LOCUS       NM_001206671            5788 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens RIC3 acetylcholine receptor chaperone (RIC3),
            transcript variant 3, mRNA.
ACCESSION   NM_001206671
VERSION     NM_001206671.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5788)
  AUTHORS   Pradhan,A., Mounford,H., Peixinho,J., Rea,E., Epeslidou,E.,
            Scott,J.S., Cull,J., Maxwell,S., Webster,R., Beeson,D., Dong,Y.Y.,
            Prekovic,S., Bermudez,I. and Newbury,D.F.
  TITLE     Unraveling the molecular interactions between alpha7 nicotinic
            receptor and a RIC3 variant associated with backward speech
  JOURNAL   Cell Mol Life Sci 81 (1), 129 (2024)
   PUBMED   38472514
  REMARK    GeneRIF: Unraveling the molecular interactions between alpha7
            nicotinic receptor and a RIC3 variant associated with backward
            speech.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5788)
  AUTHORS   Yadav,N. and Thelma,B.K.
  TITLE     Deletion induced splicing in RIC3 drives nicotinic acetylcholine
            receptor regulation with implications for endoplasmic reticulum
            stress in human astrocytes
  JOURNAL   Glia 71 (5), 1217-1232 (2023)
   PUBMED   36602087
  REMARK    GeneRIF: Deletion induced splicing in RIC3 drives nicotinic
            acetylcholine receptor regulation with implications for endoplasmic
            reticulum stress in human astrocytes.
REFERENCE   3  (bases 1 to 5788)
  AUTHORS   Brolin,K., Bandres-Ciga,S., Leonard,H., Makarious,M.B.,
            Blauwendraat,C., Mata,I.F., Foo,J.N., Pihlstrom,L., Swanberg,M.,
            Gan-Or,Z. and Tan,M.M.
  CONSRTM   International Parkinson's Disease Genomics Consortium
  TITLE     RIC3 variants are not associated with Parkinson's disease in large
            European, Latin American, or East Asian cohorts
  JOURNAL   Neurobiol Aging 109, 264-268 (2022)
   PUBMED   34538707
  REMARK    GeneRIF: RIC3 variants are not associated with Parkinson's disease
            in large European, Latin American, or East Asian cohorts.
REFERENCE   4  (bases 1 to 5788)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5788)
  AUTHORS   Treinin,M.
  TITLE     RIC-3 and nicotinic acetylcholine receptors: biogenesis,
            properties, and diversity
  JOURNAL   Biotechnol J 3 (12), 1539-1547 (2008)
   PUBMED   18956371
  REMARK    Review article
REFERENCE   6  (bases 1 to 5788)
  AUTHORS   Seredenina,T., Ferraro,T., Terstappen,G.C., Caricasole,A. and
            Roncarati,R.
  TITLE     Molecular cloning and characterization of a novel human variant of
            RIC-3, a putative chaperone of nicotinic acetylcholine receptors
  JOURNAL   Biosci Rep 28 (6), 299-306 (2008)
   PUBMED   18691158
  REMARK    GeneRIF: The RIC-3e protein is functionally active and enables
            surface expression of mature alpha7-nAChRs in cell lines not
            otherwise permissive for the expression of this receptor.
REFERENCE   7  (bases 1 to 5788)
  AUTHORS   Millar,N.S.
  TITLE     RIC-3: a nicotinic acetylcholine receptor chaperone
  JOURNAL   Br J Pharmacol 153 Suppl 1 (Suppl 1), S177-S183 (2008)
   PUBMED   18246096
  REMARK    GeneRIF: this review provides a brief history of RIC-3--REVIEW
            Review article
REFERENCE   8  (bases 1 to 5788)
  AUTHORS   Cheng,A., McDonald,N.A. and Connolly,C.N.
