LOCUS       NM_019034               2435 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ras homolog family member F, filopodia associated
            (RHOF), mRNA.
ACCESSION   NM_019034
VERSION     NM_019034.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Fan,L., Yan,H., Pellegrin,S., Morigen and Mellor,H.
  TITLE     The Rif GTPase regulates cytoskeletal signaling from plexinA4 to
            promote neurite retraction
  JOURNAL   Neurosci Lett 590, 178-183 (2015)
   PUBMED   25668492
  REMARK    GeneRIF: Rif has two separate roles in FARP1 regulation-in
            controlling its association with plexinA4, and in releasing active
            RhoA from a plexinA4/FARP1 complex.
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Fan,L. and Mellor,H.
  TITLE     The small Rho GTPase Rif and actin cytoskeletal remodelling
  JOURNAL   Biochem Soc Trans 40 (1), 268-272 (2012)
   PUBMED   22260703
  REMARK    GeneRIF: In the present review, our aim is to summarize the current
            information about the Rif effectors and how Rif remodels actin
            cytoskeleton in many aspects. [Review]
            Review article
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Wong,A.R., Clements,A., Raymond,B., Crepin,V.F. and Frankel,G.
  TITLE     The interplay between the Escherichia coli Rho guanine nucleotide
            exchange factor effectors and the mammalian RhoGEF inhibitor EspH
  JOURNAL   mBio 3 (1), e00250-11 (2012)
   PUBMED   22251971
  REMARK    GeneRIF: The authors show that enteropathogenic Escherichia coli
            translocates EspH, which inactivates mammalian RhoGEFs and triggers
            cytotoxicity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Fan,L., Pellegrin,S., Scott,A. and Mellor,H.
  TITLE     The small GTPase Rif is an alternative trigger for the formation of
            actin stress fibers in epithelial cells
  JOURNAL   J Cell Sci 123 (Pt 8), 1247-1252 (2010)
   PUBMED   20233848
  REMARK    GeneRIF: Rif GTPase is an alternative trigger of stress-fiber
            formation in epithelial cells.
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Carbone,A., Bernardini,L., Valenzano,F., Bottillo,I., De Simone,C.,
            Capizzi,R., Capalbo,A., Romano,F., Novelli,A., Dallapiccola,B. and
            Amerio,P.
  TITLE     Array-based comparative genomic hybridization in early-stage
            mycosis fungoides: recurrent deletion of tumor suppressor genes
            BCL7A, SMAC/DIABLO, and RHOF
  JOURNAL   Genes Chromosomes Cancer 47 (12), 1067-1075 (2008)
   PUBMED   18663754
  REMARK    GeneRIF: deletion of genes RHOF in early-stage mycosis fungoides.
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Ellis,S. and Mellor,H.
  TITLE     The novel Rho-family GTPase rif regulates coordinated actin-based
            membrane rearrangements
  JOURNAL   Curr Biol 10 (21), 1387-1390 (2000)
   PUBMED   11084341
  REMARK    GeneRIF: The protein encoded by this gene causes the formation of
            long, actin-rich filopodia.  In combination with RAC1 and CDC42 it
            causes additional actin rearrangments, suggesting that this protein
            is intimately involved in regulation of the cytoskeleton.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG574506.1, BQ053707.1, BU527972.1, AK000254.1, BM830620.1,
            BQ422695.1 and CA426077.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019034.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.583563.1, AK000254.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267205.7/ ENSP00000267205.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BG574506.1         277-297
            22-23               BQ053707.1         3-4
            24-739              BU527972.1         6-721
            740-1469            AK000254.1         706-1435
            1470-1717           BM830620.1         111-358
            1718-1762           BM830620.1         360-404
            1763-2298           BQ422695.1         109-644
            2299-2435           CA426077.1         17-153              c
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2435
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /note="ras homolog family member F, filopodia associated"
                     /db_xref="GeneID:54509"
                     /db_xref="HGNC:HGNC:15703"
                     /db_xref="MIM:618867"
     exon            1..193
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..691
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /note="rho in filopodia; rho family GTPase Rif; ras
                     homolog gene family, member F (in filopodia); ras homolog
