LOCUS       NM_014899               5370 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.
ACCESSION   NM_014899
VERSION     NM_014899.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5370)
  AUTHORS   Sun,Y., Liu,Y., Chen,H. and Tan,Y.
  TITLE     Circular RNA circRHOBTB3 inhibits ovarian cancer progression
            through PI3K/AKT signaling pathway
  JOURNAL   Panminerva Med 66 (1), 36-46 (2024)
   PUBMED   32720791
  REMARK    GeneRIF: Circular RNA circRHOBTB3 inhibits ovarian cancer
            progression through PI3K/AKT signaling pathway.
REFERENCE   2  (bases 1 to 5370)
  AUTHORS   Ren,A., Gong,F., Liu,G. and Fan,W.
  TITLE     NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis,
            and Warburg effects of cervical cancer through interacting with
            IGF2BP3
  JOURNAL   Mol Cell Biochem 478 (12), 2671-2681 (2023)
   PUBMED   36939994
  REMARK    GeneRIF: NR1H4-mediated circRHOBTB3 modulates the proliferation,
            metastasis, and Warburg effects of cervical cancer through
            interacting with IGF2BP3.
REFERENCE   3  (bases 1 to 5370)
  AUTHORS   Kim,K. and Kim,Y.J.
  TITLE     RhoBTB3 Regulates Proliferation and Invasion of Breast Cancer Cells
            via Col1a1
  JOURNAL   Mol Cells 45 (9), 631-639 (2022)
   PUBMED   35698915
  REMARK    GeneRIF: RhoBTB3 Regulates Proliferation and Invasion of Breast
            Cancer Cells via Col1a1.
REFERENCE   4  (bases 1 to 5370)
  AUTHORS   Yang,T., Shen,P., Chen,Q., Wu,P., Yuan,H., Ge,W., Meng,L.,
            Huang,X., Fu,Y., Zhang,Y., Hu,W., Miao,Y., Lu,Z. and Jiang,K.
  TITLE     FUS-induced circRHOBTB3 facilitates cell proliferation via
            miR-600/NACC1 mediated autophagy response in pancreatic ductal
            adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 40 (1), 261 (2021)
   PUBMED   34416910
  REMARK    GeneRIF: FUS-induced circRHOBTB3 facilitates cell proliferation via
            miR-600/NACC1 mediated autophagy response in pancreatic ductal
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5370)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 5370)
  AUTHORS   Espinosa,E.J., Calero,M., Sridevi,K. and Pfeffer,S.R.
  TITLE     RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi
            transport
  JOURNAL   Cell 137 (5), 938-948 (2009)
   PUBMED   19490898
  REMARK    GeneRIF: Study reports that the atypical Rho GTPase family member,
            RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in
            protein transport from endosomes to the trans Golgi network.
REFERENCE   7  (bases 1 to 5370)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   8  (bases 1 to 5370)
  AUTHORS   Boureux,A., Vignal,E., Faure,S. and Fort,P.
  TITLE     Evolution of the Rho family of ras-like GTPases in eukaryotes
  JOURNAL   Mol Biol Evol 24 (1), 203-216 (2007)
   PUBMED   17035353
REFERENCE   9  (bases 1 to 5370)
  AUTHORS   Ramos,S., Khademi,F., Somesh,B.P. and Rivero,F.
  TITLE     Genomic organization and expression profile of the small GTPases of
            the RhoBTB family in human and mouse
  JOURNAL   Gene 298 (2), 147-157 (2002)
   PUBMED   12426103
REFERENCE   10 (bases 1 to 5370)
  AUTHORS   Rivero,F., Dislich,H., Glockner,G. and Noegel,A.A.
  TITLE     The Dictyostelium discoideum family of Rho-related proteins
  JOURNAL   Nucleic Acids Res 29 (5), 1068-1079 (2001)
   PUBMED   11222756
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC020231.1, CN361948.1, AB020685.1 and AC008821.6.
