LOCUS       NM_001102450            5987 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 8 (RGS8), transcript
            variant 2, mRNA.
ACCESSION   NM_001102450 XM_017002635
VERSION     NM_001102450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5987)
  AUTHORS   Bai,M., Ke,S., Yu,H., Xu,Y., Yu,Y., Lu,S., Wang,C., Huang,J.,
            Ma,Y., Dai,W. and Wu,Y.
  TITLE     Key molecules associated with thyroid carcinoma prognosis: A study
            based on transcriptome sequencing and GEO datasets
  JOURNAL   Front Immunol 13, 964891 (2022)
   PUBMED   36059514
  REMARK    GeneRIF: Key molecules associated with thyroid carcinoma prognosis:
            A study based on transcriptome sequencing and GEO datasets.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5987)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5987)
  AUTHORS   Song,D., Nishiyama,M. and Kimura,S.
  TITLE     Potent inhibition of angiotensin AT1 receptor signaling by RGS8:
            importance of the C-terminal third exon part of its RGS domain
  JOURNAL   J Recept Signal Transduct Res 36 (5), 478-487 (2016)
   PUBMED   26754208
  REMARK    GeneRIF: The chimeric RGS8 domains containing the first or the
            second exon part of RGS5 showed strong inhibitory effects similar
            to that of wild type RGS8, but the chimeric domain with the third
            exon part of RGS5 lost its activity
REFERENCE   4  (bases 1 to 5987)
  AUTHORS   Wiechec,E., Wiuf,C., Overgaard,J. and Hansen,L.L.
  TITLE     High-resolution melting analysis for mutation screening of RGSL1,
            RGS16, and RGS8 in breast cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 20 (2), 397-407 (2011)
   PUBMED   21135262
  REMARK    GeneRIF: Missense mutations in RGS8 gene is associated with breast
            cancer.
REFERENCE   5  (bases 1 to 5987)
  AUTHORS   Wang,J., Lippman,S.M., Lee,J.J., Yang,H., Khuri,F.R., Kim,E.,
            Lin,J., Chang,D.W., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     Genetic variations in regulator of G-protein signaling genes as
            susceptibility loci for second primary tumor/recurrence in head and
            neck squamous cell carcinoma
  JOURNAL   Carcinogenesis 31 (10), 1755-1761 (2010)
   PUBMED   20627871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5987)
  AUTHORS   Larminie,C., Murdock,P., Walhin,J.P., Duckworth,M., Blumer,K.J.,
            Scheideler,M.A. and Garnier,M.
  TITLE     Selective expression of regulators of G-protein signaling (RGS) in
            the human central nervous system
  JOURNAL   Brain Res Mol Brain Res 122 (1), 24-34 (2004)
   PUBMED   14992813
REFERENCE   7  (bases 1 to 5987)
  AUTHORS   Masuho,I., Itoh,M., Itoh,H. and Saitoh,O.
  TITLE     The mechanism of membrane-translocation of regulator of G-protein
            signaling (RGS) 8 induced by Galpha expression
  JOURNAL   J Neurochem 88 (1), 161-168 (2004)
   PUBMED   14675160
REFERENCE   8  (bases 1 to 5987)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   9  (bases 1 to 5987)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (bases 1 to 5987)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353778.13.
            
            On or before Jan 16, 2020 this sequence version replaced
            XM_017002635.1, NM_001102450.2.
