LOCUS       NM_001393621            6551 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens RIMS binding protein 2 (RIMBP2), transcript variant
            17, mRNA.
ACCESSION   NM_001393621
VERSION     NM_001393621.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6551)
  AUTHORS   Davis,B.A., Chen,H.Y., Ye,Z., Ostlund,I., Tippani,M., Das,D.,
            Sripathy,S.R., Wang,Y., Martin,J.M., Shim,G., Panchwagh,N.M.,
            Moses,R.L., Farinelli,F., Bohlen,J.F., Li,M., Luikart,B.W.,
            Jaffe,A.E. and Maher,B.J.
  TITLE     TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of
            RIMBP2 in Patient-Derived Cortical Neurons
  JOURNAL   Biol Psychiatry 95 (7), 662-675 (2024)
   PUBMED   37573005
  REMARK    GeneRIF: TCF4 Mutations Disrupt Synaptic Function Through
            Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
REFERENCE   2  (bases 1 to 6551)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6551)
  AUTHORS   Hollingworth,P., Sweet,R., Sims,R., Harold,D., Russo,G.,
            Abraham,R., Stretton,A., Jones,N., Gerrish,A., Chapman,J.,
            Ivanov,D., Moskvina,V., Lovestone,S., Priotsi,P., Lupton,M.,
            Brayne,C., Gill,M., Lawlor,B., Lynch,A., Craig,D., McGuinness,B.,
            Johnston,J., Holmes,C., Livingston,G., Bass,N.J., Gurling,H.,
            McQuillin,A., Holmans,P., Jones,L., Devlin,B., Klei,L.,
            Barmada,M.M., Demirci,F.Y., DeKosky,S.T., Lopez,O.L., Passmore,P.,
            Owen,M.J., O'Donovan,M.C., Mayeux,R., Kamboh,M.I. and Williams,J.
  CONSRTM   GERAD Consortium; National Institute on Aging Late-Onset
            Alzheimer's Disease Family Study Group
  TITLE     Genome-wide association study of Alzheimer's disease with psychotic
            symptoms
  JOURNAL   Mol Psychiatry 17 (12), 1316-1327 (2012)
   PUBMED   22005930
REFERENCE   4  (bases 1 to 6551)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 6551)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
  REMARK    GeneRIF: RIMBP2 is identified in humans
REFERENCE   6  (bases 1 to 6551)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   7  (bases 1 to 6551)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073912.38, AC095350.8 and AC063926.36.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC073912.38        15761-15838         c
            79-213              AC095350.8         54911-55045         c
            214-336             AC063926.36        68641-68763
            337-441             AC063926.36        96395-96499
            442-492             AC063926.36        104668-104718
            493-697             AC063926.36        118711-118915
            698-843             AC063926.36        124071-124216
            844-920             AC063926.36        125135-125211
            921-1030            AC063926.36        130142-130251
            1031-1843           AC063926.36        132751-133563
            1844-1995           AC063926.36        136895-137046
            1996-2445           AC063926.36        138120-138569
            2446-2592           AC063926.36        140531-140677
            2593-2751           AC063926.36        147074-147232
            2752-2860           AC063926.36        152850-152958
            2861-3042           AC063926.36        161105-161286
            3043-3211           AC063926.36        162624-162792
            3212-3315           AC063926.36        167582-167685
            3316-3387           AC063926.36        169168-169239
            3388-3522           AC063926.36        175598-175732
            3523-6551           AC063926.36        176250-179278
FEATURES             Location/Qualifiers
     source          1..6551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..6551
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="RIMS binding protein 2"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
     exon            1..78
