LOCUS       NM_021205               3965 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ras homolog family member U (RHOU), transcript variant
            1, mRNA.
ACCESSION   NM_021205
VERSION     NM_021205.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3965)
  AUTHORS   Yang,Y., Huang,L., Zhang,N., Deng,Y.N., Cao,X., Liang,Y., Hou,H.,
            Luo,Y., Yang,Y., Li,Q. and Liang,S.
  TITLE     SUMOylation of annexin A6 retards cell migration and tumor growth
            by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma
  JOURNAL   Cell Commun Signal 22 (1), 206 (2024)
   PUBMED   38566133
  REMARK    GeneRIF: SUMOylation of annexin A6 retards cell migration and tumor
            growth by suppressing RHOU/AKT1-involved EMT in hepatocellular
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3965)
  AUTHORS   Clayton,N.S., Hodge,R.G., Infante,E., Alibhai,D., Zhou,F. and
            Ridley,A.J.
  TITLE     RhoU forms homo-oligomers to regulate cellular responses
  JOURNAL   J Cell Sci 137 (2) (2024)
   PUBMED   38180080
  REMARK    GeneRIF: RhoU forms homo-oligomers to regulate cellular responses.
REFERENCE   3  (bases 1 to 3965)
  AUTHORS   Ren,L., Fang,X., Shrestha,S.M., Ji,Q., Ye,H., Liang,Y., Liu,Y.,
            Feng,Y., Dong,J. and Shi,R.
  TITLE     LncRNA SNHG16 promotes development of oesophageal squamous cell
            carcinoma by interacting with EIF4A3 and modulating RhoU mRNA
            stability
  JOURNAL   Cell Mol Biol Lett 27 (1), 89 (2022)
   PUBMED   36221055
  REMARK    GeneRIF: LncRNA SNHG16 promotes development of oesophageal squamous
            cell carcinoma by interacting with EIF4A3 and modulating RhoU mRNA
            stability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3965)
  AUTHORS   De Piano,M., Manuelli,V., Zadra,G., Otte,J., Edqvist,P.D.,
            Ponten,F., Nowinski,S., Niaouris,A., Grigoriadis,A., Loda,M., Van
            Hemelrijck,M. and Wells,C.M.
  TITLE     Lipogenic signalling modulates prostate cancer cell adhesion and
            migration via modification of Rho GTPases
  JOURNAL   Oncogene 39 (18), 3666-3679 (2020)
   PUBMED   32139877
  REMARK    GeneRIF: Lipogenic signalling modulates prostate cancer cell
            adhesion and migration via modification of Rho GTPases.
REFERENCE   5  (bases 1 to 3965)
  AUTHORS   Yu,S., Wang,X.S., Cao,K.C., Bao,X.J. and Yu,J.
  TITLE     Identification of CDK6 and RHOU in Serum Exosome as Biomarkers for
            the Invasiveness of Non-functioning Pituitary Adenoma
  JOURNAL   Chin Med Sci J 34 (3), 168-176 (2019)
   PUBMED   31601299
  REMARK    GeneRIF: These results indicate CDK6 and RHOU play important roles
            in the invasiveness of NF-PAs, and the established diagnostic
            method is valuable for directing the clinical screening and
            postoperative treatment.
REFERENCE   6  (bases 1 to 3965)
  AUTHORS   Saras,J., Wollberg,P. and Aspenstrom,P.
  TITLE     Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding
            characteristics and cellular effects
  JOURNAL   Exp Cell Res 299 (2), 356-369 (2004)
   PUBMED   15350535
REFERENCE   7  (bases 1 to 3965)
  AUTHORS   Daigo,Y., Takayama,I., Ponder,B.A., Caldas,C., Ward,S.M.,
            Sanders,K.M. and Fujino,M.A.