            
            Summary: This gene is a member of the regulator of G protein
            signaling (RGS) family and encodes a protein with a single RGS
            domain. Regulator of G protein signaling (RGS) proteins are
            regulatory and structural components of G protein-coupled receptor
            complexes. They accelerate transit through the cycle of GTP binding
            and hydrolysis to GDP, thereby terminating signal transduction, but
            paradoxically, also accelerate receptor-stimulated activation.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an additional exon in the
            5' region, which results in an alternate 5' coding sequence, as
            compared to variant 1. The resulting isoform (2) has a shorter and
            alternate N-terminus, as compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.14072.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000515211.2/ ENSP00000511884.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               AL353778.13        90488-90723         c
            237-350             AL353778.13        78955-79068         c
            351-424             AL353778.13        77793-77866         c
            425-553             AL353778.13        75760-75888         c
            554-655             AL353778.13        73008-73109         c
            656-720             AL353778.13        72105-72169         c
            721-887             AL353778.13        54273-54439         c
            888-5987            AL353778.13        47954-53053         c
FEATURES             Location/Qualifiers
     source          1..5987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..5987
                     /gene="RGS8"
                     /note="regulator of G protein signaling 8"
                     /db_xref="GeneID:85397"
                     /db_xref="HGNC:HGNC:16810"
                     /db_xref="MIM:607189"
     exon            1..236
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            237..350
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            351..424
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            425..553
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     CDS             528..1070
                     /gene="RGS8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     regulator of G-protein signalling 8"
                     /codon_start=1
                     /product="regulator of G-protein signaling 8 isoform 2"
                     /protein_id="NP_001095920.1"
                     /db_xref="CCDS:CCDS41443.1"
                     /db_xref="GeneID:85397"
                     /db_xref="HGNC:HGNC:16810"
                     /db_xref="MIM:607189"
                     /translation="MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKR
                     LSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLV
                     SKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYP
                     RFLRSKMYLDLLSQSQRRLS"
     exon            554..655
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            656..720
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            721..887
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     exon            888..5987
                     /gene="RGS8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5968..5973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS8"
                     /note="hexamer: AATAAA"
     polyA_site      5987
                     /gene="RGS8"
                     /note="major polyA site"
ORIGIN      
        1 actcgctctt tcccttttca tgagatgcag agcctggaga ggagcggagc cggcaggagc