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..213
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..336
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..441
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..3549
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="isoform c is encoded by transcript variant 17; RIM
                     binding protein 2; protein phosphatase 1, regulatory
                     subunit 133"
                     /codon_start=1
                     /product="RIMS-binding protein 2 isoform c"
                     /protein_id="NP_001380550.1"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
                     /translation="MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKAQVEAKKEHE
                     GAVRLLESKVRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGSAVAPLDISTAP
                     SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGS
                     ARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLY
                     VYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGL
                     EGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGW
                     EPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRG
                     SSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSHVIFLNEEEFDIVK
                     AARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQ
                     DVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAV
                     ELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSKPLASSGV
                     PETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQGTPVS
                     TTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGASVD
                     DFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGT
                     SHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEES
                     ETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRG
                     ETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTR
                     RMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF
                     LEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRKKSVHFTP"
     exon            442..492
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..697
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..843
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..920
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1030
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1843
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1995
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2445
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2592
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2751
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2860
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..3042
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3043..3211
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3212..3315
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3387
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3522
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..6551
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5801..5806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      5824
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
     regulatory      6528..6533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      6551
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtaat ctgacacagt acactgcagt tgtctccgag gtgaacctcc ggagccttgg
       61 cacagctcgc ttctaaagct tggaaatgac ccgccacacc tgaagcctgc aggtgctgag
      121 gccacattcg atcagaccca agctttggga gaccgctggg gaaatttccc acttcctctc
      181 ctgagaccag gaactcagca gagaaacttt gtggtgaagg cagagtatgt gcatctcaac
      241 catccgctca ccctcgtgac cagagagcgc gatttggccg tgaaggagaa acaccagctc
      301 caagccaagc tggagaacct agaacaggtc ctgaagcata tgcgagaggc ggctgaacgg