  TITLE     Novel human, mouse and xenopus genes encoding a member of the RAS
            superfamily of low-molecular-weight GTP-binding proteins and its
            downregulation in W/WV mouse jejunum
  JOURNAL   J Gastroenterol Hepatol 19 (2), 211-217 (2004)
   PUBMED   14731133
  REMARK    GeneRIF: G28K cDNA encodes a protein of 258 amino acids with
            homology to the cell division cycle 42/G25K protein; this gene is
            located at 1q42.11-q42.3; G28K was abundantly expressed in the
            stomach and the small intestine
REFERENCE   8  (bases 1 to 3965)
  AUTHORS   Aspenstrom,P., Fransson,A. and Saras,J.
  TITLE     Rho GTPases have diverse effects on the organization of the actin
            filament system
  JOURNAL   Biochem J 377 (Pt 2), 327-337 (2004)
   PUBMED   14521508
REFERENCE   9  (bases 1 to 3965)
  AUTHORS   Kirikoshi,H. and Katoh,M.
  TITLE     Expression of WRCH1 in human cancer and down-regulation of WRCH1 by
            beta-estradiol in MCF-7 cells
  JOURNAL   Int J Oncol 20 (4), 777-783 (2002)
   PUBMED   11894124
  REMARK    GeneRIF: Down regulation of WRCH1 by estradiol in breast cancer and
            altered expression of WRCH1 is associated with other cancers
REFERENCE   10 (bases 1 to 3965)
  AUTHORS   Tao,W., Pennica,D., Xu,L., Kalejta,R.F. and Levine,A.J.
  TITLE     Wrch-1, a novel member of the Rho gene family that is regulated by
            Wnt-1
  JOURNAL   Genes Dev 15 (14), 1796-1807 (2001)
   PUBMED   11459829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF211836.1 and BC040076.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021205.5.
            
            Summary: This gene encodes a member of the Rho family of GTPases.
            This protein can activate PAK1 and JNK1, and can induce filopodium
            formation and stress fiber dissolution. It may also mediate the
            effects of WNT1 signaling in the regulation of cell morphology,
            cytoskeletal organization, and cell proliferation. A non-coding
            transcript variant of this gene results from naturally occurring
            read-through transcription between this locus and the neighboring
            DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided
            by RefSeq, Mar 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040076.1, AF211836.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366691.4/ ENSP00000355652.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AF211836.1         359-375
            18-3965             BC040076.1         1-3948
FEATURES             Location/Qualifiers
     source          1..3965
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..3965
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /note="ras homolog family member U"
                     /db_xref="GeneID:58480"
                     /db_xref="HGNC:HGNC:17794"
                     /db_xref="MIM:606366"
     exon            1..526
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1041
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /note="Ryu GTPase; 2310026M05Rik; GTP-binding protein like
                     1; ras-like gene family member U; ras homolog gene family,
