LOCUS       NM_015178               5482 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rho related BTB domain containing 2 (RHOBTB2),
            transcript variant 3, mRNA.
ACCESSION   NM_015178
VERSION     NM_015178.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5482)
  AUTHORS   Langhammer,F., Maroofian,R., Badar,R., Gregor,A., Rochman,M.,
            Ratliff,J.B., Koopmans,M., Herget,T., Hempel,M., Kortum,F.,
            Heron,D., Mignot,C., Keren,B., Brooks,S., Botti,C., Ben-Zeev,B.,
            Argilli,E., Sherr,E.H., Gowda,V.K., Srinivasan,V.M., Bakhtiari,S.,
            Kruer,M.C., Salih,M.A., Kuechler,A., Muller,E.A., Blocker,K.,
            Kuismin,O., Park,K.L., Kochhar,A., Brown,K., Ramanathan,S.,
            Clark,R.D., Elgizouli,M., Melikishvili,G., Tabatadze,N., Stark,Z.,
            Mirzaa,G.M., Ong,J., Grasshoff,U., Bevot,A., von Wintzingerode,L.,
            Jamra,R.A., Hennig,Y., Goldenberg,P., Al Alam,C., Charif,M.,
            Boulouiz,R., Bellaoui,M., Amrani,R., Al Mutairi,F., Tamim,A.M.,
            Abdulwahab,F., Alkuraya,F.S., Khouj,E.M., Alvi,J.R., Sultan,T.,
            Hashemi,N., Karimiani,E.G., Ashrafzadeh,F., Imannezhad,S.,
            Efthymiou,S., Houlden,H., Sticht,H. and Zweier,C.
  TITLE     Genotype-phenotype correlations in RHOBTB2-associated
            neurodevelopmental disorders
  JOURNAL   Genet Med 25 (8), 100885 (2023)
   PUBMED   37165955
  REMARK    GeneRIF: Genotype-phenotype correlations in RHOBTB2-associated
            neurodevelopmental disorders.
REFERENCE   2  (bases 1 to 5482)
  AUTHORS   Jove Blanco,A., Lorente Romero,J., Barredo Valderrama,E. and Castro
            de Castro,P.
  TITLE     Mild head trauma: Acute encephalopathy trigger in children with
            RHOBTB2 de novo mutation
  JOURNAL   Neurologia (Engl Ed) 37 (8), 702-703 (2022)
   PUBMED   36195378
  REMARK    GeneRIF: Mild head trauma: Acute encephalopathy trigger in children
            with RHOBTB2 de novo mutation.
REFERENCE   3  (bases 1 to 5482)
  AUTHORS   Liu,P., Ma,Q., Chen,H., Zhang,L. and Zhang,X.
  TITLE     Identification of RHOBTB2 aberration as an independent prognostic
            indicator in acute myeloid leukemia
  JOURNAL   Aging (Albany NY) 13 (11), 15269-15284 (2021)
   PUBMED   34074803
  REMARK    GeneRIF: Identification of RHOBTB2 aberration as an independent
            prognostic indicator in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 5482)
  AUTHORS   Zagaglia,S., Steel,D., Krithika,S., Hernandez-Hernandez,L.,
            Custodio,H.M., Gorman,K.M., Vezyroglou,A., Moller,R.S., King,M.D.,
            Hammer,T.B., Spaull,R., Fazeli,W., Bartolomaeus,T., Doummar,D.,
            Keren,B., Mignot,C., Bednarek,N., Cross,J.H., Mallick,A.A.,
            Sanchis-Juan,A., Basu,A., Raymond,F.L., Lynch,B.J., Majumdar,A.,
            Stamberger,H., Weckhuysen,S., Sisodiya,S.M. and Kurian,M.A.
  TITLE     RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating
            Hemiplegia of Childhood
  JOURNAL   Neurology 96 (11), e1539-e1550 (2021)
   PUBMED   33504645
  REMARK    GeneRIF: RHOBTB2 Mutations Expand the Phenotypic Spectrum of
            Alternating Hemiplegia of Childhood.
