LOCUS       NM_001364886            2551 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens regulator of G protein signaling 7 (RGS7), transcript
            variant 9, mRNA.
ACCESSION   NM_001364886 XM_005273218
VERSION     NM_001364886.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2551)
  AUTHORS   Zhu,Y., Li,J., Ba,T., Sun,Y. and Chang,X.
  TITLE     RGS7 silence protects palmitic acid-induced pancreatic beta-cell
            injury by inactivating the chemokine signaling pathway
  JOURNAL   Autoimmunity 56 (1), 2194584 (2023)
   PUBMED   36999276
  REMARK    GeneRIF: RGS7 silence protects palmitic acid-induced pancreatic
            beta-cell injury by inactivating the chemokine signaling pathway.
REFERENCE   2  (bases 1 to 2551)
  AUTHORS   Basak,M., Das,K., Mahata,T., Kumar,D., Nagar,N., Poluri,K.M.,
            Kumar,P., Das,P., Stewart,A. and Maity,B.
  TITLE     RGS7 balances acetylation/de-acetylation of p65 to control
            chemotherapy-dependent cardiac inflammation
  JOURNAL   Cell Mol Life Sci 80 (9), 255 (2023)
   PUBMED   37589751
  REMARK    GeneRIF: RGS7 balances acetylation/de-acetylation of p65 to control
            chemotherapy-dependent cardiac inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2551)
  AUTHORS   Laboute,T., Zucca,S., Holcomb,M., Patil,D.N., Garza,C.,
            Wheatley,B.A., Roy,R.N., Forli,S. and Martemyanov,K.A.
  TITLE     Orphan receptor GPR158 serves as a metabotropic glycine receptor:
            mGlyR
  JOURNAL   Science 379 (6639), 1352-1358 (2023)
   PUBMED   36996198
REFERENCE   4  (bases 1 to 2551)
  AUTHORS   Basak,M., Sengar,A.S., Das,K., Mahata,T., Kumar,M., Kumar,D.,
            Biswas,S., Sarkar,S., Kumar,P., Das,P., Stewart,A. and Maity,B.
  TITLE     A RGS7-CaMKII complex drives myocyte-intrinsic and
            myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2213537120 (2023)
   PUBMED   36574707
  REMARK    GeneRIF: A RGS7-CaMKII complex drives myocyte-intrinsic and
            myocyte-extrinsic mechanisms of chemotherapy-induced
            cardiotoxicity.
REFERENCE   5  (bases 1 to 2551)
  AUTHORS   Jeong,E., Kim,Y., Jeong,J. and Cho,Y.
  TITLE     Structure of the class C orphan GPCR GPR158 in complex with
            RGS7-Gbeta5
  JOURNAL   Nat Commun 12 (1), 6805 (2021)
   PUBMED   34815401
  REMARK    GeneRIF: Structure of the class C orphan GPCR GPR158 in complex
            with RGS7-Gbeta5.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2551)
  AUTHORS   Kim,E., Arnould,T., Sellin,L., Benzing,T., Comella,N., Kocher,O.,
            Tsiokas,L., Sukhatme,V.P. and Walz,G.
  TITLE     Interaction between RGS7 and polycystin
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6371-6376 (1999)
   PUBMED   10339594
REFERENCE   7  (bases 1 to 2551)
  AUTHORS   Saitoh,O., Kubo,Y., Odagiri,M., Ichikawa,M., Yamagata,K. and
            Sekine,T.
  TITLE     RGS7 and RGS8 differentially accelerate G protein-mediated
            modulation of K+ currents
  JOURNAL   J Biol Chem 274 (14), 9899-9904 (1999)
   PUBMED   10092682
REFERENCE   8  (bases 1 to 2551)
  AUTHORS   Levay,K., Cabrera,J.L., Satpaev,D.K. and Slepak,V.Z.
  TITLE     Gbeta5 prevents the RGS7-Galphao interaction through binding to a
            distinct Ggamma-like domain found in RGS7 and other RGS proteins
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2503-2507 (1999)
   PUBMED   10051672
REFERENCE   9  (bases 1 to 2551)
  AUTHORS   Shuey,D.J., Betty,M., Jones,P.G., Khawaja,X.Z. and Cockett,M.I.
