LOCUS       NM_001370291            6065 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens regulator of G protein signaling 6 (RGS6), transcript
            variant 32, mRNA.
ACCESSION   NM_001370291 XM_024449775
VERSION     NM_001370291.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6065)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6065)
  AUTHORS   Wang,Z., Chen,J., Wang,S., Sun,Z., Lei,Z., Zhang,H.T. and Huang,J.
  TITLE     RGS6 suppresses TGF-beta-induced epithelial-mesenchymal transition
            in non-small cell lung cancers via a novel mechanism dependent on
            its interaction with SMAD4
  JOURNAL   Cell Death Dis 13 (7), 656 (2022)
   PUBMED   35902557
  REMARK    GeneRIF: RGS6 suppresses TGF-beta-induced epithelial-mesenchymal
            transition in non-small cell lung cancers via a novel mechanism
            dependent on its interaction with SMAD4.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6065)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6065)
  AUTHORS   Luo,Z., Ahlers-Dannen,K.E., Spicer,M.M., Yang,J., Alberico,S.,
            Stevens,H.E., Narayanan,N.S. and Fisher,R.A.
  TITLE     Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice
  JOURNAL   JCI Insight 5 (13), 126769 (2019)
   PUBMED   31120439
  REMARK    GeneRIF: Age-dependent nigral dopaminergic neurodegeneration and
            alpha-synuclein accumulation in RGS6-deficient mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6065)
  AUTHORS   Guo,Y.X., Xu,Y.H., Zheng,G.H. and Jin,X.Q.
  TITLE     The novel gene HA117 promotes in vitro and in vivo drug resistance
            in mouse colon tumor cells
  JOURNAL   Cancer Gene Ther 24 (7), 304-308 (2017)
   PUBMED   28731026
  REMARK    GeneRIF: the results suggest that HA117 regulates the development
            of drug resistance in CT26 cells in vitro and in vivo.
REFERENCE   6  (bases 1 to 6065)
  AUTHORS   Chatterjee,T.K., Liu,Z. and Fisher,R.A.
  TITLE     Human RGS6 gene structure, complex alternative splicing, and role
            of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
  JOURNAL   J Biol Chem 278 (32), 30261-30271 (2003)
   PUBMED   12761221
  REMARK    GeneRIF: RGS6 gene structure, complex alternative splicing, and
            role of N terminus and G protein gamma-subunit-like (GGL) domain in
            subcellular localization of RGS6 splice variants
REFERENCE   7  (bases 1 to 6065)
  AUTHORS   Posner,B.A., Gilman,A.G. and Harris,B.A.
  TITLE     Regulators of G protein signaling 6 and 7. Purification of
            complexes with gbeta5 and assessment of their effects on g
            protein-mediated signaling pathways
  JOURNAL   J Biol Chem 274 (43), 31087-31093 (1999)
   PUBMED   10521509
REFERENCE   8  (bases 1 to 6065)
  AUTHORS   Snow,B.E., Betts,L., Mangion,J., Sondek,J. and Siderovski,D.P.
  TITLE     Fidelity of G protein beta-subunit association by the G protein
            gamma-subunit-like domains of RGS6, RGS7, and RGS11
  JOURNAL   Proc Natl Acad Sci U S A 96 (11), 6489-6494 (1999)
   PUBMED   10339615
REFERENCE   9  (bases 1 to 6065)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Hori,T. and Saito,T.
  TITLE     The human regulator of G-protein signaling protein 6 gene (RGS6)
            maps between markers WI-5202 and D14S277 on chromosome 14q24.3
  JOURNAL   J Hum Genet 44 (2), 138-140 (1999)
   PUBMED   10083744
REFERENCE   10 (bases 1 to 6065)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005993.2, AC005477.1,
            AC005157.1, AC005533.2 and AC004828.2.
            
            On May 4, 2019 this sequence version replaced XM_024449775.1.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP and GGL domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Many alternatively spliced
            transcript variants encoding different isoforms with long or short
            N-terminal domains, complete or incomplete GGL domains, and
            distinct C-terminal domains, have been described for this gene,
            however, the full-length nature of some of these variants is not
            known.[provided by RefSeq, Mar 2011].
