LOCUS       NM_001370292            5904 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 33, mRNA.
ACCESSION   NM_001370292 XM_024449777
VERSION     NM_001370292.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5904)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5904)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5904)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5904)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5904)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 5904)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 5904)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 5904)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 5904)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 5904)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449777.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.192695.1,
                                           SRR1803613.95684.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1513           AC004828.2         179699-179824       c
            1514-1700           AC004828.2         171441-171627       c
            1701-1790           AC004828.2         153703-153792       c
            1791-5904           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..5904
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5904
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1841
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 6 is encoded by transcript variant 33;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 6"
                     /protein_id="NP_001357221.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQD
                     LKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHI
                     YKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1700
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1790
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..5904
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3322
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      5876..5881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      5904
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagcaa agagcccagc caacagcgag taaaaagatg gggcttctct ttcgatgaga
     1441 tattgaagga ccaggtgggg cgggaccagt ttctacgatt cctggagtcc gaattcagtt
     1501 cagaaaacct caggttctgg ctggctgtcc aagatcttaa gaaacaaccc ctacaggatg
     1561 tggccaagag ggtagaagaa atctggcaag agtttctggc tccaggggct ccaagtgcaa
     1621 tcaacctgga ttctcacagc tatgagataa ccagtcaaaa tgtcaaagat ggagggagat
     1681 atacatttga agacgcccag gagcacatct acaagctgat gaagagtgac agctatgccc
     1741 gcttcctccg gtcaaatgct taccaggatt tgctgctggc caagaagaag ggaaagtcgc
     1801 tggcgggcaa gcgcctcacg ggcctgatgc agtcctcctg accgttccta ccgcaggtcc
     1861 agggcctggg cccgcggacc ccacaggcag gcggcggcgc tccacatctg cggacagagt
     1921 ttccttacga ggagacttgg tcactgtgaa ggagaaagag tgagggcaat gaagggcgat
     1981 ggtggggaga ctcggtgggt gaatggggag accagaaaga aagagtccac agagcctggg
     2041 ctgggcccgg tggaggctcc tgtttacagc cctctcttct ttgtacagtt gtattccaac
     2101 actccactcg ctaagaggcc ctgatcccag ctcattcagg ggagaacacg tcgtggggtt
     2161 cctgtcacga ctatcacttg agattatatt attatcctca ctccctcgct gtctggagac
     2221 ggtcacacct tctggcaaat tcaagaggca tgagtggacc gagagcacat ccagcatttg
     2281 catcacctcc ctggcacctc ccatagttac agccactaca tccccaccgc cgcctgtcat
     2341 ccctcacgtc tctgtggcca cccgggtgtc actgccagca ccaggcactg ctttcacgta
     2401 aaatgtccaa atcacatctt cagcaagaaa gcaacctcac ggattgcccc gcctcaaggt
     2461 ctttccaccc tctttgagat cagcgttcgg agaggtcccc gccagcccgg tggctgccct
     2521 caggtcccgt cacatgtctc aagggtccag cgttcgagga agcactgttg tagatgacag
     2581 agctttttgt ttcacagctg cggggattct gctgaccatc ttttagaaaa ttatttcata
     2641 atttattctg gctttgcccc cttgctcctt ggtttattcc ctcatgtttt actcaaaata
     2701 aacatggcca tgaactcagg ggccattggg attctcccct ctggcagccc caggtgggag
     2761 ctgggagggt ccccagccca ggaggtggct ggattgcagg gctggcagcc cccacgtggt
