LOCUS       NM_004310               4181 bp    mRNA    linear   PRI 09-DEC-2024
DEFINITION  Homo sapiens ras homolog family member H (RHOH), transcript variant
            6, mRNA.
ACCESSION   NM_004310
VERSION     NM_004310.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4181)
  AUTHORS   He,J., Tang,J., Feng,Q., Li,T., Wu,K., Yang,K., Jia,D. and Xia,Q.
  TITLE     Weighted gene co-expression network analysis identifies RHOH and
            TRAF1 as key candidate genes for psoriatic arthritis
  JOURNAL   Clin Rheumatol 40 (4), 1381-1391 (2021)
   PUBMED   32959187
  REMARK    GeneRIF: Weighted gene co-expression network analysis identifies
            RHOH and TRAF1 as key candidate genes for psoriatic arthritis.
REFERENCE   2  (bases 1 to 4181)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4181)
  AUTHORS   Ni,J., Shi,Q.Q., Wu,W., Sun,X., Fang,Y.Z. and Gu,J.
  TITLE     [Expression Difference of RhoH Gene in Leukemia and Its Clinical
            Significance]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 27 (3), 758-762 (2019)
   PUBMED   31204928
  REMARK    GeneRIF: In AML, RhoH expression negatively correlates with
            recurrence rate, which can be used as a prognostic indicator
            independently
REFERENCE   4  (bases 1 to 4181)
  AUTHORS   Tajadura-Ortega,V., Garg,R., Allen,R., Owczarek,C., Bright,M.D.,
            Kean,S., Mohd-Noor,A., Grigoriadis,A., Elston,T.C., Hahn,K.M. and
            Ridley,A.J.
  TITLE     An RNAi screen of Rho signalling networks identifies RhoH as a
            regulator of Rac1 in prostate cancer cell migration
  JOURNAL   BMC Biol 16 (1), 29 (2018)
   PUBMED   29510700
  REMARK    GeneRIF: RhoH promotes prostate cancer cell migration and RhoH
            expression levels correlate with prostate cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4181)
  AUTHORS   Lahousse,S., Smorowski,A.L., Denis,C., Lantoine,D., Kerckaert,J.P.
            and Galiegue-Zouitina,S.
  TITLE     Structural features of hematopoiesis-specific RhoH/ARHH gene: high
            diversity of 5'-UTR in different hematopoietic lineages suggests a
            complex post-transcriptional regulation
  JOURNAL   Gene 343 (1), 55-68 (2004)
   PUBMED   15563831
  REMARK    GeneRIF: 5' end heterogeneity of RhoH mRNAs was observed, due to
            alternative splicing of some 5' exons and to the use of these
            different transcription start sites.
REFERENCE   6  (bases 1 to 4181)
  AUTHORS   Faure,J. and Dagher,M.C.
  TITLE     Interactions between Rho GTPases and Rho GDP dissociation inhibitor
            (Rho-GDI)
  JOURNAL   Biochimie 83 (5), 409-414 (2001)
   PUBMED   11368848
REFERENCE   7  (bases 1 to 4181)
  AUTHORS   Yousefi,S., Cooper,P.R., Mueck,B., Potter,S.L. and Jarai,G.
  TITLE     cDNA representational difference analysis of human neutrophils
            stimulated by GM-CSF
  JOURNAL   Biochem Biophys Res Commun 277 (2), 401-409 (2000)
   PUBMED   11032736
REFERENCE   8  (bases 1 to 4181)
  AUTHORS   Preudhomme,C., Roumier,C., Hildebrand,M.P., Dallery-Prudhomme,E.,
            Lantoine,D., Lai,J.L., Daudignon,A., Adenis,C., Bauters,F.,
            Fenaux,P., Kerckaert,J.P. and Galiegue-Zouitina,S.
  TITLE     Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a
            GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma
  JOURNAL   Oncogene 19 (16), 2023-2032 (2000)
   PUBMED   10803463
REFERENCE   9  (bases 1 to 4181)
  AUTHORS   Dallery-Prudhomme,E., Roumier,C., Denis,C., Preudhomme,C.,
            Kerckaert,J.P. and Galiegue-Zouitina,S.
  TITLE     Genomic structure and assignment of the RhoH/TTF small GTPase gene
            (ARHH) to 4p13 by in situ hybridization
  JOURNAL   Genomics 43 (1), 89-94 (1997)
   PUBMED   9226377
REFERENCE   10 (bases 1 to 4181)
  AUTHORS   Dallery,E., Galiegue-Zouitina,S., Collyn-d'Hooghe,M., Quief,S.,
            Denis,C., Hildebrand,M.P., Lantoine,D., Deweindt,C., Tilly,H.,
            Bastard,C. et al.
  TITLE     TTF, a gene encoding a novel small G protein, fuses to the
            lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation
  JOURNAL   Oncogene 10 (11), 2171-2178 (1995)
   PUBMED   7784061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA906265.1, BC014261.2,
            BX413967.2, AA767445.1 and AC095057.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004310.4.
