LOCUS       NM_001029875            4451 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 7 binding protein
            (RGS7BP), transcript variant 1, mRNA.
ACCESSION   NM_001029875 XM_376386
VERSION     NM_001029875.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4451)
  AUTHORS   Patil,D.N., Rangarajan,E.S., Novick,S.J., Pascal,B.D.,
            Kojetin,D.J., Griffin,P.R., Izard,T. and Martemyanov,K.A.
  TITLE     Structural organization of a major neuronal G protein regulator,
            the RGS7-Gbeta5-R7BP complex
  JOURNAL   Elife 7, e42150 (2018)
   PUBMED   30540250
  REMARK    GeneRIF: Data mapped differences in deuterium exchange between the
            regulator of G protein signaling 7 (RGS7)-Gbeta5
            protein(Gbeta5)-RGS7 family binding protein (R7BP) trimer and the
            RGS7-Gbeta5 dimer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4451)
  AUTHORS   Scherer,S.L., Cain,M.D., Kanai,S.M., Kaltenbronn,K.M. and
            Blumer,K.J.
  TITLE     Regulation of neurite morphogenesis by interaction between R7
            regulator of G protein signaling complexes and G protein subunit
            Galpha13
  JOURNAL   J Biol Chem 292 (24), 9906-9918 (2017)
   PUBMED   28432124
  REMARK    GeneRIF: Data (including data from studies using transgenic mice)
            suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to
            augment signaling pathways in neurons that regulate neurite
            morphogenesis. (R7BP = RGS7 family binding protein; RGS7 =
            regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding
            protein alpha subunit 13)
REFERENCE   3  (bases 1 to 4451)
  AUTHORS   Tayou,J., Wang,Q., Jang,G.F., Pronin,A.N., Orlandi,C.,
            Martemyanov,K.A., Crabb,J.W. and Slepak,V.Z.
  TITLE     Regulator of G Protein Signaling 7 (RGS7) Can Exist in a
            Homo-oligomeric Form That Is Regulated by Galphao and R7-binding
            Protein
  JOURNAL   J Biol Chem 291 (17), 9133-9147 (2016)
   PUBMED   26895961
  REMARK    GeneRIF: R7-binding protein had a strong inhibitory effect on
            homo-oligomerization of RGS7.
REFERENCE   4  (bases 1 to 4451)
  AUTHORS   Lee,E.H., Park,B.L., Park,S.M., Lee,S.H., Park,S.W., Park,J.S.,
            Uh,S.T., Kim,M.K., Choi,I.S., Cho,S.H., Hong,C.S., Lee,J.Y.,
            Choi,B.W., Shin,H.D. and Park,C.S.
  TITLE     Association analysis of RGS7BP gene polymorphisms with aspirin
            intolerance in asthmatic patients
  JOURNAL   Ann Allergy Asthma Immunol 106 (4), 292-300 (2011)
   PUBMED   21457877
  REMARK    GeneRIF: BL3-ht2 of RGS7BP may be an important genetic variant
            associated with AERD. The haplotype of block 3 may play a
            protective role against aspirin hypersensitivity in asthma, perhaps
            by altering the responsiveness of muscarinic receptors.
REFERENCE   5  (bases 1 to 4451)
  AUTHORS   Saleem,Y. and Kim,K.S.
  TITLE     RGS11 interacts preferentially with R7BP over
            Galpha(oa)--characterization of Gbeta5-free RGS11
  JOURNAL   Biochem Biophys Res Commun 386 (1), 65-70 (2009)
   PUBMED   19497306
  REMARK    GeneRIF: the successful purification of functionally intact
            Gbeta5-free recombinant RGS11 was reported that differentially
            interact with R7BP and Galpha(oa).
REFERENCE   6  (bases 1 to 4451)
  AUTHORS   Jayaraman,M., Zhou,H., Jia,L., Cain,M.D. and Blumer,K.J.
