LOCUS       NM_001278365            4276 bp    mRNA    linear   PRI 09-DEC-2024
DEFINITION  Homo sapiens ras homolog family member H (RHOH), transcript variant
            8, mRNA.
ACCESSION   NM_001278365
VERSION     NM_001278365.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4276)
  AUTHORS   He,J., Tang,J., Feng,Q., Li,T., Wu,K., Yang,K., Jia,D. and Xia,Q.
  TITLE     Weighted gene co-expression network analysis identifies RHOH and
            TRAF1 as key candidate genes for psoriatic arthritis
  JOURNAL   Clin Rheumatol 40 (4), 1381-1391 (2021)
   PUBMED   32959187
  REMARK    GeneRIF: Weighted gene co-expression network analysis identifies
            RHOH and TRAF1 as key candidate genes for psoriatic arthritis.
REFERENCE   2  (bases 1 to 4276)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4276)
  AUTHORS   Ni,J., Shi,Q.Q., Wu,W., Sun,X., Fang,Y.Z. and Gu,J.
  TITLE     [Expression Difference of RhoH Gene in Leukemia and Its Clinical
            Significance]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 27 (3), 758-762 (2019)
   PUBMED   31204928
  REMARK    GeneRIF: In AML, RhoH expression negatively correlates with
            recurrence rate, which can be used as a prognostic indicator
            independently
REFERENCE   4  (bases 1 to 4276)
  AUTHORS   Tajadura-Ortega,V., Garg,R., Allen,R., Owczarek,C., Bright,M.D.,
            Kean,S., Mohd-Noor,A., Grigoriadis,A., Elston,T.C., Hahn,K.M. and
            Ridley,A.J.
  TITLE     An RNAi screen of Rho signalling networks identifies RhoH as a
            regulator of Rac1 in prostate cancer cell migration
  JOURNAL   BMC Biol 16 (1), 29 (2018)
   PUBMED   29510700
  REMARK    GeneRIF: RhoH promotes prostate cancer cell migration and RhoH
            expression levels correlate with prostate cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4276)
  AUTHORS   Lahousse,S., Smorowski,A.L., Denis,C., Lantoine,D., Kerckaert,J.P.
            and Galiegue-Zouitina,S.
  TITLE     Structural features of hematopoiesis-specific RhoH/ARHH gene: high
            diversity of 5'-UTR in different hematopoietic lineages suggests a
            complex post-transcriptional regulation
  JOURNAL   Gene 343 (1), 55-68 (2004)
   PUBMED   15563831
  REMARK    GeneRIF: 5' end heterogeneity of RhoH mRNAs was observed, due to
            alternative splicing of some 5' exons and to the use of these
            different transcription start sites.
REFERENCE   6  (bases 1 to 4276)
  AUTHORS   Faure,J. and Dagher,M.C.
  TITLE     Interactions between Rho GTPases and Rho GDP dissociation inhibitor
            (Rho-GDI)
  JOURNAL   Biochimie 83 (5), 409-414 (2001)
   PUBMED   11368848
REFERENCE   7  (bases 1 to 4276)
  AUTHORS   Yousefi,S., Cooper,P.R., Mueck,B., Potter,S.L. and Jarai,G.
  TITLE     cDNA representational difference analysis of human neutrophils
            stimulated by GM-CSF
  JOURNAL   Biochem Biophys Res Commun 277 (2), 401-409 (2000)
   PUBMED   11032736
REFERENCE   8  (bases 1 to 4276)
  AUTHORS   Preudhomme,C., Roumier,C., Hildebrand,M.P., Dallery-Prudhomme,E.,
            Lantoine,D., Lai,J.L., Daudignon,A., Adenis,C., Bauters,F.,
            Fenaux,P., Kerckaert,J.P. and Galiegue-Zouitina,S.
