LOCUS       NM_020829               6786 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens RIC1 homolog, RAB6A GEF complex partner 1 (RIC1),
            transcript variant 1, mRNA.
ACCESSION   NM_020829 XM_039698
VERSION     NM_020829.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6786)
  AUTHORS   Lansdon,L.A., Dickinson,A., Arlis,S., Liu,H., Hlas,A., Hahn,A.,
            Bonde,G., Long,A., Standley,J., Tyryshkina,A., Wehby,G., Lee,N.R.,
            Daack-Hirsch,S., Mohlke,K., Girirajan,S., Darbro,B.W.,
            Cornell,R.A., Houston,D.W., Murray,J.C. and Manak,J.R.
  TITLE     Genome-wide analysis of copy-number variation in humans with cleft
            lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as
            clefting genes
  JOURNAL   Am J Hum Genet 110 (1), 71-91 (2023)
   PUBMED   36493769
  REMARK    GeneRIF: Genome-wide analysis of copy-number variation in humans
            with cleft lip and/or cleft palate identifies COBLL1, RIC1, and
            ARHGEF38 as clefting genes.
REFERENCE   2  (bases 1 to 6786)
  AUTHORS   Unlu,G., Qi,X., Gamazon,E.R., Melville,D.B., Patel,N.,
            Rushing,A.R., Hashem,M., Al-Faifi,A., Chen,R., Li,B., Cox,N.J.,
            Alkuraya,F.S. and Knapik,E.W.
  TITLE     Phenome-based approach identifies RIC1-linked Mendelian syndrome
            through zebrafish models, biobank associations and clinical studies
  JOURNAL   Nat Med 26 (1), 98-109 (2020)
   PUBMED   31932796
  REMARK    GeneRIF: reduced genetically determined expression of RIC1 is
            associated with musculoskeletal and dental conditions.
REFERENCE   3  (bases 1 to 6786)
  AUTHORS   Iwakawa,R., Takenaka,M., Kohno,T., Shimada,Y., Totoki,Y.,
            Shibata,T., Tsuta,K., Nishikawa,R., Noguchi,M., Sato-Otsubo,A.,
            Ogawa,S. and Yokota,J.
  TITLE     Genome-wide identification of genes with amplification and/or
            fusion in small cell lung cancer
  JOURNAL   Genes Chromosomes Cancer 52 (9), 802-816 (2013)
   PUBMED   23716474
  REMARK    GeneRIF: KIAA1432 is a novel gene activated by amplification in
            Small Cell Lung Cancers.
REFERENCE   4  (bases 1 to 6786)
  AUTHORS   Pusapati,G.V., Luchetti,G. and Pfeffer,S.R.
  TITLE     Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the
            late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B
            GTPase
  JOURNAL   J Biol Chem 287 (50), 42129-42137 (2012)
   PUBMED   23091056
REFERENCE   5  (bases 1 to 6786)
  AUTHORS   Akiyama,M., Ishida,N., Ogawa,T., Yogo,K. and Takeya,T.