            
            Summary: The protein encoded by this gene is a member of the Ras
            superfamily of guanosine triphosphate (GTP)-metabolizing enzymes.
            The encoded protein is expressed in hematopoietic cells, where it
            functions as a negative regulator of cell growth and survival. This
            gene may be hypermutated or misexpressed in leukemias and
            lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma
            occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on
            chromosome 3, leading to the production of fusion transcripts.
            Alternative splicing in the 5' untranslated region results in
            multiple transcript variants that encode the same protein.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (6) lacks an exon in the 5' UTR,
            compared to variant 1. Variants 1 through 12 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP271287.1, SRR1163657.341450.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381799.10/ ENSP00000371219.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                DA906265.1         126-193
            69-1449             BC014261.2         1-1381
            1450-1872           BX413967.2         1-423               c
            1873-1978           AA767445.1         1-106               c
            1979-4181           AC095057.3         116600-118802
FEATURES             Location/Qualifiers
     source          1..4181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..4181
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="ras homolog family member H"
                     /db_xref="GeneID:399"
                     /db_xref="HGNC:HGNC:686"
                     /db_xref="MIM:602037"
     exon            1..270
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     exon            271..391
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     exon            392..4181
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..1176
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="rho-related GTP-binding protein RhoH; TTF,
                     translocation three four; GTP-binding protein TTF; ras
                     homolog gene family, member H"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoH precursor"
                     /protein_id="NP_004301.1"
                     /db_xref="CCDS:CCDS3458.1"
                     /db_xref="GeneID:399"
                     /db_xref="HGNC:HGNC:686"
                     /db_xref="MIM:602037"
                     /translation="MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVD
                     VFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEI
                     RSNLPCTPVLVVATQTDQREMGPHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQ
                     QVFECAVRTAVNQARRRNRRRLFSINECKIF"
     regulatory      1423..1428
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: ATTAAA"
     polyA_site      1449
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="major polyA site"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: AATGAA"
     polyA_site      1742
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: AATACA"
     polyA_site      1806
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="major polyA site"
     regulatory      1851..1856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: GATAAA"
     polyA_site      1875
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
     regulatory      2110..2115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: TATAAA"
     polyA_site      2129
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
     regulatory      4163..4168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: ATTAAA"
     polyA_site      4181
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
ORIGIN      
        1 gtcacattcg gattgctcct gctgccccac acacactaac ccaaccatct tggggtggac
       61 tccctgccag cccaactgtt gtattttcag ttcttccagt gtgaatcagt taatattctc
      121 gggaacgagg gagaggttga tcctatgagg aaatcaacca cagtgaaaag gcttgggccg
      181 cttttgtttt cacctgcttt tgttgaacaa atttgatttc cggagtcagt cattttactg
      241 tcaagacatt tcttcggcat tctgcaacag tttccaacat ggctagatcc atcagaaact
      301 gaagccgtgg agaacgctct cggggccttt gccacttctt ggagtagaag ccgacagaga
      361 gctgtttgga aacttctcct tcacacacca gttgaagact aggctttgga ggttttcaaa
      421 gcagacggtg cttggatggg cagggagaag taacattctg caaatcgccg tcagaggtcc
      481 tgaggacaca gacctacctg gcttgcattc cccttgctga atggcgtgtg ctgcagctgc
      541 ccactgaggg ctcttttccc tgggattctg gacttcagag taggacagca ggctgggaag
