LOCUS       NM_001385910            4641 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens RNA sensor RIG-I (RIGI), transcript variant 4, mRNA.
ACCESSION   NM_001385910
VERSION     NM_001385910.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4641)
  AUTHORS   Qiao,Y., Zhu,S., Yang,N., Zou,S.S., Gao,B., Wu,J., Liu,C., Li,X.,
            Liu,Y.J. and Chen,J.
  TITLE     The RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated
            innate immunity
  JOURNAL   PLoS Pathog 20 (7), e1012379 (2024)
   PUBMED   39037956
  REMARK    GeneRIF: The RNA helicase DHX35 functions as a co-sensor for
            RIG-I-mediated innate immunity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4641)
  AUTHORS   Solotchi,M. and Patel,S.S.
  TITLE     Proofreading mechanisms of the innate immune receptor RIG-I:
            distinguishing self and viral RNA
  JOURNAL   Biochem Soc Trans 52 (3), 1131-1148 (2024)
   PUBMED   38884803
  REMARK    GeneRIF: Proofreading mechanisms of the innate immune receptor
            RIG-I: distinguishing self and viral RNA.
            Review article
REFERENCE   3  (bases 1 to 4641)
  AUTHORS   Wu,B., Li,D., Bai,H., Mo,R., Li,H., Xie,J., Zhang,X., Yang,Y.,
            Li,H., Idris,A., Li,X. and Feng,R.
  TITLE     Mammalian reovirus micro1 protein attenuates RIG-I and
            MDA5-mediated signaling transduction by blocking IRF3
            phosphorylation and nuclear translocation
  JOURNAL   Mol Immunol 170, 131-143 (2024)
   PUBMED   38663254
  REMARK    GeneRIF: Mammalian reovirus micro1 protein attenuates RIG-I and
            MDA5-mediated signaling transduction by blocking IRF3
            phosphorylation and nuclear translocation.
REFERENCE   4  (bases 1 to 4641)
  AUTHORS   Huang,X., Zhou,X., Zhang,F., Wang,X., Duan,X. and Liu,K.
  TITLE     DDX58 variant triggers IFN-beta-induced autophagy in trabecular
            meshwork and influences intraocular pressure
  JOURNAL   FASEB J 38 (10), e23651 (2024)
   PUBMED   38752537
  REMARK    GeneRIF: DDX58 variant triggers IFN-beta-induced autophagy in
            trabecular meshwork and influences intraocular pressure.
REFERENCE   5  (bases 1 to 4641)
  AUTHORS   Chen,J., Wang,Q., Zhong,B., Zheng,H., Wang,D., Huang,X., Liu,L. and
            Liu,T.
  TITLE     Activation of the RIG-I/MAVS Signaling Pathway during Human
            Adenovirus Type 3 Infection Impairs the Pro-Inflammatory Response
            Induced by Secondary Infection with Staphylococcus aureus
  JOURNAL   Int J Mol Sci 25 (8), 4178 (2024)
   PUBMED   38673764
  REMARK    GeneRIF: Activation of the RIG-I/MAVS Signaling Pathway during
            Human Adenovirus Type 3 Infection Impairs the Pro-Inflammatory
            Response Induced by Secondary Infection with Staphylococcus aureus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4641)
  AUTHORS   Imaizumi,T., Yagihashi,N., Hatakeyama,M., Yamashita,K.,
            Ishikawa,A., Taima,K., Yoshida,H., Inoue,I., Fujita,T.,
            Yagihashi,S. and Satoh,K.
  TITLE     Expression of retinoic acid-inducible gene-I in vascular smooth
            muscle cells stimulated with interferon-gamma
  JOURNAL   Life Sci 75 (10), 1171-1180 (2004)
   PUBMED   15219805
  REMARK    GeneRIF: RIG-I may play some pathophysiological role in immune and
            inflammatory reactions in vascular smooth muscle cells(SMC).
REFERENCE   7  (bases 1 to 4641)
  AUTHORS   Yoneyama,M., Kikuchi,M., Natsukawa,T., Shinobu,N., Imaizumi,T.,
            Miyagishi,M., Taira,K., Akira,S. and Fujita,T.
  TITLE     The RNA helicase RIG-I has an essential function in double-stranded
            RNA-induced innate antiviral responses
  JOURNAL   Nat Immunol 5 (7), 730-737 (2004)
   PUBMED   15208624
  REMARK    GeneRIF: RIG-I is key in the detection and subsequent eradication
            of the replicating viral genomes
REFERENCE   8  (bases 1 to 4641)
  AUTHORS   Cui,X.F., Imaizumi,T., Yoshida,H., Borden,E.C. and Satoh,K.
