LOCUS       NM_015653               1490 bp    mRNA    linear   PRI 27-FEB-2025
DEFINITION  Homo sapiens RIB43A domain with coiled-coils 2 (RIBC2), mRNA.
ACCESSION   NM_015653
VERSION     NM_015653.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Xiong,M., Wang,Y.Y., Guo,W.W., Cai,S.W., Ning,X.Y., Yang,H.Y.,
            Chen,X.W., Li,B. and Xu,M.
  TITLE     A common variant rs2272804 in the 5'UTR of RIBC2 inhibits
            downstream gene expression by creating an upstream open reading
            frame
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (7), 3839-3848 (2020)
   PUBMED   32329860
  REMARK    GeneRIF: A common variant rs2272804 in the 5'UTR of RIBC2 inhibits
            downstream gene expression by creating an upstream open reading
            frame.
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Chung,M.I., Kwon,T., Tu,F., Brooks,E.R., Gupta,R., Meyer,M.,
            Baker,J.C., Marcotte,E.M. and Wallingford,J.B.
  TITLE     Coordinated genomic control of ciliogenesis and cell movement by
            RFX2
  JOURNAL   Elife 3, e01439 (2014)
   PUBMED   24424412
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Simonis,N., Rual,J.F., Lemmens,I., Boxus,M., Hirozane-Kishikawa,T.,
            Gatot,J.S., Dricot,A., Hao,T., Vertommen,D., Legros,S., Daakour,S.,
            Klitgord,N., Martin,M., Willaert,J.F., Dequiedt,F., Navratil,V.,
            Cusick,M.E., Burny,A., Van Lint,C., Hill,D.E., Tavernier,J.,
            Kettmann,R., Vidal,M. and Twizere,J.C.
  TITLE     Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses
  JOURNAL   Retrovirology 9, 26 (2012)
   PUBMED   22458338
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Arango,N.A., Pearson,E.J., Donahoe,P.K. and Teixeira,J.
  TITLE     Genomic structure and expression analysis of the mouse
            testis-specific ribbon protein (Trib) gene
  JOURNAL   Gene 343 (1), 221-227 (2004)
   PUBMED   15563848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098586.1, AL442116.1 and AL021391.3.
            
            On May 17, 2019 this sequence version replaced NM_015653.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098586.1, BC009904.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614167.2/ ENSP00000483356.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1394              AK098586.1         3-1396
            1395-1403           AL442116.1         1348-1356
            1404-1490           AL021391.3         65347-65433
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..1490
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /note="RIB43A domain with coiled-coils 2"
                     /db_xref="GeneID:26150"
                     /db_xref="HGNC:HGNC:13241"
                     /db_xref="MIM:621115"
     exon            1..323
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1343
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /codon_start=1
                     /product="RIB43A-like with coiled-coils protein 2"
                     /protein_id="NP_056468.3"
                     /db_xref="CCDS:CCDS14066.2"
                     /db_xref="GeneID:26150"
                     /db_xref="HGNC:HGNC:13241"
                     /db_xref="MIM:621115"
                     /translation="MGSQTMAVALPRDLRQDANLAKRRHAELCRQKRVFNARNRIIGG
                     DTEAWDVQVHDQKIKEATEKARHETFAAEMRQNDKIMCILENRKKRDRKNLCRAINDF
                     QQSFQKPETRREFDLSDPLALKKDLPARQSDNDVRNTISGMQKFMGEDLNFHERKKFQ
                     EEQNREWSLQQQREWKNARAEQKCAEALYTETRLQFDETAKHLQKLESTTRKAVCASV
                     KDFNKSQAIESVERKKQEKKQEQEDNLAEITNLLRGDLLSENPQQAASSFGPHRVVPD
                     RWKGMTQEQLEQIRLVQKQQIQEKLRLQEEKRQRDLDWDRRRIQGARATLLFERQQWR
                     RQRDLRRALDSSNLSLAKEQHLQKKYMNEVYTNQPTGDYFTQFNTGSR"
     exon            324..405
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     exon            406..750
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     exon            751..869
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1097
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1264
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1490
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1376..1381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /note="hexamer: TATAAA"
     polyA_site      1397
                     /gene="RIBC2"
                     /gene_synonym="C22orf11; TRIB"
                     /note="major polyA site"
ORIGIN      
        1 gttgttgaca tttccgagag agcgggagcg tctgtacctc tgcggcgtca ctgggagccc
       61 gacggaaaac tgcgctaaag gcttgtcttt cccctgcccg accgaaggag ccgaccttgc
      121 ctgcgctaca gcttccttat tttcgtcgcc tgttctcctg atcctgcgtg ttctaaaaac
      181 cccttaggct ttccatgggt tcccagacca tggcggtggc gctgcccagg gacttgcggc
      241 aggacgccaa cctggcaaag aggaggcacg cggagctgtg caggcagaag cgggtcttca
      301 acgccagaaa caggataatt gggggagaca ctgaagcctg ggatgttcaa gttcatgacc
      361 agaagataaa agaagctact gaaaaagcta gacatgaaac ctttgctgct gaaatgaggc
      421 aaaatgacaa aatcatgtgc atattggaaa accggaaaaa gagggatagg aaaaatctct
      481 gtagggctat caatgacttc caacagagct ttcagaagcc agaaactcgc cgtgaatttg
      541 atctgtccga ccccctagcc cttaagaaag atcttccagc ccggcagtca gataatgatg
      601 ttcggaatac gatatcagga atgcagaaat tcatgggaga ggatttaaac ttccatgaga
      661 ggaagaaatt ccaagaggaa caaaacagag aatggtcttt gcagcagcaa agggaatgga
      721 agaacgcccg tgctgaacaa aaatgcgcag aggccctcta cacagagaca aggctgcagt
      781 ttgacgagac agccaagcac ctccagaagc tggaaagcac caccagaaag gcagtttgtg
      841 catctgtgaa agacttcaac aagagccagg ccatcgagtc agtggaaagg aaaaagcaag
      901 agaaaaagca agaacaagag gacaacttgg ccgagatcac caacctcctg cgtggggacc
      961 tgctctccga gaacccgcag caggcagcca gctccttcgg gccccaccgc gtggtccctg
     1021 accgctggaa gggcatgacc caggagcagc tggagcagat ccgcctagtc cagaagcagc
     1081 aaatccagga gaagctgagg ctccaggaag aaaagcgcca gcgagacctg gactgggacc
     1141 ggcggaggat tcagggggct cgcgccaccc tgctgtttga gcggcagcag tggcggcggc
     1201 agcgcgacct gcgcagagct ctggacagca gcaacctcag cctggccaag gagcagcatt
     1261 tgcagaaaaa atatatgaat gaagtctata caaatcaacc cacgggagac tatttcacac
     1321 aatttaatac aggaagtcga taatgaggaa cacacccttg ttcccgtcat tcacgtataa
     1381 agagtggcta ccttaaagag tcacgtttct tttttaaaga tacactcctt gggccacaag
     1441 tacccttcag ctgtaatcgt ccactgtgga caaaacattt atctaacctc
//
