LOCUS       NM_001393624            6639 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens RIMS binding protein 2 (RIMBP2), transcript variant
            20, mRNA.
ACCESSION   NM_001393624
VERSION     NM_001393624.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6639)
  AUTHORS   Davis,B.A., Chen,H.Y., Ye,Z., Ostlund,I., Tippani,M., Das,D.,
            Sripathy,S.R., Wang,Y., Martin,J.M., Shim,G., Panchwagh,N.M.,
            Moses,R.L., Farinelli,F., Bohlen,J.F., Li,M., Luikart,B.W.,
            Jaffe,A.E. and Maher,B.J.
  TITLE     TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of
            RIMBP2 in Patient-Derived Cortical Neurons
  JOURNAL   Biol Psychiatry 95 (7), 662-675 (2024)
   PUBMED   37573005
  REMARK    GeneRIF: TCF4 Mutations Disrupt Synaptic Function Through
            Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
REFERENCE   2  (bases 1 to 6639)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6639)
  AUTHORS   Hollingworth,P., Sweet,R., Sims,R., Harold,D., Russo,G.,
            Abraham,R., Stretton,A., Jones,N., Gerrish,A., Chapman,J.,
            Ivanov,D., Moskvina,V., Lovestone,S., Priotsi,P., Lupton,M.,
            Brayne,C., Gill,M., Lawlor,B., Lynch,A., Craig,D., McGuinness,B.,
            Johnston,J., Holmes,C., Livingston,G., Bass,N.J., Gurling,H.,
            McQuillin,A., Holmans,P., Jones,L., Devlin,B., Klei,L.,
            Barmada,M.M., Demirci,F.Y., DeKosky,S.T., Lopez,O.L., Passmore,P.,
            Owen,M.J., O'Donovan,M.C., Mayeux,R., Kamboh,M.I. and Williams,J.
  CONSRTM   GERAD Consortium; National Institute on Aging Late-Onset
            Alzheimer's Disease Family Study Group
  TITLE     Genome-wide association study of Alzheimer's disease with psychotic
            symptoms
  JOURNAL   Mol Psychiatry 17 (12), 1316-1327 (2012)
   PUBMED   22005930
REFERENCE   4  (bases 1 to 6639)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 6639)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
  REMARK    GeneRIF: RIMBP2 is identified in humans
REFERENCE   6  (bases 1 to 6639)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   7  (bases 1 to 6639)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073912.38, AC095350.8 and AC063926.36.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC073912.38        15761-15838         c
            79-213              AC095350.8         54911-55045         c
            214-304             AC063926.36        12066-12156
            305-427             AC063926.36        68641-68763
            428-532             AC063926.36        96395-96499
            533-583             AC063926.36        104668-104718
            584-788             AC063926.36        118711-118915
            789-934             AC063926.36        124071-124216
            935-1011            AC063926.36        125135-125211
            1012-1121           AC063926.36        130142-130251
            1122-1934           AC063926.36        132751-133563
            1935-2086           AC063926.36        136895-137046
            2087-2536           AC063926.36        138120-138569
            2537-2683           AC063926.36        140531-140677
            2684-2842           AC063926.36        147074-147232
            2843-2951           AC063926.36        152850-152958
            2952-3133           AC063926.36        161105-161286
            3134-3302           AC063926.36        162624-162792
            3303-3406           AC063926.36        167582-167685
            3407-3478           AC063926.36        169168-169239
            3479-3613           AC063926.36        175598-175732
            3614-6639           AC063926.36        176253-179278
FEATURES             Location/Qualifiers
     source          1..6639
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..6639
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="RIMS binding protein 2"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
     exon            1..78