            
            On Nov 23, 2018 this sequence version replaced NM_014899.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.17452.1,
                                           SRR1660803.210960.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379982.8/ ENSP00000369318.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-970               BC020231.1         160-1129
            971-1488            CN361948.1         246-763
            1489-4111           AB020685.1         1477-4099
            4112-5370           AC008821.6         143678-144936       c
FEATURES             Location/Qualifiers
     source          1..5370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15"
     gene            1..5370
                     /gene="RHOBTB3"
                     /note="Rho related BTB domain containing 3"
                     /db_xref="GeneID:22836"
                     /db_xref="HGNC:HGNC:18757"
                     /db_xref="MIM:607353"
     exon            1..349
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..2183
                     /gene="RHOBTB3"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 3"
                     /protein_id="NP_055714.3"
                     /db_xref="CCDS:CCDS4077.1"
                     /db_xref="GeneID:22836"
                     /db_xref="HGNC:HGNC:18757"
                     /db_xref="MIM:607353"
                     /translation="MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLL
                     NAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNV
                     NDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTE
                     GIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHG
                     IRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCA
                     VSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDA
                     LFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLR
                     NCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFN
                     GNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQH
                     ICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQK
                     PEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM"
     exon            350..575
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            576..762
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..917
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1029
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1395
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1508
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1629
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1803
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1970
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2067
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..5370
                     /gene="RHOBTB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5350..5355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOBTB3"
                     /note="hexamer: AATAAA"
     polyA_site      5370
                     /gene="RHOBTB3"
                     /note="major polyA site"
ORIGIN      
        1 agcaggaggc gacagctgcc agccgaggag gcgcggcgga gaggggactg cggtcagctg
       61 cgtccacttg gggctgtgcg gcggtcccgc gcccggcgat gttcccgggc actccctgag
