LOCUS       NM_052924               3695 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens rhophilin Rho GTPase binding protein 1 (RHPN1), mRNA.
ACCESSION   NM_052924
VERSION     NM_052924.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3695)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3695)
  AUTHORS   Zhang,W., Han,L., Xing,P., Liu,B., Sun,Z., Zhou,W. and Dong,J.
  TITLE     LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion
            via regulating miR-485-5p/BSG axis in hepatocellular carcinoma
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 393 (12), 2543-2551 (2020)
   PUBMED   32435875
  REMARK    GeneRIF: LncRNA RHPN1-AS1 accelerates proliferation, migration, and
            invasion via regulating miR-485-5p/BSG axis in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 3695)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3695)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3695)
  AUTHORS   Ding,L., Wang,L., Li,Z., Jiang,X., Xu,Y. and Han,N.
  TITLE     The positive feedback loop of RHPN1-AS1/miR-1299/ETS1 accelerates
            the deterioration of gastric cancer
  JOURNAL   Biomed Pharmacother 124, 109848 (2020)
   PUBMED   31982726
  REMARK    GeneRIF: The positive feedback loop of RHPN1-AS1/miR-1299/ETS1
            accelerates the deterioration of gastric cancer.
REFERENCE   6  (bases 1 to 3695)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 3695)
  AUTHORS   Lal,M.A., Andersson,A.C., Katayama,K., Xiao,Z., Nukui,M.,
            Hultenby,K., Wernerson,A. and Tryggvason,K.
  TITLE     Rhophilin-1 is a key regulator of the podocyte cytoskeleton and is
            essential for glomerular filtration
  JOURNAL   J Am Soc Nephrol 26 (3), 647-662 (2015)
   PUBMED   25071083
REFERENCE   8  (bases 1 to 3695)
  AUTHORS   Jaffe,A.B., Aspenstrom,P. and Hall,A.
  TITLE     Human CNK1 acts as a scaffold protein, linking Rho and Ras signal
            transduction pathways
  JOURNAL   Mol Cell Biol 24 (4), 1736-1746 (2004)
   PUBMED   14749388
REFERENCE   9  (bases 1 to 3695)
  AUTHORS   Peck,J.W., Oberst,M., Bouker,K.B., Bowden,E. and Burbelo,P.D.
  TITLE     The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton
            organization
  JOURNAL   J Biol Chem 277 (46), 43924-43932 (2002)
   PUBMED   12221077
REFERENCE   10 (bases 1 to 3695)
  AUTHORS   Fujita,A., Nakamura,K., Kato,T., Watanabe,N., Ishizaki,T.,
            Kimura,K., Mizoguchi,A. and Narumiya,S.
  TITLE     Ropporin, a sperm-specific binding protein of rhophilin, that is
            localized in the fibrous sheath of sperm flagella
  JOURNAL   J Cell Sci 113 (Pt 1), 103-112 (2000)
   PUBMED   10591629
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX341691.2, BC025767.1 and AC105118.23.
