LOCUS       NM_012249               4780 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ras homolog family member Q (RHOQ), mRNA.
ACCESSION   NM_012249
VERSION     NM_012249.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4780)
  AUTHORS   Bridges,E., Sheldon,H., Kleibeuker,E., Ramberger,E., Zois,C.,
            Barnard,A., Harjes,U., Li,J.L., Masiero,M., MacLaren,R. and
            Harris,A.
  TITLE     RHOQ is induced by DLL4 and regulates angiogenesis by determining
            the intracellular route of the Notch intracellular domain
  JOURNAL   Angiogenesis 23 (3), 493-513 (2020)
   PUBMED   32506201
  REMARK    GeneRIF: RHOQ is induced by DLL4 and regulates angiogenesis by
            determining the intracellular route of the Notch intracellular
            domain.
REFERENCE   2  (bases 1 to 4780)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4780)
  AUTHORS   Han,S.W., Kim,H.P., Shin,J.Y., Jeong,E.G., Lee,W.C., Kim,K.Y.,
            Park,S.Y., Lee,D.W., Won,J.K., Jeong,S.Y., Park,K.J., Park,J.G.,
            Kang,G.H., Seo,J.S., Kim,J.I. and Kim,T.Y.
  TITLE     RNA editing in RHOQ promotes invasion potential in colorectal
            cancer
  JOURNAL   J Exp Med 211 (4), 613-621 (2014)
   PUBMED   24663214
  REMARK    GeneRIF: Novel tumor-associated increase of RNA editing in ras
            homologue family member Q (RHOQ) transcripts, is reported.
REFERENCE   4  (bases 1 to 4780)
  AUTHORS   Mayer,S., Kumar,R., Jaiswal,M., Soykan,T., Ahmadian,M.R., Brose,N.,
            Betz,H., Rhee,J.S. and Papadopoulos,T.
  TITLE     Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin
            clustering and hippocampal GABAergic neurotransmission
  JOURNAL   Proc Natl Acad Sci U S A 110 (51), 20795-20800 (2013)
   PUBMED   24297911
  REMARK    GeneRIF: The enhancement of Cb-induced gephyrin clustering by
            GTP-TC10 does not depend on the guanine nucleotide exchange
            activity of Cb but involves an interaction that resembles reported
            interactions of other small GTPases with their effectors
REFERENCE   5  (bases 1 to 4780)
  AUTHORS   Fujita,A., Koinuma,S., Yasuda,S., Nagai,H., Kamiguchi,H., Wada,N.
            and Nakamura,T.
  TITLE     GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic
            fusion of Rab11- and L1-containing vesicles by releasing exocyst
            component Exo70
  JOURNAL   PLoS One 8 (11), e79689 (2013)
   PUBMED   24223996
  REMARK    GeneRIF: Exocytosis of Rab11- and L1-positive vesicles may play a
            central role in TC10-mediated neurite outgrowth
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4780)
  AUTHORS   Michaelson,D., Silletti,J., Murphy,G., D'Eustachio,P., Rush,M. and
            Philips,M.R.
  TITLE     Differential localization of Rho GTPases in live cells: regulation
            by hypervariable regions and RhoGDI binding
  JOURNAL   J Cell Biol 152 (1), 111-126 (2001)
   PUBMED   11149925
REFERENCE   7  (bases 1 to 4780)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   8  (bases 1 to 4780)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
REFERENCE   9  (bases 1 to 4780)
  AUTHORS   Murphy,G.A., Solski,P.A., Jillian,S.A., Perez de la Ossa,P.,
            D'Eustachio,P., Der,C.J. and Rush,M.G.
  TITLE     Cellular functions of TC10, a Rho family GTPase: regulation of
            morphology, signal transduction and cell growth
  JOURNAL   Oncogene 18 (26), 3831-3845 (1999)
   PUBMED   10445846
REFERENCE   10 (bases 1 to 4780)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol Cell Biol 10 (4), 1793-1798 (1990)
   PUBMED   2108320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018682.4 and BC056154.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012249.3.
            
            Summary: This gene encodes a member of the Rho family of small
            GTPases, which cycle between inactive GDP-bound and active
            GTP-bound states and function as molecular switches in signal
            transduction cascades. Rho proteins promote reorganization of the
            actin cytoskeleton and regulate cell shape, attachment, and
            motility. The encoded protein is an important signalling protein
            for sarcomere assembly and has been shown to play a significant
            role in the exocytosis of the solute carrier family 2, facilitated
            glucose transporter member 4 and other proteins, possibly acting as
            the signal that turns on the membrane fusion machinery. Three
            related pseudogene have been identified on chromosomes 2 and 14.
