LOCUS       NM_001252499            1926 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens RAD9-HUS1-RAD1 interacting nuclear orphan 1 (RHNO1),
            transcript variant 1, mRNA.
ACCESSION   NM_001252499 NM_031465 NR_027363 XR_078456 XR_078774 XR_079310
VERSION     NM_001252499.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1926)
  AUTHORS   Hara,K., Tatsukawa,K., Nagata,K., Iida,N., Hishiki,A., Ohashi,E.
            and Hashimoto,H.
  TITLE     Structural basis for intra- and intermolecular interactions on RAD9
            subunit of 9-1-1 checkpoint clamp implies functional 9-1-1
            regulation by RHINO
  JOURNAL   J Biol Chem 300 (3), 105751 (2024)
   PUBMED   38354779
  REMARK    GeneRIF: Structural basis for intra- and intermolecular
            interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies
            functional 9-1-1 regulation by RHINO.
REFERENCE   2  (bases 1 to 1926)
  AUTHORS   Du,D., Wang,S., Li,T., Liu,Z., Yang,M., Sun,L. and Yuan,S.
  TITLE     RHNO1 disruption inhibits cell proliferation and induces
            mitochondrial apoptosis via PI3K/Akt pathway in hepatocellular
            carcinoma
  JOURNAL   Biochem Biophys Res Commun 673, 96-105 (2023)
   PUBMED   37364391
  REMARK    GeneRIF: RHNO1 disruption inhibits cell proliferation and induces
            mitochondrial apoptosis via PI3K/Akt pathway in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 1926)
  AUTHORS   Brambati,A., Sacco,O., Porcella,S., Heyza,J., Kareh,M.,
            Schmidt,J.C. and Sfeir,A.
  TITLE     RHINO directs MMEJ to repair DNA breaks in mitosis
  JOURNAL   Science 381 (6658), 653-660 (2023)
   PUBMED   37440612
  REMARK    GeneRIF: RHINO directs MMEJ to repair DNA breaks in mitosis.
REFERENCE   4  (bases 1 to 1926)
  AUTHORS   Barger,C.J., Chee,L., Albahrani,M., Munoz-Trujillo,C., Boghean,L.,
            Branick,C., Odunsi,K., Drapkin,R., Zou,L. and Karpf,A.R.
  TITLE     Co-regulation and function of FOXM1/RHNO1 bidirectional genes in
            cancer
  JOURNAL   Elife 10, e55070 (2021)
   PUBMED   33890574
  REMARK    GeneRIF: Co-regulation and function of FOXM1/RHNO1 bidirectional
            genes in cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1926)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1926)
  AUTHORS   Heikkinen,T., Khan,S., Huovari,E., Vilske,S., Schleutker,J.,
            Kallioniemi,A., Blomqvist,C., Aittomaki,K. and Nevanlinna,H.
  TITLE     Evaluation of the RHINO gene for breast cancer predisposition in
            Finnish breast cancer families
  JOURNAL   Breast Cancer Res Treat 144 (2), 437-441 (2014)
   PUBMED   24562772
  REMARK    GeneRIF: Germline variation in the RHINO gene is unlikely to
            influence inherited susceptibility to breast cancer.
REFERENCE   7  (bases 1 to 1926)
  AUTHORS   Cotta-Ramusino,C., McDonald,E.R. 3rd, Hurov,K., Sowa,M.E.,
            Harper,J.W. and Elledge,S.J.
  TITLE     A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1
            interacting protein required for ATR signaling
  JOURNAL   Science 332 (6035), 1313-1317 (2011)
   PUBMED   21659603
  REMARK    GeneRIF: We suggest that RHINO functions together with the 9-1-1
            complex and TopBP1 to fully activate ATR (ataxia telangiectasia and
            Rad3-related.
REFERENCE   8  (bases 1 to 1926)
  AUTHORS   Kim,J.W., Fukukawa,C., Ueda,K., Nishidate,T., Katagiri,T. and
            Nakamura,Y.
  TITLE     Involvement of C12orf32 overexpression in breast carcinogenesis
  JOURNAL   Int J Oncol 37 (4), 861-867 (2010)
   PUBMED   20811708
  REMARK    GeneRIF: Identified C12orf32 to be significantly up-regulated in
            the great majority of clinical breast cancer specimens.
REFERENCE   9  (bases 1 to 1926)
  AUTHORS   Matsuoka,S., Ballif,B.A., Smogorzewska,A., McDonald,E.R. 3rd,
            Hurov,K.E., Luo,J., Bakalarski,C.E., Zhao,Z., Solimini,N.,
            Lerenthal,Y., Shiloh,Y., Gygi,S.P. and Elledge,S.J.