  TITLE     RGS7 attenuates signal transduction through the G(alpha q) family
            of heterotrimeric G proteins in mammalian cells
  JOURNAL   J Neurochem 70 (5), 1964-1972 (1998)
   PUBMED   9572280
REFERENCE   10 (bases 1 to 2551)
  AUTHORS   Koelle,M.R. and Horvitz,H.R.
  TITLE     EGL-10 regulates G protein signaling in the C. elegans nervous
            system and shares a conserved domain with many mammalian proteins
  JOURNAL   Cell 84 (1), 115-125 (1996)
   PUBMED   8548815
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359764.18, AL512307.12, AL590682.9 and AL365184.12.
            
            On Jul 13, 2018 this sequence version replaced XM_005273218.4.
            
            Transcript Variant: This variant (9) encodes the longest isoform
            (7).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.733408.1,
                                           SRR1660809.26486.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440928.6/ ENSP00000404399.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AL359764.18        7683-7989           c
            308-435             AL359764.18        6483-6610           c
            436-532             AL512307.12        153863-153959
            533-583             AL590682.9         65938-65988         c
            584-690             AL590682.9         19459-19565         c
            691-742             AL590682.9         13576-13627         c
            743-807             AL365184.12        142467-142531       c
            808-884             AL365184.12        141188-141264       c
            885-966             AL365184.12        140999-141080       c
            967-1041            AL365184.12        99510-99584         c
            1042-1140           AL365184.12        88729-88827         c
            1141-1202           AL365184.12        87128-87189         c
            1203-1313           AL365184.12        86030-86140         c
            1314-1439           AL365184.12        84330-84455         c
            1440-1626           AL365184.12        78552-78738         c
            1627-1716           AL365184.12        75316-75405         c
            1717-1770           AL365184.12        73867-73920         c
            1771-1851           AL365184.12        73053-73133         c
            1852-2551           AL365184.12        47926-48625         c
FEATURES             Location/Qualifiers
     source          1..2551
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2551
                     /gene="RGS7"
                     /note="regulator of G protein signaling 7"
                     /db_xref="GeneID:6000"
                     /db_xref="HGNC:HGNC:10003"
                     /db_xref="MIM:602517"
     exon            1..307
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            308..435
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1845
                     /gene="RGS7"
                     /note="isoform 7 is encoded by transcript variant 9;
                     regulator of G-protein signalling 7; regulator of
                     G-protein signaling RGS7"
                     /codon_start=1
                     /product="regulator of G-protein signaling 7 isoform 7"
                     /protein_id="NP_001351815.1"
                     /db_xref="CCDS:CCDS91181.1"
                     /db_xref="GeneID:6000"
                     /db_xref="HGNC:HGNC:10003"
                     /db_xref="MIM:602517"
                     /translation="MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIR
                     TVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLK
                     DDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAF
                     ARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSS
                     RMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKM
                     SKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGM
                     DEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPG
                     APSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQA
                     KKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL"
     exon            436..532
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            533..583
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            584..690
