LOCUS       NM_014836               4411 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rho related BTB domain containing 1 (RHOBTB1),
            transcript variant 1, mRNA.
ACCESSION   NM_014836
VERSION     NM_014836.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4411)
  AUTHORS   Kumar,G., Fang,S., Golosova,D., Lu,K.T., Brozoski,D.T.,
            Vazirabad,I. and Sigmund,C.D.
  TITLE     Structure and Function of RhoBTB1 Required for Substrate
            Specificity and Cullin-3 Ubiquitination
  JOURNAL   Function (Oxf) 4 (5), zqad034 (2023)
   PUBMED   37575477
  REMARK    GeneRIF: Structure and Function of RhoBTB1 Required for Substrate
            Specificity and Cullin-3 Ubiquitination.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4411)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4411)
  AUTHORS   Long,M., Kranjc,T., Mysior,M.M. and Simpson,J.C.
  TITLE     RNA Interference Screening Identifies Novel Roles for RhoBTB1 and
            RhoBTB3 in Membrane Trafficking Events in Mammalian Cells
  JOURNAL   Cells 9 (5), 1089 (2020)
   PUBMED   32354068
  REMARK    GeneRIF: RNA Interference Screening Identifies Novel Roles for
            RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4411)
  AUTHORS   Haga,R.B., Garg,R., Collu,F., Borda D'Agua,B., Menendez,S.T.,
            Colomba,A., Fraternali,F. and Ridley,A.J.
  TITLE     RhoBTB1 interacts with ROCKs and inhibits invasion
  JOURNAL   Biochem J 476 (17), 2499-2514 (2019)
   PUBMED   31431478
  REMARK    GeneRIF: RhoBTB1 associates with ROCK1 and ROCK2 and its
            association with ROCK1 is via its Rho domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4411)
  AUTHORS   McKinnon,C.M. and Mellor,H.
  TITLE     The tumor suppressor RhoBTB1 controls Golgi integrity and breast
            cancer cell invasion through METTL7B
  JOURNAL   BMC Cancer 17 (1), 145 (2017)
   PUBMED   28219369
  REMARK    GeneRIF: RhoBTB1 regulates the integrity of the Golgi complex
            through METTL7B. RhoBTB1 is required for expression of METTL7B and
            silencing of either protein leads to fragmentation of the Golgi.
            Loss of RhoBTB1 expression is linked to Golgi fragmentation in
            breast cancer cells. Restoration of normal RhoBTB1 expression
            rescues Golgi morphology and dramatically inhibits breast cancer
            cell invasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4411)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
REFERENCE   7  (bases 1 to 4411)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4411)
  AUTHORS   Beder,L.B., Gunduz,M., Ouchida,M., Gunduz,E., Sakai,A.,
            Fukushima,K., Nagatsuka,H., Ito,S., Honjo,N., Nishizaki,K. and
            Shimizu,K.
  TITLE     Identification of a candidate tumor suppressor gene RHOBTB1 located
            at a novel allelic loss region 10q21 in head and neck cancer
  JOURNAL   J Cancer Res Clin Oncol 132 (1), 19-27 (2006)
   PUBMED   16170569
  REMARK    GeneRIF: Frequent allelic loss and decreased expression of RHOBTB1
            suggested that this gene has a role in tumorigenesis of a subset of
            HNSCC (Head-Neck Squamous Cell Carcinoma).
REFERENCE   9  (bases 1 to 4411)
  AUTHORS   Aspenstrom,P., Fransson,A. and Saras,J.
  TITLE     Rho GTPases have diverse effects on the organization of the actin
            filament system
  JOURNAL   Biochem J 377 (Pt 2), 327-337 (2004)
   PUBMED   14521508
REFERENCE   10 (bases 1 to 4411)
  AUTHORS   Ramos,S., Khademi,F., Somesh,B.P. and Rivero,F.