       61 agcatgttgc agccgctatt ctaggggcgc tgggtgaagt gggctgccct ctgccaccct
      121 ctcccaggtg ccaggaggag gtggctgact ctatcactca gggcctcacc gaaccatgcc
      181 cagctggggc ccgcaccagc cacaccttcc cagctgcgct gcccaccgcc aggcaggtga
      241 tgctgacact gctggttcag ggaccacgct tggagaacca ctacactagg gcaagcagga
      301 agagagtcct ccttctggaa ctgaagcagg cagtgtgaag acccatgtgg aacaccttaa
      361 cccgaagcct ctctgaccat ccagttggca aagaccctca ggccatgagg actggccaaa
      421 gacagtgaga ggacgtgcaa gggtaaattc ctgagccccg cagtcttatt tcctgccctg
      481 acgtccctgc ataccagccc aagggttaac cgtaagctga tgcctgtatg gcggccttac
      541 tgatgccacg caggaacaaa gggatgagga ctcgactggg atgcctgtct cacaagtcag
      601 actcgtgtag tgatttcaca gctattcttc cagacaaacc caaccgcgct ctcaagagat
      661 tatcgacaga agaagctacg aggtgggcag attcctttga tgtgcttctc tctcataagt
      721 atggggtggc tgcattccgt gccttcttga agacggagtt cagtgaggag aacctggaat
      781 tctggttggc ctgtgaggag ttcaagaaga ccaggtcaac tgcaaaactg gtctctaagg
      841 cccataggat ctttgaggag tttgtggatg tgcaggctcc acgggaggta aacattgact
      901 tccagacccg agaagccacg aggaagaacc tgcaggagcc atccctgact tgctttgacc
      961 aagcccaagg aaaagtacac agcctcatgg agaaagactc ttaccccagg ttcctgaggt
     1021 ccaaaatgta cttagatctg ctgtcccaaa gccagaggag gctcagttag acctcagaag
     1081 ggaactcctg gaaatcaccg gctttcccct ccacttgctg ccaagatcat attctaatgt
     1141 gaaatgtcat aggtgttcaa aagcggtggc attgggggtg ggaggctggg ggtgaggagg
     1201 gaatgaaggg ccattccaaa gtatgaccca gctgccggag cttggactct attccattta
     1261 cccatgtttg tgttttggtt agtggtagcg ccttgccgct gtcacccttt tctgggtcag
     1321 caacttgccc ttcatataat gccttgggtc acctctgctg agagggcaga tttgctgtgc
     1381 taggctaatc tgtaaataat gcaaatgcaa ttcccaccac ctccacaccc tcctcggtta
     1441 ggattcctga ctctccactt gttgtaaatc cctgggagga atagctgaaa gacttgggct
     1501 caactctgtg atttgtagtg gccagctctg ctcactggga tctcacagct taggagagag
     1561 gtttctgtgg aattccaggt ttctagttct gtcattgaca ggtgacctct cagagaagga
     1621 gtgaaatcca tggagttgtt tgtttcttcc atttccattg gaccagtgtg aaaaactgtg
     1681 attacttccc atcttggcct aggaaattca caagactacc ctaaccttac atttccagaa
     1741 agagtcttgg gtgatgttct tcatgacttc tgaagtggaa ctgccattaa gaaagataca
     1801 gcttgcaaat cttcctcaat tctacgaaga acttttccag aagtcaagag acgagggcaa
     1861 gtagcaccag tagacttcta ttcaaagggg taccatgtaa cctgtctgtt gctcagtgtc
     1921 ttctctgccc tcacctctct gcagcatcat acatcactga tgtcttagga tgacagcttg
     1981 gcaaagggag gtgaattcct atagcatgga gtgctcccat ggtgcctaat actttccctg
     2041 tatctccacc tccccccttc catgccggtc atgtaattat gatgggggag aatgggaatt
     2101 taggctgaaa ctctttccag catacttcct gggaaaatgc tttcttagaa agatctctct
     2161 cttggatact atgaagcacc ttctttcttg atctttgacc ttttggaatt gagcatgaaa
     2221 taggaggtgt ggctaagaag atcactgtga acatctggac gtggacaacc ttcctaaaat
     2281 gctttcatgg taccctgcag ctgctcttgg aaatgtgtca ggcaattctt ccttggagga
     2341 tgagtgagca gcctggaacc tactctagcc acccaggaaa aagctgactt tggcacaaga
     2401 ctagtgccca ggagatgaac ctttagcaga gagaccggaa agtgaaagag gggcatgtaa
     2461 gaggctggtt tccaggtgga gaggataaca gagtggagtt actattggaa taattcacga
     2521 ccagtggatt tggattcatt gcagatctac aaaacgttca gcttgactaa gtggaacagc
     2581 acatgattag gcataagctc tggagtgcag atgattgaga actgggctga accattttcc
     2641 ttttaagggg tgaggggcct tttaacgtta tgctggtggc gttctagtgc ttgtgttcct
     2701 ctccagtaac tttgagaatc tcttcctttt ttagctatag ctagaccagg ccaagaaagc
     2761 ccttgagtcc cactagtgct agggccactg cactgctaca gcacattgtt atctgtgagt
     2821 gagggtgggt gtgactgtgt gaacctcaag gggagagaag aacacatgtc tcctagccct
     2881 cacagacacc gaaaagacct gtggaatttt gtgtttgaga actccaaagc ctcaaatggg
     2941 tgttcctagt tagatcaggt agtatcctcc caaccgtggt taaaaaaaca aatcattctt
     3001 tcttagataa agctgccaga attaatttaa tgattaaatt ctctaacagg gtattttaaa
