LOCUS       NP_001095920             180 aa            linear   PRI 21-SEP-2024
DEFINITION  regulator of G-protein signaling 8 isoform 2 [Homo sapiens].
ACCESSION   NP_001095920 XP_016858124
VERSION     NP_001095920.1
DBSOURCE    REFSEQ: accession NM_001102450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 180)
  AUTHORS   Bai,M., Ke,S., Yu,H., Xu,Y., Yu,Y., Lu,S., Wang,C., Huang,J.,
            Ma,Y., Dai,W. and Wu,Y.
  TITLE     Key molecules associated with thyroid carcinoma prognosis: A study
            based on transcriptome sequencing and GEO datasets
  JOURNAL   Front Immunol 13, 964891 (2022)
   PUBMED   36059514
  REMARK    GeneRIF: Key molecules associated with thyroid carcinoma prognosis:
            A study based on transcriptome sequencing and GEO datasets.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 180)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 180)
  AUTHORS   Song,D., Nishiyama,M. and Kimura,S.
  TITLE     Potent inhibition of angiotensin AT1 receptor signaling by RGS8:
            importance of the C-terminal third exon part of its RGS domain
  JOURNAL   J Recept Signal Transduct Res 36 (5), 478-487 (2016)
   PUBMED   26754208
  REMARK    GeneRIF: The chimeric RGS8 domains containing the first or the
            second exon part of RGS5 showed strong inhibitory effects similar
            to that of wild type RGS8, but the chimeric domain with the third
            exon part of RGS5 lost its activity
REFERENCE   4  (residues 1 to 180)
  AUTHORS   Wiechec,E., Wiuf,C., Overgaard,J. and Hansen,L.L.
  TITLE     High-resolution melting analysis for mutation screening of RGSL1,
            RGS16, and RGS8 in breast cancer
  JOURNAL   Cancer Epidemiol Biomarkers Prev 20 (2), 397-407 (2011)
   PUBMED   21135262
  REMARK    GeneRIF: Missense mutations in RGS8 gene is associated with breast
            cancer.
REFERENCE   5  (residues 1 to 180)
  AUTHORS   Wang,J., Lippman,S.M., Lee,J.J., Yang,H., Khuri,F.R., Kim,E.,
            Lin,J., Chang,D.W., Lotan,R., Hong,W.K. and Wu,X.
  TITLE     Genetic variations in regulator of G-protein signaling genes as
            susceptibility loci for second primary tumor/recurrence in head and
            neck squamous cell carcinoma
  JOURNAL   Carcinogenesis 31 (10), 1755-1761 (2010)
   PUBMED   20627871
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 180)
  AUTHORS   Larminie,C., Murdock,P., Walhin,J.P., Duckworth,M., Blumer,K.J.,
            Scheideler,M.A. and Garnier,M.
  TITLE     Selective expression of regulators of G-protein signaling (RGS) in
            the human central nervous system
  JOURNAL   Brain Res Mol Brain Res 122 (1), 24-34 (2004)
   PUBMED   14992813
REFERENCE   7  (residues 1 to 180)
  AUTHORS   Masuho,I., Itoh,M., Itoh,H. and Saitoh,O.
  TITLE     The mechanism of membrane-translocation of regulator of G-protein
            signaling (RGS) 8 induced by Galpha expression
  JOURNAL   J Neurochem 88 (1), 161-168 (2004)
   PUBMED   14675160
REFERENCE   8  (residues 1 to 180)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   9  (residues 1 to 180)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   10 (residues 1 to 180)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL353778.13.
            
            On Jan 16, 2020 this sequence version replaced XP_016858124.1.
            
            Summary: This gene is a member of the regulator of G protein
            signaling (RGS) family and encodes a protein with a single RGS
            domain. Regulator of G protein signaling (RGS) proteins are
            regulatory and structural components of G protein-coupled receptor
            complexes. They accelerate transit through the cycle of GTP binding
            and hydrolysis to GDP, thereby terminating signal transduction, but
            paradoxically, also accelerate receptor-stimulated activation.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) has an additional exon in the
            5' region, which results in an alternate 5' coding sequence, as
            compared to variant 1. The resulting isoform (2) has a shorter and
            alternate N-terminus, as compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.14072.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000515211.2/ ENSP00000511884.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..180
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     Protein         1..180
                     /product="regulator of G-protein signaling 8 isoform 2"
                     /note="regulator of G-protein signalling 8"
                     /calculated_mol_wt=20786
     Site            26
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P49804; propagated from
                     UniProtKB/Swiss-Prot (P57771.1)"
     Region          46..170
                     /region_name="RGS_RGS8"
                     /note="Regulator of G protein signaling (RGS) domain found
                     in the RGS8 protein; cd08711"
                     /db_xref="CDD:188666"
     Site            order(77..79,81..82,109..110,114,116,118,120..122,
                     124..126,128..129,132,135,153,156..158,161,164)
                     /site_type="other"
                     /note="G alpha interface [polypeptide binding]"
                     /db_xref="CDD:188666"
     CDS             1..180
                     /gene="RGS8"
                     /coded_by="NM_001102450.3:528..1070"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS41443.1"
                     /db_xref="GeneID:85397"
                     /db_xref="HGNC:HGNC:16810"
                     /db_xref="MIM:607189"
ORIGIN      
        1 maallmprrn kgmrtrlgcl shksdscsdf tailpdkpnr alkrlsteea trwadsfdvl
       61 lshkygvaaf raflktefse enlefwlace efkktrstak lvskahrife efvdvqapre
      121 vnidfqtrea trknlqepsl tcfdqaqgkv hslmekdsyp rflrskmyld llsqsqrrls
//