REFERENCE   5  (bases 1 to 5482)
  AUTHORS   Straub,J., Konrad,E.D.H., Gruner,J., Toutain,A., Bok,L.A.,
            Cho,M.T., Crawford,H.P., Dubbs,H., Douglas,G., Jobling,R.,
            Johnson,D., Krock,B., Mikati,M.A., Nesbitt,A., Nicolai,J.,
            Phillips,M., Poduri,A., Ortiz-Gonzalez,X.R., Powis,Z., Santani,A.,
            Smith,L., Stegmann,A.P.A., Stumpel,C., Vreeburg,M., Fliedner,A.,
            Gregor,A., Sticht,H. and Zweier,C.
  CONSRTM   Deciphering Developmental Disorders Study
  TITLE     Missense Variants in RHOBTB2 Cause a Developmental and Epileptic
            Encephalopathy in Humans, and Altered Levels Cause Neurological
            Defects in Drosophila
  JOURNAL   Am J Hum Genet 102 (1), 44-57 (2018)
   PUBMED   29276004
  REMARK    GeneRIF: missense variants in the BTB-domain-encoding region of
            RHOBTB2 as causative for a developmental and epileptic
            encephalopathy.
REFERENCE   6  (bases 1 to 5482)
  AUTHORS   Siripurapu,V., Meth,J., Kobayashi,N. and Hamaguchi,M.
  TITLE     DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton
            and membrane-trafficking pathways
  JOURNAL   J Mol Biol 346 (1), 83-89 (2005)
   PUBMED   15663929
  REMARK    GeneRIF: two networks were found to react substantially to DBC2
            expression--one of the networks regulates cell growth through
            cell-cycle control and apoptosis; the other network is related to
            cytoskeleton and membrane trafficking
REFERENCE   7  (bases 1 to 5482)
  AUTHORS   Wilkins,A., Ping,Q. and Carpenter,C.L.
  TITLE     RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase
            complex
  JOURNAL   Genes Dev 18 (8), 856-861 (2004)
   PUBMED   15107402
REFERENCE   8  (bases 1 to 5482)
  AUTHORS   Hamaguchi,M., Meth,J.L., von Klitzing,C., Wei,W., Esposito,D.,
            Rodgers,L., Walsh,T., Welcsh,P., King,M.C. and Wigler,M.H.
  TITLE     DBC2, a candidate for a tumor suppressor gene involved in breast
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 99 (21), 13647-13652 (2002)
   PUBMED   12370419
  REMARK    GeneRIF: A previously uncharacterized gene, DBC2 (deleted in breast
            cancer), was cloned from a homozygously deleted region at human
            chromosome 8p21.
REFERENCE   9  (bases 1 to 5482)
  AUTHORS   Ramos,S., Khademi,F., Somesh,B.P. and Rivero,F.
  TITLE     Genomic organization and expression profile of the small GTPases of
            the RhoBTB family in human and mouse
  JOURNAL   Gene 298 (2), 147-157 (2002)
   PUBMED   12426103
REFERENCE   10 (bases 1 to 5482)
  AUTHORS   Rivero,F., Dislich,H., Glockner,G. and Noegel,A.A.
  TITLE     The Dictyostelium discoideum family of Rho-related proteins
  JOURNAL   Nucleic Acids Res 29 (5), 1068-1079 (2001)
   PUBMED   11222756
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107959.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 16, 2019 this sequence version replaced NM_015178.2.