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            691..742
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            743..807
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            808..884
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            885..966
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1041
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1140
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1202
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1313
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1439
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1626
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1716
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1770
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1851
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2551
                     /gene="RGS7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2531..2536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS7"
                     /note="hexamer: ATTAAA"
     polyA_site      2551
                     /gene="RGS7"
                     /note="major polyA site"
ORIGIN      
        1 gactcccgcg cgcgctcggc tggtcccagt ccccgggaga agaagcggag gagggagaga
       61 gccagcgagg cggcccaggg gagcgggcgc gagtggcggc tgccggagcc gcctgtgcac
      121 gggcggcggc gaggcgaggg tggcggtcgc ctgagcagct agagccgggg cggcgcggaa
      181 tccgcatccg ccgcgagtgt gatgaagcta ccctgcctcg ctgctccgct tgccgccagc
      241 tgacaccgcc tgcacccagc ccgcccggga ggggagacgc cgcggggccg tgaccttggc
      301 ggaggagggc acactgataa ttcttgtatc ttgagagtgg accaagtttt gggtgacatg
      361 gcccagggga ataattatgg gcagaccagc aacggggtgg ccgatgaatc acccaacatg
      421 ctggtgtaca gaaagatgga agacgtcata gcacggatgc aagatgaaaa aaatggaatt
      481 cctattcgta cggtcaaaag ctttctttcc aagataccta gcgtcttctc tggttcagac
      541 attgttcaat ggttgataaa gaacttaact atagaagatc cagtggaggc gctccatttg
      601 ggaacattaa tggctgccca cggctacttc tttccaatct cagatcatgt cctcacactc
      661 aaggatgatg gcacctttta ccggtttcaa accccctatt tttggccatc aaattgttgg
      721 gagccggaaa acacagatta tgccgtttac ctctgcaaga gaacaatgca aaacaaggca
      781 cgactggagc tcgcagacta tgaggctgag agcctggcca ggctgcagag agcatttgcc
      841 cggaagtggg agttcatttt catgcaagca gaagcacaag caaaagtgga caagaagaga
      901 gacaagattg aaaggaagat ccttgacagc caagagagag cgttctggga cgtgcacagg
      961 cccgtgcctg gatgtgtaaa tacaactgaa gtggacatta agaagtcatc cagaatgaga
     1021 aacccccaca aaacacggaa gtctgtctat ggtttacaaa atgatattag aagtcacagt
     1081 cctacccaca cacccacacc agaaactaaa cctccaacag aagatgagtt acaacaacag
     1141 ataaaatatt ggcaaataca gttagataga catcggttaa aaatgtcaaa agtcgctgac
     1201 agtctactaa gttacacgga acagtattta gaatacgacc cgtttctttt gccacctgac
     1261 ccttctaacc catggctgtc cgatgacacc actttctggg aacttgaggc aagcaaagaa
     1321 ccgagccagc agagggtaaa acgatggggt tttggcatgg acgaggcatt gaaagaccca
     1381 gttgggagag aacagttcct taaatttcta gagtcagaat tcagctcgga aaatttaaga
     1441 ttctggctgg cagtggagga cctgaaaaag aggcctatta aagaagtacc ctcaagagtt
     1501 caggaaatat ggcaagagtt tctggctccc ggagccccca gtgctattaa cttggattcc
     1561 aagagttatg acaaaaccac acagaacgtg aaggaacctg gacgatacac atttgaagat
     1621 gctcaggagc acatttacaa actgatgaaa agtgattcat acccacgttt tataagatcc
     1681 agtgcctatc aggagcttct acaggcaaag aaaaagtctg gaaactcaat ggatcgcaga
     1741 acatcttttg aaaaatttgc acagaatgtg ggcagaaaca tccctatttt cccatgccat
     1801 aaaaactgta caccaacact gagggccagc actaacctgt tatgaaaaga ggggaaatct
     1861 ctcacgtcca agaggttaac aagccttgct cagtcttact aaacggatca tcttgtagca
     1921 tgaatgcaga ctggagtcac tgcacacact ttgtagctca atgttgtgac ctggagcaga
     1981 ggacattaga acaagatgtt gcatgagcaa aggacctaaa ttgttatttt tgtgtgtaca
     2041 ttccatctcc aatggactct tccgtctcaa tgcctccatt ccaaactgtt gtctgctttc
     2101 tttctccttc tactatgctg gatctgtgtc tcttcctttt taacaagttc aagtgaagta
     2161 aaaccttttc tttttttcct tctttctctc tctctctctc tcaaagcttc agttagacac
     2221 acagttcact gaaaattcag tcagtcaaaa actggaagaa ctgtaaaaga aaaaagtata
     2281 tatcaataag tatacatgtg gcttcacatt tattaaacaa taaattccgc acagaaagtt
     2341 tcatttcacc aatgtgtcac agtcagaaac aaactcatgt cttcgtctgt tgtctgtaca
     2401 ttctccgtta atgtttctcg catttatttt tataccatat ttaaagaaga aacacctttt
     2461 actccaaatg tattaaagtt gatcccttct ctgtaaattt gtgtatgttt atattgttgt
     2521 tttatctttc attaaaagat gcagaatctc a
//