            
            On Nov 22, 2018 this sequence version replaced NM_052924.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025767.1, SRR1803613.19249.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289013.11/ ENSP00000289013.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BX341691.2         33-43
            12-2688             BC025767.1         1-2677
            2689-3642           AC105118.23        53196-54149
            3643-3694           BC025767.1         3632-3683
            3695-3695           AC105118.23        54202-54202
FEATURES             Location/Qualifiers
     source          1..3695
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3695
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /note="rhophilin Rho GTPase binding protein 1"
                     /db_xref="GeneID:114822"
                     /db_xref="HGNC:HGNC:19973"
                     /db_xref="MIM:601031"
     exon            1..172
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2125
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /note="outer dense fiber of sperm tails 5; GTP-Rho-binding
                     protein 1"
                     /codon_start=1
                     /product="rhophilin-1"
                     /protein_id="NP_443156.2"
                     /db_xref="CCDS:CCDS47927.1"
                     /db_xref="GeneID:114822"
                     /db_xref="HGNC:HGNC:19973"
                     /db_xref="MIM:601031"
                     /translation="MILEERPDGAGAGEESPRLQGCDSLTQIQCGQLQSRRAQIHQQI
                     DKELQMRTGAENLYRATSNNRVRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGS
                     EAVTVPMIPLGLKETKELDWSTPLKELISVHFGEDGASYEAEIRELEALRQAMRTPSR
                     NESGLELLTAYYNQLCFLDARFLTPARSLGLFFHWYDSLTGVPAQQRALAFEKGSVLF
                     NIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCAL
                     EQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHD
                     YVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRG
                     PVLPQELEERRQLGKAHLKRAILGQEEALRLHALCRVLREVDLLRAVISQTLQRSLAK
                     YAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKGPDIFHRLGPLSVFSAKNRW
                     RLVGPVHLTRGEGGFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWW
                     RHAEVVTELKAAGEAGASLQVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKTP
                     ASTWASPRPLLNWSRKAQQGKTGGCPQPCAPVKPAPPSSLKHPGWP"
     exon            173..288
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            289..417
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            418..493
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            494..571
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            572..696
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            697..863
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1057
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1214
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1328
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1523
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1600
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1747
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1909
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..3695
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /note="hexamer: ATTAAA"
     polyA_site      2292
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /note="major polyA site"
     regulatory      3674..3679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
                     /note="hexamer: AATAAA"
     polyA_site      3695
                     /gene="RHPN1"
                     /gene_synonym="ODF5; RHOPHILIN; RHPN"
ORIGIN      
        1 actcaggagc ccgcggccca ggtggtgcgg gcggccctag cccggctgcg gagcgctgcg
       61 cgagcggcgg gctggctgac cccgagggac ccccagcgca gcgggtgcgg cgatgatcct
      121 ggaggagagg ccggacggcg cgggcgccgg cgaggagagc ccgcggctgc agggctgtga
      181 ctccctgacg cagatccagt gcggccagct gcagagccgc agggcccaga ttcaccagca
      241 gattgacaag gagctgcaga tgcggacggg cgctgagaac ctctacagag ccaccagcaa
      301 caaccgggtg agagagacgg tcgccctgga gctgagctac gtcaactcca acctgcagct
