LOCUS       XM_047417068            9687 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens RPTOR independent companion of MTOR complex
            2 (RICTOR), transcript variant X4, mRNA.
ACCESSION   XM_047417068
VERSION     XM_047417068.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9687
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..9687
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /note="RPTOR independent companion of MTOR complex 2;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 5 mRNAs, 10 ESTs, 1811 long SRA reads, and
                     99% coverage of the annotated genomic feature by RNAseq
                     alignments, including 14 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:253260"
                     /db_xref="HGNC:HGNC:28611"
                     /db_xref="MIM:609022"
     CDS             264..5303
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /codon_start=1
                     /product="rapamycin-insensitive companion of mTOR isoform
                     X4"
                     /protein_id="XP_047273024.1"
                     /db_xref="GeneID:253260"
                     /db_xref="HGNC:HGNC:28611"
                     /db_xref="MIM:609022"
                     /translation="MRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAK
                     EVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMIT
                     VNASLFPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILK
                     NVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEG
                     QLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLE
                     VLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDL
                     MDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHH
                     LHCLPTLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIA
                     THQKRDQYLRVQKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVN
                     LRNYKDEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDG
                     QGYLEDLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLE
                     KCSVFQCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKH
                     LRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPA
                     LSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEAL
                     TTYRKPVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNV
                     RTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGT
                     CVYVLGLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLN
                     SESTSSRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKN
                     SFPFFASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDF
                     NHSDDFTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTS
                     RERLVVESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMST
                     VVSTKTIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLA
                     DCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFES
                     RLTPSRIDFKKKHVGGIRSLRPTITNNLFRFMKALSYASLDKEDLLSPINQNTLQRSS
