LOCUS       NM_004296               5583 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 2, mRNA.
ACCESSION   NM_004296
VERSION     NM_004296.7
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5583)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5583)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5583)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5583)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5583)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5583)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5583)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5583)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5583)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5583)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced NM_004296.6.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.52450.1,
                                           SRR7410571.160558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154125
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC005993.2         13141-13221         c
            82-185              AC005477.1         87628-87731         c
            186-285             AC005157.1         72588-72687         c
            286-336             AC005533.2         52351-52401         c
            337-443             AC005533.2         48552-48658         c
            444-495             AC005533.2         47246-47297         c
            496-560             AC005533.2         41107-41171         c
            561-637             AC005533.2         36846-36922         c
            638-719             AC005533.2         33976-34057         c
            720-794             AC005533.2         32230-32304         c
            795-893             AC005533.2         30089-30187         c
            894-955             AC005533.2         28600-28661         c
            956-1066            AC005533.2         11667-11777         c
            1067-1192           AC004828.2         179699-179824       c
            1193-1379           AC004828.2         171441-171627       c
            1380-1469           AC004828.2         153703-153792       c
            1470-5583           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5583
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..81
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            82..185
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1520
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 2 is encoded by transcript variant 2;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 2"
                     /protein_id="NP_004287.3"
                     /db_xref="CCDS:CCDS9808.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKGKSLAGKRLTGLMQSS"
     exon            186..285
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            286..336
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            337..443
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            444..495
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            496..560
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            561..637
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            638..719
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            720..794
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            894..955
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1192
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1379
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1469
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..5583
