LOCUS       NM_031430               1560 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rab interacting lysosomal protein (RILP), mRNA.
ACCESSION   NM_031430
VERSION     NM_031430.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Han,Y., Liu,X., Xu,L., Wei,Z., Gu,Y., Ren,Y., Hua,W., Zhang,Y.,
            Liu,X., Jiang,C., Zhuang,R., Hong,W. and Wang,T.
  TITLE     RILP Induces Cholesterol Accumulation in Lysosomes by Inhibiting
            Endoplasmic Reticulum-Endolysosome Interactions
  JOURNAL   Cells 13 (16), 1313 (2024)
   PUBMED   39195203
  REMARK    GeneRIF: RILP Induces Cholesterol Accumulation in Lysosomes by
            Inhibiting Endoplasmic Reticulum-Endolysosome Interactions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1560)
  AUTHORS   Wang,Z., Zhou,Y., Nie,D., Tan,Y., Zhao,S., Wang,G. and Wang,T.
  TITLE     RILP inhibits proliferation, migration, and invasion of PC3
            prostate cancer cells
  JOURNAL   Acta Histochem 124 (7), 151938 (2022)
   PUBMED   35981451
  REMARK    GeneRIF: RILP inhibits proliferation, migration, and invasion of
            PC3 prostate cancer cells.
REFERENCE   3  (bases 1 to 1560)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1560)
  AUTHORS   Lin,J., Zhuo,Y., Yin,Y., Qiu,L., Li,X. and Lai,F.
  TITLE     Methylation of RILP in lung cancer promotes tumor cell
            proliferation and invasion
  JOURNAL   Mol Cell Biochem 476 (2), 853-861 (2021)
   PUBMED   33128214
  REMARK    GeneRIF: Methylation of RILP in lung cancer promotes tumor cell
            proliferation and invasion.
REFERENCE   5  (bases 1 to 1560)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1560)
  AUTHORS   Cardoso,C., Leventer,R.J., Ward,H.L., Toyo-Oka,K., Chung,J.,
            Gross,A., Martin,C.L., Allanson,J., Pilz,D.T., Olney,A.H.,
            Mutchinick,O.M., Hirotsune,S., Wynshaw-Boris,A., Dobyns,W.B. and
            Ledbetter,D.H.
  TITLE     Refinement of a 400-kb critical region allows genotypic
            differentiation between isolated lissencephaly, Miller-Dieker
            syndrome, and other phenotypes secondary to deletions of 17p13.3
  JOURNAL   Am J Hum Genet 72 (4), 918-930 (2003)
   PUBMED   12621583
REFERENCE   7  (bases 1 to 1560)
  AUTHORS   Wang,T. and Hong,W.
  TITLE     Interorganellar regulation of lysosome positioning by the Golgi
            apparatus through Rab34 interaction with Rab-interacting lysosomal
            protein
  JOURNAL   Mol Biol Cell 13 (12), 4317-4332 (2002)
   PUBMED   12475955
REFERENCE   8  (bases 1 to 1560)
  AUTHORS   Jordens,I., Fernandez-Borja,M., Marsman,M., Dusseljee,S.,
            Janssen,L., Calafat,J., Janssen,H., Wubbolts,R. and Neefjes,J.
  TITLE     The Rab7 effector protein RILP controls lysosomal transport by
            inducing the recruitment of dynein-dynactin motors
  JOURNAL   Curr Biol 11 (21), 1680-1685 (2001)
   PUBMED   11696325
REFERENCE   9  (bases 1 to 1560)
  AUTHORS   Bucci,C., De Gregorio,L. and Bruni,C.B.
  TITLE     Expression analysis and chromosomal assignment of PRA1 and RILP
            genes
  JOURNAL   Biochem Biophys Res Commun 286 (4), 815-819 (2001)
   PUBMED   11520070
REFERENCE   10 (bases 1 to 1560)
  AUTHORS   Cantalupo,G., Alifano,P., Roberti,V., Bruni,C.B. and Bucci,C.
  TITLE     Rab-interacting lysosomal protein (RILP): the Rab7 effector
            required for transport to lysosomes
  JOURNAL   EMBO J 20 (4), 683-693 (2001)
   PUBMED   11179213
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ278711.1 and BC004961.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031430.2.
            
            Summary: This gene encodes a lysosomal protein that interacts with
            RAB7, a small GTPase that controls transport to endocytic
            degradative compartments. Studies using mutant forms of the two
            proteins suggest that this protein represents a downstream effector
            for RAB7, and both proteins act together in the regulation of late
            endocytic traffic. A unique region of this protein has also been
            shown to be involved in the regulation of lysosomal morphology.
