LOCUS       NM_133639               1650 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ras homolog family member V (RHOV), mRNA.
ACCESSION   NM_133639
VERSION     NM_133639.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Harlin,E.W., Ito,T., Nakano,S., Morikawa,K., Sato,K., Nishikawa,M.,
            Nakamura,K., Nagaoka,H., Nagase,T. and Ueda,H.
  TITLE     Regulation of RHOV signaling by interaction with SH3
            domain-containing adaptor proteins and phosphorylation by PKA
  JOURNAL   Biochem Biophys Res Commun 728, 150325 (2024)
   PUBMED   38959529
  REMARK    GeneRIF: Regulation of RHOV signaling by interaction with SH3
            domain-containing adaptor proteins and phosphorylation by PKA.
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Qin,Q. and Peng,B.
  TITLE     Prognostic significance of the rho GTPase RHOV and its role in
            tumor immune cell infiltration: a comprehensive pan-cancer analysis
  JOURNAL   FEBS Open Bio 13 (11), 2124-2146 (2023)
   PUBMED   37596964
  REMARK    GeneRIF: Prognostic significance of the rho GTPase RHOV and its
            role in tumor immune cell infiltration: a comprehensive pan-cancer
            analysis.
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Jin,M.L., Gong,Y., Ji,P., Hu,X. and Shao,Z.M.
  TITLE     In vivo CRISPR screens identify RhoV as a pro-metastasis factor of
            triple-negative breast cancer
  JOURNAL   Cancer Sci 114 (6), 2375-2385 (2023)
   PUBMED   36898847
  REMARK    GeneRIF: In vivo CRISPR screens identify RhoV as a pro-metastasis
            factor of triple-negative breast cancer.
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Luu,A.P., Yao,Z., Ramachandran,S., Azzopardi,S.A., Miles,L.A.,
            Schneider,W.M., Hoffmann,H.H., Bozzacco,L., Garcia,G. Jr., Gong,D.,
            Damoiseaux,R., Tang,H., Morizono,K., Rudin,C.M., Sun,R.,
            Arumugaswami,V., Poirier,J.T., MacDonald,M.R., Rice,C.M. and
            Li,M.M.H.
  TITLE     A CRISPR Activation Screen Identifies an Atypical Rho GTPase That
            Enhances Zika Viral Entry
  JOURNAL   Viruses 13 (11), 2113 (2021)
   PUBMED   34834920
  REMARK    GeneRIF: A CRISPR Activation Screen Identifies an Atypical Rho
            GTPase That Enhances Zika Viral Entry.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Zhang,D., Jiang,Q., Ge,X., Shi,Y., Ye,T., Mi,Y., Xie,T., Li,Q. and
            Ye,Q.
  TITLE     RHOV promotes lung adenocarcinoma cell growth and metastasis
            through JNK/c-Jun pathway
  JOURNAL   Int J Biol Sci 17 (10), 2622-2632 (2021)
   PUBMED   34326698
  REMARK    GeneRIF: RHOV promotes lung adenocarcinoma cell growth and
            metastasis through JNK/c-Jun pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Liu,J., Li,M., Ran,X., Fan,J.S. and Song,J.
  TITLE     Structural insight into the binding diversity between the human
            Nck2 SH3 domains and proline-rich proteins
  JOURNAL   Biochemistry 45 (23), 7171-7184 (2006)
   PUBMED   16752908
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Chenette,E.J., Abo,A. and Der,C.J.
  TITLE     Critical and distinct roles of amino- and carboxyl-terminal
            sequences in regulation of the biological activity of the Chp
            atypical Rho GTPase
  JOURNAL   J Biol Chem 280 (14), 13784-13792 (2005)
   PUBMED   15664990
  REMARK    GeneRIF: Data suggest that Chp is implicated in cell
            transformation, and the unique amino and carboxyl termini of Chp
            represent atypical mechanisms of regulation of Rho GTPase function.
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of WRCH2 on human chromosome
            15q15
  JOURNAL   Int J Oncol 20 (5), 977-982 (2002)
   PUBMED   11956592
  REMARK    GeneRIF: cloning and characterization of WRCH2 on human chromosome
            15q15
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Wherlock,M. and Mellor,H.
  TITLE     The Rho GTPase family: a Racs to Wrchs story
  JOURNAL   J Cell Sci 115 (Pt 2), 239-240 (2002)
   PUBMED   11839775
  REMARK    Review article
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Aronheim,A., Broder,Y.C., Cohen,A., Fritsch,A., Belisle,B. and
            Abo,A.
  TITLE     Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway
            and is implicated in reorganizing the actin cytoskeleton
  JOURNAL   Curr Biol 8 (20), 1125-1128 (1998)
   PUBMED   9778532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025166.7 and BC112945.1.