            
            Sequence Note: The genomic coordinates were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145240,
                              SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC005993.2         13502-14014         c
            514-617             AC005477.1         87628-87731         c
            618-717             AC005157.1         72588-72687         c
            718-768             AC005533.2         52351-52401         c
            769-875             AC005533.2         48552-48658         c
            876-927             AC005533.2         47246-47297         c
            928-992             AC005533.2         41107-41171         c
            993-1069            AC005533.2         36846-36922         c
            1070-1151           AC005533.2         33976-34057         c
            1152-1226           AC005533.2         32230-32304         c
            1227-1325           AC005533.2         30089-30187         c
            1326-1387           AC005533.2         28600-28661         c
            1388-1498           AC005533.2         11667-11777         c
            1499-1624           AC004828.2         179699-179824       c
            1625-1811           AC004828.2         171441-171627       c
            1812-1901           AC004828.2         153703-153792       c
            1902-1951           AC004828.2         149884-149933       c
            1952-6065           AC004828.2         123448-127561       c
FEATURES             Location/Qualifiers
     source          1..6065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..6065
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="regulator of G protein signaling 6"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
     exon            1..513
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            514..617
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1931
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="isoform 20 is encoded by transcript variant 32;
                     regulator of G-protein signalling 6"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 20"
                     /protein_id="NP_001357220.1"
                     /db_xref="CCDS:CCDS91897.1"
                     /db_xref="GeneID:9628"
                     /db_xref="HGNC:HGNC:10002"
                     /db_xref="MIM:603894"
                     /translation="MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKKVSKVVELP"
     exon            618..717
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            718..768
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            769..875
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            876..927
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            928..992
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1069
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1151
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1226
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1325
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1387
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1498
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1624
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1811
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1901
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1951
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..6065
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3464..3469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AACAAA"
     polyA_site      3483
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
     regulatory      6037..6042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="hexamer: AATAAA"
     polyA_site      6065
                     /gene="RGS6"
                     /gene_synonym="GAP; HA117; S914"