                     member U; GTP-binding protein SB128; wnt-1 responsive
                     Cdc42 homolog 1; CDC42-like GTPase 1; rho GTPase-like
                     protein ARHU"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoU"
                     /protein_id="NP_067028.1"
                     /db_xref="CCDS:CCDS1575.1"
                     /db_xref="GeneID:58480"
                     /db_xref="HGNC:HGNC:17794"
                     /db_xref="MIM:606366"
                     /translation="MPPQQGDPAFPDRCEAPPVPPRRERGGRGGRGPGEPGGRGRAGG
                     AEGRGVKCVLVGDGAVGKTSLVVSYTTNGYPTEYIPTAFDNFSAVVSVDGRPVRLQLC
                     DTAGQDEFDKLRPLCYTNTDIFLLCFSVVSPSSFQNVSEKWVPEIRCHCPKAPIILVG
                     TQSDLREDVKVLIELDKCKEKPVPEEAAKLCAEEIKAASYIECSALTQKNLKEVFDAA
                     IVAGIQYSDTQQQPKKSKSRTPDKMKNLSKSWWKKYCCFV"
     exon            527..585
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..3965
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /note="hexamer: ATTAAA"
     polyA_site      1286
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
     regulatory      3946..3951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /note="hexamer: AATAAA"
     polyA_site      3965
                     /gene="RHOU"
                     /gene_synonym="ARHU; CDC42L1; G28K; hG28K; WRCH1"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcttg ggatccacgg cgctcggacc gctgtcctcc aacagcgcag ggcagagcgg
       61 ctggcgccgc cggagcgcgg agccacgacc ctccctggcc gcctttgtct actggccgtg
      121 cggcccggaa ccgccactct ccagggccgg ggacgcgccc gcagctgtcg gtgacagctc
      181 ctccctaccg caaccctccg gggcggaggg gcggtcgggc cgggccctgc tagcccgcga
      241 ccgcaagccc gcgctcgcgg atcgatgccc ccgcagcagg gggaccccgc gttccccgac
      301 cgctgcgagg cgcctccggt gccgccgcgt cgggagcgcg gtggacgcgg gggacgcggg
      361 cctggggagc cggggggccg ggggcgtgcg gggggtgccg aggggcgcgg cgtcaagtgc
      421 gtgctggtcg gcgacggcgc ggtgggcaag acgagcctgg tggtgagcta caccaccaac
      481 ggctacccca ccgagtacat ccctactgcc ttcgacaact tctccgcggt ggtgtctgtg
      541 gatgggcggc ccgtgagact ccaactctgt gacactgccg gacaggatga atttgacaag
      601 ctgaggcctc tctgctacac caacacagac atcttcctgc tctgcttcag tgtcgtgagc
      661 ccctcatcct tccagaacgt cagtgagaaa tgggtgccgg agattcgatg ccactgtccc
      721 aaagccccca tcatcctagt tggaacgcag tcggatctca gagaagatgt caaagtcctc
      781 attgagttgg acaaatgcaa agaaaagcca gtgcctgaag aggcggctaa gctgtgcgcc
      841 gaggaaatca aagccgcctc ctacatcgag tgttcagcct tgactcaaaa aaacctcaaa
      901 gaggtctttg atgcagccat cgtcgctggc attcaatact cggacactca gcaacagcca
      961 aagaagtcta aaagcaggac tccagataaa atgaaaaacc tctccaagtc ctggtggaag
     1021 aagtactgct gtttcgtatg atgctggcaa gacacccaga aaggctattt tcagatgaaa
     1081 tcgatattag aagctatatt agctgaaaca actcctttta ctgcgtagaa cctatatcga
     1141 gagtgtgtgt atatgtatta taggaggagc tctcaatttt atgtattctt tctgccttta
     1201 attttcttgt ttgtttgagc ttagggatga gatacttatg caagatattt ttgaagtaaa
     1261 ttaaacattt ttcacatctc tggaaattta gagttctaga cctctggtta atttatatct
     1321 aatatgaaga agacacctct aatctggatg ttaagaatga agttctgcta cattataatg
     1381 tacagaagag caaaagggag gaacactatg gttaaccctc tcttgattaa gggctactta