     3061 cattgtttac atatgaaatg tgcatctgct gccaactcta ctgtcgaata tgaggtgcat
     3121 ataaattaga actgcacaga gttatagaaa tgtgaaacat tctgaaaggg gatttttctc
     3181 cacttccact attccaagga gaaaagcctg aacaagagtg tcgtgcgatg gcctcataga
     3241 gaggcctaga gttcttgcca actattgagg aaacgaaggc tgcagatggt ggtgtcatgg
     3301 cgccctggtg acttcctccc acaatgggga ggtgtgaaag accaagcttg gggatcctga
     3361 attttgcagc taagcaaggg tatgtgggca tgtgtccatg tgtagaggaa cgtgatagct
     3421 aaatttatgg tactcctgtg gagtgtctct gtgtgtttgt gtgtgtgtga caactgtgag
     3481 cattagacta gtacacggca gacatgatct tcccgtgggg tggagctttc ctcatacctt
     3541 gtatgccctg cttcccacaa gaggcacaga gctctccact ctgatgccta ctttcaggca
     3601 ctctggtcgt gccaacccag attttggtct gtgatgaaac aaagagaaat gtttacaaca
     3661 tctagagcaa tatccaagca tacctcatcc ctgagcttcc atgtttccca gtcctgccct
     3721 ctctcccatt gcctcttccg caagcccatg tccttgggta tcacttccat ttatttcctg
     3781 tcttccttgg ctcctcaagc cgagcctgtg ctgtggactt gccttctgga cttgaggctt
     3841 gctcagtcct gggcctatgc aggctccagg caagccaggg cagggcaagt ccaggcaagt
     3901 ctaggcagag ctgtgacttc tagaattgct ctccatccct gagtgatctt gccccactgg
     3961 agggctaact tgtttggggg ctggtgtgag attcgtcatt gcccttggca aactaaatag
     4021 aatactgtca gtatcaacca ttcatggcct tgggcacctc tggggtgagg aagaatcctc
     4081 tgaggcagtc cttctcatta aacttgagca tgcacaggaa tcacctggaa agcctgtgac
     4141 acgtgctaat tcccaggtgc acacccagag atgctgatct gatagacctg agatggggcc
     4201 cagaaatcca catttttaat aagttcctag atggctagtg gcctgtggac ttggactctt
     4261 agacagagtc tcacgacctt ggctgctcct tagaatcacc tagggagttt ttaaaaccca
     4321 gatgtccagg tcccacccca gaacagccaa atcagaagct tttgttagag acccaggcat
     4381 cagtcatttt taaagctcca caggtgattc caatgtgcag ctgaacttag gaagcattga
     4441 gtctaaggag tgaggaggaa cacagcgcgg gggcgggggg gctgggggag gggggagaca
     4501 cagctgtgtg ggccaagggg gctggtgtat ctccacatgc aagcacgtag ataccgagga
     4561 acctggccag ccctgcagcc tgactcggga tggctgcctc tatgccctct gcgtctgact
     4621 ttctcctttg agataaaggt gttttggccc aagctgagtg cattgctggg cagcggccat
     4681 gccgaaggtg gtagctgaag ggacccttga tcgaaagacg ctctgccatg ctttctgagt
     4741 cctgtctcct ccaagcttgt ctcctagact gtttcccctg tctgttttcc tgcgcccttg
     4801 tgtttggcca tttttgcatt aggctgtgtc tctgtaccca aggccacgtg acaaggtagt
     4861 tggaaccccc actcaagtgg tgagtgaaga gcgtcgtggt aataataata gtagtaacac
     4921 aacttccaaa tttctcagtg gagagtgtca cgtcctgggg gtatcaagat ctgtgaggcc
     4981 tttccaagcc ctcaccattc cctctttggt cccacgttgg gtgggcagct gggaaggtcc
     5041 tagttgattt taatctccgg tgctttcccc agaactgctg ctctgaataa accaaagctg
     5101 tgaaagagtg ttctgcgcag gctgcgggcc cagcctctgg gtgcaggccc tgggcacttg
     5161 agctgagcag ctcagctggc tctgctgtga gggaaagccg tgaacttaac tgtgctgaga
     5221 gctgggtgag ggcaaaatgg ggaagactga agaagaagga gcaggtggga gagaccagcc
     5281 gctaacatgg tgtctacttc tccgtggatc agagaaggga tgagtagcaa atgcagaggc
     5341 agggtggtct cccagcaaca aggatgtcca gagttctcct gaccctgtct gcacccactt
     5401 ccatgcaagg cagaggcatc acagttttcc atcccaggcc acccttcact cttccaagtg
     5461 tcaggcctct ttaaatctgc atccctttgg gttagaagca agagaggtgg caaagtctcc
     5521 ctggcactga gagcctgtcc caccatgcca ctcggcatga gatggtggag gaagaagcca
     5581 agagcaggga tgccttcctg tccccgtggc ctctcaggac tccacaagat gctgtggacc
     5641 aagatgagag atttcaggat ggggccactg gccttcctag gttgggctct gggtcctttc
     5701 aataaactgt tcctttcctg attcttactc ccttctggtc cttccactcc cttccctctg
     5761 ccaggtatgg aaaaggtggc tgggctcggt gtgcgctcca accccggtag cattagctga
     5821 gtcacgcggc gagcacacaa cagatttgta gcagctcatc tgccatataa accgcttggc
     5881 tgatggagtc ctcattgagt tttttcatta tcgtgtaaag tggaatcatg tcattcacct
     5941 ttactataaa caaggctgtg agaacataat aaacagaacc tgaacaa
//
