LOCUS       NM_175744               1117 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ras homolog family member C (RHOC), transcript variant
            1, mRNA.
ACCESSION   NM_175744
VERSION     NM_175744.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1117)
  AUTHORS   Yang,B., Wang,L. and Tian,Z.
  TITLE     Silencing of RhoC induces macrophage M1 polarization to inhibit
            migration and invasion in colon cancer via regulating the
            PTEN/FOXO1 pathway
  JOURNAL   Int J Exp Pathol 104 (1), 33-42 (2023)
   PUBMED   36576072
  REMARK    GeneRIF: Silencing of RhoC induces macrophage M1 polarization to
            inhibit migration and invasion in colon cancer via regulating the
            PTEN/FOXO1 pathway.
REFERENCE   2  (bases 1 to 1117)
  AUTHORS   Thomas,P., Srivastava,S., Udayashankara,A.H., Damodaran,S.,
            Yadav,L., Mathew,B., Suresh,S.B., Mandal,A.K. and Srikantia,N.
  TITLE     RhoC in association with TET2/WDR5 regulates cancer stem cells by
            epigenetically modifying the expression of pluripotency genes
  JOURNAL   Cell Mol Life Sci 80 (1), 1 (2022)
   PUBMED   36469134
  REMARK    GeneRIF: RhoC in association with TET2/WDR5 regulates cancer stem
            cells by epigenetically modifying the expression of pluripotency
            genes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1117)
  AUTHORS   Liu,X., Wang,M., Zhang,L. and Huang,L.
  TITLE     LncRNA ZFAS1 contributes to osteosarcoma progression via miR-520b
            and miR-520e-mediated inhibition of RHOC signaling
  JOURNAL   Clinics (Sao Paulo) 78, 100143 (2022)
   PUBMED   36473367
  REMARK    GeneRIF: LncRNA ZFAS1 contributes to osteosarcoma progression via
            miR-520b and miR-520e-mediated inhibition of RHOC signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1117)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1117)
  AUTHORS   Rong,G., Pan,Z., Ding,M. and Wang,L.
  TITLE     RNF168 suppresses the cancer stem cell-like traits of nonsmall cell
            lung cancer cells by mediating RhoC ubiquitination
  JOURNAL   Environ Toxicol 37 (3), 603-611 (2022)
   PUBMED   34873829
  REMARK    GeneRIF: RNF168 suppresses the cancer stem cell-like traits of
            nonsmall cell lung cancer cells by mediating RhoC ubiquitination.
REFERENCE   6  (bases 1 to 1117)
  AUTHORS   Bokoch,G.M., Bohl,B.P. and Chuang,T.H.
  TITLE     Guanine nucleotide exchange regulates membrane translocation of
            Rac/Rho GTP-binding proteins
  JOURNAL   J Biol Chem 269 (50), 31674-31679 (1994)
   PUBMED   7989340
REFERENCE   7  (bases 1 to 1117)
  AUTHORS   Fagan,K.P., Oliveira,L. and Pittler,S.J.
  TITLE     Sequence of rho small GTP-binding protein cDNAs from human retina
            and identification of novel 5' end cloning artifacts
  JOURNAL   Exp Eye Res 59 (2), 235-237 (1994)
   PUBMED   7835413
REFERENCE   8  (bases 1 to 1117)
  AUTHORS   Adamson,P., Paterson,H.F. and Hall,A.
  TITLE     Intracellular localization of the P21rho proteins
  JOURNAL   J Cell Biol 119 (3), 617-627 (1992)
   PUBMED   1383236
REFERENCE   9  (bases 1 to 1117)
  AUTHORS   Chardin,P., Madaule,P. and Tavitian,A.
  TITLE     Coding sequence of human rho cDNAs clone 6 and clone 9
  JOURNAL   Nucleic Acids Res 16 (6), 2717 (1988)
   PUBMED   3283705
REFERENCE   10 (bases 1 to 1117)
  AUTHORS   Madaule,P. and Axel,R.
  TITLE     A novel ras-related gene family
  JOURNAL   Cell 41 (1), 31-40 (1985)
   PUBMED   3888408
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CX872299.1 and BC009177.2.
            
            On Nov 30, 2019 this sequence version replaced NM_175744.4.