            
            On Nov 23, 2018 this sequence version replaced NM_133639.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112945.1, SRR1163655.191746.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220507.5/ ENSP00000220507.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC025166.7         81840-81858         c
            20-1650             BC112945.1         1-1631
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1650
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /note="ras homolog family member V"
                     /db_xref="GeneID:171177"
                     /db_xref="HGNC:HGNC:18313"
                     /db_xref="MIM:620101"
     exon            1..303
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..806
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /note="WRCH1-related GTPase; Wnt-1 responsive Cdc42
                     homolog 2; CDC42-like GTPase 2; Wnt-1 regulated Cdc42
                     homolog 2; Rho GTPase-like protein ARHV; WRCH-2;
                     GTP-binding protein-like 2; ras homolog gene family,
                     member V"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoV"
                     /protein_id="NP_598378.3"
                     /db_xref="CCDS:CCDS10068.1"
                     /db_xref="GeneID:171177"
                     /db_xref="HGNC:HGNC:18313"
                     /db_xref="MIM:620101"
                     /translation="MPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGK
                     SSLIVSYTCNGYPARYRPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPD
                     TDVFLACFSVVQPSSFQNITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQG
                     GREGPVPQPQAQGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNA
                     KGVRTLSRCRWKKFFCFV"
     exon            304..362
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..1650
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1629..1634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="RHOV"
                     /gene_synonym="ARHV; CHP; WRCH2"
                     /note="major polyA site"
ORIGIN      
        1 acccattcag tcagaggcag ccagcgggac ctgcttcacc gagcgcagcg aagccgagac
       61 ccgggctggc ccctctgctg cccccggagc gggccatgcc gccgcgggag ctgagcgagg
      121 ccgagccgcc cccgctccgg gccccgaccc ctcccccgcg gcggcgtagc gcgcccccag
      181 agctgggcat caagtgcgtg ctggtgggcg acggcgccgt gggcaagagc agcctcatcg
      241 tcagctacac ctgcaatggg taccccgcgc gctaccggcc cactgcgctg gacaccttct
      301 ctgtgcaagt cctggtggat ggagctccgg tgcgcattga gctctgggac acagcgggac
      361 aggaggattt tgaccgactt cgttcccttt gctacccgga taccgatgtc ttcctggcgt
      421 gcttcagcgt ggtgcagccc agctcctttc aaaacatcac agagaaatgg ctgcccgaga
      481 tccgcacgca caacccccag gcgcctgtgc tgctggtggg cacccaggcc gacctgaggg
      541 acgatgtcaa cgtactaatt cagctggacc aggggggccg ggagggcccc gtgccccaac
      601 cccaggctca gggtctggcc gagaagatcc gagcctgctg ctaccttgag tgctcagcct
      661 tgacgcagaa gaacttgaag gaagtatttg actcggctat tctcagtgcc attgagcaca
      721 aagcccggct ggagaagaaa ctgaatgcca aaggtgtgcg caccctctcc cgctgccgct
      781 ggaagaagtt cttctgcttc gtttgagcag ctatggctgc atagcaagta gtaggcagga
      841 ggccaaagac ttctgagacc tggggcaccc gggcctttgc ggcagctact ggcagggcct
      901 ggccacctca taggactcag ttcccttctg aacactcggg ggacatgggc ctctaactgc
      961 ccactctgat atgcctgggt gagcctagga gggaaggctc tgatttggat ttctccagtc
     1021 aaagctcaca gaaaaaaacc tggcactttg attttcatgg gatggtccta acagggtcag
     1081 tcacctccga gcagtttggg aacccagttt cttgtcctgg gccctcaggt cagcctggct
     1141 gaattaggac ccttccttgg cacaggggtg agaaagagct tggggaacgc ttggcattat
     1201 ggagggctgg aaggggctca accccgattt ggagagaagt ttgggatgga gtgggcgaga
     1261 gattgagaga gcgagcagga aaagaggtct tggagcctgg gactgatggt ggataaggcc
     1321 tggaaagaag atgacgagga ggaggagaga gggaagtggg gtggatgagg agcaggctga
     1381 cacctgggct gccctcaatc cccaaggcca gggagggcgg ggctggcccc tgggaagaac
     1441 tgggtctctg ggctccctag gcactgccca aactggctga gccaggagtg gggcaggaag
     1501 tgagagtcaa ggcccagcaa aaggaggggg aggagctgca aattagaacc tgaaggagga
     1561 ccgggttggg gatcatccct ttcctcaagg tcacacagcc tagaagctag agcagtgcag
     1621 agtctgcaaa taaaacctta agtctgtgaa
//
