LOCUS       NM_152756               9533 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens RPTOR independent companion of MTOR complex 2
            (RICTOR), transcript variant 1, mRNA.
ACCESSION   NM_152756 XM_114447
VERSION     NM_152756.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9533)
  AUTHORS   Wang,Y., Zuo,D., Huang,Z., Qiu,Y., Wu,Z., Liu,S., Zeng,Y., Qiu,Z.,
            He,W., Li,B., Yuan,Y., Niu,Y. and Qiu,J.
  TITLE     KLF4 Suppresses the Progression of Hepatocellular Carcinoma by
            Reducing Tumor ATP Synthesis through Targeting the Mir-206/RICTOR
            Axis
  JOURNAL   Int J Mol Sci 25 (13), 7165 (2024)
   PUBMED   39000273
  REMARK    GeneRIF: KLF4 Suppresses the Progression of Hepatocellular
            Carcinoma by Reducing Tumor ATP Synthesis through Targeting the
            Mir-206/RICTOR Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9533)
  AUTHORS   Ponzone,L., Audrito,V., Landi,C., Moiso,E., Levra Levron,C.,
            Ferrua,S., Savino,A., Vitale,N., Gasparrini,M., Avalle,L.,
            Vantaggiato,L., Shaba,E., Tassone,B., Saoncella,S., Orso,F.,
            Viavattene,D., Marina,E., Fiorilla,I., Burrone,G., Abili,Y.,
            Altruda,F., Bini,L., Deaglio,S., Defilippi,P., Menga,A., Poli,V.,
            Porporato,P.E., Provero,P., Raffaelli,N., Riganti,C., Taverna,D.,
            Cavallo,F. and Calautti,E.
  TITLE     RICTOR/mTORC2 downregulation in BRAFV600E melanoma cells promotes
            resistance to BRAF/MEK inhibition
  JOURNAL   Mol Cancer 23 (1), 105 (2024)
   PUBMED   38755661
  REMARK    GeneRIF: RICTOR/mTORC2 downregulation in BRAF[V600E] melanoma cells
            promotes resistance to BRAF/MEK inhibition.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9533)
  AUTHORS   Wang,C., Chen,Z., Yi,Y., Ding,Y., Xu,F., Kang,H., Lin,K., Shu,X.,
            Zhong,Z., Zhang,Z., Liu,J., Xu,Z., Liu,L., He,X., Chang,Y. and
            Zhao,Q.
  TITLE     RBM45 reprograms lipid metabolism promoting hepatocellular
            carcinoma via Rictor and ACSL1/ACSL4
  JOURNAL   Oncogene 43 (5), 328-340 (2024)
   PUBMED   38040804
  REMARK    GeneRIF: RBM45 reprograms lipid metabolism promoting hepatocellular
            carcinoma via Rictor and ACSL1/ACSL4.
REFERENCE   4  (bases 1 to 9533)
  AUTHORS   Wang,C., Kang,H., Yi,Y., Ding,Y., Wang,F., Luo,J., Ye,M., Hong,Y.,
            Xia,C., Yan,J., Liu,L., Liu,J., Zhong,Z., Zhang,Z., Zhao,Q. and
            Chang,Y.
  TITLE     Rictor mediates p53 deactivation to facilitate the malignant
            transformation of hepatocytes and promote hepatocarcinogenesis
  JOURNAL   J Transl Med 21 (1), 919 (2023)
   PUBMED   38110956
  REMARK    GeneRIF: Rictor mediates p53 deactivation to facilitate the
            malignant transformation of hepatocytes and promote
            hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9533)
  AUTHORS   Sztankovics,D., Krencz,I., Moldvai,D., Danko,T., Nagy,A., Nagy,N.,
            Bedics,G., Rokusz,A., Papp,G., Tokes,A.M., Papay,J., Sapi,Z.,
            Dezso,K., Bodor,C. and Sebestyen,A.
  TITLE     Novel RICTOR amplification harbouring entities: FISH validation of
            RICTOR amplification in tumour tissue after next-generation
            sequencing
  JOURNAL   Sci Rep 13 (1), 19610 (2023)
   PUBMED   37949943
  REMARK    GeneRIF: Novel RICTOR amplification harbouring entities: FISH
            validation of RICTOR amplification in tumour tissue after
            next-generation sequencing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9533)
  AUTHORS   Sarbassov,D.D., Guertin,D.A., Ali,S.M. and Sabatini,D.M.