      601 atgctgagtt ccatcaagtg cgtgttggtg ggcgactctg ctgtggggaa aacctctctg
      661 ttggtgcgct tcacctccga gaccttcccg gaggcctaca agcccacagt gtacgagaac
      721 acaggggtgg acgtcttcat ggatggcatc cagatcagcc tgggcctctg ggacacagcc
      781 ggcaatgacg ccttcagaag catccggccc ctgtcctacc agcaggcaga cgtggtgctg
      841 atgtgctact ctgtggccaa ccataactca ttcctgaact tgaagaacaa gtggattggt
      901 gaaattagga gcaacttgcc ctgtacccct gtgctggtgg tggccaccca gactgaccag
      961 cgggagatgg ggccccacag ggcctcctgc gtcaatgcca tggaagggaa gaaactggcc
     1021 caggatgtca gagccaaggg ctacctggag tgctcagccc ttagcaatcg gggagtacag
     1081 caggtgtttg agtgcgccgt ccgaactgcc gtcaaccagg ccaggagacg aaacagaagg
     1141 aggctcttct ccatcaatga gtgcaagatc ttctaaaccc caagagactt cacacaacac
     1201 ttatgtatgc accccaaaga ctaatgggga gagggagggc cgggaagcca ggaaagcttg
     1261 gtgttttctc tgggtacacc ccaagcagcg tctccttttg gatacagtta ttgatgaggc
     1321 ttggccactg gatgttttca ctaactacac tctacaagtg aactccttgc ccaggccagt
     1381 tagaaaatcc cttggggaac tgtgatgaat attccatctt tgattaaaaa agtgaaatag
     1441 tctccataat tttggacgat gaagtgagtt tttcaaagaa ttccatattt aaagacacat
     1501 tttatttaac taataacaaa atgtattgct tttgtatata tttagttttc acacttggaa
     1561 aatcttttcc tacatcctcg aaaacataaa ctcctctgtg agtgaaatgc ttgtacgaag
     1621 ctctgccata tgtttgtagt gttattattt tcacctcaag tagaaagtct gttgaaacca
     1681 cttggctgct ggatttaaat gggtaatcaa atttaaaaat gaccataaat gaatctttgc
     1741 aatttgtttt ctacttacct gttattcaca gttggatata aaatacagtt ccataagata
     1801 tcctaatact gcctaatgat tttaaagtta tcactatatt tttctgaaat gataaaacat
     1861 cattcattta tttactatat tgtctttcac tcaactccag ttatgcacta aatattctcc
     1921 tctcattcac caagattgat tgaaacacca tctttcaggt agagaatcag actgctccaa
     1981 gcaatggcaa cagaacttgg aacagaagca agagagtgtc actttcactt ctggtagggt
     2041 ggttcccagg cgactgcagg tcctgtgaaa gacaggggtc tcaaagttct gttaatttca
     2101 caaatttgtt ataaatttgt ctaaactgag ctgttgtggc aacataattt atgaatcgta
     2161 aggtctagtt aggcttattg gggggatatc tacatatata tgtgtatgta agggaaaaaa
     2221 ggtagaattt acagccttca aaaaagaaaa atcaaattcc aagcacagga ataagaaagc
     2281 tatatagcaa ctgctcagag aacagaaagt tatcagggga aatactgaat aaatagacac
     2341 acacatactc gcacacaacc tgctctcaca cacacaactc aaacctcatt ctatcgaata
     2401 gtttaaaagc aatggtgttg ctcatctgtt aaagtggaga acagaggact acataactta
     2461 aggtagaaat tgcaaaggct gggttgggca gggcgtggtg gctcactttg ggaggctgag
     2521 acgggtggat cacgaggcca ggagttcaag accagcctgg ccaacatggt gaaaccccgt
     2581 ctcttctaaa tattagctaa aaattagctg ggtgtggtgg cacatgcctg tagttctagc
     2641 tactcaagag gctgaggcaa aagaattgct cgaacctggg aggcggaggt tgcagtaagc
     2701 caagatcgcg ccactgcact ccagcctggg caacagaggg agactccatc tcaaaaaaaa
     2761 aaaaaagaaa agaaaaaaaa gaaagaaatt gcaaaggctg gcacctagat agatcaatca
     2821 attactgccc taatcaaaac ttagaaacac tctgaaccac ctttatgaag gtacatcatt
     2881 gttatggggt aacgtgacta ttacacacaa aaggtaaggt ggctggcata aatgactttg
     2941 attagaatta tgttgacata gccaaaccag tttctctgtt cccttgtgtg gtcaattcct
     3001 tacagctata atcagtatca aaaaccaaat gtgtgctcat tcacacattg ctttctcctt
     3061 ctctctctcc tcctatccac agccagtaaa aggcctggga ccggggtctt gatctctggt
     3121 gggaggattg cctcggttcc ctggggctga cacagctgcc ttcactcaga cttctctgct
     3181 ctccaggcgg tggcttgtac tcacctctaa gtcacccgcc tcccttgatt ggagagcccg
     3241 tgtctctagt tctcagctca gggttggggg gcttgaaaga tgaccgggca ggggagggga
     3301 agggatctca tatcctctga tatccctggg attctcttct tctccctcaa cccacagagt
     3361 cttaaatcac ggatgcgggt gttcagggcc agcctttgcc atgagaggta tttaacatgt
     3421 cagtgggaag gaatttctat tcactgcagt gggctgtccc ccaggctttt ctttctctct
     3481 tgttgaagag agatgggggt gggtatctga aagtgggaag ggccaccata catgatccta
     3541 agtgaaggaa gaggaggtgg ttccacggtg gcagcagagc aggaagggaa ggccagagag
     3601 ggcacactca aatggctttg ctgtcacctg ggcaaagaca cacaggtgag acctccacct
     3661 gttggcggga gccaagctta acagctccgt ctgggaactc tcatacctga gaccaggaat
     3721 ctatgtgtaa accctttcca gtggcagaat ctggcagaaa tggagccgat aagtgtctgt
     3781 cttcctgcta gactgctgtt cttgaaggta gcactgcctc ctggtctcct cagtgtcccc
     3841 agggctcagc acagggaagg caatggaggt aaagttgtgt taaactgaaa tggagagaaa
     3901 gacagtaatt gggcttctgt gccacacagt ggttatagaa agcaagcaga ccctcaccag
     3961 ccttgtaggg gtaagaagaa aaataggtca tatgggtaga atccgtgtgt tgtgtgttct
     4021 acataagcac atacttactt ttgcctgcct agatgcagac acaggtttct tatacttcaa
     4081 aatttgtggt acctttttgt agactattgc atatcgattc ttaactattc caagtagcag
     4141 cattaaatat gttcttgatg acattaaaga gttaattttc a
//
