LOCUS       NM_001370294            5778 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 35, mRNA.
ACCESSION   NM_001370294
VERSION     NM_001370294.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5778)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5778)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5778)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5778)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5778)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5778)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5778)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5778)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5778)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5778)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN03465419
                              [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1574           AC004828.2         171441-171627       c
            1575-1664           AC004828.2         153703-153792       c
            1665-5778           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5778
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1715
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 21 is encoded by transcript variant 35;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 21"
                     /protein_id="NP_001357223.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAERFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQN
                     VKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQS
                     S"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1574
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1664
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..5778
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3177..3182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3196
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5750..5755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5778
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaaggtt ctggctggct gtccaagatc ttaagaaaca acccctacag gatgtggcca
     1441 agagggtaga agaaatctgg caagagtttc tggctccagg ggctccaagt gcaatcaacc
     1501 tggattctca cagctatgag ataaccagtc aaaatgtcaa agatggaggg agatatacat
     1561 ttgaagacgc ccaggagcac atctacaagc tgatgaagag tgacagctat gcccgcttcc
     1621 tccggtcaaa tgcttaccag gatttgctgc tggccaagaa gaagggaaag tcgctggcgg
     1681 gcaagcgcct cacgggcctg atgcagtcct cctgaccgtt cctaccgcag gtccagggcc
     1741 tgggcccgcg gaccccacag gcaggcggcg gcgctccaca tctgcggaca gagtttcctt
     1801 acgaggagac ttggtcactg tgaaggagaa agagtgaggg caatgaaggg cgatggtggg
     1861 gagactcggt gggtgaatgg ggagaccaga aagaaagagt ccacagagcc tgggctgggc
     1921 ccggtggagg ctcctgttta cagccctctc ttctttgtac agttgtattc caacactcca
     1981 ctcgctaaga ggccctgatc ccagctcatt caggggagaa cacgtcgtgg ggttcctgtc
     2041 acgactatca cttgagatta tattattatc ctcactccct cgctgtctgg agacggtcac
     2101 accttctggc aaattcaaga ggcatgagtg gaccgagagc acatccagca tttgcatcac
     2161 ctccctggca cctcccatag ttacagccac tacatcccca ccgccgcctg tcatccctca
     2221 cgtctctgtg gccacccggg tgtcactgcc agcaccaggc actgctttca cgtaaaatgt
     2281 ccaaatcaca tcttcagcaa gaaagcaacc tcacggattg ccccgcctca aggtctttcc
     2341 accctctttg agatcagcgt tcggagaggt ccccgccagc ccggtggctg ccctcaggtc
     2401 ccgtcacatg tctcaagggt ccagcgttcg aggaagcact gttgtagatg acagagcttt
     2461 ttgtttcaca gctgcgggga ttctgctgac catcttttag aaaattattt cataatttat
     2521 tctggctttg cccccttgct ccttggttta ttccctcatg ttttactcaa aataaacatg
     2581 gccatgaact caggggccat tgggattctc ccctctggca gccccaggtg ggagctggga
     2641 gggtccccag cccaggaggt ggctggattg cagggctggc agcccccacg tggtggcatc
     2701 ctgacaggca cagtgagacc cttgctgggt caggtctcct ttgtgtgtga agctggggca