  TITLE     Molecular cloning and functional analysis of a novel Cx43 partner
            protein CIP150
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1264-1271 (2005)
   PUBMED   16112082
  REMARK    GeneRIF: These results suggest that the newly identified domain is
            essential for the proper phosphorylation and localization of Cx43,
            and CIP150 is a novel partner protein targeting this domain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354744.13, AL136875.1, BC136616.1, AL136980.5 and AA250979.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020829.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.25546.1,
                                           SRR1803614.244123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000414202.7/ ENSP00000416696.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AL354744.13        28468-28687
            221-418             AL136875.1         1-198
            419-4527            BC136616.1         1-4109
            4528-6473           AL136980.5         124801-126746
            6474-6786           AA250979.1         14-326              c
FEATURES             Location/Qualifiers
     source          1..6786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.1"
     gene            1..6786
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /note="RIC1 homolog, RAB6A GEF complex partner 1"
                     /db_xref="GeneID:57589"
                     /db_xref="HGNC:HGNC:17686"
                     /db_xref="MIM:610354"
     exon            1..347
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..4475
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /note="isoform a is encoded by transcript variant 1;
                     protein RIC1 homolog; connexin 43-interacting protein 150
                     kDa; connexin-43-interacting protein of 150 kDa; RAB6A-GEF
                     complex partner protein 1; RAB6A GEF complex partner 1;
                     guanine nucleotide exchange factor subunit RIC1"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor subunit RIC1
                     isoform a"
                     /protein_id="NP_065880.2"
                     /db_xref="CCDS:CCDS34982.2"
                     /db_xref="GeneID:57589"
                     /db_xref="HGNC:HGNC:17686"
                     /db_xref="MIM:610354"
                     /translation="MYFLSGWPKRLLCPLGSPAEAPFHVQSDPQRAFFAVLAAARLSI
                     WYSRPSVLIVTYKEPAKSSTQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSTRGDK
                     YLYEPVYPKGSPQMKGTPHFKEEQCAPALNLEMRKILDLQAPIMSLQSVLEDLLVATS
                     DGLLHLIHWEGMTNGRKAINLCTVPFSVDLQSSRVGSFLGFTDVHIRDMEYCATLDGF
                     AVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVVDGTCVAVNNKYRLMAFGCVSGSVQV
                     YTIDNSTGAMLLSHKLELTAKQYPDIWNKTGAVKLMRWSPDNSVVIVTWEYGGLSLWS
                     VFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGFGSQNTEIESDLR
                     SVVKQPSILLFQFIKSVLTVNPCMSNQEQVLLQGEDRLYLNCGEASQTQNPRSSSTHS
                     EHKPSREKSPFADGGLESQGLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNI
                     AVVGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWNDFMVLACYNINDRQEELR
                     VYLRTSNLDNAFAHVTKAQAETLLLSVFQDMVIVFRADCSICLYSIERKSDGPNTTAG
                     IQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGITLKMPQQARGAESIMLNLAGQLIMM
                     QRDRSGPQIREKDSNPNNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLS
                     CGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLY
                     DSLYTRNNAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCATLPY
                     FPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWN
                     YLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKW
                     DLCRHMIRFLKAIGSGESETPPSTPTAQEPSSSGGFEFFRNRSISLSQSAENVPASKF
                     SLQKTLSMPSGPSGKRWSKDSDCAENMYIDMMLWRHARRLLEDVRLKDLGCFAAQLGF
                     ELISWLCKERTRAARVDNFVIALKRLHKDFLWPLPIIPASSISSPFKNGKYRTVGEQL
                     LKSQSADPFLNLEMDAGISNIQRSQSWLSNIGPTHHEIDTASSHGPQMQDAFLSPLSN
                     KGDECSIGSATDLTESSSMVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQV
                     QLRYLLHIFMEAGCLDWCIVIGLILRESSIINQILVITQSSEVDGEMLQNIKTGLHAV
                     DRWASTDCPGYKPFLNIIKPQLQKLSEITEEQVQPDAFQPITMGKTPEQTSPRAEESR
                     GSSSHGSIPQGEVGSSNMVSRKEEDTAQAEEEEPFQDGTYDCSVS"
     exon            348..455
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            456..535
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            536..643
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            644..786
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            787..923
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1015
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1104
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1249
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1298
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1451
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1655
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1694
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1805
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1895
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2056
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2195
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2315
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..3044
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3203
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            3204..3340
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3627
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            3628..3819
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3997
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            3998..4186
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     exon            4187..6786
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6768..6773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /note="hexamer: AATAAA"
     polyA_site      6786
                     /gene="RIC1"
                     /gene_synonym="bA207C16.1; CATIFA; CIP150; KIAA1432"
                     /note="major polyA site"
ORIGIN      
        1 acactcggcc ccgtcagctt gggggtgcct tcgtcgcgca gccttgcgtc ggcccggccc
       61 ggccaggcca gcgggcagat gccccgagct gccgccgccg ccgccgccga ctcggccggt
      121 ggcggtgtgg gaggtgggcg accagcccgg ggccgctgag tgtgacggac gcaactgggg
      181 gcgccggggg ctccgcacgg accatgtatt ttctgagcgg ctggcccaag aggctgctgt
      241 gccctctggg gagcccggcc gaggcgcctt tccacgttca gtccgacccg cagagggctt
      301 tcttcgccgt gctggccgcg gcccgcctca gcatctggta cagccgacct agtgtgttaa
      361 ttgtaaccta caaggagcct gcaaaatcat ctactcagtt tggatcctac aagcaagctg
      421 aatggaggcc agatagtacc atgatagctg tatcaacggc aaatggatac atcttgtttt
      481 ttcatattac atctacaaga ggggacaagt acctttatga accagtgtat cccaaaggaa
      541 gtccacaaat gaaggggaca ccccatttta aggaagaaca gtgtgctcca gcattaaatt
      601 tggagatgag gaaaatactg gatttacaag cacccatcat gagtttgcag tctgtgttgg
      661 aagatctcct ggttgctact tctgatggac ttcttcatct tattcactgg gaaggaatga
      721 caaatggaag gaaagccatt aatctttgca cagtaccctt ttcagtagac ctgcagtcat
      781 ctagagtagg ttcattcctg ggcttcacag acgtacacat cagagacatg gaatactgtg