  TITLE     R9AP and R7BP: traffic cops for the RGS7 family in
            phototransduction and neuronal GPCR signaling
  JOURNAL   Trends Pharmacol Sci 30 (1), 17-24 (2009)
   PUBMED   19042037
  REMARK    Review article
REFERENCE   7  (bases 1 to 4451)
  AUTHORS   Drenan,R.M., Doupnik,C.A., Jayaraman,M., Buchwalter,A.L.,
            Kaltenbronn,K.M., Huettner,J.E., Linder,M.E. and Blumer,K.J.
  TITLE     R7BP augments the function of RGS7*Gbeta5 complexes by a plasma
            membrane-targeting mechanism
  JOURNAL   J Biol Chem 281 (38), 28222-28231 (2006)
   PUBMED   16867977
  REMARK    GeneRIF: cytoplasmic RGS7*Gbeta5*R7BP heterotrimers and RGS7*Gbeta5
            heterodimers are equivalently inefficient regulators of G
            protein-coupled receptor signaling relative to plasma
            membrane-bound heterotrimers bearing palmitoylated R7BP.
REFERENCE   8  (bases 1 to 4451)
  AUTHORS   Martemyanov,K.A., Yoo,P.J., Skiba,N.P. and Arshavsky,V.Y.
  TITLE     R7BP, a novel neuronal protein interacting with RGS proteins of the
            R7 family
  JOURNAL   J Biol Chem 280 (7), 5133-5136 (2005)
   PUBMED   15632198
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA404068.1, AK296443.1,
            AC008854.3 and BX640900.1.
            
            On May 17, 2019 this sequence version replaced NM_001029875.2.
            
            Summary: This gene encodes a protein that binds to all members of
            the R7 subfamily of regulators of G protein signaling and regulates
            their translocation between the nucleus and the plasma membrane.
            The encoded protein could be regulated by reversible
            palmitoylation, which anchors it to the plasma membrane.
            Depalmitoylation localizes the protein to the nucleus.
            Polymorphisms in this gene may be associated with risk of
            aspirin-exacerbated respiratory disease. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.263544.1,
                                           SRR1660807.186953.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334025.3/ ENSP00000334851.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               DA404068.1         69-352
            285-1372            AK296443.1         1-1088
            1373-2890           AC008854.3         78501-80018         c
            2891-4431           BX640900.1         2197-3737
            4432-4451           AC008854.3         76940-76959         c
FEATURES             Location/Qualifiers
     source          1..4451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.3"
     gene            1..4451
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="regulator of G protein signaling 7 binding protein"
                     /db_xref="GeneID:401190"
                     /db_xref="HGNC:HGNC:23271"
                     /db_xref="MIM:610890"
     exon            1..775
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             611..1384
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="isoform 1 is encoded by transcript variant 1; R7
                     family-binding protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 7-binding
                     protein isoform 1"
                     /protein_id="NP_001025046.1"
                     /db_xref="CCDS:CCDS34170.1"
                     /db_xref="GeneID:401190"
                     /db_xref="HGNC:HGNC:23271"
                     /db_xref="MIM:610890"