     2761 gagtatgcta cgaagggacc aggccaggcc acagggctct cctcccagtc tttatctgaa
     2821 ggcccagcca aagcacccct ctaaaccggt cacctagggg aaatgcaaaa acctgcaaaa
     2881 gatccacctg tattccctgt gtgtgtgtgt caaaatgacc atttgccaac ctggctgtga
     2941 ggtaatgtat gtaaagcacc gagtcaggtg cctgatacgc agtaggtgct tagcaaacgg
     3001 tagctaatac tatcatcatt gtcattgtta ttgtgacacc catgagccca cagacagagc
     3061 tgtattaagt aacctgtttt gaatccagac attcactccc ccacttgcta tgactaccct
     3121 cctttgatct atttttggtc ataggtaaaa aaaaaaatct ctcttgggag catataaaca
     3181 aaaaacatag aagcaataaa gcgatcgctg gtatttcttt tctcatgcag ccaaattcgc
     3241 cagctggtga ccaaaggctc agatgcttgc ttatttgcag acccggcctc ctgggtgctc
     3301 cccagtgacc catctttcca ccccaccacc tccaagtcct gtctatgtct gcttccacac
     3361 agccctgtcc ccagggcacc agccttctgt ccctcacagc agtgccatcg cgggcattag
     3421 gagtcttcgt tatgttgtat ccttgtgagt tcttgactac catgcccaag tttcccccac
     3481 tggcaatggt tcctctcttg gaggtacagt ggaaaccaga gagatgacag atgttgagtc
     3541 ctcagtgtct cagaggcagc aattcttgct ggacacctgc acatgctcag cacagaggct
     3601 ggtactttgg aggcactaac cacttgatga gtaaatcaat ggcataaagc cccattccaa
     3661 gttatggggt cttttgacag gcccctttca tcctctttct ctttgtataa acctcatgtt
     3721 tcagaacaaa attacagtct aagttcattt gcccccagcc ttgcccaagg atccccgggc
     3781 tgtgctgacc cctaggcata gggcaaaggg tgttcccaag cagcaggcac ctcagtgccc
     3841 tcagttatcc agggcaaggg gcctggctgc cccctgctcc tccccatgat gcaggggctt
     3901 tctaagccag gctgcagaca gggcagggtt ggcttcttgg ccattccctc tgtgccccct
     3961 tctccttctg actggtctca ccctggagat ccccagagga tctgaccaga gccaggtgga
     4021 ctgtggccct gagatggagc tggctgcagg cttacaagca cctctgggga catccagagg
     4081 ggagggtcag taagcacaac ggagctaggg agacttcaga tggactcaaa cccagagcaa
     4141 taatactctc acaccacccc acagctaagg cactcatgtt ccccagtaga tcaagccaga
     4201 agctttgcaa gaagggagtg gaacgaggct gcctatccaa ggtccatcta ccacgcagaa
     4261 cttggtcatg caagtacatt tggaaaatct ggtcttggcc cgtcccccat tggcctggtc
     4321 tacacagcca aaaattcaga ctagattaga tgtttgcagg caattctgta gcaaagcaaa
     4381 ttcccctacc ccgtcccttc cccctagaag ctgccttagc ctccctgact gggtgtggtc
     4441 tctgggccta ggactcctcc ctatgaggaa aagtgctctc cagccacatc ttggcagccc
     4501 cacaaccaca gcatcagggc agctgcagca agtgaccacc cacccgtcgg gttagacaca
     4561 caaggcacca ggcactggca tctgactaaa ataacctttc cctacatggg aagaggaaag
     4621 cttgtaggct ggcacatata aacgtccagc cgcagccaga tggcctgaac taagcagcag
     4681 gaactctctg ggctggggag gagcctcctg cccttctaga aagtgatgcg tcagctttgt
     4741 tctcctggga aggtgttgct ataccccagg aacaaagcag ggcccaactg ccagtgcagt
     4801 cagctgggcc tgcgctccag gctcaccacc gctaagtggt caggtaccgg gccagcatcc
     4861 tgggagggac ctcttgcgac tctgagttgc agcttggact agctgaacac atggggacat
     4921 gctccagggg cttcttccct ggcaggattc ctgggatttc aaactacctc accaacagga
     4981 cgctgaacca ggagcctgcc acccaactgg cccccttggt gattgtggaa ggtgatgttt
     5041 ttcctaaaat gcatccctcc tgttctgctc catatacatg tgcttcaaaa accaccacca
     5101 ggaaagcctt cccagaagag ggaaaggatt aagggctctc ttcctttggg ccctgcagaa
     5161 tgtattggag ggaggtgttg ctgcaaggtc caggagctgg gaaactctgg gctcgggggg
     5221 agataatgca ccaccagcct caaaaaggag ctgcccaagt tgaatatgta gcaaagacca
     5281 tgggataagt tgaatagtgg ccagacgaat cactaataac tcaccatggg accctctgaa
     5341 gagaggcctg tgctcgtgta accatagcaa cagcagatgc cagcaaccta ctcattagta
     5401 ccacccagtg ataaggcatc ccctgggcta gacccagggg ccataaagta gcaaagtagc
     5461 aaatgtagca ataaagggcc cgggtctata cggggacagg gtccaaatga ccaggacttg
     5521 gccctctccc cagccccgat gagggctcag agccagctgc tgtcagctgt ctggggaggg
     5581 aaggccctgc tccataccag gggtccctgt tctatactct aagcccactc accgcatgat
     5641 cacggactca tcggaatggc ctcctcttag tgcatgtggt tctctttagt ttatttttct
     5701 ggaatttggg gattggaccc cagaaccaaa catgctggta cagtctaaaa ataaatgact
     5761 tgaacccact tcaatcca
//