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..213
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..304
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            305..427
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..532
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..3637
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="isoform d is encoded by transcript variant 20; RIM
                     binding protein 2; protein phosphatase 1, regulatory
                     subunit 133"
                     /codon_start=1
                     /product="RIMS-binding protein 2 isoform d"
                     /protein_id="NP_001380553.1"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
                     /translation="MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKAQVEAKKEHE
                     GAVRLLESKVRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGSAVAPLDISTAP
                     SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGS
                     ARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLY
                     VYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGL
                     EGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGW
                     EPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRG
                     SSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSHVIFLNEEEFDIVK
                     AARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQ
                     DVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAV
                     ELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSKPLASSGV
                     PETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQGTPVS
                     TTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGASVD
                     DFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGT
                     SHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEES
                     ETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRG
                     ETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTR
                     RMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF
                     LEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRKSVHFTP"
     exon            533..583
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..788
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..934
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1011
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1121
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1934
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2086
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2536
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2683
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2842
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..2951
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3133
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3302
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3406
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3478
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3613
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..6639
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5889..5894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      5912
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
     regulatory      6616..6621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      6639
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtaat ctgacacagt acactgcagt tgtctccgag gtgaacctcc ggagccttgg
       61 cacagctcgc ttctaaagct tggaaatgac ccgccacacc tgaagcctgc aggtgctgag
      121 gccacattcg atcagaccca agctttggga gaccgctggg gaaatttccc acttcctctc
      181 ctgagaccag gaactcagca gagaaacttt gtggttaatc actggacttc cagctggaga
      241 tgccaccagg tgtcttgttg aggaagaggc ttggcagggc gtaagaacgc gtttcaagtg
      301 tctggtgaag gcagagtatg tgcatctcaa ccatccgctc accctcgtga ccagagagcg