  TITLE     Cell surface expression of 5-hydroxytryptamine type 3 receptors is
            promoted by RIC-3
  JOURNAL   J Biol Chem 280 (23), 22502-22507 (2005)
   PUBMED   15809299
  REMARK    GeneRIF: RIC-3 may play a role in 5-HT(3A) receptor folding,
            assembly, or transport to the cell surface
REFERENCE   9  (bases 1 to 5788)
  AUTHORS   Williams,M.E., Burton,B., Urrutia,A., Shcherbatko,A.,
            Chavez-Noriega,L.E., Cohen,C.J. and Aiyar,J.
  TITLE     Ric-3 promotes functional expression of the nicotinic acetylcholine
            receptor alpha7 subunit in mammalian cells
  JOURNAL   J Biol Chem 280 (2), 1257-1263 (2005)
   PUBMED   15504725
  REMARK    GeneRIF: ric-3 appears to be necessary for proper folding and/or
            assembly of alpha7 receptors in HEK293 cells
REFERENCE   10 (bases 1 to 5788)
  AUTHORS   Halevi,S., Yassin,L., Eshel,M., Sala,F., Sala,S., Criado,M. and
            Treinin,M.
  TITLE     Conservation within the RIC-3 gene family. Effectors of mammalian
            nicotinic acetylcholine receptor expression
  JOURNAL   J Biol Chem 278 (36), 34411-34417 (2003)
   PUBMED   12821669
  REMARK    GeneRIF: the hric3 locus encodes for multiple transcripts, is
            likely to produce multiple hric3 isoforms, and hric3 is expressed
            in neurons and muscles, thus enabling its interactions with
            nicotinic acetylcholine receptors in vivo
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091013.7, AY326435.1,
            AC129895.5, AC116456.12 and CB850751.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001206671.3.
            
            Summary: This gene encodes a member of the resistance to inhibitors
            of cholinesterase 3-like family which functions as a chaperone of
            specific 5-hydroxytryptamine type 3 receptor and nicotinic
            acetylcholine receptor subtypes. The encoded protein influences the
            folding and assembly of these receptor subunits in the endoplasmic
            reticulum and expression on the cell surface. This protein contains
            an N-terminal transmembrane domain, a proline-rich spacer, and a
            cytosolic C-terminal coiled-coil domain. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Oct
            2016].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            encoded isoform (a) is longer than isoform c. The isoform
            designation was changed from 'c' to 'a' to be consistent with
            isoforms cited in PMID 18691158.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.183698.1,
                                           SRR1660803.236397.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309737.11/ ENSP00000308820.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC091013.7         221227-221262
            37-239              AY326435.1         1-203
            240-240             AC129895.5         82029-82029
            241-2895            AY326435.1         205-2859
            2896-5590           AC116456.12        133696-136390       c
            5591-5788           CB850751.1         25-222              c
FEATURES             Location/Qualifiers
     source          1..5788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..5788
