LOCUS       NM_016321               1952 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Rh family C glycoprotein (RHCG), transcript variant 1,
            mRNA.
ACCESSION   NM_016321
VERSION     NM_016321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Zhang,Q., Liu,J., Yao,D., Shi,J.X., Liu,Y.J., Wei,Y.G. and Guo,S.
  TITLE     Comprehensive Analysis to Identify Rh Family C Glycoprotein (RHCG)
            as the Causative Gene for Psoriasis and Search for Alternative
            Treatment Modalities
  JOURNAL   Drug Des Devel Ther 17, 2593-2611 (2023)
   PUBMED   37664450
  REMARK    GeneRIF: Comprehensive Analysis to Identify Rh Family C
            Glycoprotein (RHCG) as the Causative Gene for Psoriasis and Search
            for Alternative Treatment Modalities.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Chen,P., Liu,C., Li,P., Wang,Q., Gao,X., Wu,H. and Huang,J.
  TITLE     High RhCG expression predicts poor survival and promotes migration
            and proliferation of gastric cancer via keeping intracellular
            alkaline
  JOURNAL   Exp Cell Res 386 (2), 111740 (2020)
   PUBMED   31756312
  REMARK    GeneRIF: High RhCG level was correlated with poor prognosis of
            gastric cancer patients.
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Xu,W., Zou,H., Wei,Z., Song,C., Tang,C., Yin,X., Wang,Y., Han,S.,
            Cai,Y. and Han,W.
  TITLE     Rh type C-glycoprotein functions as a novel tumor suppressor gene
            by inhibiting tumorigenicity and metastasis in head and neck
            squamous cell carcinoma
  JOURNAL   Aging (Albany NY) 11 (11), 3601-3623 (2019)
   PUBMED   31170090
  REMARK    GeneRIF: Our study reveals that RHCG acts as a tumor suppressor
            gene that plays a crucial role in inhibiting tumorigenicity and
            metastasis in head and neck squamous cell carcinoma.
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Verlander,J.W., Miller,R.T., Frank,A.E., Royaux,I.E., Kim,Y.H. and
            Weiner,I.D.
  TITLE     Localization of the ammonium transporter proteins RhBG and RhCG in
            mouse kidney
  JOURNAL   Am J Physiol Renal Physiol 284 (2), F323-F337 (2003)
   PUBMED   12388412
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Chen,B.S., Xu,Z.X., Xu,X., Cai,Y., Han,Y.L., Wang,J., Xia,S.H.,
            Hu,H., Wei,F., Wu,M. and Wang,M.R.
  TITLE     RhCG is downregulated in oesophageal squamous cell carcinomas, but
            expressed in multiple squamous epithelia
  JOURNAL   Eur J Cancer 38 (14), 1927-1936 (2002)
   PUBMED   12204676
  REMARK    Erratum:[Eur J Cancer. 2003 Feb;39(3):405.]
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Marini,A.M., Matassi,G., Raynal,V., Andre,B., Cartron,J.P. and
            Cherif-Zahar,B.
  TITLE     The human Rhesus-associated RhAG protein and a kidney homologue
            promote ammonium transport in yeast
  JOURNAL   Nat Genet 26 (3), 341-344 (2000)
   PUBMED   11062476
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Liu,Z., Chen,Y., Mo,R., Hui,C., Cheng,J.F., Mohandas,N. and
            Huang,C.H.
  TITLE     Characterization of human RhCG and mouse Rhcg as novel nonerythroid
            Rh glycoprotein homologues predominantly expressed in kidney and
            testis
  JOURNAL   J Biol Chem 275 (33), 25641-25651 (2000)
   PUBMED   10852913
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Ridgwell,K., Spurr,N.K., Laguda,B., MacGeoch,C., Avent,N.D. and
            Tanner,M.J.
  TITLE     Isolation of cDNA clones for a 50 kDa glycoprotein of the human
            erythrocyte membrane associated with Rh (rhesus) blood-group
            antigen expression
  JOURNAL   Biochem J 287 (Pt 1) (Pt 1), 223-228 (1992)
   PUBMED   1417776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC306265.1, AF193809.1 and BC030965.1.