            [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU794657.1, SRR1660807.165339.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238738.9/ ENSP00000238738.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC018682.4         76883-77120
            239-445             AC018682.4         77121-77327
            446-2190            BC056154.1         1-1745
            2191-4780           AC018682.4         116492-119081
FEATURES             Location/Qualifiers
     source          1..4780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..4780
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="ras homolog family member Q"
                     /db_xref="GeneID:23433"
                     /db_xref="HGNC:HGNC:17736"
                     /db_xref="MIM:605857"
     exon            1..699
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     CDS             558..1175
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="RAS-like, family 7, member A; ras-like protein
                     TC10; ras-like protein family member 7A; ras homolog gene
                     family, member Q; epididymis secretory protein Li 42"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoQ"
                     /protein_id="NP_036381.2"
                     /db_xref="CCDS:CCDS33191.1"
                     /db_xref="GeneID:23433"
                     /db_xref="HGNC:HGNC:17736"
                     /db_xref="MIM:605857"
                     /translation="MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFD
                     HYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEE
                     WVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCY
                     VECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT"
     exon            700..758
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     exon            759..923
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1019
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..4780
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="hexamer: AGTAAA"
     polyA_site      3208
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="major polyA site"
     regulatory      4214..4219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="hexamer: ATTAAA"
     polyA_site      4247
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="hexamer: AATAAA"
     polyA_site      4336
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
     regulatory      4748..4753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /note="hexamer: ATTAAA"
     polyA_site      4780
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
ORIGIN      
        1 ctcctcctgc gcgcccctcc gcgcggccct cgcagggagt ggggctcggg tgcgccggca
       61 gggccgcgcg gcggcagcag gcgggggcgc gtggcgcggg ccgcgctcgg ggaggcgcct
      121 gggcccgccc tcctccgggg cgccgcggga ggggcccggg ttggcgcggg gcggggagag
      181 ccgcctggcc cctcccctcc gccgccctcc ccaaagttgc cgtctccccc ggggccggcc
      241 ggtcttatga tccggcggat cctcctgggg aggccgggcc ggggagaggg cgcgggcgcc
      301 gagtggcggg ggcagcgggc gggcgcggcg accggggccg gggcggggat ccgggcggcg
      361 accgcggcgg cggcagcgcc ccgggcccgc cgccccctcc cctcctgcga ggggagccgc
      421 tgcatggggc cgggggggcg gccctgcggc gcggagcggc ggcgacggcg gcggaccccc
      481 caggcgggct ggggctgagc ccggggccgg ggcgggggct ccggggggac catgcccgga
      541 ggccggccgg cagcagcatg gctcacgggc ccggcgcgct gatgctcaag tgcgtggtgg
      601 tcggcgacgg ggcggtgggc aagacgtgcc tactcatgag ctatgccaac gacgccttcc
      661 cggaggagta cgtgcccacc gtcttcgacc actacgcagt cagcgtcacc gtggggggca
      721 agcagtacct cctaggactc tatgacacgg ccggacagga agactatgac cgtctgaggc
      781 ctttatctta cccaatgacc gatgtcttcc ttatatgctt ctcggtggta aatccagcct
      841 catttcaaaa tgtgaaagag gagtgggtac cggaacttaa ggaatacgca ccaaatgtac
      901 cctttttatt aataggaact cagattgatc tccgagatga ccccaaaact ttagcaagac
      961 tgaatgatat gaaagaaaaa cctatatgtg tggaacaagg acagaaacta gcaaaagaga
     1021 taggagcatg ctgctatgtg gaatgttcag ctttaaccca gaagggattg aagactgttt
     1081 ttgatgaggc tatcatagcc attttaactc caaagaaaca cactgtaaaa aaaagaatag
     1141 gatcaagatg tataaactgt tgtttaatta cgtgagaaac atcttcagtg gccaaggaaa
     1201 ctgtccattt ctctcagaaa gcaaatgaaa tgctacagct atacccagac cttttatagg
     1261 taatgaagca gttcaaaact tgaaagaaaa caaaacctgt cctcagaatt ctataaagtg
