LOCUS       NP_036381                205 aa            linear   PRI 04-APR-2024
DEFINITION  rho-related GTP-binding protein RhoQ [Homo sapiens].
ACCESSION   NP_036381
VERSION     NP_036381.2
DBSOURCE    REFSEQ: accession NM_012249.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 205)
  AUTHORS   Bridges,E., Sheldon,H., Kleibeuker,E., Ramberger,E., Zois,C.,
            Barnard,A., Harjes,U., Li,J.L., Masiero,M., MacLaren,R. and
            Harris,A.
  TITLE     RHOQ is induced by DLL4 and regulates angiogenesis by determining
            the intracellular route of the Notch intracellular domain
  JOURNAL   Angiogenesis 23 (3), 493-513 (2020)
   PUBMED   32506201
  REMARK    GeneRIF: RHOQ is induced by DLL4 and regulates angiogenesis by
            determining the intracellular route of the Notch intracellular
            domain.
REFERENCE   2  (residues 1 to 205)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 205)
  AUTHORS   Han,S.W., Kim,H.P., Shin,J.Y., Jeong,E.G., Lee,W.C., Kim,K.Y.,
            Park,S.Y., Lee,D.W., Won,J.K., Jeong,S.Y., Park,K.J., Park,J.G.,
            Kang,G.H., Seo,J.S., Kim,J.I. and Kim,T.Y.
  TITLE     RNA editing in RHOQ promotes invasion potential in colorectal
            cancer
  JOURNAL   J Exp Med 211 (4), 613-621 (2014)
   PUBMED   24663214
  REMARK    GeneRIF: Novel tumor-associated increase of RNA editing in ras
            homologue family member Q (RHOQ) transcripts, is reported.
REFERENCE   4  (residues 1 to 205)
  AUTHORS   Mayer,S., Kumar,R., Jaiswal,M., Soykan,T., Ahmadian,M.R., Brose,N.,
            Betz,H., Rhee,J.S. and Papadopoulos,T.
  TITLE     Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin
            clustering and hippocampal GABAergic neurotransmission
  JOURNAL   Proc Natl Acad Sci U S A 110 (51), 20795-20800 (2013)
   PUBMED   24297911
  REMARK    GeneRIF: The enhancement of Cb-induced gephyrin clustering by
            GTP-TC10 does not depend on the guanine nucleotide exchange
            activity of Cb but involves an interaction that resembles reported
            interactions of other small GTPases with their effectors
REFERENCE   5  (residues 1 to 205)
  AUTHORS   Fujita,A., Koinuma,S., Yasuda,S., Nagai,H., Kamiguchi,H., Wada,N.
            and Nakamura,T.
  TITLE     GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic
            fusion of Rab11- and L1-containing vesicles by releasing exocyst
            component Exo70
  JOURNAL   PLoS One 8 (11), e79689 (2013)
   PUBMED   24223996
  REMARK    GeneRIF: Exocytosis of Rab11- and L1-positive vesicles may play a
            central role in TC10-mediated neurite outgrowth
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 205)
  AUTHORS   Michaelson,D., Silletti,J., Murphy,G., D'Eustachio,P., Rush,M. and
            Philips,M.R.
  TITLE     Differential localization of Rho GTPases in live cells: regulation
            by hypervariable regions and RhoGDI binding
  JOURNAL   J Cell Biol 152 (1), 111-126 (2001)
   PUBMED   11149925
REFERENCE   7  (residues 1 to 205)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   8  (residues 1 to 205)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
REFERENCE   9  (residues 1 to 205)
  AUTHORS   Murphy,G.A., Solski,P.A., Jillian,S.A., Perez de la Ossa,P.,
            D'Eustachio,P., Der,C.J. and Rush,M.G.
  TITLE     Cellular functions of TC10, a Rho family GTPase: regulation of
            morphology, signal transduction and cell growth
  JOURNAL   Oncogene 18 (26), 3831-3845 (1999)
   PUBMED   10445846
REFERENCE   10 (residues 1 to 205)
  AUTHORS   Drivas,G.T., Shih,A., Coutavas,E., Rush,M.G. and D'Eustachio,P.