            
            Summary: The protein encoded by this gene is a small Rho GTPase and
            a candidate tumor suppressor. The encoded protein interacts with
            the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic
            cell division. This protein inhibits the growth and spread of some
            types of breast cancer. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Nov 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018260.2, AY009093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251822.7/ ENSP00000251822.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               AC107959.8         62243-62800
            559-760             AC107959.8         67120-67321
            761-864             AC107959.8         68067-68170
            865-1050            AC107959.8         68655-68840
            1051-2069           AC107959.8         69423-70441
            2070-2188           AC107959.8         70688-70806
            2189-2339           AC107959.8         73233-73383
            2340-2428           AC107959.8         77385-77473
            2429-2534           AC107959.8         78333-78438
            2535-5482           AC107959.8         79947-82894
FEATURES             Location/Qualifiers
     source          1..5482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..5482
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /note="Rho related BTB domain containing 2"
                     /db_xref="GeneID:23221"
                     /db_xref="HGNC:HGNC:18756"
                     /db_xref="MIM:607352"
     exon            1..558
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            559..760
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..2752
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /note="isoform 3 is encoded by transcript variant 3;
                     rho-related BTB domain-containing protein 2; deleted in
                     breast cancer 2 gene protein"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 2
                     isoform 3"
                     /protein_id="NP_055993.2"
                     /db_xref="CCDS:CCDS6034.1"
                     /db_xref="GeneID:23221"
                     /db_xref="HGNC:HGNC:18756"
                     /db_xref="MIM:607352"
                     /translation="MDSDMDYERPNVETIKCVVVGDNAVGKTRLICARACNATLTQYQ
                     LLATHVPTVWAIDQYRVCQEVLERSRDVVDDVSVSLRLWDTFGDHHKDRRFAYGRSDV
                     VVLCFSIANPNSLHHVKTMWYPEIKHFCPRAPVILVGCQLDLRYADLEAVNRARRPLA
                     RPIKPNEILPPEKGREVAKELGIPYYETSVVAQFGIKDVFDNAIRAALISRRHLQFWK
                     SHLRNVQRPLLQAPFLPPKPPPPIIVVPDPPSSSEECPAHLLEDPLCADVILVLQERV
                     RIFAHKIYLSTSSSKFYDLFLMDLSEGELGGPSEPGGTHPEDHQGHSDQHHHHHHHHH
                     GRDFLLRAASFDVCESVDEAGGSGPAGLRASTSDGILRGNGTGYLPGRGRVLSSWSRA
                     FVSIQEEMAEDPLTYKSRLMVVVKMDSSIQPGPFRAVLKYLYTGELDENERDLMHIAH
                     IAELLEVFDLRMMVANILNNEAFMNQEITKAFHVRRTNRVKECLAKGTFSDVTFILDD
                     GTISAHKPLLISSCDWMAAMFGGPFVESSTREVVFPYTSKSCMRAVLEYLYTGMFTSS
                     PDLDDMKLIILANRLCLPHLVALTEQYTVTGLMEATQMMVDIDGDVLVFLELAQFHCA
                     YQLADWCLHHICTNYNNVCRKFPRDMKAMSPENQEYFEKHRWPPVWYLKEEDHYQRAR
                     KEREKEDYLHLKRQPKRRWLFWNSPSSPSSSAASSSSPSSSSAVV"
     exon            761..864
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1050
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..2069
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2188
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2339
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2428
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2534
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..5482