            
            Summary: This gene encodes a member of the Rho family of small
            GTPases, which cycle between inactive GDP-bound and active
            GTP-bound states and function as molecular switches in signal
            transduction cascades. Rho proteins promote reorganization of the
            actin cytoskeleton and regulate cell shape, attachment, and
            motility. The protein encoded by this gene is prenylated at its
            C-terminus, and localizes to the cytoplasm and plasma membrane. It
            is thought to be important in cell locomotion. Overexpression of
            this gene is associated with tumor cell proliferation and
            metastasis. Multiple alternatively spliced variants, encoding the
            same protein, have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ900972.1, BC009177.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339083.12/ ENSP00000345236.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CX872299.1         277-305
            30-1117             BC009177.2         1-1088
FEATURES             Location/Qualifiers
     source          1..1117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1117
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /note="ras homolog family member C"
                     /db_xref="GeneID:389"
                     /db_xref="HGNC:HGNC:669"
                     /db_xref="MIM:165380"
     exon            1..50
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /inference="alignment:Splign:2.1.0"
     exon            51..119
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /inference="alignment:Splign:2.1.0"
     exon            120..282
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..708
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /note="oncogene RHO H9; rhoC GTPase; small GTP binding
                     protein RhoC; Rho-related GTP-binding protein RhoC;
                     RAS-related homolog 9; rho cDNA clone 9; ras homolog gene
                     family, member C; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoC precursor"
                     /protein_id="NP_786886.1"
                     /db_xref="CCDS:CCDS854.1"
                     /db_xref="GeneID:389"
                     /db_xref="HGNC:HGNC:669"
                     /db_xref="MIM:165380"
                     /translation="MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYIA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPE
                     VKHFCPNVPIILVGNKKDLRQDEHTRRELAKMKQEPVRSEEGRDMANRISAFGYLECS
                     AKTKEGVREVFEMATRAGLQVRKNKRRRGCPIL"
     exon            283..403
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /inference="alignment:Splign:2.1.0"
     exon            404..534
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /inference="alignment:Splign:2.1.0"
     exon            535..1117
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /note="hexamer: AATAAA"
     polyA_site      1117
                     /gene="RHOC"
                     /gene_synonym="ARH9; ARHC; H9; RHOH9"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagcc tccggcaccg gccgcgcagc tggaggcggc ggagcggaag ccttgacttc
       61 atctcagctc cagagcccgc cctctcttcc tgcagcctgg gaacttcagc cggctggagc
      121 cccaccatgg ctgcaatccg aaagaagctg gtgatcgttg gggatggtgc ctgtgggaag
      181 acctgcctcc tcatcgtctt cagcaaggat cagtttccgg aggtctacgt ccctactgtc
      241 tttgagaact atattgcgga cattgaggtg gacggcaagc aggtggagct ggctctgtgg
      301 gacacagcag ggcaggaaga ctatgatcga ctgcggcctc tctcctaccc ggacactgat
      361 gtcatcctca tgtgcttctc catcgacagc cctgacagcc tggaaaacat tcctgagaag
      421 tggaccccag aggtgaagca cttctgcccc aacgtgccca tcatcctggt ggggaataag
      481 aaggacctga ggcaagacga gcacaccagg agagagctgg ccaagatgaa gcaggagccc
      541 gttcggtctg aggaaggccg ggacatggcg aaccggatca gtgcctttgg ctaccttgag
      601 tgctcagcca agaccaagga gggagtgcgg gaggtgtttg agatggccac tcgggctggc
      661 ctccaggtcc gcaagaacaa gcgtcggagg ggctgtccca ttctctgaga tccccaaggc
      721 ctttcctaca tgccccctcc cttcacaggg gtacagaaat tatcccccta caaccccagc
      781 ctcctgaggg ctccatgctg aaggctccca ttttcagttc cctcctgccc aggactgcat
      841 tgttttctag ccccgaggtg gtggcacggg ccctccctcc cagcgctctg ggagccacgc
      901 ctatgccctg cccttcctca gggcccctgg ggatcttgcc ccctttgacc ttccccaaag
      961 gatggtcaca caccagcact ttatacactt ctggctcaca ggaaagtgtc tgcagtaggg
     1021 gacccagagt cccaggcccc tggagttgtt ttcggcaggg gccttgtctc tcactgcatt
     1081 tggtcagggg ggcatgaata aaggctacag gctccaa
//
