LOCUS       NM_144593               1173 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens RHEB like 1 (RHEBL1), transcript variant 1, mRNA.
ACCESSION   NM_144593
VERSION     NM_144593.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1173)
  AUTHORS   Yang,Y., Cai,Z., Pan,Z., Liu,F., Li,D., Ji,Y., Zhong,J., Luo,H.,
            Hu,S., Song,L., Yu,S., Li,T., Li,J., Ma,X., Zhang,W., Zhou,Z.,
            Liu,F. and Zhang,J.
  TITLE     Rheb1 promotes glucose-stimulated insulin secretion in human and
            mouse beta-cells by upregulating GLUT expression
  JOURNAL   Metabolism 123, 154863 (2021)
   PUBMED   34375645
  REMARK    GeneRIF: Rheb1 promotes glucose-stimulated insulin secretion in
            human and mouse beta-cells by upregulating GLUT expression.
REFERENCE   2  (bases 1 to 1173)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1173)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1173)
  AUTHORS   Kim,H.J., Byun,H.J., Park,M.K., Kim,E.J., Kang,G.J. and Lee,C.H.
  TITLE     Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced
            keratin phosphorylation and reorganization: Binding to and
            activation of AKT1
  JOURNAL   Oncotarget 8 (13), 20851-20864 (2017)
   PUBMED   28209923
  REMARK    GeneRIF: High RHEBL1 expression is associated with lung cancer.
REFERENCE   5  (bases 1 to 1173)
  AUTHORS   Sato,T., Akasu,H., Shimono,W., Matsu,C., Fujiwara,Y., Shibagaki,Y.,
            Heard,J.J., Tamanoi,F. and Hattori,S.
  TITLE     Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate
            transcarbamoylase, and dihydroorotase) protein in a GTP- and
            effector domain-dependent manner and influences its cellular
            localization and carbamoyl-phosphate synthetase (CPSase) activity
  JOURNAL   J Biol Chem 290 (2), 1096-1105 (2015)
   PUBMED   25422319
  REMARK    GeneRIF: These results establish CAD as a downstream effector of
            Rheb and suggest a possible role of Rheb in regulating de novo
            pyrimidine nucleotide synthesis.(Rheb small GTPases, which consist
            of Rheb1 and Rheb2 (also known as RhebL1)
REFERENCE   6  (bases 1 to 1173)
  AUTHORS   Bonneau,A. and Parmar,N.
  TITLE     Effects of RhebL1 silencing on the mTOR pathway
  JOURNAL   Mol Biol Rep 39 (3), 2129-2137 (2012)
   PUBMED   21655954
  REMARK    GeneRIF: RhebL1 may be impacting the mTOR pathway in a different
            manner than Rheb1.
REFERENCE   7  (bases 1 to 1173)
  AUTHORS   Yuan,J., Shan,Y., Chen,X., Tang,W., Luo,K., Ni,J., Wan,B. and Yu,L.
  TITLE     Identification and characterization of RHEBL1, a novel member of
            Ras family, which activates transcriptional activities of NF-kappa
            B
  JOURNAL   Mol Biol Rep 32 (4), 205-214 (2005)
   PUBMED   16328882
  REMARK    GeneRIF: RHEBL1 is a positive regulator of NF-kappa B-mediated gene
            transcription.
REFERENCE   8  (bases 1 to 1173)
  AUTHORS   Tee,A.R., Blenis,J. and Proud,C.G.
  TITLE     Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1
  JOURNAL   FEBS Lett 579 (21), 4763-4768 (2005)
   PUBMED   16098514
  REMARK    GeneRIF: Data show that Rheb like-1 protein (RhebL1) rescues mTOR
            signaling during nutrient withdrawal, and identify critical
            residues in Rheb and RhebL1 which are required for their efficient
            activation of mTOR signaling.
REFERENCE   9  (bases 1 to 1173)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   10 (bases 1 to 1173)
  AUTHORS   Tabancay,A.P. Jr., Gau,C.L., Machado,I.M., Uhlmann,E.J.,
            Gutmann,D.H., Guo,L. and Tamanoi,F.