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /note="RIC3 acetylcholine receptor chaperone"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
     exon            1..160
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1146
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; protein RIC-3; resistant to inhibitor of
                     cholinesterase 3; resistance to inhibitors of
                     cholinesterase 3-like protein"
                     /codon_start=1
                     /product="protein RIC-3 isoform a precursor"
                     /protein_id="NP_001193600.1"
                     /db_xref="CCDS:CCDS55742.1"
                     /db_xref="GeneID:79608"
                     /db_xref="HGNC:HGNC:30338"
                     /db_xref="MIM:610509"
                     /translation="MAYSTVQRVALASGLVLALSLLLPKAFLSRGKRQEPPPTPEGKL
                     GRFPPMMHHHQAPSDGQTPGARFQRSHLAEAFAKAKGSGGGAGGGGSGRGLMGQIIPI
                     YGFGIFLYILYILFKLSKGKTTAEDGKCYTAMPGNTHRKITSFELAQLQEKLKETEAA
                     MEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPY
                     MEDWEGYPEETYPIYDLSDCIKRRQETILVDYPDPKELSAEEIAERMGMIEEEESDHL
                     GWESLPTDPRAQEDNSVTSCDPKPETCSCCFHEDEDPAVLAENAGFSADSYPEQEETT
                     KEEWSQDFKDEGLGISTDKAYTGSMLRKRNPQGLE"
     exon            161..387
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..463
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..557
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            558..706
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..5788
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2896
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /note="major polyA site"
     polyA_site      3922
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
     regulatory      5718..5723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /note="hexamer: AATAAA"
     regulatory      5726..5731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /note="hexamer: AATACA"
     polyA_site      5740
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
     polyA_site      5743
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
     regulatory      5767..5772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
                     /note="hexamer: AATAAA"
     polyA_site      5788
                     /gene="RIC3"
                     /gene_synonym="AYST720; PRO1385; RIC-3"
ORIGIN      
        1 ggctggcgtc tgcacctgcg accaccgtga gcagtcatgg cgtactccac agtgcagaga
       61 gtcgctctgg cttctgggct tgtcctggct ctgtcgctgc tgctgcccaa ggccttcctg
      121 tcccgcggga agcggcagga gccgccgccg acacctgaag gaaaattggg ccgatttcca
      181 cctatgatgc atcatcacca ggcaccctca gatggccaga ctcctggggc tcgtttccag
      241 aggtctcacc ttgccgaggc atttgcaaag gccaaaggat caggtggagg tgctggagga
      301 ggaggtagtg gaagaggtct gatggggcag attattccaa tctacggttt tgggattttt
      361 ttatatatac tgtacattct atttaagctc tcaaagggga aaacaactgc agaggatggg
      421 aaatgctata ctgccatgcc tggaaacacc cacaggaaaa ttaccagttt tgagcttgct
      481 caactgcaag aaaaactgaa ggagacagaa gcagccatgg aaaaattaat caacagagtg
      541 ggacctaatg gtgagagcag agcacagact gtgacttctg accaagagaa acggttgcta