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3707..3712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /note="hexamer: AATGAA"
     polyA_site      3726
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
     regulatory      5459..5464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /note="hexamer: AATACA"
     polyA_site      5482
                     /gene="RHOBTB2"
                     /gene_synonym="DBC2; DEE64; EIEE64; p83"
                     /note="major polyA site"
ORIGIN      
        1 ggggcccgtc acggctgtcg tcttgggtgc gatttttttc tcctcctttt tttaccctcc
       61 cgtttttttc ttttcttttt tttttcccta tccttttttt gtgaatgaaa aaaggaggtc
      121 gcgagcggta cctgggactg cagcgccagg cgtcttcgcg gcagcgcctt cgccgcgggc
      181 ccgggcgcgt agcggcggcg gcctcgcccc tctcccggcg cccctgcgcg ccgcccgctg
      241 cctccgcagc ccggctccgc gcgccgccgt gacattgggc gcctggcgcg cggggcgatg
      301 ctgatccgga aggggcagcg gctgcagtgc agcgcgcgcg tccgctcctg ggcccacgtc
      361 cggcctgggc tgccctgccg gagtttctga gtggccgcga gctggccggg aggctggagc
      421 ccagcagcag cgcggcggcg ccggcgtcgt cccaacttgc aggcgcggag ggacccctga
      481 catttcacta aaatgagcgt gctcagcagg aagagatgtg ttcctcacgc tagaagccac
      541 cccgtcacat gtagtggtgt cccgtttaat ggattctgac atggattatg aaaggccaaa
      601 cgtagagacc atcaagtgcg ttgtggtggg ggacaacgcc gtgggtaaga ccaggctcat
      661 ctgtgcccgc gcttgcaatg ccaccctcac ccagtaccag ctgctggcca cgcatgtgcc
      721 cacagtatgg gccatcgacc aatatcgtgt gtgccaggag gtgctggaac gctcccgaga
      781 cgtggtagat gatgtcagcg tctctctgcg cctctgggac acctttggag accaccacaa
      841 agaccgtcgc tttgcttatg ggagatctga tgtggtggtt ctgtgcttct ccattgccaa
      901 ccccaattcc ctccaccatg tcaagaccat gtggtaccca gaaatcaagc acttctgccc
      961 ccgagcacct gtcatcttgg tgggctgcca gttggacctg cgctacgctg acctggaggc
     1021 tgtcaacagg gctaggcgac ccttggctag gcccatcaaa cctaatgaaa tcctgccccc
     1081 agagaagggt cgggaggtgg ccaaggagct gggcatcccc tactatgaga ccagcgtggt
     1141 ggcccagttc ggcatcaagg acgtctttga caacgccatc cgagctgcac tcatctcccg
     1201 ccgccacctg cagttctgga agtcccacct ccgcaatgtg cagcggcctc tgctgcaggc
     1261 acccttccta ccccccaagc caccgccccc gatcatcgtg gtgcccgacc ctccctccag
     1321 cagcgaggag tgccccgccc acctcctgga ggacccgctc tgcgcggacg tcatcctggt
     1381 gctgcaggag cgggtgcgca tctttgccca caagatctac ctctccacct cttcctccaa
     1441 gttctatgac ctgttcctca tggacctgag tgagggggag ctggggggcc cctcggagcc
     1501 agggggcacc cacccagagg accaccaggg ccactctgat caacaccacc accatcacca
     1561 ccaccaccat gggcgagact tcctgctccg agcagccagc tttgacgtgt gcgagagcgt
     1621 ggatgaggct gggggctccg gtcctgctgg cctccgtgct tccaccagcg acgggatctt
     1681 acggggcaac ggaacagggt acctaccggg caggggtcgt gtgctgtctt cctggagccg
     1741 agcttttgtg agcatccagg aagagatggc agaagatcct ctcacctaca aatcccggct
     1801 gatggtggtg gtgaagatgg acagttccat ccagccgggg cccttccggg ctgtcctcaa
     1861 gtacctgtac acgggggagc tagatgagaa cgagcgtgac ctcatgcaca ttgcccacat
     1921 tgctgagctg ctcgaggtct ttgatctgcg catgatggtg gccaacattc tcaacaatga
     1981 ggccttcatg aaccaggaga tcaccaaggc cttccacgtc cgccggacca accgggttaa
     2041 ggagtgcttg gcaaaaggca ccttctcaga tgtgaccttc atcctggatg atggcaccat
     2101 cagcgcccac aagcccctgt tgatttccag ctgtgactgg atggctgcca tgtttggggg
     2161 gccatttgtg gagagctcca cccgggaggt ggtgtttccc tacacaagca agagctgcat
     2221 gcgggccgtg ctggaatacc tctacaccgg catgttcacc tccagccccg acctggatga
     2281 catgaagctc atcattctag ccaaccgcct ctgcctgcca cacctggttg ccctcacaga
     2341 gcagtacaca gtgaccgggc tgatggaagc gacccagatg atggtggaca tcgatgggga
     2401 cgtccttgtg ttcctggaac tggctcagtt ccactgtgcg taccagctgg ccgactggtg
     2461 tctccaccac atctgcacca actacaacaa cgtgtgccgc aagttccccc gagacatgaa