  TITLE     ATM and ATR substrate analysis reveals extensive protein networks
            responsive to DNA damage
  JOURNAL   Science 316 (5828), 1160-1166 (2007)
   PUBMED   17525332
REFERENCE   10 (bases 1 to 1926)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB073599.1 and AI631627.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001252499.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 4 and 5 all encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB073599.1, SRR1660807.139389.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000489288.7/ ENSP00000438590.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1862              AB073599.1         1-1862
            1863-1926           AI631627.1         13-76               c
FEATURES             Location/Qualifiers
     source          1..1926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..1926
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /note="RAD9-HUS1-RAD1 interacting nuclear orphan 1"
                     /db_xref="GeneID:83695"
                     /db_xref="HGNC:HGNC:28206"
                     /db_xref="MIM:614085"
     exon            1..60
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /inference="alignment:Splign:2.1.0"
     exon            61..312
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..861
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /note="isoform 1 is encoded by transcript variant 1; Rad9,
                     Rad1, Hus1 interacting nuclear orphan; rAD9, RAD1,
                     HUS1-interacting nuclear orphan protein; RAD9, HUS1,
                     RAD1-interacting nuclear orphan protein 1"
                     /codon_start=1
                     /product="RAD9, HUS1, RAD1-interacting nuclear orphan
                     protein 1 isoform 1"
                     /protein_id="NP_001239428.1"
                     /db_xref="CCDS:CCDS8518.1"
                     /db_xref="GeneID:83695"
                     /db_xref="HGNC:HGNC:28206"
                     /db_xref="MIM:614085"
                     /translation="MPPRKKRRQPSQKAPLLFHQQPLEGPKHSCASTQLPITHTRQVP
                     SKPIDHSTITSWVSPDFDTAAGSLFPAYQKHQNRARHSSRKPTTSKFPHLTFESPQSS
                     SSETLGIPLIRECPSESEKDVSRRPLVPVLSPQSCGNMSVQALQSLPYVFIPPDIQTP
                     ESSSVKEELIPQDQKENSLLSCTLHTGTPNSPEPGPVLVKDTPEDKYGIKVTWRRRQH
                     LLAYLRERGKLSRSQFLVKS"
     exon            313..1926
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1862
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /note="major polyA site"
     regulatory      1902..1907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
                     /note="hexamer: ATTAAA"
     polyA_site      1926
                     /gene="RHNO1"
                     /gene_synonym="C12orf32; HKMT1188; RHINO"
ORIGIN      
        1 attccgggct cgaaggctgt gcggtctgcc aggagctgcg gccccgtccg gcccgggctg
       61 gcatgggttg gaattggagc ctatccccca acccgaaggc taacagcatc atgtggttac
      121 taactgttcc tcattcaccg gttgatgcct cccagaaaaa aacgccgcca gccttcccag
      181 aaagccccgc tgctgttcca ccaacaacca ctggagggcc ccaaacacag ctgtgcatct
      241 acacagcttc ccatcactca cactcgacag gtgcccagca agcccattga ccacagcacc
      301 atcacttcct gggtatcacc tgattttgat acagcagcag gaagcttgtt cccagcctac
      361 cagaaacacc aaaaccgggc gagacactca agtcgaaaac ctaccacctc caagtttcca
      421 catctaactt ttgagagtcc gcaatcttcc agttcagaga cattggggat ccccttaatc
      481 cgagagtgcc ccagtgaatc agaaaaggat gtttccagaa gacccttagt tccagtgctc
      541 agtccccaaa gctgtgggaa catgtcagtg caggcacttc agagcttacc ttatgtgttc
      601 attccacctg atatccagac cccagagtca tcgtctgtga aggaagaact cattccccaa
      661 gatcagaagg aaaacagcct tctaagctgc actcttcaca ctggcactcc taatagccca
      721 gagcctggac ctgttctggt taaagacacc cccgaggaca agtatggaat aaaggtcaca
      781 tggaggagac gacagcacct gcttgcttac ctcagggaga gagggaagct gagcagaagc
      841 caattccttg tgaaaagctg actgccatca gtaatctcaa tagaaaagag atatgttttc
      901 tggagtcata aaggaattca attcctaggg tttttgtttt tgtttttgag atgtaatatt
      961 gctctgttgc ccaggctgga gtgcagtggt atgatctcac cttactgcaa ccaccacttc
     1021 ctgggttcaa gcgattctcc tgcctcagcc tccccagtag ctgggattac aggcaccagc
     1081 caccatgcct ggctaatttt tttgtatttt tagtagagat gtggtttctc catgttggcc
     1141 aggctggtct caaaatcctg acctcaagtc atctgctggc cttgacctca caaagtgctg
     1201 gcccagccga gatttgtttt ctaagatact ttgtgtcatg aacagttcag tttagtgtca
     1261 tgaactattc acttcatatt tttcttgtat taactgttta aatttttaaa atatcttgta
     1321 gtaactcttt aaaatgtatg taagtaaatg gctgcagaaa gtttttttag agaatcctgc
     1381 ttccatcagt aatacagcaa tattacccca tccactaatg gtctttgttt ccttaaccac
     1441 tactcattaa tccttaatca cctcattcaa actaattcat tctgcatttt tgagtaccaa
     1501 ctcttgtcag gctcagtggc agcttctacg acctgatgga tggaaaaaaa tcaaactctg
     1561 tgactctatg gttgactgcc acctctgcaa ccttgactca tctgctgaaa aggcaagaag
     1621 aagaaagggc agcaagccct gttttaggga ctacataaga tgaggggaga taagggggac
     1681 atagatgagt tctttaggat tgcgtgtgtt ttgagttttt gtttctaact gaagaaatct
     1741 gtcaatatta aatagggtgg gaaaatggtt tcttagaata actgttcaac tgtgtgtaaa
     1801 taaggaaagt tttcaatgag tattacttat tgtaattaat gcagaaggac ttccccagtc
     1861 aaccgaatgt ctcggccttt tactcagaca agtagcatct cattaaaccc attcatttag
     1921 cattca
//