      121 tagcggcagc ttatcccccg cccgctagcc cgccctggtc cccggctcgc tcgctggctg
      181 gcgcggcccc ggccccgctc tgcgtcggcc ccgccgcggt ggaggcgcgc gagggggacg
      241 cggccgggga tgagcggatt gcgggtgaac tcgccgcccg ggggccccgc gaagccgtga
      301 gccgctgctt ttctccgagt cgccgccctg cccttggatt tgagatcatg tccatccaca
      361 tcgtggcgct ggggaacgag ggggacacat tccaccagga caaccggccg tcggggctta
      421 tccgcactta cctggggaga agccctctgg tctccgggga cgagagcagc ttgttgctga
      481 acgcggccag cacggtcgcg cgtccggtgt tcaccgagta tcaggccagt gcgtttggga
      541 atgtcaagct ggtggtccac gactgtcccg tctgggacat atttgacagt gattggtaca
      601 cttctcgaaa tctaattggg ggcgctgaca tcattgtgat caaatacaac gttaatgaca
      661 agttttcatt ccatgaagta aaggataatt atattccagt gataaaaaga gcattaaatt
      721 cagttccagt aattattgct gctgttggta ccagacaaaa tgaagagtta ccttgtacat
      781 gcccactatg tacctcagac agagggagct gtgttagtac aactgaaggg atccaacttg
      841 caaaagaact aggagcgacc tatcttgaac tccacagcct tgatgacttc tacataggaa
      901 agtattttgg aggagtgttg gagtatttta tgattcaagc cttaaatcag aagacaagtg
      961 aaaaaatgaa gaaaagaaaa atgagcaact cctttcatgg aattagacca cctcaacttg
     1021 aacaaccaga aaaaatgcct gtcttaaagg ctgaagcgtc acattataac tctgacttaa
     1081 ataacttgct gttctgctgc cagtgtgtgg acgtggtatt ttacaacccc aatttaaaga
     1141 aagttgtaga ggcccacaag atcgttctct gcgctgtaag ccatgttttc atgctgcttt
     1201 tcaatgtgaa gagtcccact gacattcagg attccagtat catccgaact acccaggatc
     1261 tttttgctat aaacagagat actgcatttc caggtgctag ccatgaatct tcaggcaacc
     1321 caccattacg agtcattgtt aaagacgccc tcttctgttc ttgtttatca gacatccttc
     1381 gcttcattta ttcaggtgct tttcagtggg aagaattgga agaagatatc aggaagaagt
     1441 tgaaagattc tggggatgtt tcaaatgtaa tcgagaaagt taaatgcatt ttaaaaacac
     1501 caggaaagat taattgccta aggaattgca aaacctatca agccagaaaa cctttgtggt
     1561 tttataacac ttccctcaag tttttcctta ataagccgat gcttgccgat gttgtcttcg
     1621 aaattcaagg tacgacagtg ccagcccaca gggccatcct ggtggcccgt tgtgaagtga
     1681 tggcagccat gtttaatggt aattacatgg aagcaaagag tgtcctgatt cccgtttatg
     1741 gtgtttccaa agagactttc ttgtcatttt tagaatacct gtacacagac tcctgctgcc
     1801 cagctggcat attccaggcc atgtgtctcc tgatctgtgc cgagatgtac caagtgtcca
     1861 gactgcagca catctgtgag ctgttcatca ttacccagct gcagagcatg ccaagcaggg
     1921 aactggcatc catgaacctt gatatagttg acctgcttaa aaaggccaag tttcaccact
     1981 ctgattgcct ttcaacctgg ctacttcatt tcattgctac taactacctc atcttcagtc
     2041 aaaagcctga atttcaggat ctttcagtgg aagaacgcag ttttgttgaa aagcacagat
     2101 ggccgtcgaa tatgtacttg aagcagcttg cggaatacag gaagtatatt cactcccgga
     2161 aatgtcgttg cttagtaatg taacctggag cttttataca ctacatttct tttttattat
     2221 tatgaagaat gggatacctc caggttccag taaaattctt ctgaccgaaa ccaatgtggg
     2281 tgttagaaaa attaccatat agcttaatat gtttattagt tctctttgga aaaaaactac
     2341 cactgtggtc ttaaaaggga acaaaatata ccataggcta aaactaaggc tttcactcta
     2401 gaatgcaaag ctgttttgca gctgttttcc cttaaagatg tcctgttgct ttagtgatat
     2461 ttagacccct ctcagttaag aaatgcttag attaaaaaaa aaaaattacg taggattaat
     2521 acagaaattt aatcatgtct gattaattgc tctattaaaa taaggggcat ttaaagaccc
     2581 agcataacca tttgtataat gagaaatcta ggggaaaacc aatcagtcca acatgagatt
     2641 ttaggaatag aaatttgccg gccatttgga aagtgaaatg ccacttagtt ctcaattgat
     2701 gacagtgttt gaatcatcat aaaaaaaata cctgcttttc atctggacaa cccaattgag