  TITLE     Identification of dominant negative mutants of Rheb GTPase and
            their use to implicate the involvement of human Rheb in the
            activation of p70S6K
  JOURNAL   J Biol Chem 278 (41), 39921-39930 (2003)
   PUBMED   12869548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY327412.1 and AI917432.1.
            
            On Nov 23, 2018 this sequence version replaced NM_144593.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY327412.1, BC027482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301068.11/ ENSP00000301068.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1164              AY327412.1         47-1210
            1165-1173           AI917432.1         17-25               c
FEATURES             Location/Qualifiers
     source          1..1173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..1173
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /note="RHEB like 1"
                     /db_xref="GeneID:121268"
                     /db_xref="HGNC:HGNC:21166"
                     /db_xref="MIM:618956"
     exon            1..246
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..746
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GTPase RhebL1; Ras homolog enriched in brain like 1 c;
                     rheb2; rheb-like protein 1; ras homolog enriched in brain
                     like-1 c; ras homolog enriched in brain-like protein 1"
                     /codon_start=1
                     /product="GTPase RhebL1 isoform 1"
                     /protein_id="NP_653194.1"
                     /db_xref="CCDS:CCDS8778.1"
                     /db_xref="GeneID:121268"
                     /db_xref="HGNC:HGNC:21166"
                     /db_xref="MIM:618956"
                     /translation="MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYS
                     KIVTLGKDEFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQK
                     LHEGHGKTRVPVVLVGNKADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIF
                     TKVIQEIARVENSYGQERRCHLM"
     exon            247..318
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     exon            319..386
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     exon            387..469
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     exon            470..526
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     exon            527..574
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     exon            575..656
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1173
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1146..1151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /note="hexamer: AATAAA"
     polyA_site      1173
                     /gene="RHEBL1"
                     /gene_synonym="RHEBL1c"
                     /note="major polyA site"
ORIGIN      
        1 gttagacgtg ctgtgttgtg atcacgtggg cagctccggg cgcggcgctt gttttggttt
       61 ccttctaact tgcccacggc agcttcgggg tgagcgactt tcctgcacca gctgccgcgc
      121 ctgctcacac cctgacctcg ttttcgggct ctctgagccc gcagttccgc aagcccctgg
      181 ggcgggctcc tgccatgccg ctagtccgct acaggaaggt ggtcatcctc ggataccgct
      241 gtgtagggaa gacatctttg gcacatcaat ttgtggaagg cgagttctcg gaaggctacg
      301 atcctacagt ggagaatact tacagcaaga tagtgactct tggcaaagat gagtttcacc
      361 tacatctggt ggacacagca gggcaggatg agtacagcat tctgccctat tcattcatca
      421 ttggggtcca tggttatgtg cttgtgtatt ctgtcacctc tctgcatagc ttccaagtca
      481 ttgagagtct gtaccaaaag ctacatgaag gccatgggaa aacccgggtg ccagtggttc
      541 tagtggggaa caaggcagat ctctctccag agagagaggt acaggcagtt gaaggaaaga
      601 agctggcaga gtcctggggt gcgacattta tggagtcatc tgctcgagag aatcagctga
      661 ctcaaggcat cttcaccaaa gtcatccagg agattgcccg tgtggagaat tcctatgggc
      721 aagagcgtcg ctgccatctc atgtgagccc ttgggtgtgg ggtaactgcc ttgcttctgc
      781 ccccggcact tgccatgttc cagtgggggg cagatcctca ggacttcacg ggtatggttg
      841 ccagctgtgt tcctggcccc tggacacaca gtgtggcatc ctcatgtttg cacactttcc
      901 ccaggctcca gtggcctgga tgtcaatgtt tacaaagggg caaggacctc tcatggacac
      961 tggcctctag ccctctgttt ttgtttgatg aattctgtta taacctatgg ggtcaggata
     1021 tgagtcctgg gcattattta tccaggaccc atcctcttgg gtgggttttg ggtgttggct
     1081 gggtaagggg agccggggac ttctgaaata gagctggctc cctggggtga caatgtatat
     1141 atgcaaataa attgagaaat cttttgttgt tga
//