  TITLE     Genomic organization and expression profile of the small GTPases of
            the RhoBTB family in human and mouse
  JOURNAL   Gene 298 (2), 147-157 (2002)
   PUBMED   12426103
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB453441.1, BC041791.1,
            AB018283.3 and BQ574439.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014836.4.
            
            Summary: The protein encoded by this gene belongs to the Rho family
            of the small GTPase superfamily. It contains a GTPase domain, a
            proline-rich region, a tandem of 2 BTB (broad complex, tramtrack,
            and bric-a-brac) domains, and a conserved C-terminal region. The
            protein plays a role in small GTPase-mediated signal transduction
            and the organization of the actin filament system. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform.
            Variants 1-6 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018283.3, SRR1660805.110305.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337910.10/ ENSP00000338671.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               DB453441.1         91-210
            121-3052            BC041791.1         2-2933
            3053-4407           AB018283.3         3034-4388
            4408-4411           BQ574439.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..4411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..4411
                     /gene="RHOBTB1"
                     /note="Rho related BTB domain containing 1"
                     /db_xref="GeneID:9886"
                     /db_xref="HGNC:HGNC:18738"
                     /db_xref="MIM:607351"
     exon            1..215
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..266
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..468
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..2367
                     /gene="RHOBTB1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rho-related BTB domain-containing protein 1"
                     /codon_start=1
                     /product="rho-related BTB domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_055651.1"
                     /db_xref="CCDS:CCDS7261.1"
                     /db_xref="GeneID:9886"
                     /db_xref="HGNC:HGNC:18738"
                     /db_xref="MIM:607351"
                     /translation="MDADMDYERPNVETIKCVVVGDNAVGKTRLICARACNTTLTQYQ
                     LLATHVPTVWAIDQYRVCQEVLERSRDVVDEVSVSLRLWDTFGDHHKDRRFAYGRSDV
                     VVLCFSIANPNSLNHVKSMWYPEIKHFCPRTPVILVGCQLDLRYADLEAVNRARRPLA
                     RPIKRGDILPPEKGREVAKELGLPYYETSVFDQFGIKDVFDNAIRAALISRRHLQFWK
                     SHLKKVQKPLLQAPFLPPKAPPPVIKIPECPSMGTNEAACLLDNPLCADVLFILQDQE
                     HIFAHRIYLATSSSKFYDLFLMECEESPNGSEGACEKEKQSRDFQGRILSVDPEEERE
                     EGPPRIPQADQWKSSNKSLVEALGLEAEGAVPETQTLTGWSKGFIGMHREMQVNPISK
                     RMGPMTVVRMDASVQPGPFRTLLQFLYTGQLDEKEKDLVGLAQIAEVLEMFDLRMMVE
                     NIMNKEAFMNQEITKAFHVRKANRIKECLSKGTFSDVTFKLDDGAISAHKPLLICSCE
                     WMAAMFGGSFVESANSEVYLPNINKISMQAVLDYLYTKQLSPNLDLDPLELIALANRF
                     CLPHLVALAEQHAVQELTKAATSGVGIDGEVLSYLELAQFHNAHQLAAWCLHHICTNY