      361 cggcagcagc tgcagttgga gcatgaccag gccctggctg ttctcagtgc caagcagcag
      421 gaaattgacc ttctgcagaa ggctcaggtt gaggctaaga aggagcatga aggcgcagtg
      481 cggctgctag agtccaaggt tcgagagctg gaagagaaat gccggactca aagtgagcag
      541 ttcaacctgc tgtcccggga cctggagaag ttccggcagc acgctggcaa gattgacctg
      601 ctgggtggca gcgcggtggc ccccctggac atctccacgg cccccagcaa gcctttccca
      661 cagttcatga atggcctagc cacctccctc ggcaaaggtc aggagagcgc tattggaggc
      721 agctctgcga tcggtgaata tatccggccc cttccgcagc ctggtgacag gccggagcct
      781 ctgtccgcca agcccacctt cctgtcgaga tccggtagcg caagatgcag atctgagtca
      841 gacatggaga atgaacggaa ttccaatacc tccaagcaga gatactcggg gaaggtccac
      901 ctctgtgttg cccgctatag ttacaacccc ttcgatggac cgaacgagaa ccccgaagct
      961 gagctgcccc tcacggcggg aaaatacctc tacgtctatg gagacatgga tgaggatggg
     1021 ttctatgaag gagagctcct cgatggccag aggggtctgg tgccctccaa cttcgtggac
     1081 tttgtgcagg acaacgagtc gcggttggca agcacgctgg ggaacgagca ggatcagaac
     1141 ttcatcaacc attccggcat cggcctggag ggagagcaca tcctggacct ccactcccca
     1201 acccacatag atgcgggcat caccgacaac agtgccggga ccctggacgt gaacatcgac
     1261 gacatcggag aagacatcgt gccttaccct agaaaaatca ccctcatcaa acaactcgcc
     1321 aaaagtgtta ttgtgggctg ggagcccccg gcggtgccac caggatgggg aacggtgagc
     1381 agctacaacg tcctggtgga caaggagaca cgcatgaacc tcacgctggg gagcagaact
     1441 aaagccctca tcgagaagct caacatggca gcctgcacct accgcatctc cgtgcagtgc
     1501 gtcaccagca ggggcagctc ggatgagctg cagtgcacgc tgctggtggg caaggacgtg
     1561 gtggtggccc cctcccacct gcgggtggac aacatcacgc agatctccgc ccagctctcc
     1621 tggctaccca ccaacagcaa ctacagccac gtcatcttcc tcaacgagga ggagttcgac
     1681 atcgtcaagg ccgccaggta caagtaccag ttcttcaatc tcaggcccaa catggcctat
     1741 aaggtgaagg ttctggccaa accccaccag atgccgtggc agctcccgct ggagcaaagg
     1801 gagaagaagg aggcctttgt ggagttctcc acgttgcctg caggaccccc agcaccccca
     1861 caagatgtta ccgtccaggc tggggtgacc cccgccacca tccgggtctc ctggagacca
     1921 cctgtgctga cgcccaccgg gctgtccaat ggcgcaaacg ttaccggcta cggcgtgtat
     1981 gccaaagggc agagggtggc tgaagtcatc ttccccacgg cagacagcac ggccgtggag
     2041 cttgtgcggc tgcggagcct ggaggccaag ggcgtgaccg tgcggaccct ctccgcccag
     2101 ggcgagtccg tggactctgc agttgctgcc gttccccccg agctcctggt gcctcctacc
     2161 ccccacccga gacctgcacc ccaatcaaag ccattagcaa gttctggagt ccccgaaacc
     2221 aaagacgagc acctgggtcc ccacgccagg atggatgagg cctgggagca gagccgtgca
     2281 cctggccctg tgcatgggca catgctggag ccgcccgtgg gccccggaag gcggtcgccc
     2341 tcacccagcc gcatcctgcc acagccacag ggcaccccgg tgtccaccac cgtcgccaag
     2401 gccatggccc gggaggccgc gcagagggtg gccgagagca gcaggttaga gaaaaggagc
     2461 gtcttcctag agagaagcag cgcggggcag tacgccgcct cagacgagga ggacgcctat
     2521 gactctccag acttcaagag gaggggcgcc tcggtggacg acttcctgaa aggctctgaa
     2581 cttggcaagc agccgcactg ttgccatgga gacgagtacc acacagagag cagccggggg
     2641 tctgacctct cagacatcat ggaggaggac gaggaggagc tgtattctga aatgcagctg
     2701 gaagatgggg gaaggaggcg gcccagcggc acgtcccaca atgccctcaa gattttaggg
     2761 aacccagcct ctgcaggacg ggtggatcac atgggccgga ggtttccccg tggcagcgct
     2821 ggtcctcaga ggtcccggcc cgtgacagtc ccatccatcg acgattacgg gcgagaccgc
     2881 ctttctccag acttctatga agagtcagaa actgaccctg gtgccgaaga gctcccggcc
     2941 cggatctttg tggctctctt tgactacgac ccgctcacca tgtccccaaa cccagatgct
     3001 gcagaggagg agcttccctt taaagaaggc cagatcatca aggtttatgg tgataaagac
     3061 gctgatggat tctaccgtgg ggaaacctgt gcccggcttg gccttattcc ttgtaacatg
     3121 gtctctgaga tacaagcaga tgatgaggag atgatggatc agcttcttag acagggcttt
     3181 ctccctctga atacacctgt ggagaaaata gagagaagca ggagaagtgg caggcgtcat
     3241 tcggtatcga cgcggagaat ggtggccctg tatgactacg accccagaga aagctcgccc
     3301 aacgtcgatg tcgaggccga acttacattt tgcacaggag atattattac agtttttggt
     3361 gaaattgatg aagatggatt ttattatggg gagctgaatg ggcagaaagg ccttgtgccc
