LOCUS       NM_005836                987 bp    mRNA    linear   PRI 09-MAR-2025
DEFINITION  Homo sapiens reactive intermediate imine deaminase A (RIDA), mRNA.
ACCESSION   NM_005836
VERSION     NM_005836.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 987)
  AUTHORS   Song,S., Pan,J., Zhang,Y., Xu,Y., Zhang,Q., Xie,X., Zhou,Q., Mo,F.,
            Luo,G. and Chao,N.
  TITLE     P14.5 functions to inhibit cell migration and can be used as a
            prognostic marker in hepatocellular carcinoma
  JOURNAL   Genes Genomics 45 (1), 83-91 (2023)
   PUBMED   36434386
  REMARK    GeneRIF: P14.5 functions to inhibit cell migration and can be used
            as a prognostic marker in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 987)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 987)
  AUTHORS   Siculella,L., Giannotti,L., Di Chiara Stanca,B., Calcagnile,M.,
            Rochira,A., Stanca,E., Alifano,P. and Damiano,F.
  TITLE     Evidence for a Negative Correlation between Human Reactive
            Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell
            Proliferation Rate: Role of Lysine Succinylation of RIDA
  JOURNAL   Int J Mol Sci 22 (8), 3804 (2021)
   PUBMED   33916919
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 987)
  AUTHORS   Borchert,A.J., Ernst,D.C. and Downs,D.M.
  TITLE     Reactive Enamines and Imines In Vivo: Lessons from the RidA
            Paradigm
  JOURNAL   Trends Biochem Sci 44 (10), 849-860 (2019)
   PUBMED   31103411
  REMARK    GeneRIF: The new findings regarding the biological significance of
            enamine and imine production and outline the importance of RidA in
            controlling the accumulation of reactive metabolites.
            Review article
REFERENCE   6  (bases 1 to 987)
  AUTHORS   Colombo,I., Ceciliani,F., Ronchi,S., Bartorelli,A. and Berra,B.
  TITLE     cDNA cloning and Escherichia coli expression of UK114 tumor antigen
  JOURNAL   Biochim Biophys Acta 1442 (1), 49-59 (1998)
   PUBMED   9767104
REFERENCE   7  (bases 1 to 987)
  AUTHORS   Schmiedeknecht,G., Buchler,C. and Schmitz,G.
  TITLE     A bidirectional promoter connects the p14.5 gene to the gene for
            RNase P and RNase MRP protein subunit hPOP1
  JOURNAL   Biochem Biophys Res Commun 241 (1), 59-67 (1997)
   PUBMED   9405234
REFERENCE   8  (bases 1 to 987)
  AUTHORS   Racca,S., Di Carlo,F., Bartorelli,A., Bussolati,B. and Bussolati,G.
  TITLE     Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114
  JOURNAL   Virchows Arch 431 (5), 323-328 (1997)
   PUBMED   9463573
REFERENCE   9  (bases 1 to 987)
  AUTHORS   Schmiedeknecht,G., Kerkhoff,C., Orso,E., Stohr,J., Aslanidis,C.,
            Nagy,G.M., Knuechel,R. and Schmitz,G.
  TITLE     Isolation and characterization of a 14.5-kDa
            trichloroacetic-acid-soluble translational inhibitor protein from
            human monocytes that is upregulated upon cellular differentiation
  JOURNAL   Eur J Biochem 242 (2), 339-351 (1996)
   PUBMED   8973653
REFERENCE   10 (bases 1 to 987)
  AUTHORS   Oka,T., Tsuji,H., Noda,C., Sakai,K., Hong,Y.M., Suzuki,I., Munoz,S.
            and Natori,Y.
  TITLE     Isolation and characterization of a novel perchloric acid-soluble
            protein inhibiting cell-free protein synthesis
  JOURNAL   J Biol Chem 270 (50), 30060-30067 (1995)
   PUBMED   8530410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X95384.1 and BC012592.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005836.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012592.1, X95384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254878.8/ ENSP00000254878.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               X95384.1           20-607
            589-987             BC012592.1         609-1007
FEATURES             Location/Qualifiers
     source          1..987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..987
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /note="reactive intermediate imine deaminase A"
                     /db_xref="GeneID:10247"
                     /db_xref="HGNC:HGNC:16897"
                     /db_xref="MIM:602487"
     exon            1..140
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..489
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /EC_number="3.5.99.10"
                     /note="perchloric acid-soluble protein; translational
                     inhibitor p14.5; translational inhibitor protein p14.5;
                     ribonuclease UK114; UK114 antigen homolog; 14.5 kDa
                     translational inhibitor protein; heat-responsive protein
                     12; translation inhibitor L-PSP ribonuclease; reactive
                     intermediate imine deaminase A homolog"
                     /codon_start=1
                     /product="2-iminobutanoate/2-iminopropanoate deaminase"
                     /protein_id="NP_005827.1"
                     /db_xref="CCDS:CCDS6276.1"
                     /db_xref="GeneID:10247"
                     /db_xref="HGNC:HGNC:16897"
                     /db_xref="MIM:602487"
                     /translation="MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSG
                     QLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKS
                     NFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL"
     exon            141..246
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /inference="alignment:Splign:2.1.0"
     exon            247..301
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /inference="alignment:Splign:2.1.0"
     exon            302..370
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /inference="alignment:Splign:2.1.0"
     exon            371..426
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /inference="alignment:Splign:2.1.0"
     exon            427..987
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /inference="alignment:Splign:2.1.0"
     regulatory      968..973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /note="hexamer: AATAAA"
     polyA_site      987
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /note="major polyA site"
ORIGIN      
        1 agtccagtaa gaagccagca gggctggtgc tggggcttct tctcctgaag gggctgcaag
       61 agggaaggct tagccatgtc gtccttgatc agaagggtga tcagcaccgc gaaagcccca
      121 ggggccattg gaccctacag tcaagctgta ttagtcgaca ggaccattta catttcagga
      181 cagataggca tggacccttc aagtggacag cttgtgtcag gaggggtagc agaagaagct
      241 aaacaagctc ttaaaaacat gggtgaaatt ctgaaagctg caggctgtga cttcactaac
      301 gtggtgaaaa caactgttct tctggctgac ataaatgact tcaatactgt caatgaaatc
      361 tacaaacagt atttcaagag taattttcct gctagagctg cttaccaagt tgctgcttta
      421 cccaaaggca gccgaattga aattgaagca gtagctatcc aaggaccact gacaacggca
      481 tcactataag tgggcccagt gctgtgtagt ctggaattgt taacatttta atttttacaa
      541 ttgatgtaac atcttaatta accttttaat tttcacaatt gatgacagtg tgagtttgat
      601 gaaaatatct gaagctatta tggaaatacc atgtaatagg gagagttgaa catgaatatt
      661 agagaaggaa tccagttact tttttaaatt acacctgtgt gcacctgtat tactgaatat
      721 aggaaagaga tacccattac atagttactc agtaaacaaa agagaaatac caggtaggaa
      781 agaagagtta ctattcctga gaaataatca agaacatatt taatttaaac taatgatgtg
      841 aactatttag ttttgatgtc cgttatgtga ttctgctttt acttgagtaa aattaaagtg
      901 tttaaatttg agatcaagga gaagatagtg gaacaaaatg ttatatagat aatatttttc
      961 taatggaaat aaaataggca gatttcc
//