                     /note="major polyA site"
ORIGIN      
        1 gaacggcttc gcgagttggg gcagctcctc gcgctcggcc ctgctcggcg gcgagagctc
       61 cgcctgggcg ccgcgttcct acagccgccg gagccgccag gcgccgaggg aacggacaga
      121 cctccgcgca cccttgccga ccggggcggg cagaggcggg caagcggcga acgcctggga
      181 gcgcggagag ccaggccagc ccggagcgcg ccggggacac cctgtgcgcc ccgagtcccg
      241 gcaccatgcg acccgccgcg cgtcctcgcg ggcccggggc ttcgctcttc gctcgctgag
      301 cccctgcgct cgccaccacg gaaactcgga aagaggaggc gaggctgtgg ggagcggcgc
      361 ggagacggac tagacttccc ctccgccccc aagaggctgc cggtccccgg ttccctgggc
      421 ttctccagct ttatcatgaa cctggcgcaa ggttggcttt aggaaaaatt ctggagccag
      481 agggagagtc aaggcaattc tttggttgct aagtgtgagt gaagacactc aggatggctc
      541 aaggatccgg ggatcaaaga gcagtggggg ttgctgaccc agaggagagt tctccaaaca
      601 tgatcgttta ctgcaaaatt gaagacatca ttacaaagat gcaagatgac aagacagggg
      661 gtgtgcccat cagaacagtc aagagctttc tctccaaaat ccccagtgtc gtcacaggta
      721 ctgacattgt gcagtggctt atgaagaacc tttccattga ggacccagtt gaagcaatac
      781 acttggggag ccttatcgct gcccagggct acatctttcc aatctcagac catgttctca
      841 ccatgaagga tgatggcacc ttttatcgtt tccaggctcc gtacttctgg ccttcgaact
      901 gctgggaacc tgaaaacact gactatgcca tctatctctg taagaggaca atgcaaaata
      961 aagcaaggct ggaactggca gattatgaag cagaaaactt agcaagactc cagagggcct
     1021 ttgcgaggaa gtgggaattc atctttatgc aagcagaagc acaagtaaag attgaccgga
     1081 aaaaagacaa gacagaaagg aaaattttgg atagtcaaga acgagccttt tgggatgtcc
     1141 acaggcctgt gccaggctgt gtgaacacaa cagaaatgga tatccgaaaa tgtcgacgtt
     1201 tgaagaatcc acaaaaggtt aaaaagtccg tgtatggcgt gactgaagag tcccaggcac
     1261 agagcccggt gcatgtactc agccaaccaa tcaggaaaac aacaaaagag gacatccgga
     1321 aacagataac atttttgaac gcacagatcg acagacattg tttgaaaatg tccaaagtgg
     1381 ctgaaagttt aattgcctac acggaacaat atgtggaata tgaccctttg ataacaccag
     1441 ctgagccatc caacccttgg atcagcgatg acgttgcttt gtgggacata gagatgagca
     1501 aagagcccag ccaacagcga gtaaaaagat ggggcttctc tttcgatgag atattgaagg
     1561 accaggtggg gcgggaccag tttctacgat tcctggagtc cgaattcagt tcagaaaacc
     1621 tcaggttctg gctggctgtc caagatctta agaaacaacc cctacaggat gtggccaaga
     1681 gggtagaaga aatctggcaa gagtttctgg ctccaggggc tccaagtgca atcaacctgg
     1741 attctcacag ctatgagata accagtcaaa atgtcaaaga tggagggaga tatacatttg
     1801 aagacgccca ggagcacatc tacaagctga tgaagagtga cagctatgcc cgcttcctcc
     1861 ggtcaaatgc ttaccaggat ttgctgctgg ccaagaagaa gaaagtgagc aaggtcgtag
     1921 aacttcccta gaaaagttca ctcgcagtgt gggaaagtcg ctggcgggca agcgcctcac
     1981 gggcctgatg cagtcctcct gaccgttcct accgcaggtc cagggcctgg gcccgcggac
     2041 cccacaggca ggcggcggcg ctccacatct gcggacagag tttccttacg aggagacttg
     2101 gtcactgtga aggagaaaga gtgagggcaa tgaagggcga tggtggggag actcggtggg
     2161 tgaatgggga gaccagaaag aaagagtcca cagagcctgg gctgggcccg gtggaggctc
     2221 ctgtttacag ccctctcttc tttgtacagt tgtattccaa cactccactc gctaagaggc
     2281 cctgatccca gctcattcag gggagaacac gtcgtggggt tcctgtcacg actatcactt
     2341 gagattatat tattatcctc actccctcgc tgtctggaga cggtcacacc ttctggcaaa
     2401 ttcaagaggc atgagtggac cgagagcaca tccagcattt gcatcacctc cctggcacct
     2461 cccatagtta cagccactac atccccaccg ccgcctgtca tccctcacgt ctctgtggcc
     2521 acccgggtgt cactgccagc accaggcact gctttcacgt aaaatgtcca aatcacatct
     2581 tcagcaagaa agcaacctca cggattgccc cgcctcaagg tctttccacc ctctttgaga
     2641 tcagcgttcg gagaggtccc cgccagcccg gtggctgccc tcaggtcccg tcacatgtct
     2701 caagggtcca gcgttcgagg aagcactgtt gtagatgaca gagctttttg tttcacagct
     2761 gcggggattc tgctgaccat cttttagaaa attatttcat aatttattct ggctttgccc
     2821 ccttgctcct tggtttattc cctcatgttt tactcaaaat aaacatggcc atgaactcag
     2881 gggccattgg gattctcccc tctggcagcc ccaggtggga gctgggaggg tccccagccc
     2941 aggaggtggc tggattgcag ggctggcagc ccccacgtgg tggcatcctg acaggcacag