      361 gctgaaggag gagctggagg agctcagcgg tggcgtggac cctggccggc atgggagcga
      421 agctgtcact gtccccatga tccccctggg cctgaaggag accaaggagc tggactggtc
      481 tacaccgctg aaggagctga tctcagtgca ctttggagag gacggcgcct cctacgaggc
      541 agaaatcagg gagctggagg ccctgcggca ggccatgcgg acccccagcc ggaatgagtc
      601 gggcctggag ctgctcacag cctattacaa ccagctgtgc ttcctggatg cgcgcttcct
      661 cacccctgcc aggagcctcg ggctcttctt ccactggtac gactcgctta ctggggtccc
      721 ggcccagcag cgtgccctgg ccttcgagaa gggcagcgtt ctcttcaaca tcggtgccct
      781 ccacacgcag attggggcgc gccaggaccg ctcctgcacc gagggtgccc gccgcgctat
      841 ggaggccttc cagagggccg ctggggcctt cagcctcctg agggagaact tctcccatgc
      901 gccgagccca gacatgagcg ctgcgtccct ctgcgcactg gagcagctca tgatggccca
      961 ggcccaggaa tgtgtgtttg agggcctctc accacctgcc tccatggccc cccaagactg
     1021 cctggcccag ctgcgcctgg cgcaggaggc cgcccaggtg gcagccgagt acaggctagt
     1081 gcaccggacc atggcccagc cacccgtcca cgactacgtg cctgtctcct ggactgccct
     1141 ggtgcatgtc aaggccgagt acttccgctc cctggcccac taccacgtag ccatggccct
     1201 ctgcgacggc tccccagcga ccgagggaga gctccccacg cacgagcagg tcttcctgca
     1261 gccccccacc tcctctaagc cccgaggccc tgtgctgccg caggagctgg aggagcgcag
     1321 gcagcttggc aaggcacacc tgaagcgtgc catcctgggg caggaggagg cgctgcggct
     1381 gcacgccctg tgccgcgtcc tgcgcgaggt ggacctgctt cgggctgtga tctcccagac
     1441 gctgcagcgc tcactggcca agtatgcgga gctcgaccgt gaggatgact tctgtgaggc
     1501 tgccgaggcc ccggacatcc agcctaagac ccaccagaag ccagaggcca ggatgccacg
     1561 cctgtcccag gggaaggggc ctgacatctt ccatcggctg gggcccctgt ctgtgttctc
     1621 agccaagaac cggtggcggc tggtggggcc cgtccacctg acccgaggag agggcggctt
     1681 tggcctcacg cttcggggag actcgcctgt cctcatcgct gccgtcattc cagggagcca
     1741 ggccgcggcg gctggcctga aggagggcga ctacattgtg tcagtgaatg ggcagccatg
     1801 caggtggtgg agacacgcgg aggtggtgac ggagctgaag gctgcgggag aggcgggcgc
     1861 cagcctgcag gtggtgtcgc tgctgcccag ctctagactg cccagcttgg gggaccgccg
     1921 gcccgtcctg ctgggcccca gggggcttct aaggagccag agggagcatg gttgcaagac
     1981 cccggcatcc acgtgggcca gtccccggcc cctcctcaac tggagccgaa aggcccagca
     2041 gggcaagact ggaggctgcc cccagccctg tgccccagtg aagccagctc cgccctcatc
     2101 cttgaagcac ccagggtggc cgtgagggcc aggatccctg cacgcctcag ccctggctcc
     2161 agctggcagc aagcaccgag catgccctcc ccacccagag gacctccggg caatgcctgt
     2221 cccgcctcat gctggaggct gcctcgggca cctgcctgcc cattaaagac tggtcagacc
     2281 tgtctgagcc cagtgatggg agctgtggcc tcttcaccca cacacagaag gatgccagtc
     2341 cctctgtcgg tctgaggtca gcttcctggg gctgccccac cctgagggct ccttacaggg
     2401 tgctcctcac agccatccca tctgtacccc cgggctctgt ccaccctgct gctgccctgg
     2461 gcacagaccc tgaggtctca gtcctgcctc cagccaagtt tctgcctggt gcccagtgat
     2521 tcctgctggg caccccttcg ctcactgccc ctccaccatg cagcagccag acacacccac
     2581 agcacccgca gacctctagg ccgggtccca gacatggcct tcccccaaaa tacttcctgc
     2641 tgtcctgtct gtgcacagag caagggactc cccacctctg cgccctgtgc tggtcatcat
     2701 gggctctgtg ctggtcaacc cagcaagtgt cccgtttgcc caggagtccc tggtgtcgtg
     2761 gcccaggtct catggtggcc ctaagcctgc cagccctgct gcccgccttg ctgtcctgct
     2821 ctgagcatgg gtgccaccct ccagctcctg ggcgtgtcac ttctctctga gcctggggcc
     2881 tgcatgggcc cccagccctc cccagcctgc ttgggccgct cctgctggcc tccacaggcc
     2941 gtgagctgtc agtgtctcaa gcaggggaag tgagggctgc ctccaggcct ccgtgtactg
     3001 ggtggacaat ggcccccaaa ggccgtcggc aagaacacca cctccaggac ccctacagca
     3061 gtgggctcag gacttgggca ccaagaggag agggtgggaa gggctgcaga gtcagggctg
     3121 cacccaagag gagccacgga gccggagccg gagcggaggc ccccaccgag ggccccaggg
     3181 cctggcaggt tccggaagag acagggccag cgggagtcat tccctgcagc cactaggggg
     3241 cagccgccac ccgctcagca gccctgggag gcggcacggg caggtgcgcc ttgggagggc
     3301 tgaggcaaag accccgggta gaaaggcggc ccccagctct gcgagacccc tgccctcttg
     3361 tccagtccct tccgagggtc cgcaggtgag agcagcctgc cctgcatccc aggctctggt
     3421 tccagggtcc agggccctgc gctgccacct ccctcgtgct tcagccaaga aaatgggggt
     3481 gcaagtaggg tgtttggggt cccagagacg caggcgccgc ggcgcgatct tcctgggcag
     3541 gagggcaggg ctccccaacc tgcctgagcc ggggtggggg tccaggtccc ccacttgccc
     3601 ttgtgggaaa atccctgtct cagcagaatg ggccaaggtc acgcaggtct ccccagcacg
     3661 tgttaatttg gttaataaaa ctgtggatca aggag
//