  TITLE     Retinoic acid-inducible gene-I is induced by interferon-gamma and
            regulates the expression of interferon-gamma stimulated gene 15 in
            MCF-7 cells
  JOURNAL   Biochem Cell Biol 82 (3), 401-405 (2004)
   PUBMED   15181474
  REMARK    GeneRIF: IFN-gamma induces the expression of RIG-I, which may play
            a role in the immunological effects of IFN-gamma
REFERENCE   9  (bases 1 to 4641)
  AUTHORS   Imaizumi,T., Aratani,S., Nakajima,T., Carlson,M., Matsumiya,T.,
            Tanji,K., Ookawa,K., Yoshida,H., Tsuchida,S., McIntyre,T.M.,
            Prescott,S.M., Zimmerman,G.A. and Satoh,K.
  TITLE     Retinoic acid-inducible gene-I is induced in endothelial cells by
            LPS and regulates expression of COX-2
  JOURNAL   Biochem Biophys Res Commun 292 (1), 274-279 (2002)
   PUBMED   11890704
REFERENCE   10 (bases 1 to 4641)
  AUTHORS   Chaudhary,P.M., Eby,M.T., Jasmin,A., Kumar,A., Liu,L. and Hood,L.
  TITLE     Activation of the NF-kappaB pathway by caspase 8 and its homologs
  JOURNAL   Oncogene 19 (39), 4451-4460 (2000)
   PUBMED   11002417
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353671.6 and AL161783.20.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are
            implicated in a number of cellular processes involving RNA binding
            and alteration of RNA secondary structure. This gene encodes a
            protein containing RNA helicase-DEAD box protein motifs and a
            caspase recruitment domain (CARD). It is involved in viral
            double-stranded (ds) RNA recognition and the regulation of the
            antiviral innate immune response. Mutations in this gene are
            associated with Singleton-Merten syndrome 2. [provided by RefSeq,
            Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.771339.1,
                                           SRR14038194.157807.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related :: involved in immune response or antiviral
                                   activity
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL353671.6         64015-64150         c
            137-271             AL353671.6         38759-38893         c
            272-453             AL353671.6         31715-31896         c
            454-614             AL353671.6         30345-30505         c
            615-734             AL353671.6         29255-29374         c
            735-842             AL353671.6         27298-27405         c
            843-996             AL353671.6         26688-26841         c
            997-1255            AL353671.6         25899-26157         c
            1256-1418           AL353671.6         25425-25587         c
            1419-1523           AL353671.6         23129-23233         c
            1524-1681           AL353671.6         19294-19451         c
            1682-1817           AL353671.6         18173-18308         c
            1818-1966           AL353671.6         14937-15085         c
            1967-2057           AL353671.6         10929-11019         c
            2058-2228           AL353671.6         5716-5886           c
            2229-2380           AL353671.6         4244-4395           c
            2381-2524           AL161783.20        107017-107160       c
            2525-4641           AL161783.20        102948-105064       c
FEATURES             Location/Qualifiers
     source          1..4641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.1"
     gene            1..4641
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /note="RNA sensor RIG-I"
                     /db_xref="GeneID:23586"
                     /db_xref="HGNC:HGNC:19102"
                     /db_xref="MIM:609631"
     exon            1..136
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            137..271
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            272..453
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..614
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             485..2821
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /EC_number="3.6.4.13"
                     /note="isoform 4 is encoded by transcript variant 4; RNA
                     helicase RIG-I; DEAD/H (Asp-Glu-Ala-Asp/His) box
                     polypeptide; probable ATP-dependent RNA helicase DDX58;
                     DEAD box protein 58; DEAD (Asp-Glu-Ala-Asp) box
                     polypeptide 58; retinoic acid-inducible gene 1 protein;
