LOCUS       NM_001137669            3735 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens regulator of G protein signaling like 1 (RGSL1),
            transcript variant 1, mRNA.
ACCESSION   NM_001137669 XM_001721759 XM_001725941 XM_001726587
VERSION     NM_001137669.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3735)
  AUTHORS   Wiechec,E., Overgaard,J., Kjeldsen,E. and Hansen,L.L.
  TITLE     Chromosome 1q25.3 copy number alterations in primary breast cancers
            detected by multiplex ligation-dependent probe amplification and
            allelic imbalance assays and its comparison with fluorescent in
            situ hybridization assays
  JOURNAL   Cell Oncol (Dordr) 36 (2), 113-120 (2013)
   PUBMED   23248035
  REMARK    GeneRIF: Data indicate that multiplex ligation-dependent probe
            amplification (MLPA) probes (Fig. 2) corresponding to the RGSL2,
            RGSL1 and RGS16 genes showed 64.5 % tumour samples with copy number
            gains and 5 % tumour samples with copy number losses.
REFERENCE   2  (bases 1 to 3735)
  AUTHORS   Wiechec,E., Wiuf,C., Overgaard,J. and Hansen,L.L.
  TITLE     High-resolution melting analysis for mutation screening of RGSL1,
            RGS16, and RGS8 in breast cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 20 (2), 397-407 (2011)
   PUBMED   21135262
  REMARK    GeneRIF: Missense mutations in RGSL1 gene is associated with breast
            cancer.
REFERENCE   3  (bases 1 to 3735)
  AUTHORS   Shulman,J.M., Chibnik,L.B., Aubin,C., Schneider,J.A., Bennett,D.A.
            and De Jager,P.L.
  TITLE     Intermediate phenotypes identify divergent pathways to Alzheimer's
            disease
  JOURNAL   PLoS One 5 (6), e11244 (2010)
   PUBMED   20574532
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3735)
  AUTHORS   Wiechec,E., Overgaard,J. and Hansen,L.L.
  TITLE     A fragile site within the HPC1 region at 1q25.3 affecting RGS16,
            RGSL1, and RGSL2 in human breast carcinomas
  JOURNAL   Genes Chromosomes Cancer 47 (9), 766-780 (2008)
   PUBMED   18521847
  REMARK    GeneRIF: A detailed mapping of the breakpoints revealed intragenic
            microdeletions affecting the coding regions of RGSL2, RGSL1.
REFERENCE   5  (bases 1 to 3735)
  AUTHORS   Silva,A.P., Salim,A.C., Bulgarelli,A., de Souza,J.E., Osorio,E.,
            Caballero,O.L., Iseli,C., Stevenson,B.J., Jongeneel,C.V., de
            Souza,S.J., Simpson,A.J. and Camargo,A.A.
  TITLE     Identification of 9 novel transcripts and two RGSL genes within the
            hereditary prostate cancer region (HPC1) at 1q25
  JOURNAL   Gene 310, 49-57 (2003)
   PUBMED   12801632
REFERENCE   6  (bases 1 to 3735)
  AUTHORS   Tosetti,P., Parente,V., Taglietti,V., Dunlap,K. and Toselli,M.
