LOCUS       NM_139282                747 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rhox homeobox family member 1 (RHOXF1), mRNA.
ACCESSION   NM_139282 XM_001715156
VERSION     NM_139282.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 747)
  AUTHORS   Yi,S., Wang,W., Su,L., Meng,L., Li,Y., Tan,C., Liu,Q., Zhang,H.,
            Fan,L., Lu,G., Hu,L., Du,J., Lin,G., Tan,Y.Q., Tu,C. and Zhang,Q.
  TITLE     Deleterious variants in X-linked RHOXF1 cause male infertility with
            oligo- and azoospermia
  JOURNAL   Mol Hum Reprod 30 (2) (2024)
   PUBMED   38258527
  REMARK    GeneRIF: Deleterious variants in X-linked RHOXF1 cause male
            infertility with oligo- and azoospermia.
REFERENCE   2  (bases 1 to 747)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 747)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 747)
  AUTHORS   Li,Q., O'Malley,M.E., Bartlett,D.L. and Guo,Z.S.
  TITLE     Homeobox gene Rhox5 is regulated by epigenetic mechanisms in cancer
            and stem cells and promotes cancer growth
  JOURNAL   Mol Cancer 10, 63 (2011)
   PUBMED   21609483
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 747)
  AUTHORS   Li,Q., Bartlett,D.L., Gorry,M.C., O'Malley,M.E. and Guo,Z.S.
  TITLE     Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer
            cells through overlapping and distinct molecular mechanisms
  JOURNAL   Mol Pharmacol 76 (5), 1072-1081 (2009)
   PUBMED   19679824
REFERENCE   6  (bases 1 to 747)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 747)
  AUTHORS   Zhan,M., Miura,T., Xu,X. and Rao,M.S.
  TITLE     Conservation and variation of gene regulation in embryonic stem
            cells assessed by comparative genomics
  JOURNAL   Cell Biochem Biophys 43 (3), 379-405 (2005)
   PUBMED   16244364
REFERENCE   8  (bases 1 to 747)
  AUTHORS   Wayne,C.M., MacLean,J.A., Cornwall,G. and Wilkinson,M.F.
  TITLE     Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2,
            selectively expressed in the testis
  JOURNAL   Gene 301 (1-2), 1-11 (2002)
   PUBMED   12490318
REFERENCE   9  (bases 1 to 747)
  AUTHORS   Geserick,C., Weiss,B., Schleuning,W.D. and Haendler,B.
  TITLE     OTEX, an androgen-regulated human member of the paired-like class
            of homeobox genes
  JOURNAL   Biochem J 366 (Pt 1), 367-375 (2002)
   PUBMED   11980563
  REMARK    GeneRIF: cloning and characterization of human OTEX
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY099086.1, BE675048.1 and
            AC240732.2.
            
            On May 17, 2019 this sequence version replaced NM_139282.2.
            
            Summary: This gene is a member of the PEPP subfamily of paired-like
            homoebox genes. The gene may be regulated by androgens and
            epigenetic mechanisms. The encoded nuclear protein is likely a
            transcription factor that may play a role in human reproduction.
            [provided by RefSeq, Dec 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069529.1, AY099086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217999.3/ ENSP00000217999.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-731               AY099086.1         25-755
            732-745             BE675048.1         12-25               c
            746-747             AC240732.2         28095-28096
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..747
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="Rhox homeobox family member 1"
                     /db_xref="GeneID:158800"
                     /db_xref="HGNC:HGNC:29993"
                     /db_xref="MIM:300446"
     exon            1..449
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..606
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="PEPP subfamily gene 1; paired-like homeobox protein
                     PEPP-1; ovary-, testis- and epididymis-expressed gene
                     protein"
                     /codon_start=1
                     /product="rhox homeobox family member 1"
                     /protein_id="NP_644811.1"
                     /db_xref="CCDS:CCDS14593.1"
                     /db_xref="GeneID:158800"
                     /db_xref="HGNC:HGNC:29993"
                     /db_xref="MIM:300446"
                     /translation="MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGL
                     MGNMNPEGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQ
                     PRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRR
                     HQRELMLANELRADPDDCVYIVVD"
     exon            450..495
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..747
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      725..730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="hexamer: AATAAA"
     polyA_site      747
                     /gene="RHOXF1"
                     /gene_synonym="OTEX; PEPP1"
                     /note="major polyA site"
ORIGIN      
        1 actccagctg cagacgccac ggagtttgtg caggggcgca gcgctccagc catggcgcgt
       61 tcgctcgtcc acgacaccgt gttctactgc ctgagtgtat accaggtaaa aataagcccc
      121 acacctcagc tgggggcagc atcaagcgca gaaggccatg ttggccaagg agctccaggc
      181 ctcatgggta atatgaaccc tgagggcggt gtgaaccacg agaacggcat gaaccgcgat
      241 ggcggcatga tccccgaggg cggcggtgga aaccaggagc ctcggcagca gccgcagccc
      301 ccgccggagg agccggccca ggcggccatg gagggtccgc agcccgagaa catgcagcca
      361 cgaactcggc gcacgaagtt cacgctgttg caggtggagg agctggaaag tgttttccga
      421 cacactcaat accctgatgt gcccacaaga agggaacttg ccgaaaactt aggtgtgact
      481 gaagacaaag tgcgggtttg gtttaagaat aaaagggcca gatgtaggcg acatcagaga
      541 gaattaatgc tcgccaatga actacgtgct gacccagacg actgtgtcta catcgtcgtg
      601 gactagccct agaatgccat ccttcttcag gagctagttt ggagatgggt ttttctggtg
      661 ccactgacac ctgggctgcc catgccgctc aggctaccct tatctcctct gcacttatgt
      721 tatcaataaa gaggcaaatt ctcaata
//