  TITLE     Phosphorylation and regulation of Akt/PKB by the rictor-mTOR
            complex
  JOURNAL   Science 307 (5712), 1098-1101 (2005)
   PUBMED   15718470
  REMARK    GeneRIF: results show show that target of rapamycin (TOR) kinase
            and its associated protein rictor are necessary for AKT/PKB Ser473
            phosphorylation and that a reduction in rictor or mammalian TOR
            (mTOR) expression inhibited an Akt/PKB effector
REFERENCE   7  (bases 1 to 9533)
  AUTHORS   Jacinto,E., Loewith,R., Schmidt,A., Lin,S., Ruegg,M.A., Hall,A. and
            Hall,M.N.
  TITLE     Mammalian TOR complex 2 controls the actin cytoskeleton and is
            rapamycin insensitive
  JOURNAL   Nat Cell Biol 6 (11), 1122-1128 (2004)
   PUBMED   15467718
REFERENCE   8  (bases 1 to 9533)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   9  (bases 1 to 9533)
  AUTHORS   Sarbassov,D.D., Ali,S.M., Kim,D.H., Guertin,D.A., Latek,R.R.,
            Erdjument-Bromage,H., Tempst,P. and Sabatini,D.M.
  TITLE     Rictor, a novel binding partner of mTOR, defines a
            rapamycin-insensitive and raptor-independent pathway that regulates
            the cytoskeleton
  JOURNAL   Curr Biol 14 (14), 1296-1302 (2004)
   PUBMED   15268862
REFERENCE   10 (bases 1 to 9533)
  AUTHORS   Ohara,O., Nagase,T., Mitsui,G., Kohga,H., Kikuno,R., Hiraoka,S.,
            Takahashi,Y., Kitajima,S., Saga,Y. and Koseki,H.
  TITLE     Characterization of size-fractionated cDNA libraries generated by
            the in vitro recombination-assisted method
  JOURNAL   DNA Res 9 (2), 47-57 (2002)
   PUBMED   12056414
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008964.6, AC109467.3 and AC026713.5.
            
            On Nov 23, 2018 this sequence version replaced NM_152756.4.
            
            Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a
            protein complex that integrates nutrient- and growth factor-derived
            signals to regulate cell growth (Sarbassov et al., 2004 [PubMed
            15268862]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137163.1, AY515854.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357387.8/ ENSP00000349959.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC008964.6         49126-49196
            72-119              AC008964.6         49367-49414
            120-217             AC008964.6         102389-102486
            218-282             AC008964.6         119903-119967
            283-414             AC008964.6         120859-120990
            415-478             AC008964.6         126643-126706
            479-605             AC109467.3         4675-4801
            606-775             AC109467.3         13714-13883
            776-843             AC109467.3         17100-17167
            844-911             AC109467.3         20146-20213
            912-994             AC109467.3         23791-23873
            995-1082            AC109467.3         27720-27807
            1083-1173           AC109467.3         28323-28413
            1174-1240           AC109467.3         28523-28589
            1241-1321           AC109467.3         29029-29109
            1322-1422           AC109467.3         30858-30958
            1423-1588           AC109467.3         32709-32874
            1589-1690           AC109467.3         33164-33265
            1691-1737           AC109467.3         33389-33435
            1738-1873           AC109467.3         35217-35352
            1874-2073           AC109467.3         35772-35971
            2074-2200           AC109467.3         36429-36555
            2201-2365           AC109467.3         36919-37083
            2366-2442           AC109467.3         37231-37307
            2443-2521           AC109467.3         38020-38098