                     NSVCSKFRKEIKSKSADNQEYFERHRWPPVWYLKEEDHYQRVKREREKEDIALNKHRS
                     RRKWCFWNSSPAVA"
     exon            469..572
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..758
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1732
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1851
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2002
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2091
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2197
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..4411
                     /gene="RHOBTB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4389..4394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOBTB1"
                     /note="hexamer: AATAAA"
     polyA_site      4411
                     /gene="RHOBTB1"
                     /note="major polyA site"
ORIGIN      
        1 actgggaaga gcggccacgg cgccgggcga ggcggcaggg cgaggcagtg ccatgctgcc
       61 tttgtgcaaa gttgggcggc gggcggcgcg ccgcgcgcag gggccccgca cacccgcgac
      121 cgcgcgcagc cgtggctgct gctgagtggc gggggccccc ccgctccccc cggcccttga
      181 aggcggagag agctcgcgtc tcgctcggct tcagggtaag tccagctgtg agcagagtgt
      241 tctgttcttc acttccagca agccagagtt tcataaatgg acgctgacat ggactacgaa
      301 agacccaacg ttgaaactat caaatgtgtg gtcgtgggtg acaatgccgt ggggaagacg
      361 cgcttgatct gtgccagggc gtgcaacacc acactcacgc agtatcagct gctggccacc
      421 cacgtgccaa cagtgtgggc gattgaccag taccgcgtgt gccaggaggt cttggagcgt
      481 tctcgggatg ttgttgatga agtgagtgtt tctctcaggc tttgggatac ttttggtgat
      541 catcacaaag acagacgctt tgcatatggc aggtctgatg ttgtggtcct ctgtttttcg
      601 attgctaatc ccaattccct aaatcatgtg aaaagcatgt ggtatccaga aatcaagcac
      661 ttttgccctc gaacacccgt tatccttgtt gggtgccagc ttgatctccg ctatgccgac
      721 ctggaagctg ttaatcgagc caggcgcccg ttagcaaggc ccataaagag aggggatatt
      781 ttgcccccag aaaaaggccg agaggtagca aaggaacttg gcttaccata ctatgaaaca
      841 agcgtgtttg accagtttgg tatcaaggat gtgtttgaca atgcaatccg agcagcgctg
      901 atttcccgca ggcacctgca attctggaaa tcccacctaa agaaagtcca gaaaccttta
      961 cttcaggcac ccttcctacc tccaaaagcc cctccaccgg tcatcaaaat tccagagtgt
     1021 ccttccatgg ggacaaatga agctgcctgt ttactggaca atcctctatg tgccgatgtt
     1081 ctgttcatcc ttcaggacca ggaacacatc tttgcacatc gaatttacct cgctacctct
     1141 tcttccaaat tttatgatct gtttttaatg gaatgtgaag aatccccaaa tgggagtgaa
     1201 ggagcctgtg agaaagagaa gcagagcaga gatttccagg ggcggatatt gagtgtcgac
     1261 ccagaggaag aaagggagga gggcccgcct aggattcctc aggccgacca gtggaagtct
     1321 tcaaacaaga gcctggtgga ggctctgggg ctggaagccg agggtgcagt tcctgagaca
     1381 cagactttga ccggatggag taaggggttc attggcatgc acagggaaat gcaagtcaac
     1441 cccatttcaa agcggatggg gcccatgact gtggtcagga tggacgcttc agtccagcca
     1501 ggcccttttc ggaccctgct ccagtttctt tatacgggac aactggatga aaaggaaaag
     1561 gatttggtgg gcctggctca gatcgcagag gtcctcgaga tgttcgattt gaggatgatg
     1621 gtggaaaaca tcatgaacaa ggaagccttc atgaaccagg agattacgaa agcctttcac
     1681 gtaaggaaag ccaatcggat aaaagagtgt ctcagcaagg gaacgttctc ggacgtgaca
     1741 tttaaattgg acgatggagc catcagtgcc cacaagccgc tgctgatctg tagctgtgag
     1801 tggatggcag ccatgttcgg ggggtcattt gtggaaagtg ccaacagtga ggtgtatctc