                     retinoic acid-inducible gene I protein; antiviral innate
                     immune response receptor RIG-I; DExD/H-box helicase 58"
                     /codon_start=1
                     /product="antiviral innate immune response receptor RIG-I
                     isoform 4"
                     /protein_id="NP_001372839.1"
                     /db_xref="GeneID:23586"
                     /db_xref="HGNC:HGNC:19102"
                     /db_xref="MIM:609631"
                     /translation="MMAGAEKLVECLLRSDKENWPKTLKLALEKERNKFSELWIVEKG
                     IKDVETEDLEDKMETSDIQIFYQEDPECQNLSENSCPPSEVSDTNLYSPFKPRNYQLE
                     LALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKGKVVFFANQIPVYEQQK
                     SVFSKYFERHGYRVTGISGATAENVPVEQIVENNDIIILTPQILVNNLKKGTIPSLSI
                     FTLMIFDECHNTSKQHPYNMIMFNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEA
                     LDYICKLCASLDASVIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRD
                     TESLAKRICKDLENLSQIQNREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALF
                     LYTSHLRKYNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQEL
                     ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSF
                     LKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVADEGIDIAQCNLVI
                     LYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTW
                     DEAVFREKILHIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEEC
                     HYTVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVI
                     KIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAEMSK"
     exon            615..734
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..842
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..996
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1255
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1418
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1523
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1681
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1817
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1966
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2057
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2228
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2380
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2524
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..4641
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /note="hexamer: AATATA"
     polyA_site      2940
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
     regulatory      4214..4219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /note="hexamer: AATACA"
     polyA_site      4238
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
                     /note="major polyA site"
     polyA_site      4641
                     /gene="RIGI"
                     /gene_synonym="DDX58; RIG-I; RIG1; RLR-1; SGMRT2"
ORIGIN      
        1 gaacgtagct agctgcaagc agaggccggc atgaccaccg agcagcgacg cagcctgcaa
       61 gccttccagg attatatccg gaagaccctg gaccctacct acatcctgag ctacatggcc
      121 ccctggttta gggaggaaga ggtgcagtat attcaggctg agaaaaacaa caagggccca
      181 atggaggctg ccacactttt tctcaagttc ctgttggagc tccaggagga aggctggttc
      241 cgtggctttt tggatgccct agaccatgca ggttattctg gactttatga agccattgaa
      301 agttgggatt tcaaaaaaat tgaaaagttg gaggagtata gattactttt aaaacgttta
      361 caaccagaat ttaaaaccag aattatccca accgatatca tttctgatct gtctgaatgt
      421 ttaattaatc aggaatgtga agaaattcta cagttacctt gcttagattt gctctactaa
      481 ggggatgatg gcaggtgcag agaaattggt ggaatgcctt ctcagatcag acaaggaaaa
      541 ctggcccaaa actttgaaac ttgctttgga gaaagaaagg aacaagttca gtgaactgtg
      601 gattgtagag aaaggtataa aagatgttga aacagaagat cttgaggata agatggaaac
      661 ttctgacata cagattttct accaagaaga tccagaatgc cagaatctta gtgagaattc
      721 atgtccacct tcagaagtgt ctgatacaaa cttgtacagc ccatttaaac caagaaatta
      781 ccaattagag cttgctttgc ctgctatgaa aggaaaaaac acaataatat gtgctcctac
      841 aggttgtgga aaaacctttg tttcactgct tatatgtgaa catcatctta aaaaattccc
      901 acaaggacaa aaggggaaag ttgtcttttt tgcgaatcag atcccagtgt atgaacagca
      961 gaaatctgta ttctcaaaat actttgaaag acatgggtat agagttacag gcatttctgg
     1021 agcaacagct gagaatgtcc cagtggaaca gattgttgag aacaatgaca tcatcatttt
     1081 aactccacag attcttgtga acaaccttaa aaagggaacg attccatcac tatccatctt