      841 ccacacttga tgggtttgct gttgtattta atgatggtaa agttggattt attacaccag
      901 tgtcaagtag atttactgca gagcagcttc atggagtttg gccacaagat gttgttgacg
      961 gaacgtgtgt agcagtaaat aacaagtatc gactaatggc atttggctgt gtgagtggtt
     1021 ctgtgcaggt ctatacaata gataacagca ctggagccat gctgctatct cataaattag
     1081 agctaacagc aaaacagtat cctgacattt ggaataaaac aggagctgtt aaattgatga
     1141 gatggtctcc tgacaatagt gttgtaatag tgacctggga atacggaggc ctttctttat
     1201 ggagtgtttt tggagcacag ctgatttgta cacttggagg agattttgct tataggtctg
     1261 atggcaccaa aaaagatccc cttaagatca actctatgag ctggggtgca gaaggctatc
     1321 acctatgggt aatcagcgga tttggttctc aaaacactga aattgagtct gacctcagga
     1381 gtgtagttaa acagcccagc atcctgttat ttcagtttat taagagtgta ctcactgtaa
     1441 acccttgtat gagtaaccaa gagcaggtgt tgcttcaggg tgaggatcgc ttgtacttga
     1501 actgtggaga ggcttcacaa acccagaatc ccaggagttc ttcaacacac tctgagcata
     1561 agcccagtcg agaaaagagc ccatttgcag atggaggttt agagtctcag ggattaagca
     1621 ctttacttgg acatcggcat tggcatgttg tacagatttc cagcacctat ctagagagca
     1681 attggcctat acggttttca gctattgata agcttggaca gaatattgct gtggttggca
     1741 agtttggttt tgcacattac tctttactca ccaaaaaatg gaaacttttt ggaaacatta
     1801 cccaggagca aaatatgatc gtgacaggtg gcttagcctg gtggaatgat tttatggtcc
     1861 ttgcgtgtta taacataaat gaccgtcaag aagagcttag agtatacttg cgaacatcaa
     1921 atctggacaa tgcctttgct catgtcacca aagcacaagc agaaacatta ctgcttagtg
     1981 tcttccagga catggtaata gtatttagag cagactgttc aatatgcctt tacagtattg
     2041 aaagaaaatc tgatggtcca aatactactg ctggtattca agttcttcag gaggtttcca
     2101 tgtcacgcta cattcctcac cctttcctgg tggtatctgt cactctgaca tcagtgagta
     2161 cagagaatgg aatcaccttg aaaatgccac agcaggctcg tggtgcagag agcattatgt
     2221 taaacctggc aggacagctc atcatgatgc agagggacag gtcaggccca cagatccggg
     2281 agaaggacag taaccctaat aaccaaagga aacttctgcc attctgtcct cctgttgtac
     2341 tagcccagtc tgttgaaaat gtctggacaa cgtgtcgagc aaataaacag aaacgtcacc
     2401 ttctggaggc cctctggctg agctgtggtg gtgcagggat gaaagtttgg ctccctctct
     2461 tccctaggga tcaccgcaag ccccattcct tcttgtccca gcggatcatg ctgcctttcc
     2521 acatcaacat ttacccgcta gctgttctgt ttgaagatgc tttagtcctt ggtgctgtca
     2581 atgacacttt gctctatgat tctttatata ctcggaacaa tgctagagaa cagctggagg
     2641 tgctcttccc tttctgtgtt gtggagagaa cctctcagat ctacctccac cacattctac
     2701 gtcaacttct ggtcagaaac cttggggagc aagccttgct cttggcccag tcctgtgcca
     2761 cattacctta cttccctcat gtgctggagc tcatgctcca tgaagtactg gaagaagaag
     2821 ctacctcacg ggagcccatt cccgaccctc tgcttcccac tgtggcaaaa tttatcactg
     2881 agttccccct cttcctgcag acagttgtcc attgtgccag gaagaccgaa tatgccctgt
     2941 ggaattacct ttttgcagct gttggaaacc ctaaggactt gtttgaggag tgtttgatgg
     3001 ctcaggattt ggacacagct gcctcttacc ttattatctt acagaatatg gaagtccctg
     3061 cagtaagtag gcaacatgct acccttctat tcaacacagc actagaacaa ggcaagtggg
     3121 acctttgtcg acacatgatt cgatttctta aagccattgg ctctggagaa tctgagacac
     3181 ctccatccac acccacagct caggaaccca gttcaagtgg tggatttgag ttcttcagga
     3241 atcgaagcat cagtttatcc cagtcagctg aaaatgttcc tgccagtaaa ttcagtttac
     3301 agaaaacact aagtatgcca tctggtccct ctggaaaaag atggagcaaa gacagtgact
     3361 gtgctgagaa catgtatatt gacatgatgc tctggagaca tgctcggcgc ctcttagaag
     3421 atgtgaggtt aaaggacctt ggctgctttg cagcccagct gggctttgaa ctaattagtt
     3481 ggctatgcaa ggaacgtacc cgagccgccc gggtagacaa ctttgtaata gccctgaaga
     3541 gactccacaa agatttcctg tggccacttc caatcatccc agcctcttct atcagttctc
     3601 ctttcaaaaa tggaaaatac cgaactgtgg gagagcagct gttaaagtct caatcagctg
     3661 acccattttt gaaccttgag atggatgctg gcatctccaa catccagcga agtcagagct
     3721 ggctcagcaa cattggcccc acccatcatg agatagacac agcttcatcc catggaccac
     3781 aaatgcaaga tgccttcttg tcacctttat ctaataaagg tgatgaatgc agtattggtt
