LOCUS       NM_001351226            5029 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens RIMS binding protein 2 (RIMBP2), transcript variant 1,
            mRNA.
ACCESSION   NM_001351226 XM_017019107
VERSION     NM_001351226.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5029)
  AUTHORS   Davis,B.A., Chen,H.Y., Ye,Z., Ostlund,I., Tippani,M., Das,D.,
            Sripathy,S.R., Wang,Y., Martin,J.M., Shim,G., Panchwagh,N.M.,
            Moses,R.L., Farinelli,F., Bohlen,J.F., Li,M., Luikart,B.W.,
            Jaffe,A.E. and Maher,B.J.
  TITLE     TCF4 Mutations Disrupt Synaptic Function Through Dysregulation of
            RIMBP2 in Patient-Derived Cortical Neurons
  JOURNAL   Biol Psychiatry 95 (7), 662-675 (2024)
   PUBMED   37573005
  REMARK    GeneRIF: TCF4 Mutations Disrupt Synaptic Function Through
            Dysregulation of RIMBP2 in Patient-Derived Cortical Neurons.
REFERENCE   2  (bases 1 to 5029)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5029)
  AUTHORS   Hollingworth,P., Sweet,R., Sims,R., Harold,D., Russo,G.,
            Abraham,R., Stretton,A., Jones,N., Gerrish,A., Chapman,J.,
            Ivanov,D., Moskvina,V., Lovestone,S., Priotsi,P., Lupton,M.,
            Brayne,C., Gill,M., Lawlor,B., Lynch,A., Craig,D., McGuinness,B.,
            Johnston,J., Holmes,C., Livingston,G., Bass,N.J., Gurling,H.,
            McQuillin,A., Holmans,P., Jones,L., Devlin,B., Klei,L.,
            Barmada,M.M., Demirci,F.Y., DeKosky,S.T., Lopez,O.L., Passmore,P.,
            Owen,M.J., O'Donovan,M.C., Mayeux,R., Kamboh,M.I. and Williams,J.
  CONSRTM   GERAD Consortium; National Institute on Aging Late-Onset
            Alzheimer's Disease Family Study Group
  TITLE     Genome-wide association study of Alzheimer's disease with psychotic
            symptoms
  JOURNAL   Mol Psychiatry 17 (12), 1316-1327 (2012)
   PUBMED   22005930
REFERENCE   4  (bases 1 to 5029)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   5  (bases 1 to 5029)
  AUTHORS   Mittelstaedt,T. and Schoch,S.
  TITLE     Structure and evolution of RIM-BP genes: identification of a novel
            family member
  JOURNAL   Gene 403 (1-2), 70-79 (2007)
   PUBMED   17855024
  REMARK    GeneRIF: RIMBP2 is identified in humans
REFERENCE   6  (bases 1 to 5029)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   7  (bases 1 to 5029)
  AUTHORS   Wang,Y., Sugita,S. and Sudhof,T.C.
  TITLE     The RIM/NIM family of neuronal C2 domain proteins. Interactions
            with Rab3 and a new class of Src homology 3 domain proteins
  JOURNAL   J Biol Chem 275 (26), 20033-20044 (2000)
   PUBMED   10748113
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073912.38, AC095350.8 and AC063926.36.
            
            On Jun 2, 2019 this sequence version replaced NM_001351226.1.
