LOCUS       NP_005827                137 aa            linear   PRI 09-MAR-2025
DEFINITION  2-iminobutanoate/2-iminopropanoate deaminase [Homo sapiens].
ACCESSION   NP_005827
VERSION     NP_005827.1
DBSOURCE    REFSEQ: accession NM_005836.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 137)
  AUTHORS   Song,S., Pan,J., Zhang,Y., Xu,Y., Zhang,Q., Xie,X., Zhou,Q., Mo,F.,
            Luo,G. and Chao,N.
  TITLE     P14.5 functions to inhibit cell migration and can be used as a
            prognostic marker in hepatocellular carcinoma
  JOURNAL   Genes Genomics 45 (1), 83-91 (2023)
   PUBMED   36434386
  REMARK    GeneRIF: P14.5 functions to inhibit cell migration and can be used
            as a prognostic marker in hepatocellular carcinoma.
REFERENCE   2  (residues 1 to 137)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 137)
  AUTHORS   Siculella,L., Giannotti,L., Di Chiara Stanca,B., Calcagnile,M.,
            Rochira,A., Stanca,E., Alifano,P. and Damiano,F.
  TITLE     Evidence for a Negative Correlation between Human Reactive
            Enamine-Imine Intermediate Deaminase A (RIDA) Activity and Cell
            Proliferation Rate: Role of Lysine Succinylation of RIDA
  JOURNAL   Int J Mol Sci 22 (8), 3804 (2021)
   PUBMED   33916919
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 137)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 137)
  AUTHORS   Borchert,A.J., Ernst,D.C. and Downs,D.M.
  TITLE     Reactive Enamines and Imines In Vivo: Lessons from the RidA
            Paradigm
  JOURNAL   Trends Biochem Sci 44 (10), 849-860 (2019)
   PUBMED   31103411
  REMARK    GeneRIF: The new findings regarding the biological significance of
            enamine and imine production and outline the importance of RidA in
            controlling the accumulation of reactive metabolites.
            Review article
REFERENCE   6  (residues 1 to 137)
  AUTHORS   Colombo,I., Ceciliani,F., Ronchi,S., Bartorelli,A. and Berra,B.
  TITLE     cDNA cloning and Escherichia coli expression of UK114 tumor antigen
  JOURNAL   Biochim Biophys Acta 1442 (1), 49-59 (1998)
   PUBMED   9767104
REFERENCE   7  (residues 1 to 137)
  AUTHORS   Schmiedeknecht,G., Buchler,C. and Schmitz,G.
  TITLE     A bidirectional promoter connects the p14.5 gene to the gene for
            RNase P and RNase MRP protein subunit hPOP1
  JOURNAL   Biochem Biophys Res Commun 241 (1), 59-67 (1997)
   PUBMED   9405234
REFERENCE   8  (residues 1 to 137)
  AUTHORS   Racca,S., Di Carlo,F., Bartorelli,A., Bussolati,B. and Bussolati,G.
  TITLE     Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114
  JOURNAL   Virchows Arch 431 (5), 323-328 (1997)
   PUBMED   9463573
REFERENCE   9  (residues 1 to 137)
  AUTHORS   Schmiedeknecht,G., Kerkhoff,C., Orso,E., Stohr,J., Aslanidis,C.,
            Nagy,G.M., Knuechel,R. and Schmitz,G.
  TITLE     Isolation and characterization of a 14.5-kDa
            trichloroacetic-acid-soluble translational inhibitor protein from
            human monocytes that is upregulated upon cellular differentiation
  JOURNAL   Eur J Biochem 242 (2), 339-351 (1996)
   PUBMED   8973653
REFERENCE   10 (residues 1 to 137)
  AUTHORS   Oka,T., Tsuji,H., Noda,C., Sakai,K., Hong,Y.M., Suzuki,I., Munoz,S.
            and Natori,Y.
  TITLE     Isolation and characterization of a novel perchloric acid-soluble
            protein inhibiting cell-free protein synthesis
  JOURNAL   J Biol Chem 270 (50), 30060-30067 (1995)
   PUBMED   8530410
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X95384.1 and BC012592.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012592.1, X95384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254878.8/ ENSP00000254878.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..137
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     Protein         1..137
                     /product="2-iminobutanoate/2-iminopropanoate deaminase"
                     /EC_number="3.5.99.10"
                     /note="perchloric acid-soluble protein; translational
                     inhibitor p14.5; translational inhibitor protein p14.5;
                     ribonuclease UK114; UK114 antigen homolog; 14.5 kDa
                     translational inhibitor protein; heat-responsive protein
                     12; translation inhibitor L-PSP ribonuclease; reactive
                     intermediate imine deaminase A homolog"
                     /calculated_mol_wt=14363
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0007744|PubMed:25944712; propagated from
                     UniProtKB/Swiss-Prot (P52758.1)"
     Region          6..129
                     /region_name="TIGR00004"
                     /note="reactive intermediate/imine deaminase"
                     /db_xref="CDD:129116"
     Site            order(21..22,25,27,30,32,34..35,75,77..78,80,82,93,96,
                     105..112,122,124,126)
                     /site_type="other"
                     /note="homotrimer interaction site [polypeptide binding]"
                     /db_xref="CDD:100004"
     Site            order(21,89,93,107,122)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:100004"
     Site            74
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P52758.1)"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P52758.1)"
     CDS             1..137
                     /gene="RIDA"
                     /gene_synonym="hp14.5; HRSP12; P14.5; PSP; UK114"
                     /coded_by="NM_005836.3:76..489"
                     /db_xref="CCDS:CCDS6276.1"
                     /db_xref="GeneID:10247"
                     /db_xref="HGNC:HGNC:16897"
                     /db_xref="MIM:602487"
ORIGIN      
        1 msslirrvis takapgaigp ysqavlvdrt iyisgqigmd pssgqlvsgg vaeeakqalk
       61 nmgeilkaag cdftnvvktt vlladindfn tvneiykqyf ksnfparaay qvaalpkgsr
      121 ieieavaiqg plttasl
//