     1861 ccgaacataa acaagatatc aatgcaagca gtattggatt atctctatac caagcagttg
     1921 tctcctaact tggatctgga cccgctggaa ttaattgcct tggcaaacag attttgcctg
     1981 ccacacttgg ttgcacttgc agaacagcat gccgttcagg agttgaccaa agccgccacg
     2041 agtggcgtgg gcattgacgg agaagtgctc tcttacttgg aattggctca gtttcacaat
     2101 gcccaccagt tggccgcctg gtgtttgcac cacatctgca ccaactacaa cagtgtatgc
     2161 tccaagttcc gtaaggaaat caaatcaaaa tctgcagaca accaggaata cttcgagcgg
     2221 caccgctggc cccctgtgtg gtacctgaag gaagaagatc actaccagcg tgtgaaaagg
     2281 gaacgagaga aggaagatat tgcactaaat aagcatcgct caagacgaaa gtggtgcttc
     2341 tggaattcat ctccagcagt ggcctgaaga ggaagagaaa aaaaacaaaa aacagaaacc
     2401 aatcggtaat ctgatccacc acttttcaaa gcactactat aaaattcgtc ttgttagaga
     2461 tacgacatag ttcaggtttc gggcactgat cttcctccac ttttgtgcat ttatctttgt
     2521 taggatcaaa gcacaagctc accatcaatg agcctggaca aaaagggaag ctgactctca
     2581 ctgcattcct taaactgata tgtatatttt ttttgttagg aggcttaata aactttagtc
     2641 tgttattttg tttcttttta tacaaagaaa aaaaattcag ctttcatgtt tctgattcca
     2701 gattggaaaa tatttttata tggtctgttg tattttgttg aaatgaaaat actgtgtatt
     2761 actttatttt acaggccaca attgattatg aagtcaccct gtgattctct ttgcccacat
     2821 gaccaccgag cattattacg taattagagg gttatccttt tgttgtgaaa ggaaggaggg
     2881 gactgaaatc tcccaaagtg caaattggag agtgtttaat ctttgttctg ttgaataaca
     2941 tcggtgtaat tacaaagtca actccaagaa tgtgtattta caatatttgc catgttaagt
     3001 gctggtaatt atatggttat atgtgccatg taaaatatag tgatatcaaa tattctgttg
     3061 tttccaatgt ctagtttcaa gaggacaatc tttataatca ttagaagggc ttattaaatc
     3121 ccagcattat ccagggcaaa ctcactggtg gacctgaata cataagatac cattagtgcg
     3181 ctggtgttcg gattgctgta ttagggttta catctctcag tattccttga acttgccatg
     3241 cttctgcatg cagattcttc actgacttga attgagatgg gcaagggaaa aggtccctgg
     3301 actccctcct gccatctaca ggcttgtcac atctcaccac cagaaacagg cttcctcagg
     3361 cttctcacct gtggccaact tcactttgta agacccatat ttttaactct tcccagggaa
     3421 aattcatgtt gctgcagaag taggctaagg cagaccaccc acttctgctg aaatgcattg
     3481 ggagcctgtg aaagcacaaa gctggaggct gggcgcctgc gttctcctac acggaaagga
     3541 atctaattcc aagagtctag gaaatggtgc tattgtgagt tcgttctgac tctttctcat
     3601 tctgagtttt cagtgttaaa ctaggaagtg tgacagcagg ggagctttcg tgaggcagtc
     3661 agtcattgct tctctgtaaa ttaaaatgtt acagcacaca catacacaca cagagagcat
     3721 ttcaaggcca cagctccaca cctgccatgg gatgttaatg tggcaggggg tggggctcat
     3781 tctgttggga ggtcaaatta ccaatgccaa ggactgttga ttttgttttt atttttattt
     3841 tttcttctag cttttcagaa gatggaaatg agacagttga gtccaaaccc caatgctgac
     3901 agccatatgc atttgaaaat ctatctagat tacagatggg catttattac tggcagtgga
     3961 aacaccagat agaagatctt aggagaggcc cagaaatgca tcaccttgtc atgacaaaag
     4021 agaaggcagt agagtaggga tagttacaaa tgcatccatc ttaattattt tcaataggct
     4081 tgtaaatctt atcgatggaa ggagaaagga gacaagatgt ggaagaattg acatgtatcc
     4141 caccataaaa tggtagaaga tgagttttca atgagtagtc atagttgaaa ttttacaacc
     4201 aaagctccca tttgattgta atcttgccaa aatataatgg atgtataaat gaacttgggg
     4261 tataagcaat aatatccact agtgttgtta tcagctactg taaccaagtg gctggttcat
     4321 ttggttgatg ctgattatgg cctttaacca tggtggtttg ttgtgtgttt tttatttcac
     4381 aaaaagccaa taaaattgtt tagctataaa a
//