     2521 ggccatgtcc ccagaaaacc aggagtattt cgagaagcat cggtggccac ctgtgtggta
     2581 cctgaaggag gaagatcatt accagcgggc acggaaggag cgtgagaagg aggactacct
     2641 ccacctcaag cggcagccca aacggcgttg gctcttctgg aacagtccat cctccccgtc
     2701 ttcctcggca gcctcctcct catccccatc ttcctcctcg gctgtggtct gagatgctgc
     2761 caccctcttc tgaccctgct gctgttgtcc ccatccgcct tcacccctct gctcttccgc
     2821 atcaccccat ccaccttaca gggaccaggg ggcccacgta accaggaccc agagggtgga
     2881 gctcttctta ccagccaccg tggctcagcc agagaggagc tgagccctgt ggagcagaac
     2941 gggaaccacc tgcagaggtc cccagaccca aagcaggacg ggagacaact gcttggagga
     3001 gcgaagagcc ctggcatttt atctctgggt ttgagagccc tagagtcaaa gggaaagcct
     3061 cccagcctcc agggcttctc tgtgtgtctt ggttgctgct ctggccaggg aggcagcccc
     3121 actcccagca agcagaagtg atcctcgagg gtcctgcccc tgttggccat atctttccac
     3181 cgacggactt gagtgttgca tttgttttgt gggcatttcc acacgaagcc tactcacacc
     3241 ctcactggag aagtcagggt agaaattgag ccttcagagc ccaactcaag gcttctacat
     3301 cctggggtgc agctgcaaaa ggccagacgt ggaaaggcct gtatcctgcc agtgtccctc
     3361 cgtcccaggg ggctgtgcta gcacagacct gagaatgggg acacaggtca ttcagagctc
     3421 caggcctgga agcagtgcct cttggtgcaa caagaaactt ctccctcacc ccctccttta
     3481 ccctcagatt tggagatggt aaccaaagga agcagctggg acaggtggag aaggaagtag
     3541 gaatgagtgc acggcgaccc cgtgctcctc agggccctcc cctgcctctg ggtggcactg
     3601 ctttttatag ggtggggcaa aattagcaaa aaacaaaaac caatgacaac caaactgaaa
     3661 ccgaaacgaa aaatcaacaa acactctgtc ctctatccct ccaaagaatg aaaatcagaa
     3721 aaagcccctg cctagctcac atttctataa acagaggccc ccatgatgag gaggtgaaga
     3781 tttaggttgc agaatcgact ccaatgcctt tcaggaaagg actcggcact tctctgactg
     3841 cggaggccct gaccctgcca gctggctccg agggcaacac aggggcctgg cctctagagg
     3901 gctggtgatt gaggggcccg ggctggcggc aaagaggggt ttggtctcgg ggcttaaatg
     3961 gcaccagact cttgcttttg cccatctgga gactgcaggc tcccttcctt accctcagag
     4021 agtgcttatg gtgggtgttt ttgcggggct gcaatagggg ccaaaagtca gggaaagggg
     4081 cactgacctg tagtgaaagg ccacaggaca cagccttatt actgctgggg tgggataagg
     4141 ggaaggagaa gagggagaat ggagcaggag gaaaagcaga gttggtctag agaggaggag
     4201 ggcggggctg gaggaatgtg ggggattgaa actagctccc agcccccatg gggcagcagc
     4261 tgggccacaa ttgccccttt ccgttttcta accccgactc agatttcacc acccacactc
     4321 tttttaggtg taaaagatgg agtcccacgg aggaggggca gagccaggag gcagtggggc
     4381 tgtgggctca gagctcagga gtcgccttac ctgagagaga tgttctagct gagagggcct
     4441 ggccctgggg tgggctccag gaaaacgctg gttaggcctg ggattgagct aacctgaaac
     4501 aaaggtagca ggcaggacct aatgaccaga ggttaaatcc tcatcaagag agaccaggcg
     4561 gctggaggac aagcggctct aaccctgggg gcggccatgt tgtccaggcc caggcccctc
     4621 caggactgtg gctgcctccc ctccacggcc tccagggcgg ctggctggaa agccacgcgt
     4681 atgctgccct ctacaggctg ctcggcctcc ctgcagctca gcgcagccca gggctccaag
     4741 tgaggcccag aagcccatgg gcagggctgg ggggacgaag ggggaacccg gagcacctcc
     4801 acttctaggg aagatggaca gcgtgggggc acacctgggc ctcccggaag ctgtggacga
     4861 aagggagagc gggtcctcca gggcaagggg aacgggaaat aggtctccta ggtgcctgaa
     4921 gcgctgagca acctgggtac cctggtgggg atgcagggaa ggccggggca gagaaagtga
     4981 aggtcgaccc agggctgtag gaagccatag gagagtgacc acgggattcc ctgagaaaca
     5041 gggccggccc cccaacttca gggacccacc gcccattccc cgagagctgt cggaaccaga
     5101 tgcaacccgg cagcccagag aactctcctg ggaggctgtg ggtgagccag gccaacattg
     5161 gtgtccctgt ccccagaggg aggagcaggc aggagagaga ggggaaggag gtatgaatcc
     5221 cagtccccag gaacctagct ctttaaactc tggggagtcg gattcaggaa acacccccag
     5281 gaggccaagc ctgaaaacag aggggaggga ggaaggaagg agtcccagca ggagcacagc
     5341 cctggtttcc tgtcactcag agctgattca caggaggagg ggaggttggg gggcgggaga
     5401 caaaaaccac acctcttttt atataaggtt tcatatttaa tttggtcatg gattcataaa
     5461 tacataagta ttttgtacac aa
//