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2982..2987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3001
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5555..5560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5583
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gtgaagcgca caccgacggg gacgagagcg cagaggatgg cgcttttaga tacttccagt
       61 cttccgatgt tgtgatcgca gtgtgagtga agacactcag gatggctcaa ggatccgggg
      121 atcaaagagc agtgggggtt gctgacccag aggagagttc tccaaacatg atcgtttact
      181 gcaaaattga agacatcatt acaaagatgc aagatgacaa gacagggggt gtgcccatca
      241 gaacagtcaa gagctttctc tccaaaatcc ccagtgtcgt cacaggtact gacattgtgc
      301 agtggcttat gaagaacctt tccattgagg acccagttga agcaatacac ttggggagcc
      361 ttatcgctgc ccagggctac atctttccaa tctcagacca tgttctcacc atgaaggatg
      421 atggcacctt ttatcgtttc caggctccgt acttctggcc ttcgaactgc tgggaacctg
      481 aaaacactga ctatgccatc tatctctgta agaggacaat gcaaaataaa gcaaggctgg
      541 aactggcaga ttatgaagca gaaaacttag caagactcca gagggccttt gcgaggaagt
      601 gggaattcat ctttatgcaa gcagaagcac aagtaaagat tgaccggaaa aaagacaaga
      661 cagaaaggaa aattttggat agtcaagaac gagccttttg ggatgtccac aggcctgtgc
      721 caggctgtgt gaacacaaca gaaatggata tccgaaaatg tcgacgtttg aagaatccac
      781 aaaaggttaa aaagtccgtg tatggcgtga ctgaagagtc ccaggcacag agcccggtgc
      841 atgtactcag ccaaccaatc aggaaaacaa caaaagagga catccggaaa cagataacat
      901 ttttgaacgc acagatcgac agacattgtt tgaaaatgtc caaagtggct gaaagtttaa
      961 ttgcctacac ggaacaatat gtggaatatg accctttgat aacaccagct gagccatcca
     1021 acccttggat cagcgatgac gttgctttgt gggacataga gatgagcaaa gagcccagcc
     1081 aacagcgagt aaaaagatgg ggcttctctt tcgatgagat attgaaggac caggtggggc
     1141 gggaccagtt tctacgattc ctggagtccg aattcagttc agaaaacctc aggttctggc
     1201 tggctgtcca agatcttaag aaacaacccc tacaggatgt ggccaagagg gtagaagaaa
     1261 tctggcaaga gtttctggct ccaggggctc caagtgcaat caacctggat tctcacagct
     1321 atgagataac cagtcaaaat gtcaaagatg gagggagata tacatttgaa gacgcccagg
     1381 agcacatcta caagctgatg aagagtgaca gctatgcccg cttcctccgg tcaaatgctt
     1441 accaggattt gctgctggcc aagaagaagg gaaagtcgct ggcgggcaag cgcctcacgg
     1501 gcctgatgca gtcctcctga ccgttcctac cgcaggtcca gggcctgggc ccgcggaccc
     1561 cacaggcagg cggcggcgct ccacatctgc ggacagagtt tccttacgag gagacttggt
     1621 cactgtgaag gagaaagagt gagggcaatg aagggcgatg gtggggagac tcggtgggtg
     1681 aatggggaga ccagaaagaa agagtccaca gagcctgggc tgggcccggt ggaggctcct
     1741 gtttacagcc ctctcttctt tgtacagttg tattccaaca ctccactcgc taagaggccc
     1801 tgatcccagc tcattcaggg gagaacacgt cgtggggttc ctgtcacgac tatcacttga
     1861 gattatatta ttatcctcac tccctcgctg tctggagacg gtcacacctt ctggcaaatt
     1921 caagaggcat gagtggaccg agagcacatc cagcatttgc atcacctccc tggcacctcc
     1981 catagttaca gccactacat ccccaccgcc gcctgtcatc cctcacgtct ctgtggccac
     2041 ccgggtgtca ctgccagcac caggcactgc tttcacgtaa aatgtccaaa tcacatcttc
     2101 agcaagaaag caacctcacg gattgccccg cctcaaggtc tttccaccct ctttgagatc
     2161 agcgttcgga gaggtccccg ccagcccggt ggctgccctc aggtcccgtc acatgtctca
     2221 agggtccagc gttcgaggaa gcactgttgt agatgacaga gctttttgtt tcacagctgc
     2281 ggggattctg ctgaccatct tttagaaaat tatttcataa tttattctgg ctttgccccc
     2341 ttgctccttg gtttattccc tcatgtttta ctcaaaataa acatggccat gaactcaggg
     2401 gccattggga ttctcccctc tggcagcccc aggtgggagc tgggagggtc cccagcccag
     2461 gaggtggctg gattgcaggg ctggcagccc ccacgtggtg gcatcctgac aggcacagtg
     2521 agacccttgc tgggtcaggt ctcctttgtg tgtgaagctg gggcagagta tgctacgaag
     2581 ggaccaggcc aggccacagg gctctcctcc cagtctttat ctgaaggccc agccaaagca
     2641 cccctctaaa ccggtcacct aggggaaatg caaaaacctg caaaagatcc acctgtattc