                     SVRSMVSSATYGGSDDYIGLALPVDINDIFQVKDIPYFQTKNIPPHDDRGARAFAHDA
                     GGLPSGTGGLVKNSFHLLRQQMSLTEIMNSIHSDASLFLESTEDTGLQEHTDDNCLYC
                     VCIEILGFQPSNQLSAICSHSDFQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGVS
                     QEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVINLSSSVSTKCHETGLLTI
                     KEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQDVQFLQMHEEAEAVLATPP
                     KQPIVDTSAES"
ORIGIN      
        1 gttgtgactg aaacccgtca atatggcggc gatcggccgc ggccgctctc tgaagaacct
       61 ccgagtacga gggcggaatg acagcggcga ggagaacgtc ccgctggatc tgacccgaga
      121 gtgaaaatat tagaaattac agagctacac agataacgct ctagagtaaa tgacatctca
      181 tccaaactac tgagagttta gaaccttctg ataacttaag agagattctc caaaatgtgg
      241 ccagattgca gggagtatca aatatgagaa agctaggcca tctgaataac tttactaagc
      301 ttctttgtga tattggccac agtgaagaaa aactgggctt tcactatgag gatatcataa
      361 tttgtttgcg gttagcttta ttaaatgaag caaaagaagt gcgagcagca gggctacgag
      421 cgcttcgata tctcatccaa gactccagta ttctccagaa ggtgctaaaa ttgaaagtgg
      481 actatttaat agctaggtgc attgacatac aacagagcaa cgaggtagag aggacacaag
      541 cacttcgatt agtcagaaag atgattactg tgaatgcttc cttgtttcct agttctgtga
      601 ccaactcatt aattgcagtt ggaaatgatg gacttcaaga aagagacaga atggtccgag
      661 catgcattgc cattatctgt gaactagcac ttcagaatcc agaggtggtg gcccttcgag
      721 gtggactaaa caccatcttg aaaaatgtga tcgattgcca attaagtcga ataaatgagg
      781 ccctaattac tacaattttg caccttctta atcatccaaa gactcgacag tatgtgcgag
      841 ctgatgtaga attagagaga attttagcac cctatactga ttttcactac agacatagtc
      901 cagatacagc tgaaggacag ctcaaagaag acagagaagc acgatttcta gccagtaaaa
      961 tgggaatcat agcaacattc cgatcatggg caggtattat taatttatgt aaacctggaa
     1021 attctgggat ccagtctcta ataggagtac tttgcatacc aaatatggaa ataaggcgag
     1081 gtctacttga agtgctttat gatatatttc gtcttcctct acctgttgtg actgaggagt
     1141 tcatagaagc actactcagt gtagatccag ggaggttcca agacagttgg aggctttcag
     1201 atggctttgt ggcagctgag gcaaaaacta ttcttcctca tcgtgccaga tccaggccag
     1261 acctcatgga taattatttg gcactgatac tctctgcatt tattcgtaat ggacttttag
     1321 agggtctagt tgaagtgata acaaacagtg atgatcatat ctcagttaga gctaccatcc
     1381 ttttaggaga gcttttacat atggcaaaca caattcttcc tcattcacat agccatcatt
     1441 tacactgctt gccaacccta atgaatatgg ctgcatcctt tgatatcccc aaggaaaaga
     1501 gactgcgagc cagtgcagcc ttgaactgtt taaaacgctt ccatgaaatg aagaaacgag
     1561 gacctaagcc ttatagtctt catttagacc acattattca gaaagcaatt gcaacacacc
     1621 agaaacggga tcagtatctc cgagttcaga aagatatatt tatccttaag gatacagagg
     1681 aagctctttt aattaacctt agagatagcc aagtccttca acataaagag aatcttgaat
     1741 ggaattggaa tcttataggg accattctta agtggccaaa tgtaaatcta agaaactata
     1801 aagatgaaca gttacacagg tttgtacgaa gactacttta tttttacaag cccagcagta
     1861 aattatatgc caacctggat ctggattttg ccaaggccaa acagctcacg gttgtaggtt
     1921 gccagtttac agaatttctt cttgaatctg aagaggatgg gcaaggctac ttagaagatc
     1981 tagtaaagga tattgttcag tggctcaatg cttcatctgg aatgaaaccc gaaagaagtc
     2041 ttcaaaataa tggtttattg accaccctta gtcaacacta ctttttattt attggaacac