            
            Transcript Variant: This variant (1), as well as variants 2 and 3,
            encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.446842.1,
                                           SRR14372080.2010793.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC073912.38        15761-15838         c
            79-213              AC095350.8         54911-55045         c
            214-303             AC063926.36        57494-57583
            304-426             AC063926.36        68641-68763
            427-531             AC063926.36        96395-96499
            532-582             AC063926.36        104668-104718
            583-787             AC063926.36        118711-118915
            788-933             AC063926.36        124071-124216
            934-1010            AC063926.36        125135-125211
            1011-1120           AC063926.36        130142-130251
            1121-1933           AC063926.36        132751-133563
            1934-2085           AC063926.36        136895-137046
            2086-2535           AC063926.36        138120-138569
            2536-2682           AC063926.36        140531-140677
            2683-2841           AC063926.36        147074-147232
            2842-2950           AC063926.36        152850-152958
            2951-3132           AC063926.36        161105-161286
            3133-3301           AC063926.36        162624-162792
            3302-3405           AC063926.36        167582-167685
            3406-3477           AC063926.36        169168-169239
            3478-3612           AC063926.36        175598-175732
            3613-5029           AC063926.36        177862-179278
FEATURES             Location/Qualifiers
     source          1..5029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.33"
     gene            1..5029
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="RIMS binding protein 2"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
     exon            1..78
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            79..213
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..303
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..426
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            427..531
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..3801
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="isoform a is encoded by transcript variant 1; RIM
                     binding protein 2; protein phosphatase 1, regulatory
                     subunit 133"
                     /codon_start=1
                     /product="RIMS-binding protein 2 isoform a"
                     /protein_id="NP_001338155.1"
                     /db_xref="CCDS:CCDS91774.1"
                     /db_xref="GeneID:23504"
                     /db_xref="HGNC:HGNC:30339"
                     /db_xref="MIM:611602"
                     /translation="MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKAQVEAKKEHE
                     GAVRLLESKVRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGSAVAPLDISTAP
                     SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGS
                     ARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLY
                     VYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGL
                     EGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGW
                     EPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRG
                     SSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSHVIFLNEEEFDIVK
                     AARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQ
                     DVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAV
                     ELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSKPLASSGV
                     PETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQGTPVS
                     TTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGASVD
                     DFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGT
                     SHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEES
                     ETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRG
                     ETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTR
                     RMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF
                     LEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRVPPEGSGTARRAPSPTVHLHSGSPTSS
                     MGSGSPGRGREMSSKKKKGLLSKGKKLLKKLGAVK"
     exon            532..582
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..787
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..933
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1010
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1120
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1933
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2085
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2535
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2682
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2841
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2950
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3132
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3301
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3405
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3406..3477
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3612
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..5029
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      4302
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
     regulatory      5006..5011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="hexamer: AATAAA"
     polyA_site      5029
                     /gene="RIMBP2"
                     /gene_synonym="PPP1R133; RBP2; RIM-BP2"
                     /note="major polyA site"
ORIGIN      
        1 agtttgtaat ctgacacagt acactgcagt tgtctccgag gtgaacctcc ggagccttgg
       61 cacagctcgc ttctaaagct tggaaatgac ccgccacacc tgaagcctgc aggtgctgag
      121 gccacattcg atcagaccca agctttggga gaccgctggg gaaatttccc acttcctctc
      181 ctgagaccag gaactcagca gagaaacttt gtggaaaatg aactgaagga tgccacccag
      241 ggagagtatc tcctgagatc ccatcatgca ggccttccca caagggcccg gcagcatgac
      301 aaggtgaagg cagagtatgt gcatctcaac catccgctca ccctcgtgac cagagagcgc
      361 gatttggccg tgaaggagaa acaccagctc caagccaagc tggagaacct agaacaggtc
      421 ctgaagcata tgcgagaggc ggctgaacgg cggcagcagc tgcagttgga gcatgaccag
      481 gccctggctg ttctcagtgc caagcagcag gaaattgacc ttctgcagaa ggctcaggtt
      541 gaggctaaga aggagcatga aggcgcagtg cggctgctag agtccaaggt tcgagagctg
      601 gaagagaaat gccggactca aagtgagcag ttcaacctgc tgtcccggga cctggagaag
      661 ttccggcagc acgctggcaa gattgacctg ctgggtggca gcgcggtggc ccccctggac
      721 atctccacgg cccccagcaa gcctttccca cagttcatga atggcctagc cacctccctc
      781 ggcaaaggtc aggagagcgc tattggaggc agctctgcga tcggtgaata tatccggccc
      841 cttccgcagc ctggtgacag gccggagcct ctgtccgcca agcccacctt cctgtcgaga
      901 tccggtagcg caagatgcag atctgagtca gacatggaga atgaacggaa ttccaatacc
      961 tccaagcaga gatactcggg gaaggtccac ctctgtgttg cccgctatag ttacaacccc
     1021 ttcgatggac cgaacgagaa ccccgaagct gagctgcccc tcacggcggg aaaatacctc
     1081 tacgtctatg gagacatgga tgaggatggg ttctatgaag gagagctcct cgatggccag
     1141 aggggtctgg tgccctccaa cttcgtggac tttgtgcagg acaacgagtc gcggttggca
     1201 agcacgctgg ggaacgagca ggatcagaac ttcatcaacc attccggcat cggcctggag
     1261 ggagagcaca tcctggacct ccactcccca acccacatag atgcgggcat caccgacaac
     1321 agtgccggga ccctggacgt gaacatcgac gacatcggag aagacatcgt gccttaccct
     1381 agaaaaatca ccctcatcaa acaactcgcc aaaagtgtta ttgtgggctg ggagcccccg
     1441 gcggtgccac caggatgggg aacggtgagc agctacaacg tcctggtgga caaggagaca
     1501 cgcatgaacc tcacgctggg gagcagaact aaagccctca tcgagaagct caacatggca
     1561 gcctgcacct accgcatctc cgtgcagtgc gtcaccagca ggggcagctc ggatgagctg
     1621 cagtgcacgc tgctggtggg caaggacgtg gtggtggccc cctcccacct gcgggtggac
     1681 aacatcacgc agatctccgc ccagctctcc tggctaccca ccaacagcaa ctacagccac
     1741 gtcatcttcc tcaacgagga ggagttcgac atcgtcaagg ccgccaggta caagtaccag