                     /translation="MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAH
                     KTQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQA
                     HQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEPGG
                     GTKSLDCKIEESAETPALEDSSSSPVDSQQHSWQVSTDIENTERDMREMKNLLSKLRE
                     TMPLPLKNQDDSSLLNLTPYPLVRRRKRRFFGLCCLISS"
     exon            776..942
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1073
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1221
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1292
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..4451
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2307..2312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="hexamer: AATAAA"
     polyA_site      2330
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="hexamer: ACTAAA"
     polyA_site      2526
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="major polyA site"
     regulatory      3638..3643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
     regulatory      4286..4291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
                     /note="hexamer: AATAAA"
     polyA_site      4307
                     /gene="RGS7BP"
                     /gene_synonym="R7BP"
ORIGIN      
        1 agtcccgcca cagattcatc tgggatcttc aaacagacaa gcccttagag acgagggatc
       61 aaggcagccg attagagcca attgcttgct ttggggacgg ccagtccttc caggcctggc
      121 gacagtggag ggaggggaaa gacgaaccga gtgccgctgc gggaagacac tgaagcaaga
      181 gcgacacccc tttccgcccc ccaccttgca gcgcaggctt tgaaagctgc tcccccacct
      241 gaatggaaac tcggaaccgc cgggcggcgc gttccttctc gcccagcctt gcaatccatg
      301 ccgagaggaa ggcagtgcga gcccgcgcca gcgcccagct cccgggacag ggtcggcaat
      361 gctgctgagc agaacttgat cgcgctcctt cctcgctgct agtggaagcg atgctgcacg
      421 gcacagctag cgcttccccg gctctccttc aagctgaagg ttaccgaccc gcgcagccag
      481 ccccagcact gtgagctgcg cgcctcaggt ccgggctccg gctgcttggc ggcggcgccc
      541 agggcaacaa ccgggccgcc cgcgccgggg cgcactgcac cagcggcttc ggcttggtgg
      601 atgtgtatgc atgagttctg caccgaatgg gcgcaaaaag cgccccagcc ggtccacccg
      661 ctcctcgatc ttccagatca gcaagccccc gctgcagagc ggagattggg agcgcagggg
      721 cagcggctcc gagagcgccc acaaaaccca acgagccctg gacgactgca agatgcttgt
      781 ccaagagttc aacacacaag tggccctgta ccgagagctg gtcatttcta ttggggatgt
      841 ctcggtcagc tgcccctcac tccgggcgga aatgcacaag acaagaacca aaggctgtga
      901 aatggcccgt caggcacacc aaaaattggc tgccatctca ggcccggaag atggtgagat
      961 ccatccagaa atctgtcggc tttacatcca gctgcagtgc tgcttagaaa tgtataccac
     1021 agagatgcta aaatccatat gtctgctggg gtctcttcag tttcatcgaa aaggaaagga
     1081 acctggcggg ggaaccaaga gtttggattg caaaattgag gagagtgctg aaacacctgc
     1141 cctagaagac tcctcatcat cccccgtaga tagtcagcaa cattcctggc aggtttccac
     1201 agacattgag aacactgaaa gagacatgag agaaatgaaa aaccttttaa gcaaactcag
     1261 ggaaactatg cctttaccat tgaaaaatca agatgacagc agccttctga atctaactcc
     1321 ctaccccctg gtgagaagac ggaagagaag gttctttggg ctgtgttgtc tcatctcaag
     1381 ctaggtggct cctcctggaa acccactgag aacatctgaa aaaaaatcac aaaacccgag
     1441 gacctccaga cagctgaacc acacagttat tggtttttga ctatgttttc tatgcttcct
     1501 tattactttt atctgcctcc ccctgccctt ttaaatgatt ttacacttga aagcagctgc
     1561 cgtcaagaaa aaaaagaaca gattcaaaaa ccaggctgtt tttaaaaggg aattttaaag
     1621 ctgacattgt gcatgtctgc tccaaaccac gccatgacag atgcaagaat tatgattttt
     1681 aaattattta aaggtttttt aaatgtatta tacagaggaa aaatatttca catataatag