     2101 tttcttgcca ccctcatgga gttaaaatgc tggaaaaatg cagtgtattt cagtgtctcc
     2161 ttaatctttg ctccttgaaa aaccaagatc acttgctaaa acttactgtt tctagcttgg
     2221 actatagcag agatggattg gctagagtca tcctttccaa aattttaact gcagctactg
     2281 atgcctgcag actctatgca acaaaacatt taagggtatt attgagagct aatgttgaat
     2341 tctttaataa ttggggaatt gagttgttag tgacccagct acatgataaa aacaaaacga
     2401 tttcctctga agctcttgat atcctcgatg aagcatgtga agacaaggcc aatcttcatg
     2461 ctctcattca gatgaaacca gcgttatccc accttggaga caagggtttg cttctcctgc
     2521 tgagatttct ctccattcca aaaggatttt cctatctgaa tgaaagaggt tatgtagcaa
     2581 aacaattgga aaagtggcac agggaataca actccaaata tgttgacttg attgaggaac
     2641 aactcaatga agcacttact acttaccgga agcctgttga tggtgataac tatgttcgtc
     2701 ggagtaacca aagattacag cgtcctcacg tctacctgcc tatacacctt tatggacaac
     2761 tagtacacca taaaacaggc tgccatttgt tggaagtaca gaatattatt acagaactct
     2821 gtcgtaatgt tcgtacacca gatttggata agtgggaaga aattaaaaaa ctgaaagcat
     2881 ctctttgggc cttgggaaat atcggctcat caaattgggg tctcaatttg ctacaggaag
     2941 aaaacgtgat tccagatata ctaaaacttg caaaacagtg tgaagttctt tccatcagag
     3001 ggacctgtgt atatgtactt gggctcatag ctaaaaccaa acaaggctgt gatattctaa
     3061 aatgtcacaa ctgggatgct gtgaggcata gtcgcaaaca tctgtggcca gtggttccag
     3121 atgatgtgga acaactctgt aatgaacttt catctatccc aagcactcta agtttgaact
     3181 cggagtcaac cagctctaga cataatagtg aaagtgaatc tgtgccatcg agtatgttca
     3241 tattggagga tgaccggttt ggcagcagct ctactagcac atttttcctt gatatcaatg
     3301 aagatacaga gccaacattt tatgaccgat ctggacccat aaaggataaa aattcattcc
     3361 ctttctttgc ttctagtaaa cttgtgaaga atcgtatctt aaattcgctt actttgccta
     3421 acaaaaaaca tcgtagtagc agtgatccaa aaggagggaa attatcatct gaaagtaaga
     3481 caagcaacag gcgaatcaga acacttacgg agcccagtgt tgattttaat catagtgatg
     3541 attttacacc catatccact gtacagaaaa cattacaatt agagacttca tttatgggga
     3601 ataagcacat tgaagacact ggtagtacac caagcattgg agaaaatgac ttaaaattca
     3661 ccaagaattt tggtacagag aatcacagag aaaatacaag ccgagagagg ttagtagtag
     3721 aaagttcaac gagctcacat atgaagatac gtagccaaag tttcaataca gacactacaa
     3781 caagtggcat aagttcaatg agctcaagtc cttcacgaga gacagtaggt gtagatgcta
     3841 caactatgga cacagactgt ggaagcatga gtactgtggt aagtactaaa actattaaga
     3901 caagccacta tttgacgcca cagtctaacc atctgtctct ctccaaatca aattcggtgt
     3961 ccctggtgcc tccaggttct tctcatacgc ttcctagaag agcacagtcc cttaaagcac
     4021 cctctattgc tacaattaaa agtctagcag attgtaactt tagttacaca agttctagag
     4081 atgcttttgg ctatgctaca ctgaaaagac tacagcaaca aagaatgcat ccatccttat
     4141 ctcactctga agctttggca tctccagcaa aagatgtgct atttactgat accatcacca
     4201 tgaaggccaa cagttttgag tccagattaa caccaagcag gatcgatttt aaaaagaagc
     4261 atgtcggggg aatcaggagc ttaagaccta caataacaaa caaccttttc aggttcatga
     4321 aagccttaag ttatgcatca ttagataaag aagatttatt gagtcctatt aatcaaaata
     4381 ccctgcaacg atcttcctca gtgcggtcca tggtgtccag tgccacatat gggggttcag
     4441 atgattacat tggtcttgct ctcccggtgg atataaatga tatattccag gtaaaggata
     4501 ttccctattt tcagacaaaa aacataccac cacatgatga tcgaggtgca agagcatttg
     4561 cccatgatgc aggaggtctt ccatctggaa ctggaggtct tgtaaaaaat tcttttcact