      601 catcagctcc gagaaatcac cagggtcatg aaagaaggaa aattcattga cagattttct
      661 ccagagaaag aagctgagga ggccccttac atggaggact gggaaggtta ccctgaagag
      721 acttacccaa tttatgacct ttcagactgt atcaagcgta ggcaagaaac aatcttggtg
      781 gattaccctg acccaaaaga actttctgct gaagaaatag ctgaaagaat gggaatgata
      841 gaagaggaag aatcagatca tttgggttgg gaaagtctgc ccactgaccc cagagcccag
      901 gaagataatt ctgttacctc gtgtgatcca aagccagaaa catgttcctg ctgttttcat
      961 gaagacgagg atcctgctgt cttggcagag aatgctggat tcagtgcaga tagctaccct
     1021 gagcaagagg aaaccaccaa agaagagtgg tcccaagact ttaaagatga agggttgggc
     1081 atcagcaccg ataaagcata tacaggcagc atgctgagga agcgtaaccc ccagggttta
     1141 gagtgaaaac agccagtctg aagtatccat tactcaagtc ccaaggtgac ctctctctcc
     1201 tcagatttcc ttcttggccc tgtgccctgc actttcttca ctgtgttcaa gtgtcatagc
     1261 tatcaggcca ctatcatgga tatcatgtat ccttcctggt gctcacacac ctgtcacctt
     1321 gtaaaacacg gacattagtg tgaacacagg acagcttcgc tctttctctt cctgcctttc
     1381 ctctatcaga gaagttgatc cattaagtaa ttatgtttgg tctattgtaa ttacagatgg
     1441 gaccactcag gggcaaaggt ctgactcttc ctggtaggtg taacagatag ttcacctgtg
     1501 aacgaacatc agcttacaga tgatgaggac ttaaggttgc aagaatgaag atttcagact
     1561 ccaagatccc ttattctttg ggccttgagc aggttagtag tcccctggtg agaagagaac
     1621 attttgtttg tggggctaat gggcccagag gagggtaaga ctctgctgtc taagctgaag
     1681 cctcttcctc gcagcgaggg tcttcctagg aacattgatg ctgcctcaga catcctcttt
     1741 tctccagagt agggaagact cccactgatc tgagaatgag cccagaggct tgtttgggga
     1801 ctgttttact ctgatactac ctggatatct agcttccttt acccctgttc tgcttaacag
     1861 aactgccaag cccagaagta cctttgcact cctggttttc agtggacaga ggaagcttta
     1921 gatagagact ttagaccctg ccctgcagag tcaagacttg aggccattga agctgcagga
     1981 agccctgccc agggatggtc ctgccatgag gaggctgcaa ccctataaga gggctcaaga
     2041 ttgtgaattc tgctcctgcc atgaggagct cagaaggcca ggaagccagc aataggggag
     2101 agaatctgtg tgcttatgga cagtccttac ctaaagctgt ttctgaatgt tgcacccttt
     2161 gagaaatttc ttctcagaac cataaattga aacaaatgag gactgatctt gtatacaaag
     2221 tgccaactca agagggaagt tggagtatgt ctgttgcaga gaaccaatat agcagtgccc
     2281 aggggtagag accatgtgtt ccatactcgg atatttgggt ctttttgaga gagctgggga
     2341 aagtagcagc aactagatta agactgggag gattttgacc aaactaaagg ccttttctcc
     2401 ttactgcatc tgacgtgtgt cttcttgaga caagatagca cccatgaatt acatcatgag
     2461 gtatgtgtga attcagttta catgtaagac ctgagagttc gaagagggca cattcccaaa
     2521 gacattccca gtcatgaaat gtagaagact ggaaaattaa gacattatgt aaaggtagat
     2581 atggctttta gagttacatt atgcttggca tgaataaggt gccaggaaaa cagtttaaaa
     2641 ttatacatca gcatacagac tgctgttaga aggtatggga tcatattaag ataatctgtc
     2701 agctactact aggcatttat tgttaattga gttacagaaa gtcattcaag actgagttta
     2761 tagaaagcat attgcatcta tctctgtgta gaacatttga ttcacattgt gaagaatgca
     2821 gtttaaaata tactgaatgc aatctagatg tattgtacac gaaaggtgaa aaataacagg
     2881 tgctctttac tgtttagata aattgttttc tgtgttattt cccttcgttc actgtgaggg
     2941 gttgattcat gaggagagcc ctgggttcct ggctcaggtt tacttttggc cttaggatag
     3001 gattccctta ttagagataa atactgctgt tctcttctag ctcattcatt catttagcag
     3061 tcaattgctc agtgccaggt gctaggaaca gaggctcaat ctctaccctc agaaaactca
     3121 gtgtgacgag agagagcctg acagataaaa tgaactatga ccctgtaaga gggctcagga
     3181 tcgtgaatcc tgcaggcaga gaaacatgag ccataatctg tccctgcatt ttctagctgt