     2821 ggcatcctga caggcacagt gagacccttg ctgggtcagg tctcctttgt gtgtgaagct
     2881 ggggcagagt atgctacgaa gggaccaggc caggccacag ggctctcctc ccagtcttta
     2941 tctgaaggcc cagccaaagc acccctctaa accggtcacc taggggaaat gcaaaaacct
     3001 gcaaaagatc cacctgtatt ccctgtgtgt gtgtgtcaaa atgaccattt gccaacctgg
     3061 ctgtgaggta atgtatgtaa agcaccgagt caggtgcctg atacgcagta ggtgcttagc
     3121 aaacggtagc taatactatc atcattgtca ttgttattgt gacacccatg agcccacaga
     3181 cagagctgta ttaagtaacc tgttttgaat ccagacattc actcccccac ttgctatgac
     3241 taccctcctt tgatctattt ttggtcatag gtaaaaaaaa aaatctctct tgggagcata
     3301 taaacaaaaa acatagaagc aataaagcga tcgctggtat ttcttttctc atgcagccaa
     3361 attcgccagc tggtgaccaa aggctcagat gcttgcttat ttgcagaccc ggcctcctgg
     3421 gtgctcccca gtgacccatc tttccacccc accacctcca agtcctgtct atgtctgctt
     3481 ccacacagcc ctgtccccag ggcaccagcc ttctgtccct cacagcagtg ccatcgcggg
     3541 cattaggagt cttcgttatg ttgtatcctt gtgagttctt gactaccatg cccaagtttc
     3601 ccccactggc aatggttcct ctcttggagg tacagtggaa accagagaga tgacagatgt
     3661 tgagtcctca gtgtctcaga ggcagcaatt cttgctggac acctgcacat gctcagcaca
     3721 gaggctggta ctttggaggc actaaccact tgatgagtaa atcaatggca taaagcccca
     3781 ttccaagtta tggggtcttt tgacaggccc ctttcatcct ctttctcttt gtataaacct
     3841 catgtttcag aacaaaatta cagtctaagt tcatttgccc ccagccttgc ccaaggatcc
     3901 ccgggctgtg ctgaccccta ggcatagggc aaagggtgtt cccaagcagc aggcacctca
     3961 gtgccctcag ttatccaggg caaggggcct ggctgccccc tgctcctccc catgatgcag
     4021 gggctttcta agccaggctg cagacagggc agggttggct tcttggccat tccctctgtg
     4081 cccccttctc cttctgactg gtctcaccct ggagatcccc agaggatctg accagagcca
     4141 ggtggactgt ggccctgaga tggagctggc tgcaggctta caagcacctc tggggacatc
     4201 cagaggggag ggtcagtaag cacaacggag ctagggagac ttcagatgga ctcaaaccca
     4261 gagcaataat actctcacac caccccacag ctaaggcact catgttcccc agtagatcaa
     4321 gccagaagct ttgcaagaag ggagtggaac gaggctgcct atccaaggtc catctaccac
     4381 gcagaacttg gtcatgcaag tacatttgga aaatctggtc ttggcccgtc ccccattggc
     4441 ctggtctaca cagccaaaaa ttcagactag attagatgtt tgcaggcaat tctgtagcaa
     4501 agcaaattcc cctaccccgt cccttccccc tagaagctgc cttagcctcc ctgactgggt
     4561 gtggtctctg ggcctaggac tcctccctat gaggaaaagt gctctccagc cacatcttgg
     4621 cagccccaca accacagcat cagggcagct gcagcaagtg accacccacc cgtcgggtta
     4681 gacacacaag gcaccaggca ctggcatctg actaaaataa cctttcccta catgggaaga
     4741 ggaaagcttg taggctggca catataaacg tccagccgca gccagatggc ctgaactaag
     4801 cagcaggaac tctctgggct ggggaggagc ctcctgccct tctagaaagt gatgcgtcag
     4861 ctttgttctc ctgggaaggt gttgctatac cccaggaaca aagcagggcc caactgccag
     4921 tgcagtcagc tgggcctgcg ctccaggctc accaccgcta agtggtcagg taccgggcca
     4981 gcatcctggg agggacctct tgcgactctg agttgcagct tggactagct gaacacatgg
     5041 ggacatgctc caggggcttc ttccctggca ggattcctgg gatttcaaac tacctcacca
     5101 acaggacgct gaaccaggag cctgccaccc aactggcccc cttggtgatt gtggaaggtg
     5161 atgtttttcc taaaatgcat ccctcctgtt ctgctccata tacatgtgct tcaaaaacca
     5221 ccaccaggaa agccttccca gaagagggaa aggattaagg gctctcttcc tttgggccct
     5281 gcagaatgta ttggagggag gtgttgctgc aaggtccagg agctgggaaa ctctgggctc
     5341 ggggggagat aatgcaccac cagcctcaaa aaggagctgc ccaagttgaa tatgtagcaa
     5401 agaccatggg ataagttgaa tagtggccag acgaatcact aataactcac catgggaccc
     5461 tctgaagaga ggcctgtgct cgtgtaacca tagcaacagc agatgccagc aacctactca
     5521 ttagtaccac ccagtgataa ggcatcccct gggctagacc caggggccat aaagtagcaa
     5581 agtagcaaat gtagcaataa agggcccggg tctatacggg gacagggtcc aaatgaccag
     5641 gacttggccc tctccccagc cccgatgagg gctcagagcc agctgctgtc agctgtctgg
     5701 ggagggaagg ccctgctcca taccaggggt ccctgttcta tactctaagc ccactcaccg
     5761 catgatcacg gactcatcgg aatggcctcc tcttagtgca tgtggttctc tttagtttat
     5821 ttttctggaa tttggggatt ggaccccaga accaaacatg ctggtacagt ctaaaaataa
     5881 atgacttgaa cccacttcaa tcca
//