     1441 atgcacagtg cattatgtac acaggtcaac catggtaaca atagttctta gctttgaaac
     1501 tccatgcaaa ccatgccttt tttttaagga gcaaaaatct gagaaaaaaa gtgagagacc
     1561 tctgcctaca aaacctcaaa ccagtcactt ttgtcaattg ctaataccca gttacttatg
     1621 atttaaaaac aaccaacaga aaacatccca ctgactgtat ggcactctgt agtcaaaaaa
     1681 ggaaacttcc ttattgggac ttttctttct tagtccagtt gtgttgacac atatgaacac
     1741 agacaaagtg ctatgcggag gaaagcaagt gttggtcagt agtttcatgt tttagggagt
     1801 ggttcctgtg gagatcagaa agtgacattt gctttcggta ctgtaatacg tgcaccaaac
     1861 tgcctcaatc ctaggtaacg agggcaacag ggagcacctg tctggattgt ttttaaacct
     1921 ccatactcaa gctgtctctt cggcagggag gtgaatactc ttgaaaggcc aacagcaagt
     1981 gtttgtggga cacaacacag ataatttttt cttaagtcgg ccaagatgta cttctctgtg
     2041 tgcacaccca tgcacactca tgcacacaga tacataggtc tgtatggctg tatttgctgt
     2101 tgattcagac tttcacacca ttaatgggga aaagcgtggc cacaaaaaca gatgctagga
     2161 agcttggctt cctcttcttg ttgacccttt tttgaaccaa catctttttt attatattca
     2221 gagtatgttt ttaagtgtat cttaatatat acatttttta ggacatctta aatctaaaca
     2281 aaaaataaaa tgaacatctc ttgaaacctg ttaaaacaac cagttaaagc cacagatggc
     2341 tttcagggca gtagcagcag aggccagtgg actctgagga ctcctgaggg gcggggcgtg
     2401 tagccagcca ggtgcatgcc gggaccatgg cccccatact tggctgcttc ctgtgacagt
     2461 gaaatacatc cttcaaggtg gcagctgtta gggctgaatc ttctggagaa aaaggtgcca
     2521 tctcaggaga atagctttta ctctggtagg aatgcttccg agacaccaca aggcagcctg
     2581 aacactcagt tgcagggtcg ggcttgcggt gggtgaccca gagccaccaa agtcacatcc
     2641 acaactaatg agggaaatct gtaaagccag ttagatagaa gaattttatt tttctgtggg
     2701 ttttgtgttg tcttttttat gttaaaaaga aatccagttt gtgtttttct atagaaaaag
     2761 taaaagatca ggttatactt taggttaggg gttctattta ttcctgttag taaataaaat
     2821 taacaaattt ctttgtttaa caaaagatta atctttaaac cactaaaata catagactga
     2881 ttgattattc aacacattgg aattgatgtc ggtcatagtt tcctgaagca tttagttaca
     2941 acctgaagga ataaaatgat ttgtggaaat gcttaaaata gacctaactg aatacagtct
     3001 catcttgccg cgcctggctt acctatctgt ggaaagctag gcttcccagg ctgggctctg
     3061 cctgtctggt gcctggaggt gtgggaggga agatgagtta tttaactggt aagcgatttg
     3121 aaacactatt tttatattaa agtaaatggc atggagtata gtgcaaattc atttttaaga
     3181 tagaacacaa aacttgaaag aagttttatg cgtgtgacag tgtatggggc tgcagttggt
     3241 ctccctggag gggacttcca cacctcctgc ctttaggcca tgggtggaaa gtgctcagtg
     3301 aagtacacct gtgtggccca gttctgaaag ctttatacag ttgaatttta agtggggttg
     3361 ataacacctt ggactgttag tgttaaaaat ctagtgggtt gacctttaaa tgcaacagtt
     3421 tttaaaatat attgctgcat tttatagaat agtaaaggta cgattatact tgagattttc
     3481 ctccattttt atttcttcgt gaacatagag tttggggccg aaaatgtttt taaagtatgt
     3541 gtttgagtta aatataaagt tggttcactt caaagctaaa aaattgttaa acttgcagct
     3601 tggtattgca gagaagattt tataagaatt ttgctttaga gaatgccact ttggctgaac
     3661 tacaagtgta ggccaccatt ataatttata aatacagcat acttcaaaac tgtttgttat
     3721 ctcttgttac catgtatgta taaatggacc ttttataacc ttgttctctg cttgacagac
     3781 tcaagagaaa ctacccaggt attacacaag ccaaaatggg agcaaggcct tctctccaga
     3841 ctatcgtaac ctggtgcctt accaagttgt gcttttctgt tttcaagtgt aaatgatgtt
     3901 gagcagaatg ttgtacttga aaatgctata agtgagatgg tatgaaataa attctgactt
     3961 atgaa
//