     4621 tgctacgaca gcagatgagt cttacggaaa taatgaattc aatccattca gatgcctctc
     4681 tgtttttaga aagtacagaa gacactggac tacaggaaca tacagatgat aactgccttt
     4741 attgtgtctg tattgaaatt ctgggtttcc agcccagcaa ccaactgagt gcaatatgta
     4801 gtcattcaga ctttcaagat attccatatt ctgattggtg tgagcagact atccataatc
     4861 ctttagaagt ggttccctct aagttttcgg ggatttctgg atgcagtgat ggggtgtctc
     4921 aagaaggctc agctagcagc accaaaagca cagaattgtt actaggtgtt aaaacaattc
     4981 cagatgatac accaatgtgc cgtatactcc ttcgcaaaga agttctaaga ttagtcatta
     5041 atttgagtag ttcagtttca actaaatgtc atgagactgg gcttttaaca attaaggaga
     5101 agtatcctca aacatttgat gacatatgcc tttactctga ggtttcccat ttgctgtcac
     5161 actgcacatt cagacttccg tgtcggaggt tcatacaaga attatttcaa gatgtacagt
     5221 ttctacaaat gcatgaagaa gcagaggctg tgttggcaac accaccaaag caacctatag
     5281 ttgatacatc tgctgaatcc tgacctcata tttatgatgg atatagatac atactatata
     5341 tattcatatt tgtggatttc ctaaaagcct cagaaaatac gactgactag gcagcaaaga
     5401 caggagtatc ttctgtacac tgttccgcag ttactggtac atgaacagtt ggaactgctg
     5461 actttcctaa ccaaaacaac ttccttctct cctttgttga gccttttgag gggttcatga
     5521 ttcattacca cagttttaag agtttcagtt accattgtat gcaagagcca agcactgaat
     5581 acctacatag gttttctatt ttctttcatt ttaaaagcat aatgacagtg gaacaataat
     5641 gggatatgca gaagcaccct tcacaagtta tttctgaatg atttttaggg taaataatac
     5701 agatgccttg tttgttaact aacttgtgga aagcaggaat cagtgtctct aaggctgcat
     5761 cctattacca caatggggtg tgctataact gctggtatta gagagggaac tttggccctt
     5821 tcacgttttt cttaatgttt gtaacactac ttcagaggtt tataacctca aagcagaaga
     5881 agagcctcaa caacccggga cttataagtt atttttatgt tactagactt gcataaagat
     5941 tcttgttttc caactcttca ttttgttgca atgtgttatt acaggatata tgaaccaatt
     6001 aaggtttttc actacagttc ttgaataaaa tttaaaaatc attttttatt ttaattaaaa
     6061 atatttccca tttatagaat gcatatattt gcaatggact tccactttca tcaactttcc
     6121 atctcatcgc tttaaacagg aacttgaaca agcactgtta gtttagacct aaaggatagg
     6181 aaagcattaa ataatacttt ggatctcctg aggaaaagat aagtttgctt gcaatttaca
     6241 cattccatgg ggaaagaaga gccatatttc cttaaaaaaa acattaataa agcttgttat
     6301 tgagaaaaat tgtagtgaaa agccttaagt accaaatttt aaagcagcag taacttaatt
     6361 tttatatcag tgtttttgtt ttgcacaaac taaatgcagt ggtaggtggg tttatgagta
     6421 tattaattgc ctttatccat ttgtgaagtt aagttgatga gggcaaggtt tttgtttgtt
     6481 taatttgtat atgtctaaag gtatttggaa ctttttacag gaattaaaca tatatgcaaa
     6541 tttgtatata aaaatagcat ggccatcatt tgaatgcttg taaatgaaag gattatcttt
     6601 tttgagatct atatataaat agaaatagaa aatccagctg gactgattag gattcttttt
     6661 taattcattt gtgtataaca tttttattac aattacacat cagttttgac acagtcatag
     6721 caacattaat attttcccat gatgcagatc ctttttgtaa tgggcttgtt ctttgagatc
     6781 tctgtaaaga accctgtgaa ctagaaaaca taactcacag agatactttt ttaaaaaatt
     6841 tatttactgg aactgaaagt tccagttggg atgaagcatt tcatctcact tcataacacc
     6901 tctttgactg cacttcagtg aattgttctt atgtgcactg tgtagcaact tacattataa
     6961 caaagcagat aagggctgta agctgctgct tatgttgaaa agtggttctt cagattttct
     7021 ctcataaaat ccagttgaag ataaataatt tttttatact ttatcactga acccaagtgt
     7081 ttatttaaat gtcaacagta cttctaagaa cgttgcctgt catcgtggtc tttggtcttg