  TITLE     Chick RGS2L demonstrates concentration-dependent selectivity for
            pertussis toxin-sensitive and -insensitive pathways that inhibit
            L-type Ca2+ channels
  JOURNAL   J Physiol 549 (Pt 1), 157-169 (2003)
   PUBMED   12651916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC142944.1 and AF508902.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001137669.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142944.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294854.13/ ENSP00000457748.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3604              BC142944.1         1-3604
            3605-3735           AF508902.1         266-396
FEATURES             Location/Qualifiers
     source          1..3735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..3735
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /note="regulator of G protein signaling like 1"
                     /db_xref="GeneID:353299"
                     /db_xref="HGNC:HGNC:18636"
                     /db_xref="MIM:611012"
     exon            1..33
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3251
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulator of G-protein signaling like 2; regulator of
                     G-protein signaling protein-like"
                     /codon_start=1
                     /product="regulator of G-protein signaling protein-like
                     isoform 1"
                     /protein_id="NP_001131141.1"
                     /db_xref="CCDS:CCDS58049.1"
                     /db_xref="GeneID:353299"
                     /db_xref="HGNC:HGNC:18636"
                     /db_xref="MIM:611012"
                     /translation="MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVEN
                     SQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGE
                     ELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNL
                     SIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETR
                     LYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIG
                     MPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPF
                     ETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLN
                     LKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQ
                     TIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQ
                     HKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELT
                     SPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRS
                     NRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKIS
                     IETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHV
                     MKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISF
                     IRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQE
                     NGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVIL
                     MRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVV
                     MYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEW
                     LQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK"
     exon            34..116
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            117..191
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..321
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            322..483
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1451
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1514
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1737
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1845
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1951
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2145
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2263
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2384
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2514
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2689
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2828
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2953
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3063
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3150
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3217
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3416
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3735
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3712..3717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /note="hexamer: AATAAA"
     polyA_site      3735
                     /gene="RGSL1"
                     /gene_synonym="RGSL; RGSL2"
                     /note="major polyA site"
ORIGIN      
