LOCUS       NM_004040               2367 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens ras homolog family member B (RHOB), mRNA.
ACCESSION   NM_004040
VERSION     NM_004040.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Wang,W., Jia,Y., Liu,Y., Lv,X., Guo,L., Meng,S. and Wang,C.
  TITLE     Downregulation of RhoB Inhibits Cervical Cancer Progression and
            Enhances Cisplatin Sensitivity
  JOURNAL   Genes (Basel) 15 (9), 1186 (2024)
   PUBMED   39336777
  REMARK    GeneRIF: Downregulation of RhoB Inhibits Cervical Cancer
            Progression and Enhances Cisplatin Sensitivity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Khair,H.H.A. and Karagoz,I.D.
  TITLE     MiR-21-5p knockdown inhibits epithelial to mesenchymal transition
            in A549 lung adenocarcinoma cells by upregulating RhoB
  JOURNAL   Mol Biol Rep 51 (1), 837 (2024)
   PUBMED   39042337
  REMARK    GeneRIF: MiR-21-5p knockdown inhibits epithelial to mesenchymal
            transition in A549 lung adenocarcinoma cells by upregulating RhoB.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Zhang,F., Zhang,M., Chen,Z., Yu,B., He,X., Luo,Y., Ai,F. and Hu,W.
  TITLE     PITPNA-AS1 Inhibits Cell Proliferation and Migration in Ovarian
            Cancer by Regulating the MIR-223-3p/RHOB Axis
  JOURNAL   Rev Invest Clin 76 (2), 103-115 (2024)
   PUBMED   38753591
  REMARK    GeneRIF: PITPNA-AS1 Inhibits Cell Proliferation and Migration in
            Ovarian Cancer by Regulating the MIR-223-3p/RHOB Axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2367)
  AUTHORS   Zaoui,K. and Duhamel,S.
  TITLE     RhoB as a tumor suppressor: It's all about localization
  JOURNAL   Eur J Cell Biol 102 (2), 151313 (2023)
   PUBMED   36996579
  REMARK    GeneRIF: RhoB as a tumor suppressor: It's all about localization.
REFERENCE   5  (bases 1 to 2367)
  AUTHORS   Yang,J., Pei,G., Sun,X., Xiao,Y., Miao,C., Zhou,L., Wang,B.,
            Yang,L., Yu,M., Zhang,Z.S., Keller,E.T., Yao,Z. and Wang,Q.
  TITLE     RhoB affects colitis through modulating cell signaling and
            intestinal microbiome
  JOURNAL   Microbiome 10 (1), 149 (2022)
   PUBMED   36114582
  REMARK    GeneRIF: RhoB affects colitis through modulating cell signaling and
            intestinal microbiome.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2367)
  AUTHORS   Robertson,D., Paterson,H.F., Adamson,P., Hall,A. and Monaghan,P.
  TITLE     Ultrastructural localization of ras-related proteins using
            epitope-tagged plasmids
  JOURNAL   J Histochem Cytochem 43 (5), 471-480 (1995)
   PUBMED   7537292
REFERENCE   7  (bases 1 to 2367)
  AUTHORS   Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
  TITLE     Post-translational modifications of p21rho proteins
  JOURNAL   J Biol Chem 267 (28), 20033-20038 (1992)
   PUBMED   1400319
REFERENCE   8  (bases 1 to 2367)
  AUTHORS   Cannizzaro,L.A., Madaule,P., Hecht,F., Axel,R., Croce,C.M. and
            Huebner,K.
  TITLE     Chromosome localization of human ARH genes, a ras-related gene
            family
  JOURNAL   Genomics 6 (2), 197-203 (1990)
   PUBMED   2407642
REFERENCE   9  (bases 1 to 2367)
  AUTHORS   Chardin,P., Madaule,P. and Tavitian,A.
  TITLE     Coding sequence of human rho cDNAs clone 6 and clone 9
  JOURNAL   Nucleic Acids Res 16 (6), 2717 (1988)
   PUBMED   3283705
REFERENCE   10 (bases 1 to 2367)
  AUTHORS   Madaule,P. and Axel,R.
  TITLE     A novel ras-related gene family
  JOURNAL   Cell 41 (1), 31-40 (1985)
   PUBMED   3888408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK310813.1, AK124398.1, AC023137.5 and CA443347.1.