     1801 ttcttcaatc tcaggcccaa catggcctat aaggtgaagg ttctggccaa accccaccag
     1861 atgccgtggc agctcccgct ggagcaaagg gagaagaagg aggcctttgt ggagttctcc
     1921 acgttgcctg caggaccccc agcaccccca caagatgtta ccgtccaggc tggggtgacc
     1981 cccgccacca tccgggtctc ctggagacca cctgtgctga cgcccaccgg gctgtccaat
     2041 ggcgcaaacg ttaccggcta cggcgtgtat gccaaagggc agagggtggc tgaagtcatc
     2101 ttccccacgg cagacagcac ggccgtggag cttgtgcggc tgcggagcct ggaggccaag
     2161 ggcgtgaccg tgcggaccct ctccgcccag ggcgagtccg tggactctgc agttgctgcc
     2221 gttccccccg agctcctggt gcctcctacc ccccacccga gacctgcacc ccaatcaaag
     2281 ccattagcaa gttctggagt ccccgaaacc aaagacgagc acctgggtcc ccacgccagg
     2341 atggatgagg cctgggagca gagccgtgca cctggccctg tgcatgggca catgctggag
     2401 ccgcccgtgg gccccggaag gcggtcgccc tcacccagcc gcatcctgcc acagccacag
     2461 ggcaccccgg tgtccaccac cgtcgccaag gccatggccc gggaggccgc gcagagggtg
     2521 gccgagagca gcaggttaga gaaaaggagc gtcttcctag agagaagcag cgcggggcag
     2581 tacgccgcct cagacgagga ggacgcctat gactctccag acttcaagag gaggggcgcc
     2641 tcggtggacg acttcctgaa aggctctgaa cttggcaagc agccgcactg ttgccatgga
     2701 gacgagtacc acacagagag cagccggggg tctgacctct cagacatcat ggaggaggac
     2761 gaggaggagc tgtattctga aatgcagctg gaagatgggg gaaggaggcg gcccagcggc
     2821 acgtcccaca atgccctcaa gattttaggg aacccagcct ctgcaggacg ggtggatcac
     2881 atgggccgga ggtttccccg tggcagcgct ggtcctcaga ggtcccggcc cgtgacagtc
     2941 ccatccatcg acgattacgg gcgagaccgc ctttctccag acttctatga agagtcagaa
     3001 actgaccctg gtgccgaaga gctcccggcc cggatctttg tggctctctt tgactacgac
     3061 ccgctcacca tgtccccaaa cccagatgct gcagaggagg agcttccctt taaagaaggc
     3121 cagatcatca aggtttatgg tgataaagac gctgatggat tctaccgtgg ggaaacctgt
     3181 gcccggcttg gccttattcc ttgtaacatg gtctctgaga tacaagcaga tgatgaggag
     3241 atgatggatc agcttcttag acagggcttt ctccctctga atacacctgt ggagaaaata
     3301 gagagaagca ggagaagtgg caggcgtcat tcggtatcga cgcggagaat ggtggccctg
     3361 tatgactacg accccagaga aagctcgccc aacgtcgatg tcgaggccga acttacattt
     3421 tgcacaggag atattattac agtttttggt gaaattgatg aagatggatt ttattatggg
     3481 gagctgaatg ggcagaaagg ccttgtgccc tcaaacttct tggaagaagt gcctgatgac
     3541 gtagaagtct atctttctga tgctccatcc cactactctc aagatacgcc aatgcgctca
     3601 aaggcaaaaa gggttcctcc tgagggttca ggtacagcaa ggagagctcc atcccccaca
     3661 gtccatctcc attcggggtc acctacgtca tctatgggtt ctggtagtcc tgggagaggc
     3721 agggaaatgt cctcgaaaaa gaaaaagggg ctgctttcca aaggcaagaa actgctgaaa
     3781 aagctgggtg cagtgaaatg attcatgtgc ttccggacaa ctgccaaatc tatgtaattt
     3841 tctttaattc caaactaggg ctttcatgac tcaagtactt cctaaaaaaa cccaatcttc
     3901 tcccctgaca ccagtagaga aatgcacttt tgcactacca accactttaa accaaccacg
     3961 agaacaaaga ggagcggttg ctctctgtca ccgctggcag tctgctctca ttgtccaagc
     4021 tctgatttgg gaggtgggag gggacgtctt attaacaaac gggggcgcat agctatcacc
     4081 tgtagctccc tccctacctg taattccagt ctttgtgcat ttgtcatctg cccttaaagg
     4141 aatgattttc aacctttctc ccttctcaaa atgcttgcct cataatgcat aactttcact
     4201 ttgactctgg tcttgaaatt cctagtttaa ttcgccttga tgttctgcct tataaatgca
     4261 caatgatttg tactgtctaa taaaaacagt gtatactttg tatgtgtcgt gcattcagtg
     4321 gtcttcatcc tgacacagtg gtttgagatc aagttgtaca ggctgtgcat tttaagatac
     4381 tagtttcagt ctttcaaagc cagccaggct acacacagaa aatgtttact caatcattca
     4441 aaaaagagaa aaggagagaa agtaactttg tttggtaaag caccagtact ccaaccttcc
     4501 agaaagccga ttatcttcat tgcttttaat gttctattct gtggcatatg gttttctgtt
     4561 actttcgttg tcaaaatgcc atacccaaat acacagcaat gaatggcaca caagtaatcc
     4621 acataatgca taagccacac caaaaccaga ctcaatttaa atctgctcca aatgagtcca
     4681 tacccatctt catcattggc atttgaacaa aagacttact tacaaagttg ctggcagatg
     4741 tatttgatgg ttactctttt gtaattcttg tccacttgta aattgttttt actctttata
     4801 catacttttc agactgcctt tcttttgtaa tttatggacg gtttataaat gaatgacaaa
     4861 gctttcccca ttgtgtcttc aaaaacgcta ttataaattg taatataata gtatgtggta
     4921 gatttattat taaaggaaat ccatgtgtgg ttaagctctg tgtgggtgtg tgcatgtgca
     4981 cagttagtgt aaaatatttt ctagaaataa aatttgttat tttatacaa
//