  TITLE     Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a
            GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma
  JOURNAL   Oncogene 19 (16), 2023-2032 (2000)
   PUBMED   10803463
REFERENCE   9  (bases 1 to 4276)
  AUTHORS   Dallery-Prudhomme,E., Roumier,C., Denis,C., Preudhomme,C.,
            Kerckaert,J.P. and Galiegue-Zouitina,S.
  TITLE     Genomic structure and assignment of the RhoH/TTF small GTPase gene
            (ARHH) to 4p13 by in situ hybridization
  JOURNAL   Genomics 43 (1), 89-94 (1997)
   PUBMED   9226377
REFERENCE   10 (bases 1 to 4276)
  AUTHORS   Dallery,E., Galiegue-Zouitina,S., Collyn-d'Hooghe,M., Quief,S.,
            Denis,C., Hildebrand,M.P., Lantoine,D., Deweindt,C., Tilly,H.,
            Bastard,C. et al.
  TITLE     TTF, a gene encoding a novel small G protein, fuses to the
            lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation
  JOURNAL   Oncogene 10 (11), 2171-2178 (1995)
   PUBMED   7784061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC095057.3, BI818548.1,
            DA951252.1, DA906265.1, BC014261.2, BX413967.2 and AA767445.1.
            
            On May 31, 2019 this sequence version replaced NM_001278365.1.
            
            Summary: The protein encoded by this gene is a member of the Ras
            superfamily of guanosine triphosphate (GTP)-metabolizing enzymes.
            The encoded protein is expressed in hematopoietic cells, where it
            functions as a negative regulator of cell growth and survival. This
            gene may be hypermutated or misexpressed in leukemias and
            lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma
            occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on
            chromosome 3, leading to the production of fusion transcripts.
            Alternative splicing in the 5' untranslated region results in
            multiple transcript variants that encode the same protein.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (8) differs in the 5' most exons
            and lacks an exon in the 5' UTR, compared to variant 1. Variants 1
            through 12 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1163658.147968.1, SRR1163658.288121.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1965299, SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC095057.3         64794-64806
            14-152              BI818548.1         5-143
            153-286             DA951252.1         145-278
            287-550             DA906265.1         317-580
            551-1544            BC014261.2         388-1381
            1545-1967           BX413967.2         1-423               c
            1968-2073           AA767445.1         1-106               c
            2074-4276           AC095057.3         116600-118802
FEATURES             Location/Qualifiers
     source          1..4276
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p14"
     gene            1..4276
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="ras homolog family member H"
                     /db_xref="GeneID:399"
                     /db_xref="HGNC:HGNC:686"
                     /db_xref="MIM:602037"
     exon            1..165
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     exon            166..365
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     exon            366..486
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     exon            487..4276
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /inference="alignment:Splign:2.1.0"
     CDS             696..1271