  TITLE     Characterization of four novel ras-like genes expressed in a human
            teratocarcinoma cell line
  JOURNAL   Mol Cell Biol 10 (4), 1793-1798 (1990)
   PUBMED   2108320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018682.4 and BC056154.1.
            
            On Jul 13, 2004 this sequence version replaced NP_036381.1.
            
            Summary: This gene encodes a member of the Rho family of small
            GTPases, which cycle between inactive GDP-bound and active
            GTP-bound states and function as molecular switches in signal
            transduction cascades. Rho proteins promote reorganization of the
            actin cytoskeleton and regulate cell shape, attachment, and
            motility. The encoded protein is an important signalling protein
            for sarcomere assembly and has been shown to play a significant
            role in the exocytosis of the solute carrier family 2, facilitated
            glucose transporter member 4 and other proteins, possibly acting as
            the signal that turns on the membrane fusion machinery. Three
            related pseudogene have been identified on chromosomes 2 and 14.
            [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU794657.1, SRR1660807.165339.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238738.9/ ENSP00000238738.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..205
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     Protein         1..205
                     /product="rho-related GTP-binding protein RhoQ"
                     /note="RAS-like, family 7, member A; ras-like protein
                     TC10; ras-like protein family member 7A; ras homolog gene
                     family, member Q; epididymis secretory protein Li 42"
                     /calculated_mol_wt=22528
     mat_peptide     1..202
                     /product="Rho-related GTP-binding protein RhoQ.
                     /id=PRO_0000198871"
                     /note="propagated from UniProtKB/Swiss-Prot (P17081.2)"
                     /calculated_mol_wt=22332
     Region          10..183
                     /region_name="Tc10"
                     /note="Rho GTPase TC10 (Tc10); cd04135"
                     /db_xref="CDD:206707"
     Site            order(11,41..42,45..46,48,50,58,62..63,65..67,73,76)
                     /site_type="other"
                     /note="putative GEF (guanine nucleotide exchange factor)
                     interaction site [polypeptide binding]"
                     /db_xref="CDD:206707"
     Site            16..23
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206707"
     Site            order(19..24,63..64,66,122,124,165..166)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206707"
     Region          38..46
                     /region_name="Effector region. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P17081.2)"
     Site            40..46
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206707"
     Site            41
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206707"
     Site            order(42,65,73,75)
                     /site_type="active"
                     /note="putative GDI (guanine nucleotide dissociation
                     inhibitor) interaction [active]"
                     /db_xref="CDD:206707"
     Site            order(42..43,67,73)
                     /site_type="other"
                     /note="putative GAP (GTPase-activating protein)
                     interaction site [polypeptide binding]"
                     /db_xref="CDD:206707"
     Site            order(43..44,73,76)
                     /site_type="active"
                     /note="putative effector interaction site [active]"
                     /db_xref="CDD:206707"
     Site            63..66
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206707"
     Site            order(66..67,73..76,81..83)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206707"
     Site            121..124
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206707"
     Site            164..166
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206707"
     Site            202
                     /site_type="methylation"
                     /note="Cysteine methyl ester. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P17081.2)"
     CDS             1..205
                     /gene="RHOQ"
                     /gene_synonym="ARHQ; HEL-S-42; RASL7A; TC10; TC10A"
                     /coded_by="NM_012249.4:558..1175"
                     /db_xref="CCDS:CCDS33191.1"
                     /db_xref="GeneID:23433"
                     /db_xref="HGNC:HGNC:17736"
                     /db_xref="MIM:605857"
ORIGIN      
        1 mahgpgalml kcvvvgdgav gktcllmsya ndafpeeyvp tvfdhyavsv tvggkqyllg
       61 lydtagqedy drlrplsypm tdvflicfsv vnpasfqnvk eewvpelkey apnvpfllig
      121 tqidlrddpk tlarlndmke kpicveqgqk lakeigaccy vecsaltqkg lktvfdeaii
      181 ailtpkkhtv kkrigsrcin cclit
//
