa ccccgaagct gagctgcccc tcacggcggg aaaatacctc
     1081 tacgtctatg gagacatgga tgaggatggg ttctatgaag gagagctcct cgatggccag
     1141 aggggtctgg tgccctccaa cttcgtggac tttgtgcagg acaacgagtc gcggttggca
     1201 agcacgctgg ggaacgagca ggatcagaac ttcatcaacc attccggcat cggcctggag
     1261 ggagagcaca tcctggacct ccactcccca acccacatag atgcgggcat caccgacaac
     1321 agtgccggga ccctggacgt gaacatcgac gacatcggag aagacatcgt gccttaccct
     1381 agaaaaatca ccctcatcaa acaactcgcc aaaagtgtta ttgtgggctg ggagcccccg
     1441 gcggtgccac caggatgggg aacggtgagc agctacaacg tcctggtgga caaggagaca
     1501 cgcatgaacc tcacgctggg gagcagaact aaagccctca tcgagaagct caacatggca
     1561 gcctgcacct accgcatctc cgtgcagtgc gtcaccagca ggggcagctc ggatgagctg
     1621 cagtgcacgc tgctggtggg caaggacgtg gtggtggccc cctcccacct gcgggtggac
     1681 aacatcacgc agatctccgc ccagctctcc tggctaccca ccaacagcaa ctacagccac
     1741 gtcatcttcc tcaacgagga ggagttcgac atcgtcaagg ccgccaggta caagtaccag
     1801 ttcttcaatc tcaggcccaa catggcctat aaggtgaagg ttctggccaa accccaccag
     1861 atgccgtggc agctcccgct ggagcaaagg gagaagaagg aggcctttgt ggagttctcc
     1921 acgttgcctg caggaccccc agcaccccca caagatgtta ccgtccaggc tggggtgacc
     1981 cccgccacca tccgggtctc ctggagacca cctgtgctga cgcccaccgg gctgtccaat
     2041 ggcgcaaacg ttaccggcta cggcgtgtat gccaaagggc agagggtggc tgaagtcatc
     2101 ttccccacgg cagacagcac ggccgtggag cttgtgcggc tgcggagcct ggaggccaag
     2161 ggcgtgaccg tgcggaccct ctccgcccag ggcgagtccg tggactctgc agttgctgcc
     2221 gttccccccg agctcctggt gcctcctacc ccccacccga gacctgcacc ccaatcaaag
     2281 ccattagcaa gttctggagt ccccgaaacc aaagacgagc acctgggtcc ccacgccagg
     2341 atggatgagg cctgggagca gagccgtgca cctggccctg tgcatgggca catgctggag
     2401 ccgcccgtgg gccccggaag gcggtcgccc tcacccagcc gcatcctgcc acagccacag
     2461 ggcaccccgg tgtccaccac cgtcgccaag gccatggccc gggaggccgc gcagagggtg
     2521 gccgagagca gcaggttaga gaaaaggagc gtcttcctag agagaagcag cgcggggcag
     2581 tacgccgcct cagacgagga ggacgcctat gactctccag acttcaagag gaggggcgcc
     2641 tcggtggacg acttcctgaa aggctctgaa cttggcaagc agccgcactg ttgccatgga
     2701 gacgagtacc acacagagag cagccggggg tctgacctct cagacatcat ggaggaggac
     2761 gaggaggagc tgtattctga aatgcagctg gaagatgggg gaaggaggcg gcccagcggc
     2821 acgtcccaca atgccctcaa ggactgcact gaccatagga cctcggaagg cactttctgg
     2881 gagcagcccg agtttcccca ccagccccac aggaagagac ttttcagtat ccccgaagta
     2941 gcggaagagg acggagagtg ctgtgggctg ctacacaagc agggtgcagg gccgtccccc
     3001 agggccagga cggggctggc cagagagccc aggcccggca ggccctacag gggcgacgag
     3061 gcccctcggg gctcctggtt cccggtgaag cacaggggct cgggggccgt cccccacgtg
     3121 gaggacttcc ttctggaaga caggggctgt cggttcagcc gctcggccac ccggagcccg
     3181 gacagcggcc tggactgtgg gagtgaagag gacgagtcgc ggtttggctt cggaaacacc
     3241 gtggccgcgt gcagcccagg ccctggtcac tgtccctgca ggaggggccc gaggccgctg
     3301 ctggcccggc ggcggacgct gacccggcag agcagcgtgg aggaggactt tggggagcag
     3361 gtgggccctg gtggcctcct caggaacgac gacccccagc ccggcccgga gaggccgccc