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="rho-related GTP-binding protein RhoH; TTF,
                     translocation three four; GTP-binding protein TTF; ras
                     homolog gene family, member H"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoH precursor"
                     /protein_id="NP_001265294.1"
                     /db_xref="CCDS:CCDS3458.1"
                     /db_xref="GeneID:399"
                     /db_xref="HGNC:HGNC:686"
                     /db_xref="MIM:602037"
                     /translation="MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVD
                     VFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEI
                     RSNLPCTPVLVVATQTDQREMGPHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQ
                     QVFECAVRTAVNQARRRNRRRLFSINECKIF"
     regulatory      1518..1523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: ATTAAA"
     polyA_site      1544
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="major polyA site"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: AATGAA"
     polyA_site      1837
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
     regulatory      1877..1882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: AATACA"
     polyA_site      1901
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="major polyA site"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: GATAAA"
     polyA_site      1970
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
     regulatory      2205..2210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: TATAAA"
     polyA_site      2224
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
                     /note="hexamer: ATTAAA"
     polyA_site      4276
                     /gene="RHOH"
                     /gene_synonym="ARHH; IMD129; TTF"
ORIGIN      
        1 agggtttaaa gtgtttacca taaagggcag ctgtgaggct gtgagatggg agaatcaatc
       61 tatttattgg tcagaaagtg gttgttcagt accttggatt tctgagtggg caaggctgga
      121 ccctgagccc tgggacctct gaagtgaaca ctgcagggcc atttgcccaa ctgttgtatt
      181 ttcagttctt ccagtgtgaa tcagttaata ttctcgggaa cgagggagag gttgatccta
      241 tgaggaaatc aaccacagtg aaaaggcttg ggccgctttt gttttcacct gcttttgttg
      301 aacaaatttg atttccggag tcagtcattt tactgtcaag acatttcttc ggcattctgc
      361 aacagtttcc aacatggcta gatccatcag aaactgaagc cgtggagaac gctctcgggg
      421 cctttgccac ttcttggagt agaagccgac agagagctgt ttggaaactt ctccttcaca
      481 caccagttga agactaggct ttggaggttt tcaaagcaga cggtgcttgg atgggcaggg
      541 agaagtaaca ttctgcaaat cgccgtcaga ggtcctgagg acacagacct acctggcttg
      601 cattcccctt gctgaatggc gtgtgctgca gctgcccact gagggctctt ttccctggga
      661 ttctggactt cagagtagga cagcaggctg ggaagatgct gagttccatc aagtgcgtgt
      721 tggtgggcga ctctgctgtg gggaaaacct ctctgttggt gcgcttcacc tccgagacct
      781 tcccggaggc ctacaagccc acagtgtacg agaacacagg ggtggacgtc ttcatggatg
      841 gcatccagat cagcctgggc ctctgggaca cagccggcaa tgacgccttc agaagcatcc
      901 ggcccctgtc ctaccagcag gcagacgtgg tgctgatgtg ctactctgtg gccaaccata
      961 actcattcct gaacttgaag aacaagtgga ttggtgaaat taggagcaac ttgccctgta
     1021 cccctgtgct ggtggtggcc acccagactg accagcggga gatggggccc cacagggcct
     1081 cctgcgtcaa tgccatggaa gggaagaaac tggcccagga tgtcagagcc aagggctacc
     1141 tggagtgctc agcccttagc aatcggggag tacagcaggt gtttgagtgc gccgtccgaa
     1201 ctgccgtcaa ccaggccagg agacgaaaca gaaggaggct cttctccatc aatgagtgca
     1261 agatcttcta aaccccaaga gacttcacac aacacttatg tatgcacccc aaagactaat
     1321 ggggagaggg agggccggga agccaggaaa gcttggtgtt ttctctgggt acaccccaag
     1381 cagcgtctcc ttttggatac agttattgat gaggcttggc cactggatgt tttcactaac