     1141 tactttgatg atatttgatg aatgccacaa cactagtaaa caacacccgt acaatatgat
     1201 catgtttaat tatctagatc agaaacttgg aggatcttca ggcccactgc cccaggtcat
     1261 tgggctgact gcctcggttg gtgttgggga tgccaaaaac acagatgaag ccttggatta
     1321 tatctgcaag ctgtgtgctt ctcttgatgc gtcagtgata gcaacagtca aacacaatct
     1381 ggaggaactg gagcaagttg tttataagcc ccagaagttt ttcaggaaag tggaatcacg
     1441 gattagcgac aaatttaaat acatcatagc tcagctgatg agggacacag agagtctggc
     1501 aaagagaatc tgcaaagacc tcgaaaactt atctcaaatt caaaataggg aatttggaac
     1561 acagaaatat gaacaatgga ttgttacagt tcagaaagca tgcatggtgt tccagatgcc
     1621 agacaaagat gaagagagca ggatttgtaa agccctgttt ttatacactt cacatttgcg
     1681 gaaatataat gatgccctca ttatcagtga gcatgcacga atgaaagatg ctctggatta
     1741 cttgaaagac ttcttcagca atgtccgagc agcaggattc gatgagattg agcaagatct
     1801 tactcagaga tttgaagaaa agctgcagga actagaaagt gtttccaggg atcccagcaa
     1861 tgagaatcct aaacttgaag acctctgctt catcttacaa gaagagtacc acttaaaccc
     1921 agagacaata acaattctct ttgtgaaaac cagagcactt gtggacgctt taaaaaattg
     1981 gattgaagga aatcctaaac tcagttttct aaaacctggc atattgactg gacgtggcaa
     2041 aacaaatcag aacacaggaa tgaccctccc ggcacagaag tgtatattgg atgcattcaa
     2101 agccagtgga gatcacaata ttctgattgc cacctcagtt gctgatgaag gcattgacat
     2161 tgcacagtgc aatcttgtca tcctttatga gtatgtgggc aatgtcatca aaatgatcca
     2221 aaccagaggc agaggaagag caagaggtag caagtgcttc cttctgacta gtaatgctgg
     2281 tgtaattgaa aaagaacaaa taaacatgta caaagaaaaa atgatgaatg actctatttt
     2341 acgccttcag acatgggacg aagcagtatt tagggaaaag attctgcata tacagactca
     2401 tgaaaaattc atcagagata gtcaagaaaa accaaaacct gtacctgata aggaaaataa
     2461 aaaactgctc tgcagaaagt gcaaagcctt ggcatgttac acagctgacg taagagtgat
     2521 agaggaatgc cattacactg tgcttggaga tgcttttaag gaatgctttg tgagtagacc
     2581 acatcccaag ccaaagcagt tttcaagttt tgaaaaaaga gcaaagatat tctgtgcccg
     2641 acagaactgc agccatgact ggggaatcca tgtgaagtac aagacatttg agattccagt
     2701 tataaaaatt gaaagttttg tggtggagga tattgcaact ggagttcaga cactgtactc
     2761 gaagtggaag gactttcatt ttgagaagat accatttgat ccagcagaaa tgtccaaatg
     2821 atatcaggtc ctcaatcttc agctacaggg aatgagtaac tttgagtgga gaagaaacaa
     2881 acatagtggg tataatcatg gatcgcttgt acccctgtga aaatatattt tttaaaaata
     2941 tctttagcag tttgtactat attatatatg caaagcacaa atgagtgaat cacagcactg
     3001 agtattttgt aggccaacag agctcatagt acttgggaaa aattaaaaag cctcatttct
     3061 agccttcttt ttagagtcaa ctgccaacaa acacacagta atcactctgt acacactggg
     3121 atagatgaat gaatggaatg ttgggaattt ttatctccct ttgtctcctt aacctactgt
     3181 aaactggctt ttgcccttaa caatctactg aaattgttct tttgaaggtt accagtgact
     3241 ctggttgcca aatccactgg gcacttctta accttctatt tgacctctgc gcatttggcc
     3301 ctgttgagca ctcttcttga agctctccct gggcttctct ctcttctagt tctattctag
     3361 tcttttttta ttgagtcctc ctctttgctg atcccttcca agggttcaat atatatacat
     3421 gtatatactg tacatatgta tatgtaacta atatacatac atacaggtat gtatatgtaa
     3481 tggttatatg tactcatgtt cctggtgtag caacgtgtgg tatggctaca cagagaacat
     3541 gagaacataa agccattttt atgcttacta ctaaaagctg tccactgtag agttgctgta
     3601 tgtagcaatg tgtatccact ctacagtggt cagcttttag tagagagcat aaaaatgata
     3661 aaatacttct tgaaaactta gtttactata catcttgccc tattaatatg ttctcttaac
     3721 gtgtgccatt gttctctttg accattttcc tataatgatg ttgatgttca acacctggac
     3781 tgaatgtctg ttctcagatc ccttggatgt tacagatgag gcagtctgac tgtcctttct
     3841 acttgaaaga ttagaatatg tatccaaatg gcattcacgt gtcacttagc aaggtttgct
     3901 gatgcttcaa agagcttagt ttgcggtttc ctggacgtgg aaacaagtat ctgagttccc
     3961 tggagatcaa cgggatgagg tgttacagct gcctccctct tcatgcaatc tggtgagcag
     4021 tggtgcaggc ggggagccag agaaacttgc cagttatata acttctcttt ggcttttctt
     4081 catctgtaaa acaaggataa tactgaactg taagggttag tggagagttt ttaattaaaa
     4141 gaatgtgtga aaagtacatg acacagtagt tgcttgataa tagttactag tagtagtatt
     4201 cttactaaga cccaatacaa atggattatt taaaccaagt ttatgagttg gttttttttc
     4261 attttctatt tgtattttat taagagtgtc ttttcttatg tgattttttt taattgctat
     4321 ttgatatggt ttggctatat gtccccaccc aaatctcatc ttgaattata atccccatgt
     4381 gtcaagggag ggacctgacg ggaggtgatt ggatcacggg ggcagttgtc cccatgctgt
     4441 tcttgggata gtgagttagt tctcatgaga tctgatggtt ttataagtgt ttgacaattc
     4501 ctcctttaca cacactctct ctctcatctg ctgccatgta agacttgcct gcttcccctt
     4561 ctgccatgat tgtaagtttc ctgaggcctc ctcagccatg tggaactgtg aatctattaa
     4621 gcctcttttc tttataaatg a
//