     3421 tcaaacttct tggaagaagt gcctgatgac gtagaagtct atctttctga tgctccatcc
     3481 cactactctc aagatacgcc aatgcgctca aaggcaaaaa ggaagaagag tgttcatttc
     3541 acaccttaat caggcaatgt agccttcacg taagtgagca actgaagata ccgataaaga
     3601 taccaactta agctacctta accgggccag tgtggtagac ttaaggcttc attgtggggt
     3661 taaaaaaaaa aaaagataca aagaaatatg tctcaaaaaa ctattggacc taaataatta
     3721 gaatattact tggtctcagt tgtaaagcaa ctgaatttat agtgaagcaa atcatcttta
     3781 ataatcattt cctactattt gcattaagaa tatttgaaag gccaacattg ggaacatatt
     3841 tcttaacaag ctaactgtgt gtttacatag agagagctgc atattgcatt gttagccact
     3901 cttggaaaaa gcacaaccta acaaacatgt ttactatagg aagctttact ttagaaactt
     3961 aacccaaggt caagcagatg agtagtgaac acaggtgatc gagtgttggc tctgaacact
     4021 ccaaacactg gctcgagtgg ccagaacgtg ttttccttaa gtaaccctgc ctctacctta
     4081 cgagagagct atgctcctcc tcaaagcaca atcatcctgt gacagaagtt gctgcaacac
     4141 gcgtttgttg ttggtatacc aatgcaatac taagttgatg aagcacgcag ctcaaatgat
     4201 cacattagat ggaatagatg gtatcttcag gtgtactttg ggatgcttta ctaggtgttt
     4261 tccattagaa ttagaccttg attttaaatc caagcaagct tgaagcccct tggcttacag
     4321 catttgcctg ctgaatacta aacactcaca tggcaagagt tgctctggag aggtagggcc
     4381 agaggaatgc tgctgcactg ccaactcagg cacatgctta gctgtaaagg gaagcgaggt
     4441 gaagtcgtcc tgcagcgtat tagagtaaaa gtctacccct ctgaagcact attaagcgct
     4501 taacgtatat ttaaatacta ccatgtgcta tctactgagg aagattcatg ttcaattatt
     4561 tggaaataat gcaagcatcc actaagggcc tttaagcttt ctttgattat aattaaggtt
     4621 cattttagtt tttttttttc tttcaaccag tgtgccatct ccaatatttc tatagtatac
     4681 caaccacccc aggaatgcac tttaacaata tcaggatttt atataaccaa atagtttcaa
     4741 atacaacaaa attcccttta tgaactttcg ctttttaaga ctactgatgg gtactcggcc
     4801 aactttacta tcaacctaat ttcagatcat gtctcccctg cccttagtct tcatttatga
     4861 agtgaattat tacctgcctt agctttgcca aagcaacggc caccccgcac tccctcgaga
     4921 cagagaaacg gaacccacac atttatgtct ggggcctctc tctggcgtgc tgtgggagag
     4981 gacctttgct tctcatggca tacttcaaca actgaaagaa caaatgaacc cccctgacct
     5041 ttcctggtgg gaaacgggga cagtacgatg ttaccaagtg aattctgttg ttggcgctca
     5101 cacactcaat aaactgtaac actgtaccta ctaggttcct cctgagggtt caggtacagc
     5161 aaggagagct ccatccccca cagtccatct ccattcgggg tcacctacgt catctatggg
     5221 ttctggtagt cctgggagag gcagggaaat gtcctcgaaa aagaaaaagg ggctgctttc
     5281 caaaggcaag aaactgctga aaaagctggg tgcagtgaaa tgattcatgt gcttccggac
     5341 aactgccaaa tctatgtaat tttctttaat tccaaactag ggctttcatg actcaagtac
     5401 ttcctaaaaa aacccaatct tctcccctga caccagtaga gaaatgcact tttgcactac
     5461 caaccacttt aaaccaacca cgagaacaaa gaggagcggt tgctctctgt caccgctggc
     5521 agtctgctct cattgtccaa gctctgattt gggaggtggg aggggacgtc ttattaacaa
     5581 acgggggcgc atagctatca cctgtagctc cctccctacc tgtaattcca gtctttgtgc
     5641 atttgtcatc tgcccttaaa ggaatgattt tcaacctttc tcccttctca aaatgcttgc
     5701 ctcataatgc ataactttca ctttgactct ggtcttgaaa ttcctagttt aattcgcctt
     5761 gatgttctgc cttataaatg cacaatgatt tgtactgtct aataaaaaca gtgtatactt
     5821 tgtatgtgtc gtgcattcag tggtcttcat cctgacacag tggtttgaga tcaagttgta
     5881 caggctgtgc attttaagat actagtttca gtctttcaaa gccagccagg ctacacacag
     5941 aaaatgttta ctcaatcatt caaaaaagag aaaaggagag aaagtaactt tgtttggtaa
     6001 agcaccagta ctccaacctt ccagaaagcc gattatcttc attgctttta atgttctatt
     6061 ctgtggcata tggttttctg ttactttcgt tgtcaaaatg ccatacccaa atacacagca
     6121 atgaatggca cacaagtaat ccacataatg cataagccac accaaaacca gactcaattt
     6181 aaatctgctc caaatgagtc catacccatc ttcatcattg gcatttgaac aaaagactta
     6241 cttacaaagt tgctggcaga tgtatttgat ggttactctt ttgtaattct tgtccacttg
     6301 taaattgttt ttactcttta tacatacttt tcagactgcc tttcttttgt aatttatgga
     6361 cggtttataa atgaatgaca aagctttccc cattgtgtct tcaaaaacgc tattataaat
     6421 tgtaatataa tagtatgtgg tagatttatt attaaaggaa atccatgtgt ggttaagctc
     6481 tgtgtgggtg tgtgcatgtg cacagttagt gtaaaatatt ttctagaaat aaaatttgtt
     6541 attttataca a
//