     3421 cccaggaagc acggctgggg cgagcccacc gagcaccaag attttcgggg tgtctggaag
     3481 aaaagcataa ccatgcccga cagtagggca gctgcccccc acgcaaagcc acctcccaga
     3541 gtcgcacaag gccccctgat tttagggaac ccagcctctg caggacgggt ggatcacatg
     3601 ggccggaggt ttccccgtgg cagcgctggt cctcagaggt cccggcccgt gacagtccca
     3661 tccatcgacg attacgggcg agaccgcctt tctccagact tctatgaaga gtcagaaact
     3721 gaccctggtg ccgaagagct cccggcccgg atctttgtgg ctctctttga ctacgacccg
     3781 ctcaccatgt ccccaaaccc agatgctgca gaggaggagc ttccctttaa agaaggccag
     3841 atcatcaagg tttatggtga taaagacgct gatggattct accgtgggga aacctgtgcc
     3901 cggcttggcc ttattccttg taacatggtc tctgagatac aagcagatga tgaggagatg
     3961 atggatcagc ttcttagaca gggctttctc cctctgaata cacctgtgga gaaaatagag
     4021 agaagcagga gaagtggcag gcgtcattcg gtatcgacgc ggagaatggt ggccctgtat
     4081 gactacgacc ccagagaaag ctcgcccaac gtcgatgtcg aggccgaact tacattttgc
     4141 acaggagata ttattacagt ttttggtgaa attgatgaag atggatttta ttatggggag
     4201 ctgaatgggc agaaaggcct tgtgccctca aacttcttgg aagaagtgcc tgatgacgta
     4261 gaagtctatc tttctgatgc tccatcccac tactctcaag atacgccaat gcgctcaaag
     4321 gcaaaaaggg ttcctcctga gggttcaggt acagcaagga gagctccatc ccccacagtc
     4381 catctccatt cggggtcacc tacgtcatct atgggttctg gtagtcctgg gagaggcagg
     4441 gaaatgtcct cgaaaaagaa aaaggggctg ctttccaaag gcaagaaact gctgaaaaag
     4501 ctgggtgcag tgaaatgatt catgtgcttc cggacaactg ccaaatctat gtaattttct
     4561 ttaattccaa actagggctt tcatgactca agtacttcct aaaaaaaccc aatcttctcc
     4621 cctgacacca gtagagaaat gcacttttgc actaccaacc actttaaacc aaccacgaga
     4681 acaaagagga gcggttgctc tctgtcaccg ctggcagtct gctctcattg tccaagctct
     4741 gatttgggag gtgggagggg acgtcttatt aacaaacggg ggcgcatagc tatcacctgt
     4801 agctccctcc ctacctgtaa ttccagtctt tgtgcatttg tcatctgccc ttaaaggaat
     4861 gattttcaac ctttctccct tctcaaaatg cttgcctcat aatgcataac tttcactttg
     4921 actctggtct tgaaattcct agtttaattc gccttgatgt tctgccttat aaatgcacaa
     4981 tgatttgtac tgtctaataa aaacagtgta tactttgtat gtgtcgtgca ttcagtggtc
     5041 ttcatcctga cacagtggtt tgagatcaag ttgtacaggc tgtgcatttt aagatactag
     5101 tttcagtctt tcaaagccag ccaggctaca cacagaaaat gtttactcaa tcattcaaaa
     5161 aagagaaaag gagagaaagt aactttgttt ggtaaagcac cagtactcca accttccaga
     5221 aagccgatta tcttcattgc ttttaatgtt ctattctgtg gcatatggtt ttctgttact
     5281 ttcgttgtca aaatgccata cccaaataca cagcaatgaa tggcacacaa gtaatccaca
     5341 taatgcataa gccacaccaa aaccagactc aatttaaatc tgctccaaat gagtccatac
     5401 ccatcttcat cattggcatt tgaacaaaag acttacttac aaagttgctg gcagatgtat
     5461 ttgatggtta ctcttttgta attcttgtcc acttgtaaat tgtttttact ctttatacat
     5521 acttttcaga ctgcctttct tttgtaattt atggacggtt tataaatgaa tgacaaagct
     5581 ttccccattg tgtcttcaaa aacgctatta taaattgtaa tataatagta tgtggtagat
     5641 ttattattaa aggaaatcca tgtgtggtta agctctgtgt gggtgtgtgc atgtgcacag
     5701 ttagtgtaaa atattttcta gaaataaaat ttgttatttt atacaa
//