            2522-2631           AC109467.3         40046-40155
            2632-2719           AC109467.3         40889-40976
            2720-2812           AC109467.3         42197-42289
            2813-2919           AC109467.3         42659-42765
            2920-3149           AC109467.3         43325-43554
            3150-4158           AC109467.3         45030-46038
            4159-4336           AC109467.3         48309-48486
            4337-4421           AC109467.3         49198-49282
            4422-4655           AC109467.3         50026-50259
            4656-4811           AC109467.3         50682-50837
            4812-4935           AC109467.3         51181-51304
            4936-5074           AC109467.3         52779-52917
            5075-6135           AC109467.3         53372-54432
            6136-9533           AC026713.5         1-3398
FEATURES             Location/Qualifiers
     source          1..9533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..9533
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /note="RPTOR independent companion of MTOR complex 2"
                     /db_xref="GeneID:253260"
                     /db_xref="HGNC:HGNC:28611"
                     /db_xref="MIM:609022"
     exon            1..71
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..5149
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rapamycin-insensitive companion of mTOR; pianissimo;
                     TORC2-specific protein AVO3; AVO3 homolog"
                     /codon_start=1
                     /product="rapamycin-insensitive companion of mTOR isoform
                     1"
                     /protein_id="NP_689969.2"
                     /db_xref="CCDS:CCDS34148.1"
                     /db_xref="GeneID:253260"
                     /db_xref="HGNC:HGNC:28611"
                     /db_xref="MIM:609022"
                     /translation="MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQN
                     VARLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKEVRAA
                     GLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASL
                     FPSSVTNSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDC
                     QLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKED
                     REARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDI
                     FRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYL
                     ALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLP
                     TLMNMAASFDIPKEKRLRASAALNCLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKR
                     DQYLRVQKDIFILKDTEEALLINLRDSQVLQHKENLEWNWNLIGTILKWPNVNLRNYK
                     DEQLHRFVRRLLYFYKPSSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLE
                     DLVKDIVQWLNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVF
                     QCLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLL
                     RANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLG
                     DKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHREYNSKYVDLIEEQLNEALTTYRK
                     PVDGDNYVRRSNQRLQRPHVYLPIHLYGQLVHHKTGCHLLEVQNIITELCRNVRTPDL
                     DKWEEIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVL
                     GLIAKTKQGCDILKCHNWDAVRHSRKHLWPVVPDDVEQLCNELSSIPSTLSLNSESTS
                     SRHNSESESVPSSMFILEDDRFGSSSTSTFFLDINEDTEPTFYDRSGPIKDKNSFPFF
                     ASSKLVKNRILNSLTLPNKKHRSSSDPKGGKLSSESKTSNRRIRTLTEPSVDFNHSDD
                     FTPISTVQKTLQLETSFMGNKHIEDTGSTPSIGENDLKFTKNFGTENHRENTSRERLV
                     VESSTSSHMKIRSQSFNTDTTTSGISSMSSSPSRETVGVDATTMDTDCGSMSTVVSTK
                     TIKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFS
                     YTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPS
                     RFMKALSYASLDKEDLLSPINQNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDI
                     FQVKDIPYFQTKNIPPHDDRGARAFAHDAGGLPSGTGGLVKNSFHLLRQQMSLTEIMN
                     SIHSDASLFLESTEDTGLQEHTDDNCLYCVCIEILGFQPSNQLSAICSHSDFQDIPYS
                     DWCEQTIHNPLEVVPSKFSGISGCSDGVSQEGSASSTKSTELLLGVKTIPDDTPMCRI
                     LLRKEVLRLVINLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLP
                     CRRFIQELFQDVQFLQMHEEAEAVLATPPKQPIVDTSAES"
     exon            72..119
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            120..217
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            218..282
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            283..414
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            415..478
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            479..605
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            606..775
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            776..843
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            844..911
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            912..994
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1082
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1173
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1240
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1321
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1422
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1588
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1690
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1737
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1873
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2073
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2200
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2365
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2442
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2521
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2631
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2719
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2812
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2919
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3149
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..4158
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4336
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            4337..4421
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..4655
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            4656..4811
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..4935
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            4936..5074
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     exon            5075..9533
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9508..9513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /note="hexamer: AATAAA"
     polyA_site      9533
                     /gene="RICTOR"
                     /gene_synonym="AVO3; hAVO3; PIA"
                     /note="major polyA site"
ORIGIN      
        1 gttgtgactg aaacccgtca atatggcggc gatcggccgc ggccgctctc tgaagaacct
       61 ccgagtacga gggcggaatg acagcggcga ggagaacgtc ccgctggatc tgacccgaga
      121 accttctgat aacttaagag agattctcca aaatgtggcc agattgcagg gagtatcaaa
      181 tatgagaaag ctaggccatc tgaataactt tactaagctt ctttgtgata ttggccacag
      241 tgaagaaaaa ctgggctttc actatgagga tatcataatt tgtttgcggt tagctttatt
      301 aaatgaagca aaagaagtgc gagcagcagg gctacgagcg cttcgatatc tcatccaaga
      361 ctccagtatt ctccagaagg tgctaaaatt gaaagtggac tatttaatag ctaggtgcat
      421 tgacatacaa cagagcaacg aggtagagag gacacaagca cttcgattag tcagaaagat