     1741 tatatctata gctcttgctg atctcatgtt aaaatttatc gtatatgaaa gaagtcttta
     1801 aacatagaaa tctatttaaa actgaaaaac tgtgttcaaa aatccaatct atcaatatca
     1861 ttagaaataa tattataagc aaacatatac cacctcacct attgctttct ctgcactcat
     1921 ttacatttag tcttccattc tgtcagaatc taagagcttc aacataaaag tatcttaatt
     1981 tataaagcaa caaaaaccac atatgaaaag tactaaaatt ttgtaaatac acaataatcc
     2041 taataccttc gtacaaatgc atatgggcaa ctaatttctt tttgatccaa tgatgtcttt
     2101 ttcagcttct tggagaatga agtaatccag ttaggaaatg gtgtagtaac atatacaatt
     2161 gccctcaaat gtaaaatcaa atattattac attttgttct aattgaaatc tgaagcatgg
     2221 tgtctgcaca tcagcatagt gttaaatctt atagggcatg ctggaattag ctcagattat
     2281 aaaaatattt aacattttac attgttaata aagtttttta gttaagctaa gcttgtctca
     2341 ttttagatga ctatgcagat aagatttttc caacgtgtac ttggtgtctt gtcttatgct
     2401 tagactcttg aaagcaggac acattaagca atactatatt ttagaaagga ggaagccaca
     2461 tgctttgttt ttctgctcac agctttgttg tgatcttcct tcactaaact tgtaacatgg
     2521 tacaaatttt gttataccgt ctcctgttct tcctttggcc catttcccag acagaatttc
     2581 ccatgggttg agagatcaag tctttgcact ttttttcttg ttttccatag tctgaaaaac
     2641 cttcaagtca gacaggaggc accagtgtcc agtacaatag aaggatgagc tagatgccga
     2701 taagtggttt atccaagaca catctttagt cccaaccctg ttctttacca atacttatgt
     2761 gcacaggcat ttatatgtat accaatattt ttacctaaaa actaaatata ttaaggcctt
     2821 ttgctttagt gaagatgaac tactgtaata attattgtat taggttgaat tatatgaaat
     2881 ttcctatatg tgactgtttt gacctacaaa atggcaattt cttatagttc accctaatat
     2941 ccaatgtgga aattatactt ggaattgtct tctagctctt ttgattgaaa gtgaaagaat
     3001 taaagggttg gaagagaacg ttatacaggt ctctatttag atcataccag ctggtttttg
     3061 gccttattct ttgaatctag agttgtgttc caaggaacca gtaattaatg catggttata
     3121 ggtatacctg gcttcaaaaa aaagaagtag ccgtggaaag ctatatgaga aaatcacaat
     3181 tttctgaatc aaatatttgt aaaacaattt ggctatttaa agactcttag ggtaaatact
     3241 ccctggaaaa gcaagcaatc cagacttatc tggtctgcaa accttgattt cagcttaata
     3301 tcctttcctg aatctaattc attttcaccc actaaggtca tttcatttaa gatccattgt
     3361 ttttgaaatt ttgaagtagc ccagtttggc agctctcagc acctgcctct gccctctcct
     3421 atacttcaac tatattgaac tctagcttca atctagttcc tactaatcca tgcaaaagtt
     3481 attaactgat aagcccaatc ttgttcagca cgttcttcta aatgcctgac ctaaataact
     3541 tctgcttggt taacttgtgt tcattctcac cttagcctca gtgtgaaagt aacacttacc
     3601 ttctgtgcaa ttgtcctttg tacaactgaa gactgttaat aaattcaggt ctcacctcca
     3661 tgtctgaaaa ggctatagta gctattcatg gagatgggaa tttgtctaat tacctagcca
     3721 gagtttgcat atttaaggta atatattcag ctaccgtatc ttttattcat agtgcctgtt
     3781 ttccagcctt tgatcagttt tgtagttccc gtggataaac tccaagatct aaagatcctc
     3841 tttcagtagc atatactaaa attaagttta gtgctcaaaa ccctggtaac ctacactggc
     3901 ccaaggttac agtaggtaat tcaccgtctc acattagaca ggccaatgca tcccttagga
     3961 gctgccccac tctcctctca cctaccaaag gattttctca ggtgtggttc caagcgataa
     4021 agttctactg tctcggcttc ctgctggtaa ttcgctttca gattagcaat aacactgagc
     4081 tgatctctag ggttaagaag agaacattga actcattttg tcgcatgtac ccacaggctt
     4141 gaaacagaaa atgatgtaaa cttttgtggc atacattcac ccattttccc accatatctt
     4201 tactatcctg tgttgatttt tttttcaaat tacaaagaca atacatgttc tttgtgggaa
     4261 atctgaaaaa tactaccaaa tagaaaataa aaatcacctg aattccacca cgaccacatt
     4321 gtttaaaacc acatttctgg gttttaaatc agtcagtggc tgggcccaaa ggcacttttg
     4381 ggtaagataa gtgaagaaat gcccacaagg ccaaggtgtc acttaaaaaa acaaacaaaa
     4441 aaaacaagcc a
//