                     family member F (in filopodia)"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoF"
                     /protein_id="NP_061907.2"
                     /db_xref="CCDS:CCDS9222.1"
                     /db_xref="GeneID:54509"
                     /db_xref="HGNC:HGNC:15703"
                     /db_xref="MIM:618867"
                     /translation="MDAPGALAQTAAPGPGRKELKIVIVGDGGCGKTSLLMVYSQGSF
                     PEHYAPSVFEKYTASVTVGSKEVTLNLYDTAGQEDYDRLRPLSYQNTHLVLICYDVMN
                     PTSYDNVLIKWFPEVTHFCRGIPMVLIGCKTDLRKDKEQLRKLRAAQLEPITYMQGLS
                     ACEQIRAALYLECSAKFRENVEDVFREAAKVALSALKKAQRQKKRRLCLLL"
     exon            194..281
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /inference="alignment:Splign:2.1.0"
     exon            282..391
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /inference="alignment:Splign:2.1.0"
     exon            392..526
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /inference="alignment:Splign:2.1.0"
     exon            527..2435
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1006..1011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /note="hexamer: AATGAA"
     polyA_site      1014
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /note="major polyA site"
     polyA_site      1035
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /note="hexamer: AATAAA"
     polyA_site      2435
                     /gene="RHOF"
                     /gene_synonym="ARHF; RIF"
                     /note="major polyA site"
ORIGIN      
        1 ctcttggctc cgctagtgcc cggcgcgccg ccgccagtgc tgcgggctcc gggcaatgga
       61 tgcccccggg gccctggccc agaccgccgc ccccggtccg ggcaggaagg agctgaagat
      121 cgtgatcgtg ggcgacggcg gctgcggcaa gacctcgctg ctcatggtgt acagccaggg
      181 ctccttcccc gagcactacg ccccatcggt gttcgagaag tacacggcca gcgtgaccgt
      241 tggcagcaag gaggtgaccc tgaacctcta cgacacggcc gggcaagaag actatgaccg
      301 gctgcggccc ctgtcctacc agaacaccca cctcgtgctc atctgctatg acgtcatgaa
      361 tcccaccagc tacgacaacg tcctcatcaa gtggttccct gaggtcacgc atttctgccg
      421 cgggatcccc atggtgctca tcggctgcaa gacagacctg aggaaggaca aggagcagct
      481 gcggaagctc cgggccgccc agctggagcc catcacctac atgcagggcc tgagcgcctg
      541 cgaacagatc cgagctgctc tctacctgga atgttccgcc aagtttcggg agaatgtgga
      601 ggacgtcttc cgggaggccg ccaaggtggc tctcagcgct ctgaagaagg cgcaacggca
      661 gaagaagcgc cggctctgcc tgctgctctg acccagggca gacagacctc acgacagcac
      721 tgacagggcc cgggggccca ggtgccgatt gcaccaggga ggctgcccca tcccgaccct
      781 ccagctcatg gtgtctgggg cctgcggcta gactcttgga acattctgga actctctcct
      841 ttcctggctg gggctctgac cacaaactcc cctccaggct gcccctggga catggtggtg
      901 atgtgggtgc aggagccagt gtctgttgtc gggactcgca agtgccctca tcacagccac
      961 ccccaccacg agtgtctccc cagtgcagac tcaagttatg cttgaaatga aaaagtctat
     1021 ctggtagtgg gtaaacgtag acctggcact gttccacgcg ggcgccccaa gcctgccact
     1081 cctgtgtccc tgcctccctg ggctcccgag ataggcacca ctgtatcctc cagctccttc
     1141 cttccttccc ccaggaacac ggaggccacc gagggggctg ggcctatcag gaggacacag
     1201 gctgcagcct ggcacccacc cctcccatct ccaccccaca tggaagactt gtcttcaact
     1261 tggccactgt ctttgcagag ctgggcacat gtgcccaggg ggcagaaaaa atggcttctc
     1321 agttgttaaa agtataccct ggaccaccca tctgaccatc tccttaaggt ttcacccaaa
     1381 gcccccagtg tcagagactt gggatgggaa gaacagtcgg ctcccagtgt ggtcatgagc
     1441 aagttttctg tggactgttc cccccactgt ggtaggacag gactggccca cttagtcctc
     1501 aagctcccaa cctgctgtcc ctcaagcccc gcttctacca gcctgtggag ttcaggaggc
     1561 gagacatcct ggcctccttt gagaactgat gggatctacc ccctgtccac gcgggacagt
     1621 ttctcagaac tggttcatag accacctgtg tcaccaacag ccagatacct aatccctgag
     1681 cctcctttgg gaaggtctgg ggccgagggt ctgggaattt tttttttttt ttttttttgg
     1741 gacagagtct cattctgtca ctcaggctag agtgcagtgg catgatcttg gctcactgca
     1801 agctccacct cctgggttca agcgattctc ttgcctcagc ctcctgagta gctgggacta
     1861 catgcgcaca ccaccacgtc cggctaattt ttgtattttt agtagagaca gggtttcacc
     1921 atgttggcca ggctggtctt gaactcctga cctcgtgatc cacccgcctt agcctcccaa
     1981 agtgctggga ttacaggcgt gagccaccgt gcccggccca ggacttttaa aacaagcatc
     2041 ccaggggatt ccggtgccta ccagaagtcg caagctgctt ggctctggag ggcgcctagg
     2101 agtcggtgtc gcctaagatg ggataatggc ttcaggcaac tcctagcctt ccccatatct
     2161 cctgcctcag cccccctggc ccagtgctgg ggcgtcagct aaacctgagc ttccaagaag
     2221 tcaggttgcc aaaggaagga gccttctgag accctcccca acccacccag gttcccaagg
     2281 ccctgccgta ccctggggaa tcaaccaagg agttcttgtt ctcgaagaac cccaggcctc
     2341 atgatggtct acggtagagg tccaacaact acagcctgtg ggccacatct ggccacagcc
     2401 tgatttgtaa ataaagtttt attggaacac agcaa
//