     2761 ccactttatc tccttttggc aatctgagta ggcggggaac ctaggcaggg ctggctttct
     2821 tagcgtgtaa cttgtgtagc agcacagggc ccacacttag aaggacccca cacttggttc
     2881 aaggctctgc tatagcggaa attcttaata atgtttgaag aagggcccca tgatttcatt
     2941 ttgtgctgag ccctcaaaat tatgtctgtt tcgtggtggg aaatatccta tgttttcttg
     3001 ctcaaacacc tttctctctg aaagcagaaa aaggcactga tataaaggga agagaaggag
     3061 gctcaccgga gggaagagaa catagtgaag attcccgcct ttggggaggt ctggaccacc
     3121 cagggcctcc actgccacct tggctggcaa gggagaaatg tgttgtgttg tcttagcttt
     3181 aaaacagtca cagttcttgc tctatcatag atgaacaaat actttcttga tcattctgta
     3241 agaccaggag gttggtaaga gtgactaacc agcctaactt taatacacat gtataaagat
     3301 gttcacagag aaagatgctc tgtagagaat ttgctaccga agttggctca agaatttgtt
     3361 tttagtgtta tttaccaaga ttaggacgtc agtggcttaa attctttgaa ttcttttcaa
     3421 ggactgcaag attatttgat aaagagtagc atgaatcttg tgctctaata ttacacagta
     3481 agttcaaaga aaggatgtaa gtcaaagact tgttacatag agggaaaatg gactgggata
     3541 gaggacagac tgatagtttc tttctttcat atcacatgta tagagaaata attatatcag
     3601 aaactcacaa acctagacat ggaaaaacag attactgtct attgtcagca tcattttcat
     3661 ctgtaagtca ctactggaat atatttttct tttaatttcc agtgacttta gaatacacac
     3721 agtttttccg acttttcaaa aatttgatta aatggtttta tagtataata ttgggacccc
     3781 ataccgttag cccttgtatg tataccaaca ctgccaaagt aaaacattag gtcaggcatg
     3841 gtggctcagg cctgtaatcc cagcattttg ggaggctgag gcaagtggat aacttgaggt
     3901 catgagttcg aaaccagcct ggccaaaaca gtgaaacccc gtctctacta aaaatacaaa
     3961 attagccaga tgtggtggcg cacacctgta atcccagcta ctcaggaagc tgaggcagga
     4021 aaatcgcttg aacctgggag gtggaagttg cagtgagccg agatcgcacc actgcactcc
     4081 agcctgggtg acaagagcga aactccatct caaaaaaaaa aaaaaaacca aagtgaaaca
     4141 ctaaaaattc cctatagata tattccagga aatattttaa ttgggctgat tttaattagg
     4201 ctgtatcatt gatgattact ggaatcgatt ttatgtcttt tgtattttaa tcacttgagt
     4261 taatcaacca ctggcaaatc ccatttgaca aagattagca ttgtaaaaaa cagatactgt
     4321 ggtagatttc tagaaattca ttcacattta agacttctaa aatggaataa tagccttttg
     4381 tttttcatga gcatattcgc acccctatat gaattacagc atttaaagtt caaaatcagt
     4441 aacttttaat ctaggaaatt gaaaaatatt aagttgcaaa gcaaaaaaag gtattttctt
     4501 gaaaatacta tttaatgttt aactagacta taggtagttc cttaaggttg tttgacctga
     4561 agtggagttg ggtttggaag ctggtgccca gttggtgtgg agtgtgtagt tttgttatga
     4621 aagttctcta ccacctacct gtgtgagtga caccaacatc cagatgtcac agctctccag
     4681 agctagtcag aagagaaatc aaattagtgt ttaaacccat ttgcatattg acttgtcagt
     4741 acctttaact caatttaata taacaagaaa tcgtaaaata cttataacct atcttagaga
     4801 aatgagtgct ggttttgaga gttgtttttt aactgaaaga ttatttctag atgggtagtg
     4861 ctttgtgctg gtttctgctt ccatatattt cccagtcatt ttaattagag aagatactct
     4921 atggtagaac taaggccttt cctttcttgg ccaaagtctt taccctattt aaccctttgt
     4981 atatttctga ctgctcactg ttcatattat aggggaccag atttgtaata tagaattctc
     5041 cataacatga atgaaattaa ttctgtccaa gccagcatgg tggcttcata ttaagtagta
     5101 acagaagtct gaacaattgg ataaatttga cttccaagac agctaaactt ttcaactgca
     5161 attttaaaaa ctacactaca ctgttatagt taatctgaca aaaatgtcct caaagagtac
     5221 tttattttat ttaaagcatc tgtttaattc aacctttaat aattttgcaa agaagggtat
     5281 gtgtgtattt taatatagcc tgacctgaat ttatatgttt ttagctttag tatttaactt
     5341 tttgtaacaa ataaaccttt tttaaaacaa
//