            
            On May 17, 2019 this sequence version replaced NM_004040.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7346977.918421.1, BC066954.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272233.6/ ENSP00000272233.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               AK310813.1         6-407
            403-1376            AK124398.1         403-1376
            1377-1377           AC023137.5         38901-38901
            1378-2111           AK124398.1         1378-2111
            2112-2366           AK124398.1         2113-2367
            2367-2367           CA443347.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..2367
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /note="ras homolog family member B"
                     /db_xref="GeneID:388"
                     /db_xref="HGNC:HGNC:668"
                     /db_xref="MIM:165370"
     exon            1..2367
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /inference="alignment:Splign:2.1.0"
     CDS             393..983
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /note="oncogene RHO H6; Aplysia RAS-related homolog 6; h6;
                     rho cDNA clone 6; ras homolog gene family, member B"
                     /codon_start=1
                     /product="rho-related GTP-binding protein RhoB"
                     /protein_id="NP_004031.1"
                     /db_xref="CCDS:CCDS1699.1"
                     /db_xref="GeneID:388"
                     /db_xref="HGNC:HGNC:668"
                     /db_xref="MIM:165370"
                     /translation="MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVA
                     DIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPE
                     VKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECS
                     AKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL"
     regulatory      2255..2260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /note="hexamer: AATAAA"
     polyA_site      2276
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /note="major polyA site"
     regulatory      2341..2346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /note="hexamer: ATTAAA"
     polyA_site      2367
                     /gene="RHOB"
                     /gene_synonym="ARH6; ARHB; MST081; MSTP081; RHOH6"
                     /note="major polyA site"
ORIGIN      
        1 atctgccacc gcagtctggt tggagctgtt gtcttgtatg ctcagcgagg cccggagaga
       61 cccgggagag agctaggccg agtccaccgc ccgagtctgc tgcccgagcc cgcgttacgc
      121 acaaagccgc cgatccccgg cctggggtga gcagagcgac caccgcccgg gagcagcgcg
      181 gcgagacgca cggtgcgccc tatgcccccg cgcccccacc gcccccgccg cggcagccga
      241 agcgcagcga gagaacgcgc caccgcgggg cccgggtgca gctagcgacc ctctcgccac
      301 ctgcgcgcag cccgaggtga gcagtgagcg gcgagcggga gggcagcgag gcgttcgcgg
      361 gccccctcct gctgcccggg cccggcccgc tcatggcggc catccgcaag aagctggtgg
      421 tggtgggcga cggcgcgtgt ggcaagacgt gcctgctgat cgtgttcagt aaggacgagt
      481 tccccgaggt gtacgtgccc accgtcttcg agaactatgt ggccgacatt gaggtggacg
      541 gcaagcaggt ggagctggcg ctgtgggaca cggcgggcca ggaggactac gaccgcctgc
      601 ggccgctctc ctacccggac accgacgtca ttctcatgtg cttctcggtg gacagcccgg
      661 actcgctgga gaacatcccc gagaagtggg tccccgaggt gaagcacttc tgtcccaatg
      721 tgcccatcat cctggtggcc aacaaaaaag acctgcgcag cgacgagcat gtccgcacag
      781 agctggcccg catgaagcag gaacccgtgc gcacggatga cggccgcgcc atggccgtgc
      841 gcatccaagc ctacgactac ctcgagtgct ctgccaagac caaggaaggc gtgcgcgagg
      901 tcttcgagac ggccacgcgc gccgcgctgc agaagcgcta cggctcccag aacggctgca
      961 tcaactgctg caaggtgcta tgagggccgc gcccgtcgcg cctgcccctg ccggcacggc
     1021 tccccctcct ggaccagtcc cccgcgagcc cggagaaggg gagacccgtg tcccacaagg
     1081 accccaccgg cctgcctggc atctgtctgc tgacgcctct ggcttgcgcc aggacttggc
     1141 gtgggcaccg ggcgccccca tcccagtgtc tgtgtgcgtc cagctgtgtt gcacaggcct
     1201 gggctcccca ctgagtgcca agggtcccct gagcatgctt ttctgaagag ccgggcctca
     1261 gagtgtgtgg ctgtgtgtct gttcgactcc cctcgcccca ttttcacccc acccccgcct
     1321 ctgatccccg ggggcgagat tggcgcggga gtgtggccgc gccccatcag atgttcgccc
     1381 ttcaccagcg ggagcttgat atcccttgtc tgtaacatag accccgggta ctgcgggagg
     1441 ggagggctgc tggggaggat ggggggatgt tatataaata tagatataat tttattttcg
     1501 gagctaagat ggtgttattt aagggtggtg atgggtgagc gctctggccc aggctgggcc
     1561 agactcccgc ccaagcatga acaggacttg accatctttc caacccctgg ggaagacatt
     1621 tgcaactgac ttggggagga cacagcttca gcacagcctc tcctgcgggc cagcccgctg
     1681 cgaaccctcc accagctacc ggagggagga gggaggatgc gctgtggggt tgtttttgcc
     1741 ataagcgaac tttgtgcctg tcctagaagt gaaaattgtt cagtccaaga aactgatgtt
     1801 atttgattta tttaaaggct aaaatttgtt tttttattct ttgcacaatt gtttcattgt
     1861 ttgacactta atgcactcgt catttgcata cgacagtagc attctgacca cacttgtacg
     1921 ctgtaacctc atctacttct gatgttttta aaaaatgact tttaacaagg agagggaaaa
     1981 gaaacccact aaattttgct ttgtttcctt gaagaatgtg gcaacactgt tttgtgattt
     2041 tatttgtgca ggtcatgcac acagttttga taaagggcag taacaagtat tggggcctat
     2101 tttttttttt tccacaaggc attctctaaa gctatgtgaa attttctctg cacctctgta
     2161 cagagaatac acctgcccct gtatatcctt ttttcccctc ccctccctcc cagtggtact
     2221 tctactaaat tgttgtcttg ttttttattt tttaaataaa ctgacaaatg acaaaatggt
     2281 gagcttatga tgtttacata aaagttctat aagctgtgta tacagttttt tatgtaaaat
     2341 attaaaagac tatgatgatg acattta
//