            
            On Nov 24, 2018 this sequence version replaced NM_016321.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes a protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030965.1, AK290899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156670 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268122.9/ ENSP00000268122.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DC306265.1         31-45
            16-1515             AF193809.1         1-1500
            1516-1948           BC030965.1         1516-1948
            1949-1952           AF193809.1         1934-1937
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..1952
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /note="Rh family C glycoprotein"
                     /db_xref="GeneID:51458"
                     /db_xref="HGNC:HGNC:18140"
                     /db_xref="MIM:605381"
     exon            1..223
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1479
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /note="Rh type C glycoprotein; Rhesus blood group, C
                     glycoprotein; rh glycoprotein kidney; tumor-related
                     protein DRC2; rh family type C glycoprotein; rhesus blood
                     group family type C glycoprotein"
                     /codon_start=1
                     /product="ammonium transporter Rh type C"
                     /protein_id="NP_057405.1"
                     /db_xref="CCDS:CCDS10351.1"
                     /db_xref="GeneID:51458"
                     /db_xref="HGNC:HGNC:18140"
                     /db_xref="MIM:605381"
                     /translation="MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSER
                     THKNLSDMENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQW
                     ALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVT
                     LFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSD
                     LFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGK
                     LDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHI
                     QDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFNGDWTARTQGK
                     FQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPED
                     PTFKPSGPSVPSVPMVSPLPMASSVPLVP"
     exon            224..410
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            411..561
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            562..709
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..876
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1014
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1151
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1276
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1350
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1503
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1952
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="RHCG"
                     /gene_synonym="C15orf6; PDRC2; RHGK; SLC42A3"
                     /note="major polyA site"
ORIGIN      
        1 gaaccgcccg ctgccagccc ggccaggcac ccctgcagca tggcctggaa caccaacctc
       61 cgctggcggc tgccgctcac ctgcctgctc ctgcaggtga ttatggtgat tctcttcggg
      121 gtgttcgtgc gctacgactt cgaggccgac gcccactggt ggtcagagag gacgcacaag
      181 aacttgagcg acatggagaa cgaattctac tatcgctacc caagcttcca ggacgtgcac
      241 gtgatggtct tcgtgggctt cggcttcctc atgactttcc tgcagcgcta cggcttcagc
      301 gccgtgggct tcaacttcct gttggcagcc ttcggcatcc agtgggcgct gctcatgcag
      361 ggctggttcc acttcttaca agaccgctac atcgtcgtgg gcgtggagaa cctcatcaac
      421 gctgacttct gcgtggcctc tgtctgcgtg gcctttgggg cagttctggg taaagtcagc
      481 cccattcagc tgctcatcat gactttcttc caagtgaccc tcttcgctgt gaatgagttc
      541 attctcctta acctgctaaa ggtgaaggat gcaggaggct ccatgaccat ccacacattt
      601 ggcgcctact ttgggctcac agtgacccgg atcctctacc gacgcaacct agagcagagc
      661 aaggagagac agaattctgt gtaccagtcg gacctctttg ccatgattgg caccctcttc
      721 ctgtggatgt actggcccag cttcaactca gccatatcct accatgggga cagccagcac
      781 cgagccgcca tcaacaccta ctgctccttg gcagcctgcg tgcttacctc ggtggcaata
      841 tccagtgccc tgcacaagaa gggcaagctg gacatggtgc acatccagaa tgccacgctc
      901 gcaggagggg tggccgtggg taccgctgct gagatgatgc tcatgcctta cggtgccctc
      961 atcatcggct tcgtctgcgg catcatctcc accctgggtt ttgtatacct gaccccattc
     1021 ctggagtccc ggctgcacat ccaggacaca tgtggcatta acaatctgca tggcattcct
     1081 ggcatcatag gcggcatcgt gggtgctgtg acagcggcct ccgccagcct tgaagtctat
     1141 ggaaaagaag ggcttgtcca ttcctttgac tttcaaggtt tcaacgggga ctggaccgca
     1201 agaacacagg gaaagttcca gatttatggt ctcttggtga ccctggccat ggccctgatg
     1261 ggtggcatca ttgtggggct cattttgaga ttaccattct ggggacaacc ttcagatgag
     1321 aactgctttg aggatgcggt ctactgggag atgcctgaag ggaacagcac tgtctacatc
     1381 cctgaggacc ccaccttcaa gccctcagga ccctcagtac cctcagtacc catggtgtcc
     1441 ccactaccca tggcttcctc ggtacccttg gtaccctagg ctcccagggc aggtgaggag
     1501 caggctccac agactgtcct ggggcccaga ggagctggtg ctgacctagc tagggatgca
     1561 agagtgagca agcagcaccc ccacctgctg gcttggcctc aaggtgcctc cacccctgcc
     1621 ctccccttca tcccaggggg tctgactgag aatggagaag gagaagctac aaagtgggca
     1681 tccaagccgg gttctggctg cagaagttct gcctctgcct ggggtcttgg ccacattgga
     1741 gaaaaacagg ctcaaagtgg ggctgggacc tggtgggtga acctgagctc tcccaggaga
     1801 caacttagct gccagtcacc acctatgagg ctcttctacc ccgtgcctgc acctcggcca
     1861 gcatctccta tgctccctgg gtcccccaga cctctctgtg ttgtgtgcgt ggcagcctcc
     1921 aggaataaac attcttgttg tcctttgtaa aa
//