     1321 tattaagaat gttccttaaa ggtttaagaa gcagtaagca gcatctgaag ccacaatcta
     1381 ttataaatac tttatttcaa ctagaaggta caatctctca ggggtttcat agtttaaaaa
     1441 gctacaatca catcatgttg taactacgta aaaaacagag ctgtaaatgg aactgcttgg
     1501 ctttgaccat acacatttct gcccagccct tacagaatct gcacaaagaa atatctccct
     1561 ttgctccagt taattgttct tgtatgtaag ttgctttcta ttccagtata tccagagtgg
     1621 tgaaataaca aggccagcca cgtagccaaa ggtcgctcca agcgtacagg agatgggcca
     1681 tacctgagga gagaatgtat gagatcaaaa aagaacaaat gttttattat tacttgagca
     1741 caagtgtaac ctaaatattt ctatattaaa gcttaatgtg ctttcttaaa gaatgccaaa
     1801 agtgtaataa ggtcataact gcatttatca tgaacactaa aaatgtacac attttagtta
     1861 atgtgcatta aactgtaaca aggcttctgg caattgtaga tttagtttga cgctccccaa
     1921 agtgcatgag acacatgcta aaattacaaa ttaaaatttt gggtcagact ttgccataat
     1981 gatagactca atttagctct ctgaactagt tggtaatttt ttttttttaa ttcccacttt
     2041 ggctgtgtac atcaaatgaa atgagaagtg tgtatgctga ccaaaccaca agaaactttc
     2101 tttaagttgt gttaaagagg aaagacctag aatccaagcg tgttacatga aaattgtaac
     2161 agagcagctg cttccacctt tcagatatag atgttggaac cacagcagaa gttatagagc
     2221 gacaacttat atacacacct agaatgtaag ttaaacaaaa taccggcttc cagagacccc
     2281 ttttctccag ccatattaca tcaggctaga agtaattaat gttgatttat ttcatctaca
     2341 agcagttggt ccctaagtga aaggctctgc ttgaaaaaaa aaagaaaaaa aagttggagg
     2401 aaaattttca tgttcttctg tgaagcttat ttggtacact ggagccattt ctaatctttc
     2461 tctgggggga acaggccaca gaactgtgtt agaggtgaac catcttaatt actagttcta
     2521 ttacctaatt cagcttcctt gtttggtctg ctgtggatct gccttattgc atatgccatg
     2581 catcagataa tggatgcatc agataatggt gttagacaaa gcttcattgt gaacaaccta
     2641 atgcatttta gagaaacaat ctcatcacat tttttctagc ctttcctaca tttaaacttg
     2701 ctgttgccca aattataatt ttttaaatgt ctttggtggg cttctgttaa ttcacatgac
     2761 ttgagcttat agctatgtct actgcacaga ttgggtaatg gaacactaaa cttttatact
     2821 tgaaaatgac agccttaaat gctcatatca gtcacaaatc taggatgtac tgtcttgttg
     2881 tatgtgagct ttgtagagat ttttaaaaat ataagcatca ccttcccatt gaagagtgga
     2941 gagagtctac tggatgactg gccaggaact ttctctctga atcggacatt tggatgtctt
     3001 ctttcttcca agaaatggtg gttcacatta aagtatcatg gccttatgta tgctcaaatg
     3061 gaatcttatg taactttctt atttaatttt ggtctgctta tttttagata aaattgaaag
     3121 gaattgtata aatcaattaa catattagct gagttgtcca acacatggta taaacgaatt
     3181 acaacagtaa actattacac atttccaact tgcctttggg gatttatgag gatttttttt
     3241 ggtgggggga gggggctcca attcatatct ctgaaaccct tcacacttgg tttactaatt
     3301 caaagttaga agtctagaat ttgccctgcc ctaacagaaa cagattagga atttgtctac
     3361 acaaactggt gtcacctgtt tcttgactgg gatttggttt cctcattata aatatgggag
     3421 gtagaacaga gatctccaac gtctctccca tttatcacag taattttctt attcacagta
     3481 atcattgttg gatgttacct tttcagcttc acattctcaa gatggtaaaa atcatgtata
     3541 tagattatca gaactctaag caaagatgac tgtcacatct gaagctgagg tgccttaggt
     3601 actctactga ccttgatggg tttggagttc cccattgctt atcaagagct ttttaattgc
     3661 tttggttctt tagtttttct ttttgcaaaa atccttcctg tcactttaac taaaaaccaa
     3721 agatttgttt tctattgata agcagactag agaaaaactg ccttattttc agaagcatgt
     3781 cttcattcaa agcttaggct tcaatagaaa ttcagactaa tcactgaaat gactatttca
     3841 aactagtgaa atatctggga aataaactgc ttcaaaaata ttttactgac atgaattttg
     3901 ctagtgaata caaatacact gcctcaaata aggccatgta tgaatgaact tacaagatat
     3961 ttgagttaat cagtgtttgc atatagagaa ttagttctaa agttcttaaa aataaattta
     4021 ggggctccct gaaattttat ttaatacttt gctaacttac actcttgttt tatctccaca
     4081 ggtacatttt aggttagctc atggtgaatt ctatttacaa taagtggagc ttggattaat
     4141 gggttttgtt atgaattatc ttagtgactt tagacactgt ttccatttga tttttaacta
     4201 tttaaaatac caaattaaat accagtttgt tggttgttac ttttaaatga ttgttacttt
     4261 aacagtgtcc cttcttaaca catggggtta caaataaaat actatgcata gtttactatc
     4321 tacgtaaagc actgaacttt ttaccttagt agtttttatt tattacccta tgtaaacatt
     4381 taggataata ctctttcctc tatttatgct gagagtctac taatcattgg caaagtatga
     4441 gtccctatac tctgttaaaa aaagctcact gttaaagtat agggagaata gtaatccctc
     4501 atgaatccca gctagattcc aatttgggtt actaaattgt attttaatca ttttgtaatt
     4561 tcagtatggc tctttgttct caaacacata cataccacca cgcacattct tttaaacagc
     4621 tgccacacct cacctccaac agaatgccaa aaatgaaatg ttaaaaaatt ttgtctaatg
     4681 aagggttacg gcttggaaca cttggttatt catgttatgt aaatcaagaa gtgcatgcca
     4741 tcagcaaatt aaaatgtgga ctggctttga agactgttaa
//