     3001 tgagaccctt gctgggtcag gtctcctttg tgtgtgaagc tggggcagag tatgctacga
     3061 agggaccagg ccaggccaca gggctctcct cccagtcttt atctgaaggc ccagccaaag
     3121 cacccctcta aaccggtcac ctaggggaaa tgcaaaaacc tgcaaaagat ccacctgtat
     3181 tccctgtgtg tgtgtgtcaa aatgaccatt tgccaacctg gctgtgaggt aatgtatgta
     3241 aagcaccgag tcaggtgcct gatacgcagt aggtgcttag caaacggtag ctaatactat
     3301 catcattgtc attgttattg tgacacccat gagcccacag acagagctgt attaagtaac
     3361 ctgttttgaa tccagacatt cactccccca cttgctatga ctaccctcct ttgatctatt
     3421 tttggtcata ggtaaaaaaa aaaatctctc ttgggagcat ataaacaaaa aacatagaag
     3481 caataaagcg atcgctggta tttcttttct catgcagcca aattcgccag ctggtgacca
     3541 aaggctcaga tgcttgctta tttgcagacc cggcctcctg ggtgctcccc agtgacccat
     3601 ctttccaccc caccacctcc aagtcctgtc tatgtctgct tccacacagc cctgtcccca
     3661 gggcaccagc cttctgtccc tcacagcagt gccatcgcgg gcattaggag tcttcgttat
     3721 gttgtatcct tgtgagttct tgactaccat gcccaagttt cccccactgg caatggttcc
     3781 tctcttggag gtacagtgga aaccagagag atgacagatg ttgagtcctc agtgtctcag
     3841 aggcagcaat tcttgctgga cacctgcaca tgctcagcac agaggctggt actttggagg
     3901 cactaaccac ttgatgagta aatcaatggc ataaagcccc attccaagtt atggggtctt
     3961 ttgacaggcc cctttcatcc tctttctctt tgtataaacc tcatgtttca gaacaaaatt
     4021 acagtctaag ttcatttgcc cccagccttg cccaaggatc cccgggctgt gctgacccct
     4081 aggcataggg caaagggtgt tcccaagcag caggcacctc agtgccctca gttatccagg
     4141 gcaaggggcc tggctgcccc ctgctcctcc ccatgatgca ggggctttct aagccaggct
     4201 gcagacaggg cagggttggc ttcttggcca ttccctctgt gcccccttct ccttctgact
     4261 ggtctcaccc tggagatccc cagaggatct gaccagagcc aggtggactg tggccctgag
     4321 atggagctgg ctgcaggctt acaagcacct ctggggacat ccagagggga gggtcagtaa
     4381 gcacaacgga gctagggaga cttcagatgg actcaaaccc agagcaataa tactctcaca
     4441 ccaccccaca gctaaggcac tcatgttccc cagtagatca agccagaagc tttgcaagaa
     4501 gggagtggaa cgaggctgcc tatccaaggt ccatctacca cgcagaactt ggtcatgcaa
     4561 gtacatttgg aaaatctggt cttggcccgt cccccattgg cctggtctac acagccaaaa
     4621 attcagacta gattagatgt ttgcaggcaa ttctgtagca aagcaaattc ccctaccccg
     4681 tcccttcccc ctagaagctg ccttagcctc cctgactggg tgtggtctct gggcctagga
     4741 ctcctcccta tgaggaaaag tgctctccag ccacatcttg gcagccccac aaccacagca
     4801 tcagggcagc tgcagcaagt gaccacccac ccgtcgggtt agacacacaa ggcaccaggc
     4861 actggcatct gactaaaata acctttccct acatgggaag aggaaagctt gtaggctggc
     4921 acatataaac gtccagccgc agccagatgg cctgaactaa gcagcaggaa ctctctgggc
     4981 tggggaggag cctcctgccc ttctagaaag tgatgcgtca gctttgttct cctgggaagg
     5041 tgttgctata ccccaggaac aaagcagggc ccaactgcca gtgcagtcag ctgggcctgc
     5101 gctccaggct caccaccgct aagtggtcag gtaccgggcc agcatcctgg gagggacctc
     5161 ttgcgactct gagttgcagc ttggactagc tgaacacatg gggacatgct ccaggggctt
     5221 cttccctggc aggattcctg ggatttcaaa ctacctcacc aacaggacgc tgaaccagga
     5281 gcctgccacc caactggccc ccttggtgat tgtggaaggt gatgtttttc ctaaaatgca
     5341 tccctcctgt tctgctccat atacatgtgc ttcaaaaacc accaccagga aagccttccc
     5401 agaagaggga aaggattaag ggctctcttc ctttgggccc tgcagaatgt attggaggga
     5461 ggtgttgctg caaggtccag gagctgggaa actctgggct cggggggaga taatgcacca
     5521 ccagcctcaa aaaggagctg cccaagttga atatgtagca aagaccatgg gataagttga
     5581 atagtggcca gacgaatcac taataactca ccatgggacc ctctgaagag aggcctgtgc
     5641 tcgtgtaacc atagcaacag cagatgccag caacctactc attagtacca cccagtgata
     5701 aggcatcccc tgggctagac ccaggggcca taaagtagca aagtagcaaa tgtagcaata
     5761 aagggcccgg gtctatacgg ggacagggtc caaatgacca ggacttggcc ctctccccag
     5821 ccccgatgag ggctcagagc cagctgctgt cagctgtctg gggagggaag gccctgctcc
     5881 ataccagggg tccctgttct atactctaag cccactcacc gcatgatcac ggactcatcg
     5941 gaatggcctc ctcttagtgc atgtggttct ctttagttta tttttctgga atttggggat
     6001 tggaccccag aaccaaacat gctggtacag tctaaaaata aatgacttga acccacttca
     6061 atcca
//