      481 gattactgtg aatgcttcct tgtttcctag ttctgtgacc aactcattaa ttgcagttgg
      541 aaatgatgga cttcaagaaa gagacagaat ggtccgagca tgcattgcca ttatctgtga
      601 actagcactt cagaatccag aggtggtggc ccttcgaggt ggactaaaca ccatcttgaa
      661 aaatgtgatc gattgccaat taagtcgaat aaatgaggcc ctaattacta caattttgca
      721 ccttcttaat catccaaaga ctcgacagta tgtgcgagct gatgtagaat tagagagaat
      781 tttagcaccc tatactgatt ttcactacag acatagtcca gatacagctg aaggacagct
      841 caaagaagac agagaagcac gatttctagc cagtaaaatg ggaatcatag caacattccg
      901 atcatgggca ggtattatta atttatgtaa acctggaaat tctgggatcc agtctctaat
      961 aggagtactt tgcataccaa atatggaaat aaggcgaggt ctacttgaag tgctttatga
     1021 tatatttcgt cttcctctac ctgttgtgac tgaggagttc atagaagcac tactcagtgt
     1081 agatccaggg aggttccaag acagttggag gctttcagat ggctttgtgg cagctgaggc
     1141 aaaaactatt cttcctcatc gtgccagatc caggccagac ctcatggata attatttggc
     1201 actgatactc tctgcattta ttcgtaatgg acttttagag ggtctagttg aagtgataac
     1261 aaacagtgat gatcatatct cagttagagc taccatcctt ttaggagagc ttttacatat
     1321 ggcaaacaca attcttcctc attcacatag ccatcattta cactgcttgc caaccctaat
     1381 gaatatggct gcatcctttg atatccccaa ggaaaagaga ctgcgagcca gtgcagcctt
     1441 gaactgttta aaacgcttcc atgaaatgaa gaaacgagga cctaagcctt atagtcttca
     1501 tttagaccac attattcaga aagcaattgc aacacaccag aaacgggatc agtatctccg
     1561 agttcagaaa gatatattta tccttaagga tacagaggaa gctcttttaa ttaaccttag
     1621 agatagccaa gtccttcaac ataaagagaa tcttgaatgg aattggaatc ttatagggac
     1681 cattcttaag tggccaaatg taaatctaag aaactataaa gatgaacagt tacacaggtt
     1741 tgtacgaaga ctactttatt tttacaagcc cagcagtaaa ttatatgcca acctggatct
     1801 ggattttgcc aaggccaaac agctcacggt tgtaggttgc cagtttacag aatttcttct
     1861 tgaatctgaa gaggatgggc aaggctactt agaagatcta gtaaaggata ttgttcagtg
     1921 gctcaatgct tcatctggaa tgaaacccga aagaagtctt caaaataatg gtttattgac
     1981 cacccttagt caacactact ttttatttat tggaacactt tcttgccacc ctcatggagt
     2041 taaaatgctg gaaaaatgca gtgtatttca gtgtctcctt aatctttgct ccttgaaaaa
     2101 ccaagatcac ttgctaaaac ttactgtttc tagcttggac tatagcagag atggattggc
     2161 tagagtcatc ctttccaaaa ttttaactgc agctactgat gcctgcagac tctatgcaac
     2221 aaaacattta agggtattat tgagagctaa tgttgaattc tttaataatt ggggaattga
     2281 gttgttagtg acccagctac atgataaaaa caaaacgatt tcctctgaag ctcttgatat
     2341 cctcgatgaa gcatgtgaag acaaggccaa tcttcatgct ctcattcaga tgaaaccagc
     2401 gttatcccac cttggagaca agggtttgct tctcctgctg agatttctct ccattccaaa
     2461 aggattttcc tatctgaatg aaagaggtta tgtagcaaaa caattggaaa agtggcacag
     2521 ggaatacaac tccaaatatg ttgacttgat tgaggaacaa ctcaatgaag cacttactac
     2581 ttaccggaag cctgttgatg gtgataacta tgttcgtcgg agtaaccaaa gattacagcg
     2641 tcctcacgtc tacctgccta tacaccttta tggacaacta gtacaccata aaacaggctg
     2701 ccatttgttg gaagtacaga atattattac agaactctgt cgtaatgttc gtacaccaga
     2761 tttggataag tgggaagaaa ttaaaaaact gaaagcatct ctttgggcct tgggaaatat
     2821 cggctcatca aattggggtc tcaatttgct acaggaagaa aacgtgattc cagatatact
     2881 aaaacttgca aaacagtgtg aagttctttc catcagaggg acctgtgtat atgtacttgg
     2941 gctcatagct aaaaccaaac aaggctgtga tattctaaaa tgtcacaact gggatgctgt
     3001 gaggcatagt cgcaaacatc tgtggccagt ggttccagat gatgtggaac aactctgtaa
     3061 tgaactttca tctatcccaa gcactctaag tttgaactcg gagtcaacca gctctagaca
     3121 taatagtgaa agtgaatctg tgccatcgag tatgttcata ttggaggatg accggtttgg
     3181 cagcagctct actagcacat ttttccttga tatcaatgaa gatacagagc caacatttta
     3241 tgaccgatct ggacccataa aggataaaaa ttcattccct ttctttgctt ctagtaaact
     3301 tgtgaagaat cgtatcttaa attcgcttac tttgcctaac aaaaaacatc gtagtagcag
     3361 tgatccaaaa ggagggaaat tatcatctga aagtaagaca agcaacaggc gaatcagaac
     3421 acttacggag cccagtgttg attttaatca tagtgatgat tttacaccca tatccactgt