            [provided by RefSeq, Sep 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ404317.1, BC031621.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301336.7/ ENSP00000301336.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1543              AJ278711.1         233-1775
            1544-1560           BC004961.1         1325-1341
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..1560
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /note="Rab interacting lysosomal protein"
                     /db_xref="GeneID:83547"
                     /db_xref="HGNC:HGNC:30266"
                     /db_xref="MIM:607848"
     exon            1..290
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1268
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /codon_start=1
                     /product="rab-interacting lysosomal protein"
                     /protein_id="NP_113618.2"
                     /db_xref="CCDS:CCDS11009.1"
                     /db_xref="GeneID:83547"
                     /db_xref="HGNC:HGNC:30266"
                     /db_xref="MIM:607848"
                     /translation="MEPRRAAPGVPGWGSREAAGSASAAELVYHLAGALGTELQDLAR
                     RFGPEAAAGLVPLVVRALELLEQAAVGPAPDSLQVSAQPAEQELRRLREENERLRREL
                     RAGPQEERALLRQLKEVTDRQRDELRAHNRDLRQRGQETEALQEQLQRLLLVNAELRH
                     KLAAMQTQLRAAQDRERERQQPGEAATPQAKERARGQAGRPGHQHGQEPEWATAGAGA
                     PGNPEDPAEAAQQLGRPSEAGQCRFSREEFEQILQERNELKAKVFLLKEELAYFQREL
                     LTDHRVPGLLLEAMKVAVRKQRKKIKAKMLGTPEEAESSEDEAGPWILLSDDKGDHPP
                     PPESKIQSFFGLWYRGKAESSEDETSSPAPSKLGGEEEAQPQSPAPDPPCSALHEHLC
                     LGASAAPEA"
     exon            291..384
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     exon            385..491
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     exon            492..737
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     exon            738..883
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1006
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1090
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1560
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /note="hexamer: AATAAA"
     polyA_site      1560
                     /gene="RILP"
                     /gene_synonym="PP10141"
                     /note="major polyA site"
ORIGIN      
        1 gcttttcccc gtcccagtgg agggtggggt gggggggtcg cagccctaag cctctgggag
       61 acatggagcc caggagggcg gcgcccgggg tgcctggctg ggggtctcgg gaggccgcgg
      121 ggtcggcatc ggccgcggag cttgtgtacc atctagccgg ggccctgggc actgagctgc
      181 aggatctggc gcgccgtttc gggccggagg cggcggccgg gctggtgccg ctagtggtgc
      241 gggcgctgga gctcttggaa caggctgccg tggggcccgc cccggactcg ctgcaggtgt
      301 cggcgcagcc ggcggagcag gagctgcggc ggctgcggga ggagaacgag cgcctccgca
      361 gggagctgcg cgcggggcca caggaggagc gcgcgctgct gcggcagctc aaggaggtca
      421 cggaccgaca gcgggacgaa ctccgggcgc acaaccgcga cctgcggcag cgcggccagg
      481 agaccgaggc gttgcaggag cagctgcagc gcctcctgct ggtgaacgct gagctgcggc
      541 acaagctggc ggccatgcag acccagctgc gcgccgcgca ggaccgcgag agggagcgcc
      601 agcagcctgg cgaagccgcg actccgcagg ctaaagagcg agcgcggggg caggccgggc
      661 ggcccgggca ccagcacgga caggagcccg aatgggcgac cgccggcgca ggcgccccag
      721 ggaaccctga ggacccggcg gaggccgcgc agcagctcgg gcgcccctcg gaggcagggc
      781 agtgccgctt cagtcgggag gagtttgagc agatccttca ggagcggaat gaactcaaag
      841 ccaaagtgtt cctgctcaag gaggaactgg cctacttcca gcgggagctg ctcacagacc
      901 accgggtccc cggccttctg ctcgaggcca tgaaggtggc tgtccggaag cagcggaaga
      961 agatcaaggc caagatgtta gggacaccag aggaagcaga gagcagtgag gatgaggctg
     1021 gcccatggat cctgctctcc gatgacaagg gagaccatcc cccacccccg gagtccaaaa
     1081 tacagagttt ctttggccta tggtatcggg gtaaagctga atcctctgag gatgagacca
     1141 gcagccctgc acccagcaag ctagggggag aagaggaggc ccaaccacag tctccagctc
     1201 ctgatccgcc ctgttctgcc ctccacgaac acctttgtct gggggcctca gccgccccag
     1261 aggcctgact taggggtctg gctgtggaag gatgtgtggc ctcaaatgag gacagggctc
     1321 ccgccttcac agccctcgcc aggggtctgc cccaatcctg gcctgcatca gggcaggacg
     1381 gggtctcagc ccgcctccct ctctacgtct ctgtaccgag cctctggggc cagatataag
     1441 agtgcctctc tgagtctcag tttccccatc catgaaatga gagctgactg cctagctccc
     1501 agggctttgt gcagacggcc tgagctcatg taataaagaa ctgcccgtaa tacacagaaa
//
