LOCUS       NM_145058               1752 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens Rab interacting lysosomal protein like 2 (RILPL2),
            transcript variant 1, mRNA.
ACCESSION   NM_145058
VERSION     NM_145058.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1752)
  AUTHORS   Chen,D., Zhang,H., Zhao,L., Liu,X., Xue,S., Wu,P. and Jiang,H.
  TITLE     Prognostic value of RILPL2 and its correlation with tumor immune
            microenvironment and glycolysis in non-small cell lung cancer
  JOURNAL   Cell Cycle 22 (7), 841-857 (2023)
   PUBMED   36536539
  REMARK    GeneRIF: Prognostic value of RILPL2 and its correlation with tumor
            immune microenvironment and glycolysis in non-small cell lung
            cancer.
REFERENCE   2  (bases 1 to 1752)
  AUTHORS   Dhekne,H.S., Yanatori,I., Vides,E.G., Sobu,Y., Diez,F., Tonelli,F.
            and Pfeffer,S.R.
  TITLE     LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during
            ciliogenesis blockade
  JOURNAL   Life Sci Alliance 4 (5), e202101050 (2021)
   PUBMED   33727250
  REMARK    GeneRIF: LRRK2-phosphorylated Rab10 sequesters Myosin Va with
            RILPL2 during ciliogenesis blockade.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1752)
  AUTHORS   Waschbusch,D., Purlyte,E., Pal,P., McGrath,E., Alessi,D.R. and
            Khan,A.R.
  TITLE     Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2
            Phosphorylation of Switch 2
  JOURNAL   Structure 28 (4), 406-417 (2020)
   PUBMED   32017888
  REMARK    GeneRIF: Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2
            Phosphorylation of Switch 2.
REFERENCE   4  (bases 1 to 1752)
  AUTHORS   Steger,M., Diez,F., Dhekne,H.S., Lis,P., Nirujogi,R.S., Karayel,O.,
            Tonelli,F., Martinez,T.N., Lorentzen,E., Pfeffer,S.R., Alessi,D.R.
            and Mann,M.
  TITLE     Systematic proteomic analysis of LRRK2-mediated Rab GTPase
            phosphorylation establishes a connection to ciliogenesis
  JOURNAL   Elife 6, e31012 (2017)
   PUBMED   29125462
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1752)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   6  (bases 1 to 1752)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   7  (bases 1 to 1752)
  AUTHORS   Dolan,P.T., Zhang,C., Khadka,S., Arumugaswami,V., Vangeloff,A.D.,
            Heaton,N.S., Sahasrabudhe,S., Randall,G., Sun,R. and LaCount,D.J.
  TITLE     Identification and comparative analysis of hepatitis C virus-host
            cell protein interactions
  JOURNAL   Mol Biosyst 9 (12), 3199-3209 (2013)
   PUBMED   24136289
REFERENCE   8  (bases 1 to 1752)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   9  (bases 1 to 1752)
  AUTHORS   Wang,T., Wong,K.K. and Hong,W.
  TITLE     A unique region of RILP distinguishes it from its related proteins
            in its regulation of lysosomal morphology and interaction with Rab7
            and Rab34
  JOURNAL   Mol Biol Cell 15 (2), 815-826 (2004)
   PUBMED   14668488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145423.8, BC013042.2 and
            EB386182.1.
            
            On Aug 11, 2020 this sequence version replaced NM_145058.2.