     3481 acagaaaaca ttacaattag agacttcatt tatggggaat aagcacattg aagacactgg
     3541 tagtacacca agcattggag aaaatgactt aaaattcacc aagaattttg gtacagagaa
     3601 tcacagagaa aatacaagcc gagagaggtt agtagtagaa agttcaacga gctcacatat
     3661 gaagatacgt agccaaagtt tcaatacaga cactacaaca agtggcataa gttcaatgag
     3721 ctcaagtcct tcacgagaga cagtaggtgt agatgctaca actatggaca cagactgtgg
     3781 aagcatgagt actgtggtaa gtactaaaac tattaagaca agccactatt tgacgccaca
     3841 gtctaaccat ctgtctctct ccaaatcaaa ttcggtgtcc ctggtgcctc caggttcttc
     3901 tcatacgctt cctagaagag cacagtccct taaagcaccc tctattgcta caattaaaag
     3961 tctagcagat tgtaacttta gttacacaag ttctagagat gcttttggct atgctacact
     4021 gaaaagacta cagcaacaaa gaatgcatcc atccttatct cactctgaag ctttggcatc
     4081 tccagcaaaa gatgtgctat ttactgatac catcaccatg aaggccaaca gttttgagtc
     4141 cagattaaca ccaagcaggt tcatgaaagc cttaagttat gcatcattag ataaagaaga
     4201 tttattgagt cctattaatc aaaataccct gcaacgatct tcctcagtgc ggtccatggt
     4261 gtccagtgcc acatatgggg gttcagatga ttacattggt cttgctctcc cggtggatat
     4321 aaatgatata ttccaggtaa aggatattcc ctattttcag acaaaaaaca taccaccaca
     4381 tgatgatcga ggtgcaagag catttgccca tgatgcagga ggtcttccat ctggaactgg
     4441 aggtcttgta aaaaattctt ttcacttgct acgacagcag atgagtctta cggaaataat
     4501 gaattcaatc cattcagatg cctctctgtt tttagaaagt acagaagaca ctggactaca
     4561 ggaacataca gatgataact gcctttattg tgtctgtatt gaaattctgg gtttccagcc
     4621 cagcaaccaa ctgagtgcaa tatgtagtca ttcagacttt caagatattc catattctga
     4681 ttggtgtgag cagactatcc ataatccttt agaagtggtt ccctctaagt tttcggggat
     4741 ttctggatgc agtgatgggg tgtctcaaga aggctcagct agcagcacca aaagcacaga
     4801 attgttacta ggtgttaaaa caattccaga tgatacacca atgtgccgta tactccttcg
     4861 caaagaagtt ctaagattag tcattaattt gagtagttca gtttcaacta aatgtcatga
     4921 gactgggctt ttaacaatta aggagaagta tcctcaaaca tttgatgaca tatgccttta
     4981 ctctgaggtt tcccatttgc tgtcacactg cacattcaga cttccgtgtc ggaggttcat
     5041 acaagaatta tttcaagatg tacagtttct acaaatgcat gaagaagcag aggctgtgtt
     5101 ggcaacacca ccaaagcaac ctatagttga tacatctgct gaatcctgac ctcatattta
     5161 tgatggatat agatacatac tatatatatt catatttgtg gatttcctaa aagcctcaga
     5221 aaatacgact gactaggcag caaagacagg agtatcttct gtacactgtt ccgcagttac
     5281 tggtacatga acagttggaa ctgctgactt tcctaaccaa aacaacttcc ttctctcctt
     5341 tgttgagcct tttgaggggt tcatgattca ttaccacagt tttaagagtt tcagttacca
     5401 ttgtatgcaa gagccaagca ctgaatacct acataggttt tctattttct ttcattttaa
     5461 aagcataatg acagtggaac aataatggga tatgcagaag cacccttcac aagttatttc
     5521 tgaatgattt ttagggtaaa taatacagat gccttgtttg ttaactaact tgtggaaagc
     5581 aggaatcagt gtctctaagg ctgcatccta ttaccacaat ggggtgtgct ataactgctg
     5641 gtattagaga gggaactttg gccctttcac gtttttctta atgtttgtaa cactacttca
     5701 gaggtttata acctcaaagc agaagaagag cctcaacaac ccgggactta taagttattt
     5761 ttatgttact agacttgcat aaagattctt gttttccaac tcttcatttt gttgcaatgt
     5821 gttattacag gatatatgaa ccaattaagg tttttcacta cagttcttga ataaaattta
     5881 aaaatcattt tttattttaa ttaaaaatat ttcccattta tagaatgcat atatttgcaa
     5941 tggacttcca ctttcatcaa ctttccatct catcgcttta aacaggaact tgaacaagca
     6001 ctgttagttt agacctaaag gataggaaag cattaaataa tactttggat ctcctgagga
     6061 aaagataagt ttgcttgcaa tttacacatt ccatggggaa agaagagcca tatttcctta
     6121 aaaaaaacat taataaagct tgttattgag aaaaattgta gtgaaaagcc ttaagtacca
     6181 aattttaaag cagcagtaac ttaattttta tatcagtgtt tttgttttgc acaaactaaa
     6241 tgcagtggta ggtgggttta tgagtatatt aattgccttt atccatttgt gaagttaagt
     6301 tgatgagggc aaggtttttg tttgtttaat ttgtatatgt ctaaaggtat ttggaacttt
     6361 ttacaggaat taaacatata tgcaaatttg tatataaaaa tagcatggcc atcatttgaa
     6421 tgcttgtaaa tgaaaggatt atcttttttg agatctatat ataaatagaa atagaaaatc
     6481 cagctggact gattaggatt cttttttaat tcatttgtgt ataacatttt tattacaatt
