LOCUS       NM_001665               1295 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens ras homolog family member G (RHOG), mRNA.
ACCESSION   NM_001665
VERSION     NM_001665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1295)
  AUTHORS   Kukimoto-Niino,M., Katsura,K., Ishizuka-Katsura,Y.,
            Mishima-Tsumagari,C., Yonemochi,M., Inoue,M., Nakagawa,R.,
            Kaushik,R., Zhang,K.Y.J. and Shirouzu,M.
  TITLE     RhoG facilitates a conformational transition in the guanine
            nucleotide exchange factor complex DOCK5/ELMO1 to an open state
  JOURNAL   J Biol Chem 300 (7), 107459 (2024)
   PUBMED   38857861
  REMARK    GeneRIF: RhoG facilitates a conformational transition in the
            guanine nucleotide exchange factor complex DOCK5/ELMO1 to an open
            state.
REFERENCE   2  (bases 1 to 1295)
  AUTHORS   Cai,S., Shi,C.J., Lu,J.X., Wang,Y.P., Yuan,T. and Wang,X.P.
  TITLE     miR-124-3p inhibits the viability and motility of glioblastoma
            multiforme by targeting RhoG
  JOURNAL   Int J Mol Med 47 (5) (2021)
   PUBMED   33649803
  REMARK    GeneRIF: miR1243p inhibits the viability and motility of
            glioblastoma multiforme by targeting RhoG.
REFERENCE   3  (bases 1 to 1295)
  AUTHORS   Kalinichenko,A., Perinetti Casoni,G., Dupre,L., Trotta,L.,
            Huemer,J., Galgano,D., German,Y., Haladik,B., Pazmandi,J.,
            Thian,M., Yuce Petronczki,O., Chiang,S.C., Taskinen,M., Hekkala,A.,
            Kauppila,S., Lindgren,O., Tapiainen,T., Kraakman,M.J.,
            Vettenranta,K., Lomakin,A.J., Saarela,J., Seppanen,M.R.J.,
            Bryceson,Y.T. and Boztug,K.
  TITLE     RhoG deficiency abrogates cytotoxicity of human lymphocytes and
            causes hemophagocytic lymphohistiocytosis
  JOURNAL   Blood 137 (15), 2033-2045 (2021)
   PUBMED   33513601
  REMARK    GeneRIF: RhoG deficiency abrogates cytotoxicity of human
            lymphocytes and causes hemophagocytic lymphohistiocytosis.
REFERENCE   4  (bases 1 to 1295)
  AUTHORS   Jun,J.H., Son,M.J., Lee,H.G., Shim,K.Y., Baek,W.K., Kim,J.Y. and
            Joo,C.K.
  TITLE     Regulation of Ras homolog family member G by microRNA-124 regulates
            proliferation and migration of human retinal pigment epithelial
            cells
  JOURNAL   Sci Rep 10 (1), 15420 (2020)
   PUBMED   32963317
  REMARK    GeneRIF: Regulation of Ras homolog family member G by microRNA-124
            regulates proliferation and migration of human retinal pigment
            epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1295)
  AUTHORS   Xu,Z.D., Hao,T. and Gan,Y.H.
  TITLE     RhoG/Rac1 signaling pathway involved in migration and invasion of
            salivary adenoid cystic carcinoma cells
  JOURNAL   Oral Dis 26 (2), 302-312 (2020)
   PUBMED   31793126
  REMARK    GeneRIF: RhoG/Rac1 signaling pathway was involved in salivary
            adenoid cystic carcinoma (SACC) cell migration and invasion.
            RhoG/Rac1 at least partially mediated epiregulin/Src/AKT/ERK1/2
            signaling to promote SACC cell migration and invasion.
REFERENCE   6  (bases 1 to 1295)
  AUTHORS   Le Gallic,L. and Fort,P.
  TITLE     Structure of the human ARHG locus encoding the Rho/Rac-like RhoG
            GTPase
  JOURNAL   Genomics 42 (1), 157-160 (1997)
   PUBMED   9177787
REFERENCE   7  (bases 1 to 1295)
  AUTHORS   Zalcman,G., Closson,V., Camonis,J., Honore,N., Rousseau-Merck,M.F.,
            Tavitian,A. and Olofsson,B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
REFERENCE   8  (bases 1 to 1295)
  AUTHORS   Taviaux,S.A., Vincent,S., Fort,P. and Demaille,J.G.
  TITLE     Localization of ARHG, a member of the RAS homolog gene family, to
            11p15.5-11p15.4 by fluorescence in situ hybridization
  JOURNAL   Genomics 16 (3), 788-790 (1993)
   PUBMED   8325658
REFERENCE   9  (bases 1 to 1295)
  AUTHORS   Miki,T., Smith,C.L., Long,J.E., Eva,A. and Fleming,T.P.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
REFERENCE   10 (bases 1 to 1295)
  AUTHORS   Vincent,S., Jeanteur,P. and Fort,P.