            
            Summary: This gene encodes a protein that contains a
            rab-interacting lysosomal protein-like domain. This protein may be
            involved in regulating lysosome morphology. This protein may also
            be a target for the Hepatitis C virus and assist in viral
            replication. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB085763.1, AK056934.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280571.10/ ENSP00000280571.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC145423.8         76604-76781         c
            179-1364            BC013042.2         1-1186
            1365-1752           EB386182.1         1-388
FEATURES             Location/Qualifiers
     source          1..1752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..1752
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /note="Rab interacting lysosomal protein like 2"
                     /db_xref="GeneID:196383"
                     /db_xref="HGNC:HGNC:28787"
                     /db_xref="MIM:614093"
     exon            1..603
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..900
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /note="p40phox-binding protein; rab-interacting lysosomal
                     protein-like 2"
                     /codon_start=1
                     /product="RILP-like protein 2"
                     /protein_id="NP_659495.1"
                     /db_xref="CCDS:CCDS9248.1"
                     /db_xref="GeneID:196383"
                     /db_xref="HGNC:HGNC:28787"
                     /db_xref="MIM:614093"
                     /translation="MEEPPVREEEEEEGEEDEERDEVGPEGALGKSPFQLTAEDVYDI
                     SYLLGRELMALGSDPRVTQLQFKVVRVLEMLEALVNEGSLALEELKMERDHLRKEVEG
                     LRRQSPPASGEVNLGPNKMVVDLTDPNRPRFTLQELRDVLQERNKLKSQLLVVQEELQ
                     CYKSGLIPPREGPGGRREKDAVVTSAKNAGRNKEEKTIIKKLFFFRSGKQT"
     exon            604..755
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..869
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1752
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /note="hexamer: ATTAAA"
     polyA_site      1402
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /note="major polyA site"
     regulatory      1729..1734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
                     /note="hexamer: AGTAAA"
     polyA_site      1752
                     /gene="RILPL2"
                     /gene_synonym="RLP2"
ORIGIN      
        1 cttttccgtt gtcccttcgc gccccaaacc acatcctgga gcgcactctc cagcgtggct
       61 ggcagcgggg acggtgcgcc ggggcgcagg cccaagagtc gcgtgcgcgg ccccttgcac
      121 catccccccg ggcccacccc cgggccgcgc tgattgggca ggtagggact ctgcccagcg
      181 gaaagttttg ggtgccggga ggaagtctaa cctttgggag actccaagac agcagctccg
      241 aggtcggcgg gggtctgggt ggccatggag gagccccctg tgcgagaaga ggaagaggag
      301 gagggagagg aggacgagga gagggacgag gttgggcccg agggggcgct gggcaagagc
      361 cccttccagc tgaccgccga ggacgtgtat gacatctcct acctgttggg ccgcgagctt
      421 atggccctgg gcagcgaccc ccgggtgacg cagctgcagt tcaaagtcgt ccgcgtcctg
      481 gagatgctgg aggcgctggt gaatgagggc agcctggcgc tggaggagct gaagatggag
      541 agggaccacc tcaggaagga ggtggagggg ctgcggagac agagccctcc ggccagcggg
      601 gaggtgaacc tgggcccaaa caaaatggtg gttgacctga cagatcccaa ccgaccccgc
      661 ttcactctgc aggagctaag ggatgtgctg caggaacgca acaaactcaa gtcgcagctc
      721 ctggtggtgc aggaagagct gcagtgctac aagagtggcc tgattccacc aagagaaggc
      781 ccaggaggaa gaagagaaaa agatgctgtg gttactagtg ccaaaaatgc tggcaggaac
      841 aaggaggaga agacaatcat aaaaaagctg ttcttttttc gatcggggaa acagacctag
      901 atccaaggcc acaagtaagg ctatggctct gattctagaa gacaaccttc caagatgcct
      961 ggcaaaacca cctccctgtg ccacacagac acactaggcc tgtgtattta tttccccttc
     1021 aaagcagact gaggagggag gagacgaggt tctcttggca tcactttctc cctggctgca
     1081 gaactagaca cccttgaaga tttggcctgg gccagtgaga ctgaaatcaa gaaaaacaga
     1141 agggatgtgc agggtggggg ggtccacttc ctgctcccat gtcaaccccc agggcctcca
     1201 gcgtgcagac gcgtgtccta ctcatctgct cccacggatg accctggtct tcaatggtta
     1261 gcagaaggga gaaaagaaag caggaaaatg tgctattgag attccagtgg tgacttcact
     1321 gatatttagt gaatatttga tttagccaac atgcctttct ttatgtgatt ttgtattaaa
     1381 gtaaaatgat ttttatactt tctatagctt atctagagtg gtctcttagt tacgatggta
     1441 cacatggtat atgtgtgtat atgtcatata tctacatttc attgtataat gaatcaattg
     1501 cattcattca gtctaagcga tgcacgatta tctggtgtca ctatgaaggg aaagattgct
     1561 gcaaactaaa atgttaagaa gctatcgatt ttaggactca tcctgatttc agaggtgtta
     1621 agatgtgaac aaaatgcatt taggaatcaa tgaaacagag agcgggtgtc tgcacttcgc
     1681 aaaggaacta atgaggctgc cgcaaccatt ccgtgagcct gtcttcttag taaataacag
     1741 tggcttactc aa
//