     1441 tacactctac aagtgaactc cttgcccagg ccagttagaa aatcccttgg ggaactgtga
     1501 tgaatattcc atctttgatt aaaaaagtga aatagtctcc ataattttgg acgatgaagt
     1561 gagtttttca aagaattcca tatttaaaga cacattttat ttaactaata acaaaatgta
     1621 ttgcttttgt atatatttag ttttcacact tggaaaatct tttcctacat cctcgaaaac
     1681 ataaactcct ctgtgagtga aatgcttgta cgaagctctg ccatatgttt gtagtgttat
     1741 tattttcacc tcaagtagaa agtctgttga aaccacttgg ctgctggatt taaatgggta
     1801 atcaaattta aaaatgacca taaatgaatc tttgcaattt gttttctact tacctgttat
     1861 tcacagttgg atataaaata cagttccata agatatccta atactgccta atgattttaa
     1921 agttatcact atatttttct gaaatgataa aacatcattc atttatttac tatattgtct
     1981 ttcactcaac tccagttatg cactaaatat tctcctctca ttcaccaaga ttgattgaaa
     2041 caccatcttt caggtagaga atcagactgc tccaagcaat ggcaacagaa cttggaacag
     2101 aagcaagaga gtgtcacttt cacttctggt agggtggttc ccaggcgact gcaggtcctg
     2161 tgaaagacag gggtctcaaa gttctgttaa tttcacaaat ttgttataaa tttgtctaaa
     2221 ctgagctgtt gtggcaacat aatttatgaa tcgtaaggtc tagttaggct tattgggggg
     2281 atatctacat atatatgtgt atgtaaggga aaaaaggtag aatttacagc cttcaaaaaa
     2341 gaaaaatcaa attccaagca caggaataag aaagctatat agcaactgct cagagaacag
     2401 aaagttatca ggggaaatac tgaataaata gacacacaca tactcgcaca caacctgctc
     2461 tcacacacac aactcaaacc tcattctatc gaatagttta aaagcaatgg tgttgctcat
     2521 ctgttaaagt ggagaacaga ggactacata acttaaggta gaaattgcaa aggctgggtt
     2581 gggcagggcg tggtggctca ctttgggagg ctgagacggg tggatcacga ggccaggagt
     2641 tcaagaccag cctggccaac atggtgaaac cccgtctctt ctaaatatta gctaaaaatt
     2701 agctgggtgt ggtggcacat gcctgtagtt ctagctactc aagaggctga ggcaaaagaa
     2761 ttgctcgaac ctgggaggcg gaggttgcag taagccaaga tcgcgccact gcactccagc
     2821 ctgggcaaca gagggagact ccatctcaaa aaaaaaaaaa agaaaagaaa aaaaagaaag
     2881 aaattgcaaa ggctggcacc tagatagatc aatcaattac tgccctaatc aaaacttaga
     2941 aacactctga accaccttta tgaaggtaca tcattgttat ggggtaacgt gactattaca
     3001 cacaaaaggt aaggtggctg gcataaatga ctttgattag aattatgttg acatagccaa
     3061 accagtttct ctgttccctt gtgtggtcaa ttccttacag ctataatcag tatcaaaaac
     3121 caaatgtgtg ctcattcaca cattgctttc tccttctctc tctcctccta tccacagcca
     3181 gtaaaaggcc tgggaccggg gtcttgatct ctggtgggag gattgcctcg gttccctggg
     3241 gctgacacag ctgccttcac tcagacttct ctgctctcca ggcggtggct tgtactcacc
     3301 tctaagtcac ccgcctccct tgattggaga gcccgtgtct ctagttctca gctcagggtt
     3361 ggggggcttg aaagatgacc gggcagggga ggggaaggga tctcatatcc tctgatatcc
     3421 ctgggattct cttcttctcc ctcaacccac agagtcttaa atcacggatg cgggtgttca
     3481 gggccagcct ttgccatgag aggtatttaa catgtcagtg ggaaggaatt tctattcact
     3541 gcagtgggct gtcccccagg cttttctttc tctcttgttg aagagagatg ggggtgggta
     3601 tctgaaagtg ggaagggcca ccatacatga tcctaagtga aggaagagga ggtggttcca
     3661 cggtggcagc agagcaggaa gggaaggcca gagagggcac actcaaatgg ctttgctgtc
     3721 acctgggcaa agacacacag gtgagacctc cacctgttgg cgggagccaa gcttaacagc
     3781 tccgtctggg aactctcata cctgagacca ggaatctatg tgtaaaccct ttccagtggc
     3841 agaatctggc agaaatggag ccgataagtg tctgtcttcc tgctagactg ctgttcttga
     3901 aggtagcact gcctcctggt ctcctcagtg tccccagggc tcagcacagg gaaggcaatg
     3961 gaggtaaagt tgtgttaaac tgaaatggag agaaagacag taattgggct tctgtgccac
     4021 acagtggtta tagaaagcaa gcagaccctc accagccttg taggggtaag aagaaaaata
     4081 ggtcatatgg gtagaatccg tgtgttgtgt gttctacata agcacatact tacttttgcc
     4141 tgcctagatg cagacacagg tttcttatac ttcaaaattt gtggtacctt tttgtagact
     4201 attgcatatc gattcttaac tattccaagt agcagcatta aatatgttct tgatgacatt
     4261 aaagagttaa ttttca
//