     2701 cctgtgtgtg tgtgtcaaaa tgaccatttg ccaacctggc tgtgaggtaa tgtatgtaaa
     2761 gcaccgagtc aggtgcctga tacgcagtag gtgcttagca aacggtagct aatactatca
     2821 tcattgtcat tgttattgtg acacccatga gcccacagac agagctgtat taagtaacct
     2881 gttttgaatc cagacattca ctcccccact tgctatgact accctccttt gatctatttt
     2941 tggtcatagg taaaaaaaaa aatctctctt gggagcatat aaacaaaaaa catagaagca
     3001 ataaagcgat cgctggtatt tcttttctca tgcagccaaa ttcgccagct ggtgaccaaa
     3061 ggctcagatg cttgcttatt tgcagacccg gcctcctggg tgctccccag tgacccatct
     3121 ttccacccca ccacctccaa gtcctgtcta tgtctgcttc cacacagccc tgtccccagg
     3181 gcaccagcct tctgtccctc acagcagtgc catcgcgggc attaggagtc ttcgttatgt
     3241 tgtatccttg tgagttcttg actaccatgc ccaagtttcc cccactggca atggttcctc
     3301 tcttggaggt acagtggaaa ccagagagat gacagatgtt gagtcctcag tgtctcagag
     3361 gcagcaattc ttgctggaca cctgcacatg ctcagcacag aggctggtac tttggaggca
     3421 ctaaccactt gatgagtaaa tcaatggcat aaagccccat tccaagttat ggggtctttt
     3481 gacaggcccc tttcatcctc tttctctttg tataaacctc atgtttcaga acaaaattac
     3541 agtctaagtt catttgcccc cagccttgcc caaggatccc cgggctgtgc tgacccctag
     3601 gcatagggca aagggtgttc ccaagcagca ggcacctcag tgccctcagt tatccagggc
     3661 aaggggcctg gctgccccct gctcctcccc atgatgcagg ggctttctaa gccaggctgc
     3721 agacagggca gggttggctt cttggccatt ccctctgtgc ccccttctcc ttctgactgg
     3781 tctcaccctg gagatcccca gaggatctga ccagagccag gtggactgtg gccctgagat
     3841 ggagctggct gcaggcttac aagcacctct ggggacatcc agaggggagg gtcagtaagc
     3901 acaacggagc tagggagact tcagatggac tcaaacccag agcaataata ctctcacacc
     3961 accccacagc taaggcactc atgttcccca gtagatcaag ccagaagctt tgcaagaagg
     4021 gagtggaacg aggctgccta tccaaggtcc atctaccacg cagaacttgg tcatgcaagt
     4081 acatttggaa aatctggtct tggcccgtcc cccattggcc tggtctacac agccaaaaat
     4141 tcagactaga ttagatgttt gcaggcaatt ctgtagcaaa gcaaattccc ctaccccgtc
     4201 ccttccccct agaagctgcc ttagcctccc tgactgggtg tggtctctgg gcctaggact
     4261 cctccctatg aggaaaagtg ctctccagcc acatcttggc agccccacaa ccacagcatc
     4321 agggcagctg cagcaagtga ccacccaccc gtcgggttag acacacaagg caccaggcac
     4381 tggcatctga ctaaaataac ctttccctac atgggaagag gaaagcttgt aggctggcac
     4441 atataaacgt ccagccgcag ccagatggcc tgaactaagc agcaggaact ctctgggctg
     4501 gggaggagcc tcctgccctt ctagaaagtg atgcgtcagc tttgttctcc tgggaaggtg
     4561 ttgctatacc ccaggaacaa agcagggccc aactgccagt gcagtcagct gggcctgcgc
     4621 tccaggctca ccaccgctaa gtggtcaggt accgggccag catcctggga gggacctctt
     4681 gcgactctga gttgcagctt ggactagctg aacacatggg gacatgctcc aggggcttct
     4741 tccctggcag gattcctggg atttcaaact acctcaccaa caggacgctg aaccaggagc
     4801 ctgccaccca actggccccc ttggtgattg tggaaggtga tgtttttcct aaaatgcatc
     4861 cctcctgttc tgctccatat acatgtgctt caaaaaccac caccaggaaa gccttcccag
     4921 aagagggaaa ggattaaggg ctctcttcct ttgggccctg cagaatgtat tggagggagg
     4981 tgttgctgca aggtccagga gctgggaaac tctgggctcg gggggagata atgcaccacc
     5041 agcctcaaaa aggagctgcc caagttgaat atgtagcaaa gaccatggga taagttgaat
     5101 agtggccaga cgaatcacta ataactcacc atgggaccct ctgaagagag gcctgtgctc
     5161 gtgtaaccat agcaacagca gatgccagca acctactcat tagtaccacc cagtgataag
     5221 gcatcccctg ggctagaccc aggggccata aagtagcaaa gtagcaaatg tagcaataaa
     5281 gggcccgggt ctatacgggg acagggtcca aatgaccagg acttggccct ctccccagcc
     5341 ccgatgaggg ctcagagcca gctgctgtca gctgtctggg gagggaaggc cctgctccat
     5401 accaggggtc cctgttctat actctaagcc cactcaccgc atgatcacgg actcatcgga
     5461 atggcctcct cttagtgcat gtggttctct ttagtttatt tttctggaat ttggggattg
     5521 gaccccagaa ccaaacatgc tggtacagtc taaaaataaa tgacttgaac ccacttcaat
     5581 cca
//