        1 gtcaggaaga gcatggcaac atgagcagtg ctgagataat tggttctaca aatcttataa
       61 ttctgctaga ggatgaagtc tttgccgatt ttttcaacac atttctttcc ctcccggttt
      121 ttggtcagac accattttat actgttgaaa attcacagtg gagcttgtgg ccagaaatac
      181 cttgtaactt gattgccaaa tacaaagggt tattgacctg gttggaaaaa tgccgattac
      241 ctttcttctg taaaacaaac ttgtgtttcc attacattct ctgtcaggag ttcatcagtt
      301 tcattaagtc cccagaagga ggtgaagaat tggtggattt ctggatcctt gctgagaaca
      361 tcctgagcat agatgagatg gacctggaag tgagagacta ctacctgtcc ctcctcctca
      421 tgctgagggc cactcatctg caggagggct ccagggtggt aaccctctgt aacatgaaca
      481 tcaagtccct cctgaacctc tccatctggc atcccaacca atcaaccact aggagggaga
      541 tcctgagcca catgcagaaa gtggctctgt tcaaactcca gagctattgg cttcccaact
      601 tttacaccca caccaagatg accatggcca aggaggaagc atgccatggt ctgatgcaag
      661 agtacgagac tcgcttatac agcgtttgct acacccacat aggagggctc cctctgaaca
      721 tgagcatcaa gaagtgccac cactttcaga aacggtactc aagcaggaaa gccaagagga
      781 agatgtggca attggtagat cctgactctt ggtctctgga aatggatctc aagccagatg
      841 ctattggtat gcccctacag gagacatgtc ctcaagagaa ggtggttata caaatgcctt
      901 ccctgaaaat ggcttcttca aaggaaacaa gaatcagttc cctggaaaag gatatgcatt
      961 atgcaaaaat atccagcatg gagaataaag ccaagagcca cctccacatg gaagccccct
     1021 ttgagacaaa ggtctctacc cacctgagga ctgtcatccc cattgtcaat cactcctcca
     1081 agatgacaat tcagaaggcc atcaagcaaa gcttctcctt aggatacatc cacttggcct
     1141 tgtgtgctga tgcctgtgca gggaaccctt tccgggacca cctgaagaag ctgaatttga
     1201 aagtggagat ccaacttctt gacctctggc aggacttgca gcatttcctc agtgtccttc
     1261 tgaataacaa aaagaatggg aatgcaatct ttcgtcactt gctgggtgac agaatctgcg
     1321 agctctacct gaatgagcag attggtccgt gcttaccact caaatcccaa accattcagg
     1381 gcctgaagga actattgccc tctggggatg tgatcccctg gattcccaaa gcccagaagg
     1441 agatttgcaa gatgctcagt ccctggtatg atgagtttct agatgaagag gactactggt
     1501 ttctcctttt tacgacacag aacaggttca tcagctccag acagcataaa agagaattta
     1561 taggcaaaga agagaacatt cttctttata agaggattca gcagtctcta gagttaagcc
     1621 aggctttggc tgacatgaag gaaatggact ataggcagtg gcgaaagata gctactgagg
     1681 acctgaagca aggaggctct ctccaggtag agctgacatc tccagtgttt ctaacagaca
     1741 taactaaaat gtcctttgag gagctttgct acaagaaccc aaagatggcc atacagaaga
     1801 tcagtgatga ctacaaaata tactgtgaga aagcacctaa aatagatttt aaaatggaaa
     1861 ttatcaagga aacaaagaca gtttcacgct caaataggaa aatgtccttg ctcaaaagaa
     1921 ctcttgtaag gaagccatca atgagaccca gaaacttgac agaagtcctc ttaaatacac
     1981 agcacttgga gttcttcagg gagttcctca aggaacggaa ggctaaaatc ccattgcaat
     2041 ttctcacagc tgtacagaag atcagtatag agaccaatga aaagatttgc aagtctctca
     2101 tagaaaatgt aatcaagact ttcttccaag gccaactctc tcctgaagaa atgctgcagt
     2161 gtgatgcccc tattatcaaa gaaatcgctt ccatgcgtca tgtcaccaca agcacactgt
     2221 taacgctcca gggacatgtt atgaaatcta tagaagaaaa gtggtttaaa gattatcaag
     2281 acctgttccc acctcaccat caggaggtgg aagtgcaaag tgaagtacaa atttcgtcta
     2341 ggaagccctc aaagatagtg tcaacttacc tacaggaatc ccagaagaaa ggctggatga
     2401 gaatgatcag ctttatcagg agtttttgca agtaccgcag atttatgttg aatcctagta
     2461 agcgccagga atttgaagac tatcttcacc aggaaatgca aaatagcaag gaaaatttca
     2521 ccacagcaca caacacatcg ggacgttcag ctccaccctc cacaaatgtc cggagtgcag
     2581 accaagagaa tggagaaata acccttgtaa agcgtcgtat atttggccac aggattatca
     2641 ctgtcaactt tgcgatcaat gatctatatt tcttttctga aatggagaaa tttaatgatc
     2701 tggtcagttc agcccacatg ctgcaggtca accgggcata taatgagaat gatgtgatcc
     2761 taatgcggtc caaaatgaac attatccaaa aactcttcct gaattctgac atccctccaa
     2821 agctgagggt gaatgtccct gagttccaga aggatgccat ccttgctgcc atcacagagg
     2881 gctacctaga tcggagcgtc ttccatgggg ctatcatgtc tgtcttcccc gttgttatgt
     2941 acttctggaa aaggttttgt ttctggaagg caacccgctc ttacttacag tataggggga
     3001 agaagttcaa ggacagaaaa agccctccta aatctacgga caagtatcct ttctcgagtg
     3061 gaggagacaa tgccatctta aggttcacct tgctcagagg tattgagtgg ttgcagcctc
     3121 aacgggaagc aataagttca gttcaaaatt cttcatcaag caaacttact cagccaagac
     3181 tcgtggtatc tgccatgcag ctgcatcccg tccagggaca aaaattatcc tacatcaaaa
     3241 aagagaagta atcaagcgag acccccagca gagataaatc atctcttaga ggcctcctaa
     3301 cactgacaga aacttttctg gtcaaaaatg aaaggtcctg gtaccatctt ccccagaaac
     3361 gatcaagaag ggcaatgggt tgacagccca gatatggcag gaccagactg caatgggaat
     3421 ctcatacagc ccattcagac taaagggtga tggaaagaag cagaggaaag cagaaacagc
     3481 aagagtgact gagacctgct gtcatctata tagaagcctt tctgatacat gtcagagagt
     3541 gacatgaagt ctcccctctt tatacacacg tatgaaaata catctatccc tcattttgag
     3601 agcctccaac tgatccaagt gtcatccgga ggaggaggtg gcccgtatgt gcaggacctc
     3661 agggtgccag ccctcaccca tacacctcca gggctgcagg tcattagcca gaataaagga
     3721 tgtccacatt cacaa
//