      361 cgatttggcc gtgaaggaga aacaccagct ccaagccaag ctggagaacc tagaacaggt
      421 cctgaagcat atgcgagagg cggctgaacg gcggcagcag ctgcagttgg agcatgacca
      481 ggccctggct gttctcagtg ccaagcagca ggaaattgac cttctgcaga aggctcaggt
      541 tgaggctaag aaggagcatg aaggcgcagt gcggctgcta gagtccaagg ttcgagagct
      601 ggaagagaaa tgccggactc aaagtgagca gttcaacctg ctgtcccggg acctggagaa
      661 gttccggcag cacgctggca agattgacct gctgggtggc agcgcggtgg cccccctgga
      721 catctccacg gcccccagca agcctttccc acagttcatg aatggcctag ccacctccct
      781 cggcaaaggt caggagagcg ctattggagg cagctctgcg atcggtgaat atatccggcc
      841 ccttccgcag cctggtgaca ggccggagcc tctgtccgcc aagcccacct tcctgtcgag
      901 atccggtagc gcaagatgca gatctgagtc agacatggag aatgaacgga attccaatac
      961 ctccaagcag agatactcgg ggaaggtcca cctctgtgtt gcccgctata gttacaaccc
     1021 cttcgatgga ccgaacgaga accccgaagc tgagctgccc ctcacggcgg gaaaatacct
     1081 ctacgtctat ggagacatgg atgaggatgg gttctatgaa ggagagctcc tcgatggcca
     1141 gaggggtctg gtgccctcca acttcgtgga ctttgtgcag gacaacgagt cgcggttggc
     1201 aagcacgctg gggaacgagc aggatcagaa cttcatcaac cattccggca tcggcctgga
     1261 gggagagcac atcctggacc tccactcccc aacccacata gatgcgggca tcaccgacaa
     1321 cagtgccggg accctggacg tgaacatcga cgacatcgga gaagacatcg tgccttaccc
     1381 tagaaaaatc accctcatca aacaactcgc caaaagtgtt attgtgggct gggagccccc
     1441 ggcggtgcca ccaggatggg gaacggtgag cagctacaac gtcctggtgg acaaggagac
     1501 acgcatgaac ctcacgctgg ggagcagaac taaagccctc atcgagaagc tcaacatggc
     1561 agcctgcacc taccgcatct ccgtgcagtg cgtcaccagc aggggcagct cggatgagct
     1621 gcagtgcacg ctgctggtgg gcaaggacgt ggtggtggcc ccctcccacc tgcgggtgga
     1681 caacatcacg cagatctccg cccagctctc ctggctaccc accaacagca actacagcca
     1741 cgtcatcttc ctcaacgagg aggagttcga catcgtcaag gccgccaggt acaagtacca
     1801 gttcttcaat ctcaggccca acatggccta taaggtgaag gttctggcca aaccccacca
     1861 gatgccgtgg cagctcccgc tggagcaaag ggagaagaag gaggcctttg tggagttctc
     1921 cacgttgcct gcaggacccc cagcaccccc acaagatgtt accgtccagg ctggggtgac
     1981 ccccgccacc atccgggtct cctggagacc acctgtgctg acgcccaccg ggctgtccaa
     2041 tggcgcaaac gttaccggct acggcgtgta tgccaaaggg cagagggtgg ctgaagtcat
     2101 cttccccacg gcagacagca cggccgtgga gcttgtgcgg ctgcggagcc tggaggccaa
     2161 gggcgtgacc gtgcggaccc tctccgccca gggcgagtcc gtggactctg cagttgctgc
     2221 cgttcccccc gagctcctgg tgcctcctac cccccacccg agacctgcac cccaatcaaa
     2281 gccattagca agttctggag tccccgaaac caaagacgag cacctgggtc cccacgccag
     2341 gatggatgag gcctgggagc agagccgtgc acctggccct gtgcatgggc acatgctgga
     2401 gccgcccgtg ggccccggaa ggcggtcgcc ctcacccagc cgcatcctgc cacagccaca
     2461 gggcaccccg gtgtccacca ccgtcgccaa ggccatggcc cgggaggccg cgcagagggt
     2521 ggccgagagc agcaggttag agaaaaggag cgtcttccta gagagaagca gcgcggggca
     2581 gtacgccgcc tcagacgagg aggacgccta tgactctcca gacttcaaga ggaggggcgc
     2641 ctcggtggac gacttcctga aaggctctga acttggcaag cagccgcact gttgccatgg
     2701 agacgagtac cacacagaga gcagccgggg gtctgacctc tcagacatca tggaggagga
     2761 cgaggaggag ctgtattctg aaatgcagct ggaagatggg ggaaggaggc ggcccagcgg
     2821 cacgtcccac aatgccctca agattttagg gaacccagcc tctgcaggac gggtggatca
     2881 catgggccgg aggtttcccc gtggcagcgc tggtcctcag aggtcccggc ccgtgacagt
     2941 cccatccatc gacgattacg ggcgagaccg cctttctcca gacttctatg aagagtcaga
     3001 aactgaccct ggtgccgaag agctcccggc ccggatcttt gtggctctct ttgactacga
     3061 cccgctcacc atgtccccaa acccagatgc tgcagaggag gagcttccct ttaaagaagg
     3121 ccagatcatc aaggtttatg gtgataaaga cgctgatgga ttctaccgtg gggaaacctg
     3181 tgcccggctt ggccttattc cttgtaacat ggtctctgag atacaagcag atgatgagga
     3241 gatgatggat cagcttctta gacagggctt tctccctctg aatacacctg tggagaaaat
     3301 agagagaagc aggagaagtg gcaggcgtca ttcggtatcg acgcggagaa tggtggccct
     3361 gtatgactac gaccccagag aaagctcgcc caacgtcgat gtcgaggccg aacttacatt
     3421 ttgcacagga gatattatta cagtttttgg tgaaattgat gaagatggat tttattatgg
