LOCUS       NM_001144956             669 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens regulatory subunit of type II PKA R-subunit domain
            containing 1 (RIIAD1), mRNA.
ACCESSION   NM_001144956 XM_001721352 XM_371311 XM_937062
VERSION     NM_001144956.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 669)
  AUTHORS   Gregory,S.G., Barlow,K.F., McLay,K.E., Kaul,R., Swarbreck,D.,
            Dunham,A., Scott,C.E., Howe,K.L., Woodfine,K., Spencer,C.C.,
            Jones,M.C., Gillson,C., Searle,S., Zhou,Y., Kokocinski,F.,
            McDonald,L., Evans,R., Phillips,K., Atkinson,A., Cooper,R.,
            Jones,C., Hall,R.E., Andrews,T.D., Lloyd,C., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Anderson,F., Andrew,R.W., Ashwell,R.I.,
            Aubin,K., Babbage,A.K., Bagguley,C.L., Bailey,J., Beasley,H.,
            Bethel,G., Bird,C.P., Bray-Allen,S., Brown,J.Y., Brown,A.J.,
            Buckley,D., Burton,J., Bye,J., Carder,C., Chapman,J.C., Clark,S.Y.,
            Clarke,G., Clee,C., Cobley,V., Collier,R.E., Corby,N.,
            Coville,G.J., Davies,J., Deadman,R., Dunn,M., Earthrowl,M.,
            Ellington,A.G., Errington,H., Frankish,A., Frankland,J., French,L.,
            Garner,P., Garnett,J., Gay,L., Ghori,M.R., Gibson,R., Gilby,L.M.,
            Gillett,W., Glithero,R.J., Grafham,D.V., Griffiths,C.,
            Griffiths-Jones,S., Grocock,R., Hammond,S., Harrison,E.S., Hart,E.,
            Haugen,E., Heath,P.D., Holmes,S., Holt,K., Howden,P.J., Hunt,A.R.,
            Hunt,S.E., Hunter,G., Isherwood,J., James,R., Johnson,C.,
            Johnson,D., Joy,A., Kay,M., Kershaw,J.K., Kibukawa,M.,
            Kimberley,A.M., King,A., Knights,A.J., Lad,H., Laird,G., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Loveland,J., Lovell,J., Lush,M.J.,
            Lyne,R., Martin,S., Mashreghi-Mohammadi,M., Matthews,L.,
            Matthews,N.S., McLaren,S., Milne,S., Mistry,S., Moore,M.J.,
            Nickerson,T., O'Dell,C.N., Oliver,K., Palmeiri,A., Palmer,S.A.,
            Parker,A., Patel,D., Pearce,A.V., Peck,A.I., Pelan,S., Phelps,K.,
            Phillimore,B.J., Plumb,R., Rajan,J., Raymond,C., Rouse,G.,
            Saenphimmachak,C., Sehra,H.K., Sheridan,E., Shownkeen,R., Sims,S.,
            Skuce,C.D., Smith,M., Steward,C., Subramanian,S., Sycamore,N.,
            Tracey,A., Tromans,A., Van Helmond,Z., Wall,M., Wallis,J.M.,
            White,S., Whitehead,S.L., Wilkinson,J.E., Willey,D.L., Williams,H.,
            Wilming,L., Wray,P.W., Wu,Z., Coulson,A., Vaudin,M., Sulston,J.E.,
            Durbin,R., Hubbard,T., Wooster,R., Dunham,I., Carter,N.P.,
            McVean,G., Ross,M.T., Harrow,J., Olson,M.V., Beck,S., Rogers,J.,
            Bentley,D.R., Banerjee,R., Bryant,S.P., Burford,D.C., Burrill,W.D.,
            Clegg,S.M., Dhami,P., Dovey,O., Faulkner,L.M., Gribble,S.M.,
            Langford,C.F., Pandian,R.D., Porter,K.M. and Prigmore,E.
  TITLE     The DNA sequence and biological annotation of human chromosome 1
  JOURNAL   Nature 441 (7091), 315-321 (2006)
   PUBMED   16710414
  REMARK    Erratum:[Nature. 2006 Oct 26;443(7114):1013. Banerjee, R [added];
            Bryant, SP [added]; Burford, DC [added]; Burrill, WDH [added];
            Clegg, SM [added]; Dhami, P [added]; Dovey, O [added]; Faulkner, LM
            [added]; Gribble, SM [added]; Langford, CF [added]; Pandian, RD
            [added]; Porter, KM [added]; Prigmore, E]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY019544.1, AA393535.1, CK300240.1 and AL589765.19.
            
            On May 17, 2019 this sequence version replaced NM_001144956.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX281741.1, HY019544.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000479191.2/ ENSP00000419249.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                HY019544.1         11-87
            78-463              AA393535.1         53-438
            464-470             CK300240.1         19-25               c
            471-669             AL589765.19        51982-52180
FEATURES             Location/Qualifiers
     source          1..669
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..669
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /note="regulatory subunit of type II PKA R-subunit domain
                     containing 1"
                     /db_xref="GeneID:284485"
                     /db_xref="HGNC:HGNC:26686"
     exon            1..99
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..294
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /note="RIIa domain-containing protein C1orf230; RIIa
                     domain-containing protein ENSP00000357824; regulatory
                     subunit of type II PKA R-subunit (RIIa) domain containing
                     1"
                     /codon_start=1
                     /product="RIIa domain-containing protein 1"
                     /protein_id="NP_001138428.1"
                     /db_xref="CCDS:CCDS53368.1"
                     /db_xref="GeneID:284485"
                     /db_xref="HGNC:HGNC:26686"
                     /translation="METLPGLLQRPDPGALSAAQLEQLRKFKIQTRIANEKYLRTHKE
                     VEWLISGFFREIFLKRPDNILEFAADYFTDPRLPNKIHMQLIKDKKAA"
     exon            100..176
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /inference="alignment:Splign:2.1.0"
     exon            177..223
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /inference="alignment:Splign:2.1.0"
     exon            224..351
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /inference="alignment:Splign:2.1.0"
     exon            352..669
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /inference="alignment:Splign:2.1.0"
     regulatory      448..453
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /note="hexamer: ATTAAA"
     polyA_site      459
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
     polyA_site      470
                     /gene="RIIAD1"
                     /gene_synonym="C1orf230; NCRNA00166"
                     /note="major polyA site"
ORIGIN      
        1 gacgaccgca gcaagatgga gacgctgcca ggcttgctgc agcggcccga ccccggggcg
       61 cttagcgcag cgcagctgga gcagctgcga aaattcaaga ttcagactcg gattgctaac
      121 gaaaagtacc taaggaccca caaagaagta gagtggctca taagtggttt cttcagagaa
      181 atatttttga aaagaccaga caacatccta gaatttgctg cagactactt cacggatcca
      241 agacttccca acaagattca catgcagcta attaaagaca agaaagcggc ttaattagca
      301 aaatcatgat gctcagctgt tgggagagac cagacggaat ccagcctcgg gggtcatctg
      361 gaggcatgag agccctactg ccatcagtgt gggtttccaa gctgccttgg gctctgtcta
      421 ctgtcgcaaa agcttttaaa gatattcatt aaacacggac cttcctgctc tctctgcttt
      481 atttcactca agaggaggaa gccatccttc aggggagggc tgctgtgccc cactttgacg
      541 tgtgaggcag ccggcctgtt tctgctttca gggcggccag gggcctcttg ctgggtcagt
      601 gggctgtcgt gcccaccccc tgggaagaac acagctgatc acgggggcac agaaacaagc
      661 aagtccatg
//