     3241 ggaatcttgg gtcagctcct taactggtct gagctttggc ttcagggtag taaagggagg
     3301 ggtattaaag gtcctggtta aatgaaatca tcagtgtgtg taaaacagca ttggttctag
     3361 ctcatacatg ataaccactc attaagtggt aattatgttt ttattataag ggctatgctg
     3421 taattcagac atgggcccaa aactacagga aagataaatt gtttttgcta aagtattgcc
     3481 aagaaacttc acagtttctt gggaggtggg ccttgaggca tgcaaagaac ttcttcaggt
     3541 aggcaaagaa gagaggacac tcttggcaga aagagttgtt gaaaaaagca gtagggtgtg
     3601 aaaatacatg gatgttcaag tattttggtg aggctgttat gtaaagtgtt gttggtcttt
     3661 ggggaaaatt ggcttatgga aattcctgcc agaagtacta agcccttatg gtggttcttc
     3721 ctgccctagc tcttggttgg tttatatata aggaatatat ttgtgtattt atatatcaga
     3781 catttggatg tacctttcag ttatttagga tttagaaaat tctttttgga ttttccagaa
     3841 ttattttatc cttcggggat gacagttata tgtgtatata caacccagga tgacaaaatc
     3901 atgggtccgg tttttgttgc cagggctgct gtctcttttc ttgcggtctt catttctcac
     3961 gagggtgctg ggaacttgat cagtcccctg gccttttggc actgtggcag agtacacaag
     4021 tcataccttt atggacagtt agctcacaaa acaactgcat aatctgggat cactcttggt
     4081 aaatcaggtg ggtggtgcag ccaggagatc ccctttcctg gtcacaacag gagcacaaag
     4141 aaaccattat ctccatgact agctccagaa gctgggccca gggagtcgtg atgaggagtg
     4201 gaggtgtatt tggcctgtag aatcaacggc ctttgagaac catacaatgc accttatatg
     4261 gcttgggtga tcaaataact taaggtccaa attcaaacac tttggaaaaa gggagcttta
     4321 atataattat gccaaggtga taggcataaa ctaagactgt cctggacgta gggtcacccc
     4381 tgtctatagc catttaagat ttttgaacct gatgactaaa caaacaaaac cctctttcct
     4441 ttttagaata tcctgtatgc gctatttccc accagaggca gaggccacag gagataggcc
     4501 atggttcagg taggaaatgc tcttggtcac atcagaactc tagatctggg ggaataaaca
     4561 aacccgaatt attaccacac tctcaaagtt ctcttcaatc tggactattt gtattccaaa
     4621 gaaaaattta gtgctttagc tattcagcaa tattgagaaa aaacatgaac acatttatga
     4681 ctttgccttg accattgact tttctaaaat gtgcttcctt ttcctttatt tccctttttt
     4741 tatacaaaga aaatagccca aatttctcct cttaggtcat tccttaacct ctcagagaac
     4801 cagtttcccc atgaattggg aataatgctc tatttacagg gctgtttgga ttaaataaga
     4861 tgctgtttat aaagtgtctg tgccagggca aagcatgtgg taggtgcttg gtgacagcat
     4921 gatccctgtc accactctgt caagtccagt gttgctgaga tgtcacacct gacaccctct
     4981 aaggctaccc tgattgccag gagtggccca gggcccttct gcagtctccg ggtgccttta
     5041 gttataacct cttgtctggg tcagaccatt agctttcatg tctgcttcta gctacaactg
     5101 tagcctccct tccttttgcc ttcaaatctg ccacagctgc ccggcaacaa aaaaagattc
     5161 ctaagcatct cgaggtcctg tttaaatggg ttagggtcca agcaagccct gagacatcaa
     5221 gtggttgggt cttttatacc tttttcatct ctacagccct gttctcttcc taaggccagg
     5281 cccacagggg atactgagga accaccagcc ccttcaggcg gcacagcaga ccctgaagag
     5341 aactgctcta acttaagtac cttctgactt caccattttt ccagcctctg ggtgtggttc
     5401 tgatgaacct taaacttgaa aggcacaggc cagaggaagg acagtgttga cccacatgtc
     5461 attggtgagg ttatgatctc tttgctatta tcacctactt acccacctga ggctcctagg
     5521 aaacaatgaa tgaaaggtat agaaaaaaat taggaagtaa acagggcttt tttccccttt
     5581 atgaaaaaag tacacagaag tgttgaaacg attcaagttt aatttgttga tatatgtgtg
     5641 tacttagaca aacactaaat tctacaacat acataatgtc aacatgggaa aataccaagt
     5701 ttgtcattgc acataccaat aaataaatac atttgctcca gaataccaaa gtttattcaa
     5761 aaagtcaata aaagcacagt tttgcaaa
//