     7141 gataactaaa ctgcctttcc agagaaccaa atgtcagagt tactagacca aatagtggtt
     7201 aaaacctcca aaggaagtaa tgtaatctta ttcataatgg gattaacata ttttagacat
     7261 tcattttaaa cactacctca gttaatatag agtataaaaa tctgtggttt aatccctcaa
     7321 aagttaacag taattttttt tttgtcttac acacacacac accccctccc ccaccatcac
     7381 tatccctgta ccctcacctt ggtcatctat cctgaaataa ggcttagtta gtattggcct
     7441 gaatgttttg tgtttttttt tttgtttttt ttttttactg ttactttgaa aaatatgtat
     7501 gtatacctta tcatatctgc ctatatcact tactttgggg agatactcag agctttgtgg
     7561 ttatcagtat actaaaaaaa aaaaaaagtc tacgcttaaa tttatagtgc tatttggttt
     7621 ctccatgatt tcactgacag gtctaataca ttttctttga gtacttgttt gtaaaaagta
     7681 gactttatgg tgaaaaatac atgcagtgcc aagtgattaa cttaagtgtt taaaaatatt
     7741 aaattatagc agaagaggtt aggaatgata tcagcagtaa tagaaataat tgagaaaatc
     7801 atctataaat aatagatatt acagactata gaataccaaa ataatgtcaa tactgtagtt
     7861 tttaaagatt ttaggattaa tcttagtcca tataaatttg tactattggt aattattgaa
     7921 taattgggag gaatctgggc agttgtgctg gttgtaaact atgaatttct aatcgtaaag
     7981 tgaattgtta tttctaattg aacttttttt caagaacaga tttcagcctc acatactaag
     8041 taaatactga taaataagga aattagaaat ttagtattca taattaaata tgctctaaaa
     8101 tttcctatac ttttatttcc tgtttattct taggtagatt ggaaggggga aacagtctgt
     8161 tctccctaat taaatttttt ctaataacga ttagtagaat atggacattc tatatgacag
     8221 tgacattaaa agaggctctt tggaagtata tacattatta acataatgtg tacaagtcct
     8281 tttgaaatga caactttaat gggtttcagc tcttttatct agagcttgag ataattcaag
     8341 ctgagttttt cagggcatat cacaacggcc aagtgttcag cagtgggata tcaatgctta
     8401 tttacatttt cctactgcta tttatataaa atgttattcc attcagagga tgccttttat
     8461 ccccacatta aagcacagat cattaagcaa taaaaaccaa attgtctgtc attcaaatta
     8521 taactgcagt tatttttgca tggtaagagt gaggtgctaa ttttgtgtga gatgaacttt
     8581 gtaaactact ttgggaaatg ttctttggaa gtaaggtttt ttctccttta gtcttatgct
     8641 tccacttttg tctcagattc acaatccatt aaaacatggg gaaaaaagaa aaggtaaaat
     8701 tgagagactt ttgttagagg agctatttgg aatgaaccaa catttcagat tttccaaaat
     8761 gtaagttagg aagtctccat tgtctctgca ttaacaaaat acactgttac tatcttaatc
     8821 tcaagagtgt cattacagtg agaatctcat ttaaaagcat accagtgaaa ttaatagcag
     8881 tgcttatcaa agaacactga aatctgtgag aatctttcta ggagcattct tttcttcttt
     8941 tagttccaag ttccagggta tttttcattc ctagtaggtt tatatgactc acagaatgtg
     9001 gacttttttc ctgtttggag tatttttgta atgtaagtat cggatagctg caccacagca
     9061 tgcataaatt gcacattttg ttttactttc tttatagaat atttaatttc aaaaatataa
     9121 tttatgccaa aaaaagcata cctttcaatt ttgctacttg gttgatttag cacaaaatgc
     9181 aaagtcttgg ggcagagagg gggagtgaaa aaaattttat aggtaattgt tacaaaaata
     9241 cctgtcagaa accctaaagc tgcattgtaa aacaaatggt gtaaactagt tttgaaaagt
     9301 ggtaaggaat tgtgaaaaaa atctcagact taatgctctc taaccacatg agtttcttct
     9361 tttttattta gtaatacgct gctacatatt tggaggttct ggtgtttgta ggtcactgaa
     9421 cagacattga aatctgattt atattgtata actgtaacat agaaagaaaa agtatttata
     9481 ttttttctgt aagaatattt cattgagttg tgtataattt aaataagatt tgtccccaaa
     9541 tggttttgct caccttgatt ttttttgttg tgattttctt gtttttgtat aatgtgtata
     9601 gtttatgtca agggcattaa aagcctcctg aagcataatc ttatcaaagg gatacattgt
     9661 taataaaatg tacttaaaat tcttaaa
//