     3481 ggagctgaat gggcagaaag gccttgtgcc ctcaaacttc ttggaagaag tgcctgatga
     3541 cgtagaagtc tatctttctg atgctccatc ccactactct caagatacgc caatgcgctc
     3601 aaaggcaaaa aggaagagtg ttcatttcac accttaatca ggcaatgtag ccttcacgta
     3661 agtgagcaac tgaagatacc gataaagata ccaacttaag ctaccttaac cgggccagtg
     3721 tggtagactt aaggcttcat tgtggggtta aaaaaaaaaa aagatacaaa gaaatatgtc
     3781 tcaaaaaact attggaccta aataattaga atattacttg gtctcagttg taaagcaact
     3841 gaatttatag tgaagcaaat catctttaat aatcatttcc tactatttgc attaagaata
     3901 tttgaaaggc caacattggg aacatatttc ttaacaagct aactgtgtgt ttacatagag
     3961 agagctgcat attgcattgt tagccactct tggaaaaagc acaacctaac aaacatgttt
     4021 actataggaa gctttacttt agaaacttaa cccaaggtca agcagatgag tagtgaacac
     4081 aggtgatcga gtgttggctc tgaacactcc aaacactggc tcgagtggcc agaacgtgtt
     4141 ttccttaagt aaccctgcct ctaccttacg agagagctat gctcctcctc aaagcacaat
     4201 catcctgtga cagaagttgc tgcaacacgc gtttgttgtt ggtataccaa tgcaatacta
     4261 agttgatgaa gcacgcagct caaatgatca cattagatgg aatagatggt atcttcaggt
     4321 gtactttggg atgctttact aggtgttttc cattagaatt agaccttgat tttaaatcca
     4381 agcaagcttg aagccccttg gcttacagca tttgcctgct gaatactaaa cactcacatg
     4441 gcaagagttg ctctggagag gtagggccag aggaatgctg ctgcactgcc aactcaggca
     4501 catgcttagc tgtaaaggga agcgaggtga agtcgtcctg cagcgtatta gagtaaaagt
     4561 ctacccctct gaagcactat taagcgctta acgtatattt aaatactacc atgtgctatc
     4621 tactgaggaa gattcatgtt caattatttg gaaataatgc aagcatccac taagggcctt
     4681 taagctttct ttgattataa ttaaggttca ttttagtttt tttttttctt tcaaccagtg
     4741 tgccatctcc aatatttcta tagtatacca accaccccag gaatgcactt taacaatatc
     4801 aggattttat ataaccaaat agtttcaaat acaacaaaat tccctttatg aactttcgct
     4861 ttttaagact actgatgggt actcggccaa ctttactatc aacctaattt cagatcatgt
     4921 ctcccctgcc cttagtcttc atttatgaag tgaattatta cctgccttag ctttgccaaa
     4981 gcaacggcca ccccgcactc cctcgagaca gagaaacgga acccacacat ttatgtctgg
     5041 ggcctctctc tggcgtgctg tgggagagga cctttgcttc tcatggcata cttcaacaac
     5101 tgaaagaaca aatgaacccc cctgaccttt cctggtggga aacggggaca gtacgatgtt
     5161 accaagtgaa ttctgttgtt ggcgctcaca cactcaataa actgtaacac tgtacctact
     5221 aggttcctcc tgagggttca ggtacagcaa ggagagctcc atcccccaca gtccatctcc
     5281 attcggggtc acctacgtca tctatgggtt ctggtagtcc tgggagaggc agggaaatgt
     5341 cctcgaaaaa gaaaaagggg ctgctttcca aaggcaagaa actgctgaaa aagctgggtg
     5401 cagtgaaatg attcatgtgc ttccggacaa ctgccaaatc tatgtaattt tctttaattc
     5461 caaactaggg ctttcatgac tcaagtactt cctaaaaaaa cccaatcttc tcccctgaca
     5521 ccagtagaga aatgcacttt tgcactacca accactttaa accaaccacg agaacaaaga
     5581 ggagcggttg ctctctgtca ccgctggcag tctgctctca ttgtccaagc tctgatttgg
     5641 gaggtgggag gggacgtctt attaacaaac gggggcgcat agctatcacc tgtagctccc
     5701 tccctacctg taattccagt ctttgtgcat ttgtcatctg cccttaaagg aatgattttc
     5761 aacctttctc ccttctcaaa atgcttgcct cataatgcat aactttcact ttgactctgg
     5821 tcttgaaatt cctagtttaa ttcgccttga tgttctgcct tataaatgca caatgatttg
     5881 tactgtctaa taaaaacagt gtatactttg tatgtgtcgt gcattcagtg gtcttcatcc
     5941 tgacacagtg gtttgagatc aagttgtaca ggctgtgcat tttaagatac tagtttcagt
     6001 ctttcaaagc cagccaggct acacacagaa aatgtttact caatcattca aaaaagagaa
     6061 aaggagagaa agtaactttg tttggtaaag caccagtact ccaaccttcc agaaagccga
     6121 ttatcttcat tgcttttaat gttctattct gtggcatatg gttttctgtt actttcgttg
     6181 tcaaaatgcc atacccaaat acacagcaat gaatggcaca caagtaatcc acataatgca
     6241 taagccacac caaaaccaga ctcaatttaa atctgctcca aatgagtcca tacccatctt
     6301 catcattggc atttgaacaa aagacttact tacaaagttg ctggcagatg tatttgatgg
     6361 ttactctttt gtaattcttg tccacttgta aattgttttt actctttata catacttttc
     6421 agactgcctt tcttttgtaa tttatggacg gtttataaat gaatgacaaa gctttcccca
     6481 ttgtgtcttc aaaaacgcta ttataaattg taatataata gtatgtggta gatttattat
     6541 taaaggaaat ccatgtgtgg ttaagctctg tgtgggtgtg tgcatgtgca cagttagtgt
     6601 aaaatatttt ctagaaataa aatttgttat tttatacaa
//