     3841 cagccacaga cttgactgaa agtagctcca tggtggatgg cgactggaca atggtggatg
     3901 aaaatttctc tacactcagt ttaactcagt cagagctgga gcacatttcc atggagttgg
     3961 ccagtaaagg gcctcataaa tcccaggtcc agcttcggta tttgctacac attttcatgg
     4021 aggcagggtg cctagactgg tgcatcgtta taggcctgat tcttagagaa tcctcaataa
     4081 tcaatcagat tttggttatt acacagtctt cagaggtaga tggagagatg ttacagaaca
     4141 taaagacagg gctccatgca gtggaccgat gggcctctac agactgtcct ggatataagc
     4201 catttttaaa catcattaag ccacaactgc agaagctcag tgagataaca gaagagcagg
     4261 tccagccaga tgccttccaa ccaataacta tgggtaagac tccagaacag actagccccc
     4321 gggcagagga gagcaggggc tcctccagcc atggaagcat cccccagggt gaagttggaa
     4381 gcagcaatat ggtcagccgg aaagaggagg acacagccca agcagaggag gaagaacctt
     4441 ttcaggatgg gacttacgac tgttctgtgt cctaacagtg aggttccatc acaaaggggc
     4501 agtattaatt agcagcagcg tgcagctcag tacgttgtaa catagttgga tgatttaaca
     4561 ggagaactca gttcagagac tcttcggtaa gtattagtag attttaacta attctttctt
     4621 gtctaagaaa tctttttgac tccataaaaa tgtgatataa agcatctttc ataaaaaaat
     4681 tttaagctgc agtgaaaagt aaatattgta cagatgtaca tgagaatatt ttggttttac
     4741 tcaaaggttg gtagctctta aaccacagga attgttttgc cccaggtgag cttacttttt
     4801 cactacttac atcttctcac atttcccggt tctgcattat gtccagattg ctttttaaaa
     4861 aataaatgct aaggtgcttg ctatagtctg tcaggtactt gagctacctg tttgctccct
     4921 tggatacagc tggactcttt aatcagtcct cctgaataga ttgctaccct ggggcacaat
     4981 atgtgccagt gtgatggaaa cattctcctt ggctttacta gccagtcaaa tcccagtcca
     5041 gaattgatgg aagctattta cctgtgagtt aatgtgcttg ttttagcaag cttgattccc
     5101 attagaccaa tgtgggcaga ggtctgaggg ggttcttctc aattttgctg ttagatacca
     5161 ctaaactatt ttgtattaaa gaacagtatc tttttgtgaa tactcttgtg taaatatatt
     5221 caaaggcact gttcatattt tagggcttgt attataattt gcaaggtttt aatgctggat
     5281 tctgcatgtc tacacataca aagacagggc ttgctcctct gcaaaactga ggaagacagg
     5341 tttattggct tggtcatgaa gtaacagaaa tggtcacact gatcatgaaa tgcagcaagt
     5401 tttgtgcaaa ttaacatagt ctcttattta ttgcttttgt aaattgaata aagatggact
     5461 tctatgtaaa tagactgctg aatcctgtat taccacggct actaaaaatt agtgtgtaaa
     5521 gaatgcattc ttcattgtaa acttaaagta ttttatgtac ttctagaaat gacttaaatt
     5581 tgttttcata cattatgaaa acaactgcat actccttaat tgctttaaac acccatccac
     5641 tgtatgtaat tctaattacc ttataacagt attaagacag cttgtttgta ctgtgcaatt
     5701 tgaacaagga atgcaatgtt attttttaca aaaaacaaac ttgtttattt ttataataac
     5761 gatgtatttg atgtggacca aattcgtacc actatctaaa atagcctctt ttctcatagt
     5821 gcagttgtag tttagaaaca aaacttggtc ctctctcctt gctttttaaa gtaaatggct
     5881 agatttagtt gtcttagcca ggtttccttt gaagagaaac tcaaaaccat tttgaaactg
     5941 cttagttcag aatacatcga agtatttaaa attactgagt tgggtaattt actatcattt
     6001 actttttaca ttacaagtgc aataatattt cacaaaatga aactcccgaa tgggtggagt
     6061 atgtgattat tggtacctgg tccttctggt gctattttta tttaagtctt tgtttcaaac
     6121 cacctttccc tgaatcttaa agataatgtt ttgcatgtga gtacatgcag cccagcaaga
     6181 aactaaactg aactctcttc tcctatccta gtccattaag gagaagaacc agcattgctt
     6241 ttgtgtttgg tgtgaatatt cagtcaataa aaatgattta ccattataaa gagctgtgat
     6301 cttttcaagt atctgaaata aaacactgtg ctgctgagtt catctcaaac attcttgaaa
     6361 gcagggcacc agtataagtt aactgtattc ctgtgggtta ggccgtgaat gaatcatttc
     6421 ttttatacaa tattctttta caactaatag agataggagg cccccaggca agaagtttgg
     6481 caggtttaca gaaaatttgg taatttattt gttatatacc ttaattttta aaaacccatt
     6541 tttattgtgg tgtttggttc acatatcaac tgtttaagcc ataattttag ccaatgaatt
     6601 taaatattca gtataactat ttgaggttta ctagatgcat ttattaataa attatttgct
     6661 gaaaccaaaa caagtcattg ggggtgtggg aataaaatca acctttgctt gtaattaaag
     6721 ttgctgctat ttctgtaatg tgtatttttc tccccttggt aaagggcaat aaaaccatta
     6781 cacaaa
//