  TITLE     Growth-regulated expression of rhoG, a new member of the ras
            homolog gene family
  JOURNAL   Mol Cell Biol 12 (7), 3138-3148 (1992)
   PUBMED   1620121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB125569.1, BC104178.2 and AA424888.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001665.3.
            
            Summary: This gene encodes a member of the Rho family of small
            GTPases, which cycle between inactive GDP-bound and active
            GTP-bound states and function as molecular switches in signal
            transduction cascades. Rho proteins promote reorganization of the
            actin cytoskeleton and regulate cell shape, attachment, and
            motility. The encoded protein facilitates translocation of a
            functional guanine nucleotide exchange factor (GEF) complex from
            the cytoplasm to the plasma membrane where ras-related C3 botulinum
            toxin substrate 1 is activated to promote lamellipodium formation
            and cell migration. Two related pseudogene have been identified on
            chromosomes 20 and X. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP271543.1, BP252655.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000351018.5/ ENSP00000339467.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CB125569.1         25-73
            50-1004             BC104178.2         1-955
            1005-1295           AA424888.1         14-304              c
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1295
                     /gene="RHOG"
                     /gene_synonym="ARHG"
                     /note="ras homolog family member G"
                     /db_xref="GeneID:391"
                     /db_xref="HGNC:HGNC:672"
                     /db_xref="MIM:179505"
     exon            1..66
                     /gene="RHOG"
                     /gene_synonym="ARHG"
                     /inference="alignment:Splign:2.1.0"
     exon            67..1295
                     /gene="RHOG"
                     /gene_synonym="ARHG"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..710
                     /gene="RHOG"
                     /gene_synonym="ARHG"
                     /note="ras homolog gene family, member G (rho G)"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoG"
                     /protein_id="NP_001656.2"
                     /db_xref="CCDS:CCDS7748.1"
                     /db_xref="GeneID:391"
                     /db_xref="HGNC:HGNC:672"
                     /db_xref="MIM:179505"
                     /translation="MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQS
                     AVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVC
                     HHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSAL
                     QQDGVKEVFAEAVRAVLNPTPIKRGRSCILL"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOG"
                     /gene_synonym="ARHG"
                     /note="hexamer: AATAAA"
     polyA_site      1295
                     /gene="RHOG"
                     /gene_synonym="ARHG"
                     /note="major polyA site"
ORIGIN      
        1 acttccttct cgagcccgga gccgctgccg ccgcccccag ctcccccgcc tcggggaggg
       61 caccaggtca ctgcagccag aggggtccag aagagagagg aggcactgcc tccactacag
      121 caactgcacc cacgatgcag agcatcaagt gcgtggtggt gggtgatggg gctgtgggca
      181 agacgtgcct gctcatctgc tacacaacta acgctttccc caaagagtac atccccaccg
      241 tgttcgacaa ttacagcgcg cagagcgcag ttgacgggcg cacagtgaac ctgaacctgt
      301 gggacactgc gggccaggag gagtatgacc gcctccgtac actctcctac cctcagacca
      361 acgttttcgt catctgtttc tccattgcca gtccgccgtc ctatgagaac gtgcggcaca
      421 agtggcatcc agaggtgtgc caccactgcc ctgatgtgcc catcctgctg gtgggcacca
      481 agaaggacct gagagcccag cctgacaccc tacggcgcct caaggagcag ggccaggcgc
      541 ccatcacacc gcagcagggc caggcactgg ccaagcagat ccacgctgtg cgctacctcg
      601 aatgctcagc cctgcaacag gatggtgtca aggaagtgtt cgccgaggct gtccgggctg
      661 tgctcaaccc cacgccgatc aagcgtgggc ggtcctgcat cctcttgtga ccctggcact
      721 tggcttggag gctgcccctg ccctcccccc accagttgtg ccttggtgcc ttgtccgcct
      781 cagctgtgcc ttaaggacta attctggcac ccctttccag ggggttccct gaatgccttt
      841 ttctctgagt gcctttttct ccttaaggag gcctgcagag aaaggggctt tgggctctgc
      901 ccccctctgc ttgggaacac tgggtattct catgagctca tccaagccaa ggttggaccc
      961 ctccccaaga ggccaaccca gtgccccctc ccattttccg ctactgacca gttcatccag
     1021 ctttccacac agttgttgct gcctattgtg gtgccgcctc aggttagggg ctctcagcca
     1081 tctctaacct ctgccctcgc tgctcttgga attgcgcccc caagatgctc tctcccttct
     1141 ccaatgaggg agccacagaa tcctgagaag gtgaatgtgc cctaacctgc tcctctgtgc
     1201 ctaggcctta cgcatttgct gactgactca gcccccatgc ttctggggac ctttcctacc
     1261 cccatcagca tcaataaaac ctcctgtctc cagtg
//