     6541 acacatcagt tttgacacag tcatagcaac attaatattt tcccatgatg cagatccttt
     6601 ttgtaatggg cttgttcttt gagatctctg taaagaaccc tgtgaactag aaaacataac
     6661 tcacagagat acttttttaa aaaatttatt tactggaact gaaagttcca gttgggatga
     6721 agcatttcat ctcacttcat aacacctctt tgactgcact tcagtgaatt gttcttatgt
     6781 gcactgtgta gcaacttaca ttataacaaa gcagataagg gctgtaagct gctgcttatg
     6841 ttgaaaagtg gttcttcaga ttttctctca taaaatccag ttgaagataa ataatttttt
     6901 tatactttat cactgaaccc aagtgtttat ttaaatgtca acagtacttc taagaacgtt
     6961 gcctgtcatc gtggtctttg gtcttggata actaaactgc ctttccagag aaccaaatgt
     7021 cagagttact agaccaaata gtggttaaaa cctccaaagg aagtaatgta atcttattca
     7081 taatgggatt aacatatttt agacattcat tttaaacact acctcagtta atatagagta
     7141 taaaaatctg tggtttaatc cctcaaaagt taacagtaat tttttttttg tcttacacac
     7201 acacacaccc cctcccccac catcactatc cctgtaccct caccttggtc atctatcctg
     7261 aaataaggct tagttagtat tggcctgaat gttttgtgtt tttttttttg tttttttttt
     7321 ttactgttac tttgaaaaat atgtatgtat accttatcat atctgcctat atcacttact
     7381 ttggggagat actcagagct ttgtggttat cagtatacta aaaaaaaaaa aaagtctacg
     7441 cttaaattta tagtgctatt tggtttctcc atgatttcac tgacaggtct aatacatttt
     7501 ctttgagtac ttgtttgtaa aaagtagact ttatggtgaa aaatacatgc agtgccaagt
     7561 gattaactta agtgtttaaa aatattaaat tatagcagaa gaggttagga atgatatcag
     7621 cagtaataga aataattgag aaaatcatct ataaataata gatattacag actatagaat
     7681 accaaaataa tgtcaatact gtagttttta aagattttag gattaatctt agtccatata
     7741 aatttgtact attggtaatt attgaataat tgggaggaat ctgggcagtt gtgctggttg
     7801 taaactatga atttctaatc gtaaagtgaa ttgttatttc taattgaact ttttttcaag
     7861 aacagatttc agcctcacat actaagtaaa tactgataaa taaggaaatt agaaatttag
     7921 tattcataat taaatatgct ctaaaatttc ctatactttt atttcctgtt tattcttagg
     7981 tagattggaa gggggaaaca gtctgttctc cctaattaaa ttttttctaa taacgattag
     8041 tagaatatgg acattctata tgacagtgac attaaaagag gctctttgga agtatataca
     8101 ttattaacat aatgtgtaca agtccttttg aaatgacaac tttaatgggt ttcagctctt
     8161 ttatctagag cttgagataa ttcaagctga gtttttcagg gcatatcaca acggccaagt
     8221 gttcagcagt gggatatcaa tgcttattta cattttccta ctgctattta tataaaatgt
     8281 tattccattc agaggatgcc ttttatcccc acattaaagc acagatcatt aagcaataaa
     8341 aaccaaattg tctgtcattc aaattataac tgcagttatt tttgcatggt aagagtgagg
     8401 tgctaatttt gtgtgagatg aactttgtaa actactttgg gaaatgttct ttggaagtaa
     8461 ggttttttct cctttagtct tatgcttcca cttttgtctc agattcacaa tccattaaaa
     8521 catggggaaa aaagaaaagg taaaattgag agacttttgt tagaggagct atttggaatg
     8581 aaccaacatt tcagattttc caaaatgtaa gttaggaagt ctccattgtc tctgcattaa
     8641 caaaatacac tgttactatc ttaatctcaa gagtgtcatt acagtgagaa tctcatttaa
     8701 aagcatacca gtgaaattaa tagcagtgct tatcaaagaa cactgaaatc tgtgagaatc
     8761 tttctaggag cattcttttc ttcttttagt tccaagttcc agggtatttt tcattcctag
     8821 taggtttata tgactcacag aatgtggact tttttcctgt ttggagtatt tttgtaatgt
     8881 aagtatcgga tagctgcacc acagcatgca taaattgcac attttgtttt actttcttta
     8941 tagaatattt aatttcaaaa atataattta tgccaaaaaa agcatacctt tcaattttgc
     9001 tacttggttg atttagcaca aaatgcaaag tcttggggca gagaggggga gtgaaaaaaa
     9061 ttttataggt aattgttaca aaaatacctg tcagaaaccc taaagctgca ttgtaaaaca
     9121 aatggtgtaa actagttttg aaaagtggta aggaattgtg aaaaaaatct cagacttaat
     9181 gctctctaac cacatgagtt tcttcttttt tatttagtaa tacgctgcta catatttgga
     9241 ggttctggtg tttgtaggtc actgaacaga cattgaaatc tgatttatat tgtataactg
     9301 taacatagaa agaaaaagta tttatatttt ttctgtaaga atatttcatt gagttgtgta
     9361 taatttaaat aagatttgtc cccaaatggt tttgctcacc ttgatttttt ttgttgtgat
     9421 tttcttgttt ttgtataatg tgtatagttt atgtcaaggg cattaaaagc ctcctgaagc
     9481 ataatcttat caaagggata cattgttaat aaaatgtact taaaattctt aaa
//
